{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:11:16Z","timestamp":1786997476454,"version":"build-2736575974"},"reference-count":28,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Ministry of Health, Labor and Welfare of Japan"},{"name":"Research on Measures for Intractable Disease","award":["2011-002"],"award-info":[{"award-number":["2011-002"]}]},{"name":"Research on Measures for Intractable Disease","award":["2014-063"],"award-info":[{"award-number":["2014-063"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","thrombosisresearch.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.thromres.2015.09.011","type":"journal-article","created":{"date-parts":[[2015,9,16]],"date-time":"2015-09-16T07:39:33Z","timestamp":1442389173000},"page":"1110-1115","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Thromboembolism as the adverse event of combined oral contraceptives in Japan"],"prefix":"10.1016","volume":"136","author":[{"given":"Kazuko","family":"Sugiura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Ojima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.thromres.2015.09.011_bb0005","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/S0140-6736(61)91061-3","article-title":"Pulmonary embolism","volume":"278","author":"Jordan","year":"1961","journal-title":"Lancet"},{"key":"10.1016\/j.thromres.2015.09.011_bb0010","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1016\/S0140-6736(95)91926-0","article-title":"Venous thromboembolic disease and combined oral contraceptives: results of international multicentre case\u2013control study","volume":"346","year":"1995","journal-title":"Lancet"},{"key":"10.1016\/j.thromres.2015.09.011_bb0015","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1016\/S0140-6736(95)91927-9","article-title":"Effect of different progestagens in low oestrogen oral contraceptives on venous thromboembolic disease","volume":"346","year":"1995","journal-title":"Lancet"},{"key":"10.1016\/j.thromres.2015.09.011_bb0020","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1016\/S0140-6736(95)91928-7","article-title":"Risk of idiopathic cardiovascular death and nonfatal venous thromboembolism in women using oral contraceptives with differing progestagen components","volume":"346","author":"Jick","year":"1995","journal-title":"Lancet"},{"key":"10.1016\/j.thromres.2015.09.011_bb0025","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1136\/bmj.321.7270.1190","article-title":"Risk of venous thromboembolism among users of third generation oral contraceptives compared with users of oral contraceptives with levonorgestrel before and after 1995: cohort and case\u2013control analysis","volume":"321","author":"Jick","year":"2000","journal-title":"BMJ"},{"key":"10.1016\/j.thromres.2015.09.011_bb0030","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1136\/bmj.312.7023.83","article-title":"Third generation oral contraceptives and risk of venous thromboembolic disorders: an international case\u2013control study","volume":"312","author":"Spitzer","year":"1996","journal-title":"BMJ"},{"key":"10.1016\/j.thromres.2015.09.011_bb0035","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0140-6736(96)07496-X","article-title":"Population-based study of risk of venous thromboembolism associated with various oral contraceptives","volume":"349","author":"Farmer","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.thromres.2015.09.011_bb0040","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0010-7824(01)00307-9","article-title":"Oral contraceptives and venous thromboembolism. A five-year national case\u2013control study","volume":"65","author":"Lidegaard","year":"2002","journal-title":"Contraception"},{"key":"10.1016\/j.thromres.2015.09.011_bb0045","doi-asserted-by":"crossref","first-page":"d6423","DOI":"10.1136\/bmj.d6423","article-title":"Risk of venous thromboembolism from use of oral contraceptives containing different progestogens and oestrogen doses: Danish cohort study, 2001\u20139","volume":"343","author":"Lidegaard","year":"2011","journal-title":"BMJ"},{"key":"10.1016\/j.thromres.2015.09.011_bb0050","doi-asserted-by":"crossref","first-page":"f5298","DOI":"10.1136\/bmj.f5298","article-title":"Different combined oral contraceptives and the risk of venous thrombosis: systematic review and network meta-analysis","volume":"347","author":"Stegeman","year":"2013","journal-title":"BMJ"},{"key":"10.1016\/j.thromres.2015.09.011_bb0055","doi-asserted-by":"crossref","first-page":"h2135","DOI":"10.1136\/bmj.h2135","article-title":"Use of combined oral contraceptives and risk of venous thromboembolism: nested case\u2013control studies using the QResearch and the CPRD databases","volume":"350","author":"Vinogradova","year":"2015","journal-title":"BMJ"},{"key":"10.1016\/j.thromres.2015.09.011_bb0060","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1093\/humupd\/5.6.672","article-title":"Biological coagulation findings in third-generation oral contraceptives","volume":"5","author":"Conard","year":"1999","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.thromres.2015.09.011_bb0065","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.1093\/humrep\/17.12.3235","article-title":"Effects of different progestin regimens in hormone replacement therapy on blood coagulation factor VII and tissue factor pathway inhibitor","volume":"17","author":"Bladbjerg","year":"2002","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.thromres.2015.09.011_bb0070","doi-asserted-by":"crossref","first-page":"13444","DOI":"10.1074\/jbc.M109.062430","article-title":"Down-regulation of PROS1 gene expression by 17beta-estradiol via estrogen receptor alpha (ERalpha)-Sp1 interaction recruiting receptor-interacting protein 140 and the corepressor-HDAC3 complex","volume":"285","author":"Suzuki","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.thromres.2015.09.011_bb0075","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.thromres.2014.04.004","article-title":"Oestrogen induced downregulation of TFPI expression is mediated by ER\u03b1","volume":"134","author":"Ali","year":"2014","journal-title":"Thromb. Res."},{"key":"10.1016\/j.thromres.2015.09.011_bb0080","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1111\/j.1538-7836.2007.02730.x","article-title":"Upregulation of protein S by progestins","volume":"5","author":"Hughes","year":"2007","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2015.09.011_bb0085","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1055\/s-2005-872431","article-title":"Thromboembolism during hormone therapy in Japanese women","volume":"31","author":"Adachi","year":"2005","journal-title":"Semin. Thromb. Hemost."},{"key":"10.1016\/j.thromres.2015.09.011_bb0090","first-page":"CD004861","article-title":"Progestogens in combined oral contraceptives for contraception","volume":"3","author":"Maitra","year":"2004","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.thromres.2015.09.011_bb0095","author":"FDA Drug Safety Communication"},{"key":"10.1016\/j.thromres.2015.09.011_bb0100","doi-asserted-by":"crossref","first-page":"e4944","DOI":"10.1136\/bmj.e4944","article-title":"Assessing the risk of venous thromboembolic events in women taking progestin-only contraception: a meta-analysis","volume":"345","author":"Mantha","year":"2012","journal-title":"BMJ"},{"key":"10.1016\/j.thromres.2015.09.011_bb0105","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/S0140-6736(01)06522-9","article-title":"Risk of venous thromboembolism with cyproterone or levonorgestrel contraceptives","volume":"358","author":"Vasilakis-Scaramozza","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.thromres.2015.09.011_bb0110","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.contraception.2014.01.023","article-title":"Cardiovascular and general safety of a 24-day regimen of drospirenone-containing combined oral contraceptives: final results from the international active surveillance study of women taking oral contraceptives","volume":"89","author":"Dinger","year":"2014","journal-title":"Contraception"},{"key":"10.1016\/j.thromres.2015.09.011_bb0115","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1056\/NEJMoa1111840","article-title":"Thrombotic stroke and myocardial infarction with hormonal contraception","volume":"366","author":"Lidegaard","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.thromres.2015.09.011_bb0120","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1253\/circj.CJ-13-0886","article-title":"Current venous thromboembolism management and outcomes in Japan","volume":"78","author":"Nakamura","year":"2014","journal-title":"Circ. J."},{"key":"10.1016\/j.thromres.2015.09.011_bb0125","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1253\/circj.71.772","article-title":"Unusual pulmonary embolism\u2013septic pulmonary embolism and amniotic fluid embolism\u2013","volume":"71","author":"Sakuma","year":"2007","journal-title":"Circ. J."},{"key":"10.1016\/j.thromres.2015.09.011_bb0130","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1253\/circj.71.1765","article-title":"Pulmonary embolism is an important cause of death in young adults","volume":"71","author":"Sakuma","year":"2007","journal-title":"Circ. J."},{"key":"10.1016\/j.thromres.2015.09.011_bb0135","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1253\/circj.72.753","article-title":"Pulmonary thromboembolism in obstetrics and gynecology increased by 6.5 fold over the last decade in Japan","volume":"72","author":"Kobayashi","year":"2008","journal-title":"Circ. J."},{"key":"10.1016\/j.thromres.2015.09.011_bb0140","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1253\/circj.CJ-08-0372","article-title":"Venous thromboembolism\u2013deep vein thrombosis with pulmonary embolism, deep vein thrombosis alone, pulmonary embolism alone\u2013","volume":"73","author":"Sakuma","year":"2009","journal-title":"Circ. J."}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384815301225?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384815301225?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T06:48:40Z","timestamp":1620802120000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049384815301225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["S0049384815301225"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2015.09.011","relation":{},"ISSN":["0049-3848"],"issn-type":[{"value":"0049-3848","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Thromboembolism as the adverse event of combined oral contraceptives in Japan","name":"articletitle","label":"Article Title"},{"value":"Thrombosis Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.thromres.2015.09.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}