{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T15:42:47Z","timestamp":1762875767457},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","thrombosisresearch.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.thromres.2016.02.025","type":"journal-article","created":{"date-parts":[[2016,2,27]],"date-time":"2016-02-27T12:21:51Z","timestamp":1456575711000},"page":"106-109","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Toll-like receptor 9 gene expression in the post-thrombotic syndrome, residual thrombosis and recurrent deep venous thrombosis: A case-control study"],"prefix":"10.1016","volume":"140","author":[{"given":"Y. Whitney","family":"Cheung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annemieke C.","family":"Bouman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Castoldi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone J.","family":"Wielders","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henri M.H.","family":"Spronk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo","family":"ten Cate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arina J.","family":"ten Cate-Hoek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marije","family":"ten Wolde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.thromres.2016.02.025_bb0005","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/S0140-6736(96)12215-7","article-title":"Randomised trial of effect of compression stockings in patients with symptomatic proximal-vein thrombosis","volume":"349","author":"Brandjes","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.thromres.2016.02.025_bb0010","first-page":"423","article-title":"The clinical course of deep-vein thrombosis. prospective long-term follow-up of 528 symptomatic patients","volume":"82","author":"Prandoni","year":"1997","journal-title":"Haematologica"},{"key":"10.1016\/j.thromres.2016.02.025_bb0015","doi-asserted-by":"crossref","first-page":"698","DOI":"10.7326\/0003-4819-149-10-200811180-00004","article-title":"Determinants and time course of the postthrombotic syndrome after acute deep venous thrombosis","volume":"149","author":"Kahn","year":"2008","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.thromres.2016.02.025_bb0020","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/j.1365-2141.2009.07601.x","article-title":"Post-thrombotic syndrome: prevalence, prognostication and need for progress","volume":"145","author":"Prandoni","year":"2009","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.thromres.2016.02.025_bb0025","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1111\/j.1538-7836.2009.03294.x","volume":"7","author":"Kahn","year":"2009","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2016.02.025_bb0030","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s11739-009-0336-2","article-title":"The postthrombotic syndrome","volume":"5","author":"Pesavento","year":"2010","journal-title":"Intern. Emerg. Med."},{"key":"10.1016\/j.thromres.2016.02.025_bb0035","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.jvs.2010.08.050","article-title":"An update on etiology, prevention, and therapy of postthrombotic syndrome","volume":"53","author":"Henke","year":"2011","journal-title":"J. Vasc. Surg."},{"issue":"Suppl. 3","key":"10.1016\/j.thromres.2016.02.025_bb0040","doi-asserted-by":"crossref","first-page":"S89","DOI":"10.1016\/S0049-3848(11)70024-X","article-title":"The post thrombotic syndrome","volume":"127","author":"Kahn","year":"2011","journal-title":"Thromb. Res."},{"issue":"Suppl A","key":"10.1016\/j.thromres.2016.02.025_bb0045","doi-asserted-by":"crossref","first-page":"A116","DOI":"10.1016\/j.jvs.2007.02.034","article-title":"Molecular characterization of post-thrombotic syndrome","volume":"45","author":"Phillips","year":"2007","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.thromres.2016.02.025_bb0050","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jvs.2010.07.043","article-title":"Postthrombotic vein wall remodeling: preliminary observations","volume":"53","author":"Deatrick","year":"2011","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.thromres.2016.02.025_bb0055","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.it.2004.04.011","article-title":"The immunobiology of the TLR9 subfamily","volume":"25","author":"Wagner","year":"2004","journal-title":"Trends Immunol."},{"key":"10.1016\/j.thromres.2016.02.025_bb0060","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1160\/TH14-12-1031","article-title":"Divergent effects of Tlr9 deletion in experimental late venous thrombosis resolution and vein wall injury","volume":"114","author":"Dewyer","year":"2015","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.thromres.2016.02.025_bb0065","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1161\/ATVBAHA.110.216317","article-title":"Toll-like receptor 9 signaling is critical for early experimental deep vein thrombosis resolution","volume":"31","author":"Henke","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.thromres.2016.02.025_bb0070","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1111\/j.1538-7836.2009.03339.x","article-title":"Measurement properties of the Villalta scale to define and classify the severity of the post-thrombotic syndrome","volume":"7","author":"Kahn","year":"2009","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2016.02.025_bb0075","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1186\/1756-0500-4-427","article-title":"Selection of reliable reference genes for quantitative real-time PCR in human T cells and neutrophils","volume":"4","author":"Ledderose","year":"2011","journal-title":"BMC Res Notes"},{"key":"10.1016\/j.thromres.2016.02.025_bb0080","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.thromres.2014.06.010","article-title":"Biomarkers for post thrombotic syndrome: a case-control study","volume":"134","author":"Bouman","year":"2014","journal-title":"Thromb. Res."},{"key":"10.1016\/j.thromres.2016.02.025_bb0085","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.thromres.2015.06.024","article-title":"Predictive value of markers of inflammation in the postthrombotic syndrome: a systematic review: inflammatory biomarkers and PTS","volume":"136","author":"Rabinovich","year":"2015","journal-title":"Thromb. Res."},{"key":"10.1016\/j.thromres.2016.02.025_bb0090","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.jvs.2004.07.004","article-title":"C-reactive protein and red cell aggregation correlate with late venous function after acute deep venous thrombosis","volume":"40","author":"Krieger","year":"2004","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.thromres.2016.02.025_bb0095","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.thromres.2014.12.024","article-title":"Long-term increased factor VIII levels are associated to interleukin-6 levels but not to post-thrombotic syndrome in patients with deep venous thrombosis","volume":"135","author":"Bittar","year":"2015","journal-title":"Thromb. Res."},{"key":"10.1016\/j.thromres.2016.02.025_bb0100","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1177\/1076029612462760","article-title":"Severe post-thrombotic syndrome is associated with higher levels of factor VIII","volume":"19","author":"Bittar","year":"2013","journal-title":"Clin. Appl. Thromb. Hemost."},{"key":"10.1016\/j.thromres.2016.02.025_bb0105","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1111\/j.1538-7836.2012.04798.x","article-title":"Markers of coagulation, fibrinolysis and inflammation in relation to post-thrombotic syndrome","volume":"10","author":"Bouman","year":"2012","journal-title":"J. Thromb. Haemost."}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384816300536?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384816300536?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,14]],"date-time":"2018-09-14T20:57:35Z","timestamp":1536958655000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049384816300536"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":21,"alternative-id":["S0049384816300536"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2016.02.025","relation":{},"ISSN":["0049-3848"],"issn-type":[{"value":"0049-3848","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Toll-like receptor 9 gene expression in the post-thrombotic syndrome, residual thrombosis and recurrent deep venous thrombosis: A case-control study","name":"articletitle","label":"Article Title"},{"value":"Thrombosis Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.thromres.2016.02.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}