{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T03:53:40Z","timestamp":1793505220449,"version":"4.5.0"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","thrombosisresearch.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.thromres.2017.07.024","type":"journal-article","created":{"date-parts":[[2017,7,25]],"date-time":"2017-07-25T01:46:27Z","timestamp":1500947187000},"page":"129-135","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Post-thrombotic syndrome in children"],"prefix":"10.1016","volume":"164","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6725-3035","authenticated-orcid":false,"given":"Marisol","family":"Betensky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil A.","family":"Goldenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.thromres.2017.07.024_bb0005","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.hoc.2009.11.005","article-title":"Venous thromboembolism in children","volume":"24","author":"Goldenberg","year":"2010","journal-title":"Hematol. Oncol. Clin. North Am."},{"issue":"4","key":"10.1016\/j.thromres.2017.07.024_bb0010","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1542\/peds.2009-0768","article-title":"Dramatic increase in venous thromboembolism in children's hospitals in the United States from 2001 to 2007","volume":"124","author":"Raffini","year":"2009","journal-title":"Pediatrics"},{"issue":"2","key":"10.1016\/j.thromres.2017.07.024_bb0015","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1002\/pbc.23388","article-title":"Pediatric venous thromboembolism in the United States: a tertiary care complication of chronic diseases","volume":"59","author":"Setty","year":"2012","journal-title":"Pediatr. Blood Cancer"},{"issue":"4\u20135","key":"10.1016\/j.thromres.2017.07.024_bb0020","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.thromres.2003.09.008","article-title":"A cross-sectional study evaluating post-thrombotic syndrome in children","volume":"111","author":"Kuhle","year":"2003","journal-title":"Thromb. Res."},{"issue":"11","key":"10.1016\/j.thromres.2017.07.024_bb0025","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.3324\/haematol.2010.026989","article-title":"Post-thrombotic syndrome in children: a systematic review of frequency of occurrence, validity of outcome measures, and prognostic factors","volume":"95","author":"Goldenberg","year":"2010","journal-title":"Haematologica"},{"issue":"3","key":"10.1016\/j.thromres.2017.07.024_bb0030","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1002\/pbc.24840","article-title":"Health-related quality of life in children and young adults with post-thrombotic syndrome: results from a cross-sectional study","volume":"61","author":"Kumar","year":"2014","journal-title":"Pediatr. Blood Cancer"},{"issue":"3","key":"10.1016\/j.thromres.2017.07.024_bb0035","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1111\/jth.12809","volume":"13","author":"Rajpurkar","year":"2015","journal-title":"J. Thromb. Haemost."},{"issue":"2","key":"10.1016\/j.thromres.2017.07.024_bb0040","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0741-5214(95)70271-7","article-title":"Relationship between changes in deep venous system and the development of the postthrombotic syndrome after an acute episode of lower limb vein thrombosis: a one-to-six year follow up","volume":"21","author":"Johnson","year":"1995","journal-title":"J. Vasc. Surg."},{"issue":"2","key":"10.1016\/j.thromres.2017.07.024_bb0045","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1067\/mva.2002.121066","article-title":"Coagulation, fibrinolysis, and recanalization after acute deep venous thrombosis","volume":"35","author":"Meissner","year":"2002","journal-title":"J. Vasc. Surg."},{"issue":"3","key":"10.1016\/j.thromres.2017.07.024_bb0050","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1053\/j.semvascsurg.2005.05.003","article-title":"The role of inflammation in early and late venous thrombosis: are there clinical implications?","volume":"18","author":"Wakefield","year":"2005","journal-title":"Semin. Vasc. Surg."},{"issue":"4","key":"10.1016\/j.thromres.2017.07.024_bb0055","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1067\/mva.2002.121746","article-title":"Inflammatory response in the acute phase of deep venous thrombosis","volume":"35","author":"Roumen-Klappe","year":"2002","journal-title":"J. Vasc. Surg."},{"issue":"3\u20134","key":"10.1016\/j.thromres.2017.07.024_bb0060","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1159\/000090937","article-title":"Postthrombotic syndrome in children","volume":"115","author":"Manco-Johnson","year":"2006","journal-title":"Acta Haematol."},{"issue":"3","key":"10.1016\/j.thromres.2017.07.024_bb0065","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0268-960X(02)00008-5","article-title":"The post-thrombotic syndrome: current knowledge, controversies, and directions for future research","volume":"16","author":"Kahn","year":"2002","journal-title":"Blood Rev."},{"issue":"3","key":"10.1016\/j.thromres.2017.07.024_bb0070","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/jth.12814","article-title":"Inflammation markers and their trajectories after deep venous thrombosis in relation to risk of post-thrombotic syndrome","volume":"13","author":"Rabinovich","year":"2015","journal-title":"J. Thromb. Heamost."},{"issue":"3","key":"10.1016\/j.thromres.2017.07.024_bb0075","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.thromres.2014.12.024","article-title":"Long-term increased factor VIII levels are associated to interleukin-6 levels but not to post-thrombotic syndrome in patients with deep venous thrombosis","volume":"135","author":"Bittar","year":"2015","journal-title":"Thromb. Res."},{"issue":"3","key":"10.1016\/j.thromres.2017.07.024_bb0080","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1160\/TH08-08-0511","article-title":"Levels of inflammatory markers and the development of the post-thrombotic syndrome","volume":"101","author":"Shbaklo","year":"2009","journal-title":"Thromb. Haemost."},{"issue":"5","key":"10.1016\/j.thromres.2017.07.024_bb0085","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/S0741-5214(03)00431-2","article-title":"Neutropenia impairs venous thrombosis resolution in the rat","volume":"38","author":"Varma","year":"2003","journal-title":"J. Vasc. Surg."},{"issue":"5","key":"10.1016\/j.thromres.2017.07.024_bb0090","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/S0741-5214(99)70014-5","article-title":"Monocyte chemotactic protein-1 (MCP-1) accelerates the organization and resolution of venous thrombi","volume":"30","author":"Humphries","year":"1999","journal-title":"J. Vasc. Surg."},{"issue":"8","key":"10.1016\/j.thromres.2017.07.024_bb0095","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1161\/01.ATV.0000227510.36653.ed","article-title":"Familial elevated factor VIII in children with symptomatic venous thrombosis and post-thrombotic syndrome: results of a multicenter study","volume":"26","author":"Kreuz","year":"2006","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"2","key":"10.1016\/j.thromres.2017.07.024_bb0100","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.thromres.2014.12.005","article-title":"Prevalence and risk factors for post thrombotic syndrome after deep vein thrombosis in children: a cohort study","volume":"135","author":"Kumar","year":"2015","journal-title":"Thromb. Res."},{"issue":"4","key":"10.1016\/j.thromres.2017.07.024_bb0105","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/MPH.0b013e318162bcf5","article-title":"Post-thrombotic syndrome in children: a single center experience","volume":"30","author":"Sharathkumar","year":"2008","journal-title":"J. Pediatr. Hematol. Oncol."},{"issue":"7","key":"10.1016\/j.thromres.2017.07.024_bb0110","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1002\/pbc.25438","article-title":"Prevalence of post-thrombotic syndrome after cardiac catheterization","volume":"62","author":"Luceri","year":"2015","journal-title":"Pediatr. Blood Cancer"},{"issue":"11","key":"10.1016\/j.thromres.2017.07.024_bb0115","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1056\/NEJMoa040161","article-title":"Mountain States Regional Thrombophilia Group. Elevated plasma factor VIII and D-dimer levels as predictors of poor outcomes of thrombosis in children","volume":"351","author":"Goldenberg","year":"2004","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.thromres.2017.07.024_bb0120","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.thromres.2012.10.012","article-title":"Acute prognostic factors for post-thrombotic syndrome in children with limb DVT: a bi-institutional cohort study","volume":"131","author":"Lyle","year":"2013","journal-title":"Thromb. Res."},{"issue":"6","key":"10.1016\/j.thromres.2017.07.024_bb0125","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/j.jpedsurg.2008.02.036","article-title":"Determination of risk factors for deep venous thrombosis in hospitalized children","volume":"43","author":"Vu","year":"2008","journal-title":"J. Pediatr. Surg."},{"issue":"5 Pt 1","key":"10.1016\/j.thromres.2017.07.024_bb0130","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1542\/peds.96.5.939","article-title":"Neonatal thrombosis: report of a prospective Canadian and international registry","volume":"96","author":"Schmidt","year":"1995","journal-title":"Pediatrics"},{"issue":"2","key":"10.1016\/j.thromres.2017.07.024_bb0135","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/pbc.25302","article-title":"Post-thrombotic syndrome after central venous catheter removal in childhood cancer survivors: a prospective cohort study","volume":"62","author":"Polen","year":"2015","journal-title":"Pediatr. Blood Cancer"},{"issue":"1","key":"10.1016\/j.thromres.2017.07.024_bb0140","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/pbc.22459","article-title":"Post-thrombotic syndrome after central venous catheter removal in childhood cancer survivors is associated with a history of obstruction","volume":"55","author":"Revel-Vilk","year":"2010","journal-title":"Pediatr. Blood Cancer"},{"issue":"14","key":"10.1016\/j.thromres.2017.07.024_bb0145","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1182\/blood-2016-03-704585","article-title":"Postthrombotic syndrome and other outcomes of lower extremity deep vein thrombosis in children","volume":"128","author":"Avila","year":"2016","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.thromres.2017.07.024_bb0150","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1182\/blood-2014-04-570531","article-title":"Postthrombotic syndrome following upper extremity deep vein thrombosis in children","volume":"124","author":"Avila","year":"2014","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.thromres.2017.07.024_bb0155","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1111\/j.1538-7836.2012.04798.x","article-title":"Markers of coagulation, fibrinolysis and inflammation in relation to post-thrombotic syndrome","volume":"10","author":"Bouman","year":"2012","journal-title":"J. Thromb. Haemost."},{"issue":"4","key":"10.1016\/j.thromres.2017.07.024_bb0160","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1111\/j.1538-7836.2009.03286.x","article-title":"Inflammation in deep vein thrombosis and the development of post-thrombotic syndrome: a prospective study","volume":"7","author":"Roumen-Klappe","year":"2009","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2017.07.024_bb0165","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1182\/asheducation-2016.1.413","article-title":"The post-thrombotic syndrome","volume":"1","author":"Kahn","year":"2016","journal-title":"Hematology Am. Soc. Hematol. Educ. Program"},{"issue":"6","key":"10.1016\/j.thromres.2017.07.024_bb0170","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1067\/mva.2000.107094","article-title":"Venous severity scoring: an adjunct to venous outcome assessment","volume":"31","author":"Rutherford","year":"2000","journal-title":"J. Vasc. Surg."},{"issue":"1","key":"10.1016\/j.thromres.2017.07.024_bb0175","first-page":"9","article-title":"Pain in children: comparison of assessment scales","volume":"14","author":"Wong","year":"1988","journal-title":"Pediatr. Nurs."},{"issue":"1","key":"10.1016\/j.thromres.2017.07.024_bb0180","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1182\/blood-2006-12-061234","article-title":"A thrombolytic regimen for high-risk deep venous thrombosis may substantially reduce the risk of postthrombotic syndrome in children","volume":"110","author":"Goldenberg","year":"2007","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.thromres.2017.07.024_bb0185","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.jpeds.2010.07.003","article-title":"Validation of upper extremity post-thrombotic syndrome outcome measurement in children","volume":"157","author":"Goldenberg","year":"2010","journal-title":"J. Pediatr."},{"issue":"8","key":"10.1016\/j.thromres.2017.07.024_bb0190","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1097\/MPH.0000000000000399","article-title":"Comparison of 3 postthrombotic syndrome assessment scales demonstrates significant variability in children and adolescents with deep vein thrombosis","volume":"37","author":"Raffini","year":"2015","journal-title":"J. Pediatr. Hematol. Oncol."},{"issue":"9","key":"10.1016\/j.thromres.2017.07.024_bb0195","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1111\/jth.13038","article-title":"Kids-DOTT Trial Investigators. Multicenter randomized controlled trial on Duration of Therapy for Thrombosis in Children and Young Adults (the Kids-DOTT trial): pilot\/feasibility phase findings","volume":"13","author":"Goldenberg","year":"2015","journal-title":"J. Thromb. Haemost."},{"issue":"5","key":"10.1016\/j.thromres.2017.07.024_bb0200","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1111\/j.1538-7836.2009.03339.x","article-title":"Measurement properties of the Villalta scale to define and classify the severity of the post-thrombotic syndrome","volume":"7","author":"Kahn","year":"2009","journal-title":"J. Thromb. Haemost."},{"issue":"4","key":"10.1016\/j.thromres.2017.07.024_bb0205","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1111\/j.1538-7836.2008.02901.x","article-title":"Prevalence of post-thrombotic syndrome following asymptomatic thrombosis in survivors of acute lymphoblastic leukemia","volume":"6","author":"Kuhle","year":"2008","journal-title":"J. Thromb. Haemost."},{"issue":"6","key":"10.1016\/j.thromres.2017.07.024_bb0210","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1111\/j.1365-2516.2011.02515.x","article-title":"Deep venous thrombosis screening in patients with inherited bleeding disorders and central venous catheters","volume":"17","author":"Cost","year":"2011","journal-title":"Haemophilia"},{"issue":"3","key":"10.1016\/j.thromres.2017.07.024_bb0215","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1111\/j.1538-7836.2011.04594.x","article-title":"Definition of post-thrombotic syndrome following lower extremity deep venous thrombosis and standardization of outcome measurement in pediatric clinical investigations","volume":"10","author":"Goldenberg","year":"2012","journal-title":"J. Thromb. Haemost."},{"issue":"18","key":"10.1016\/j.thromres.2017.07.024_bb0220","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1161\/CIR.0000000000000130","article-title":"The post-thrombotic syndrome: evidence-based prevention, diagnosis, and treatment strategies: a scientific statement from the American Heart Association","volume":"130","author":"Kahn","year":"2014","journal-title":"Circulation"},{"issue":"7","key":"10.1016\/j.thromres.2017.07.024_bb0225","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1111\/j.1538-7836.2012.04779.x","article-title":"Risk-prediction tool for identifying hospitalized children with a predisposition for development of venous thrombo-embolism: Peds-Clot clinical Decision Rule","volume":"10","author":"Sharathkumar","year":"2012","journal-title":"J. Thromb. Haemost."},{"issue":"12","key":"10.1016\/j.thromres.2017.07.024_bb0230","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1542\/hpeds.2014-0241","article-title":"Development and implementation results of a Venous Thromboembolism Prophylaxis Guideline in a tertiary care pediatric hospital","volume":"5","author":"Mahajerin","year":"2015","journal-title":"Hosp. Pediatr."},{"issue":"5","key":"10.1016\/j.thromres.2017.07.024_bb0235","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1067\/mpd.2001.118192","article-title":"Venous thromboembolism in childhood: a prospective two-year registry in The Netherlands","volume":"139","author":"van Ommen","year":"2001","journal-title":"J. Pediatr."},{"issue":"8","key":"10.1016\/j.thromres.2017.07.024_bb0240","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.amjmed.2010.01.027","article-title":"Venous compression for prevention of postthrombotic syndrome: a meta-analysis","volume":"123","author":"Musani","year":"2010","journal-title":"Am. J. Med."},{"issue":"9938","key":"10.1016\/j.thromres.2017.07.024_bb0245","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0140-6736(14)61159-4","article-title":"Compression stockings to prevent post-thrombotic syndrome","volume":"384","author":"Labropoulos","year":"2014","journal-title":"Lancet"},{"issue":"2 Suppl","key":"10.1016\/j.thromres.2017.07.024_bb0250","doi-asserted-by":"crossref","first-page":"e737S","DOI":"10.1378\/chest.11-2308","article-title":"Antithrombotic therapy in neonates and children: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines","volume":"141","author":"Monagle","year":"2012","journal-title":"Chest"},{"issue":"10","key":"10.1016\/j.thromres.2017.07.024_bb0255","doi-asserted-by":"crossref","first-page":"e190","DOI":"10.1111\/j.1440-1754.2012.02579.x","article-title":"An adolescent patient with post-thrombotic syndrome achieves excellence in sport","volume":"48","author":"Jones","year":"2012","journal-title":"J. Paediatr. Child Health"},{"issue":"3","key":"10.1016\/j.thromres.2017.07.024_bb0260","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1002\/pbc.22077","article-title":"The use of elastic compression stockings for post-thrombotic syndrome in a child","volume":"53","author":"Biss","year":"2009","journal-title":"Pediatr. Blood Cancer"},{"issue":"Suppl. 4","key":"10.1016\/j.thromres.2017.07.024_bb0265","doi-asserted-by":"crossref","first-page":"S62","DOI":"10.1016\/S0049-3848(09)70146-X","article-title":"Valvular dysfunction and venous obstruction in the post-thrombotic syndrome","volume":"123","author":"Vedantham","year":"2009","journal-title":"Thromb. Res."},{"issue":"3","key":"10.1016\/j.thromres.2017.07.024_bb0270","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.jvs.2011.10.032","article-title":"Postthrombotic morbidity correlates with residual thrombus following catheter-directed thrombolysis for iliofemoral deep vein thrombosis","volume":"55","author":"Comerota","year":"2012","journal-title":"J. Vasc. Surg."},{"issue":"2","key":"10.1016\/j.thromres.2017.07.024_bb0275","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jvir.2010.10.013","article-title":"Percutaneous mechanical and pharmacomechanical thrombolysis for occlusive deep vein thrombosis of the proximal limb in adolescent subjects: findings from an institution-based prospective inception cohort study of pediatric venous thromboembolism","volume":"22","author":"Goldenberg","year":"2011","journal-title":"J. Vasc. Interv. Radiol."},{"issue":"2 Suppl","key":"10.1016\/j.thromres.2017.07.024_bb0280","doi-asserted-by":"crossref","first-page":"e419S","DOI":"10.1378\/chest.11-2301","article-title":"Antithrombotic therapy for VTE disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines","volume":"141","author":"Kearon","year":"2012","journal-title":"Chest"},{"issue":"3","key":"10.1016\/j.thromres.2017.07.024_bb0285","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1055\/s-0038-1651011","article-title":"A double blind three center clinical trial on the short-term efficacy of 0-(beta-hydroxyethyl)-rutosides in patients with post-thrombotic syndrome","volume":"62","author":"de Jongste","year":"1989","journal-title":"Thromb. Haemost."},{"issue":"2","key":"10.1016\/j.thromres.2017.07.024_bb0290","first-page":"100","article-title":"Effects of defibrotide in patients with chronic deep insufficiency. The PROVEDIS study","volume":"23","author":"Coccheri","year":"2004","journal-title":"Int. Angiol."},{"issue":"1","key":"10.1016\/j.thromres.2017.07.024_bb0295","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1055\/s-0037-1616166","article-title":"Elastic stockings, hydroxyethylrutosides or both for the treatment of post-thrombotic syndrome","volume":"93","author":"Prandoni","year":"2005","journal-title":"Thromb. Haemost."},{"issue":"1","key":"10.1016\/j.thromres.2017.07.024_bb0300","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1177\/026835559400900111","article-title":"A prospective study of the long-term efficacy of two different venoactive drugs in patients with post-thrombotic syndrome","volume":"9","author":"Monreal","year":"1994","journal-title":"Phlebology"},{"key":"10.1016\/j.thromres.2017.07.024_bb0305","first-page":"11","article-title":"Horse chestnut seed extract for chronic venous insufficiency","volume":"14","author":"Pittler","year":"2012","journal-title":"Cochrane Database Syst. Rev."},{"issue":"1","key":"10.1016\/j.thromres.2017.07.024_bb0310","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jvs.2003.09.036","article-title":"Structured exercise improves calf muscle pump function in chronic venous insufficiency: a randomized trial","volume":"39","author":"Padberg","year":"2004","journal-title":"J. Vasc. Surg."},{"issue":"1","key":"10.1016\/j.thromres.2017.07.024_bb0315","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1503\/cmaj.100248","article-title":"Six-month exercise training program to treat post-thrombotic syndrome: a randomized controlled two-centre trial","volume":"183","author":"Kahn","year":"2011","journal-title":"CMAJ"}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384817304358?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384817304358?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,31]],"date-time":"2022-07-31T12:21:57Z","timestamp":1659270117000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049384817304358"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":63,"alternative-id":["S0049384817304358"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2017.07.024","relation":{},"ISSN":["0049-3848"],"issn-type":[{"value":"0049-3848","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Post-thrombotic syndrome in children","name":"articletitle","label":"Article Title"},{"value":"Thrombosis Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.thromres.2017.07.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}