{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T14:33:54Z","timestamp":1768314834049,"version":"3.49.0"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100010198","name":"Ministerio de Econom\u00eda, Industria y Competitividad","doi-asserted-by":"crossref","award":["PI11\/00246"],"award-info":[{"award-number":["PI11\/00246"]}],"id":[{"id":"10.13039\/501100010198","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","thrombosisresearch.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.thromres.2017.12.002","type":"journal-article","created":{"date-parts":[[2017,12,6]],"date-time":"2017-12-06T04:04:21Z","timestamp":1512533061000},"page":"1-6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Diclofenac for reversal of right ventricular dysfunction in acute normotensive pulmonary embolism: A pilot study"],"prefix":"10.1016","volume":"162","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4571-7721","authenticated-orcid":false,"given":"David","family":"Jimenez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Nieto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas","family":"Corres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Covadonga","family":"Fern\u00e1ndez-Golf\u00edn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deisy","family":"Barrios","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel","family":"Morillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Andres","family":"Quezada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Menno","family":"Huisman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger D.","family":"Yusen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Kline","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.thromres.2017.12.002_bb0005","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0008-6363(00)00168-1","article-title":"Pathophysiology and treatment of haemodynamic instability in acute pulmonary embolism: the pivotal role of pulmonary vasoconstriction","volume":"48","author":"Smulders","year":"2000","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.thromres.2017.12.002_bb0010","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1111\/j.1553-2712.2008.00203.x","article-title":"Direct comparison of the diagnostic accuracy of fifty protein biological markers of pulmonary embolism for use in the emergency department","volume":"15","author":"Nordenholz","year":"2008","journal-title":"Acad. Emerg. Med."},{"key":"10.1016\/j.thromres.2017.12.002_bb0015","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1111\/j.1553-2712.2008.00204.x","article-title":"Tandem measurement of d-dimer and myeloperoxidase of C-reactive protein to effectively screen for pulmonary embolism in the emergency department","volume":"15","author":"Mitchell","year":"2008","journal-title":"Acad. Emerg. Med."},{"key":"10.1016\/j.thromres.2017.12.002_bb0020","doi-asserted-by":"crossref","first-page":"454S","DOI":"10.1378\/chest.08-0658","article-title":"Antithrombotic therapy for venous thromboembolic disease: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th edition)","volume":"133","author":"Kearon","year":"2008","journal-title":"Chest"},{"key":"10.1016\/j.thromres.2017.12.002_bb0025","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1161\/01.CIR.77.2.353","article-title":"Intravenous and intrapulmonary recombinant tissue-type plasminogen activator in the treatment of acute massive pulmonary embolism","volume":"77","author":"Verstraete","year":"1988","journal-title":"Circulation"},{"key":"10.1016\/j.thromres.2017.12.002_bb0030","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1001\/jama.2014.5990","article-title":"Thrombolysis for pulmonary embolism and risk of all-cause mortality, major bleeding, and intracraneal hemorrhage","volume":"311","author":"Chatterjee","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.thromres.2017.12.002_bb0035","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1093\/eurheartj\/ehu218","article-title":"Systemic thrombolytic therapy for acute pulmonary embolism: a systematic review and metaanalysis","volume":"36","author":"Marti","year":"2015","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.thromres.2017.12.002_bb0040","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.jacc.2010.05.071","article-title":"Clinical characteristics, management, and outcomes of patients diagnosed with acute pulmonary embolism in the emergency department initial report of EMPEROR (Multicenter Emergency Medicine Pulmonary Embolism in the Real World Registry)","volume":"57","author":"Pollack","year":"2011","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.thromres.2017.12.002_bb0045","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1097\/FJC.0b013e3181b2b699","article-title":"Proinflammatory events in right ventricular damage during pulmonary embolism: effects of treatment with ketorolac in rats","volume":"54","author":"Watts","year":"2009","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.thromres.2017.12.002_bb0050","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1001\/jama.1990.03440200057023","article-title":"Value of ventilation\/perfusion scan in acute pulmonary embolism: results of the prospective investigation of the pulmonary embolism diagnosis (PIOPED)","volume":"263","author":"PIOPED Investigators","year":"1990","journal-title":"JAMA"},{"key":"10.1016\/j.thromres.2017.12.002_bb0055","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1148\/radiology.185.2.1410342","article-title":"Central pulmonary thromboembolism: diagnosis with spiral volumetric CT with the single-breath-hold-technique-comparison with pulmonary angiography","volume":"185","author":"Remy-Jardin","year":"1992","journal-title":"Radiology"},{"key":"10.1016\/j.thromres.2017.12.002_bb0060","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1093\/eurheartj\/ehr108","article-title":"Multidetector computed tomography for acute pulmonary embolism: diagnosis and risk stratification in a single test","volume":"32","author":"Becattini","year":"2011","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.thromres.2017.12.002_bb0065","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1111\/j.1538-7836.2005.01204.x","article-title":"Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients","volume":"3","author":"Schulman","year":"2005","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2017.12.002_bb0070","doi-asserted-by":"crossref","first-page":"e82","DOI":"10.1016\/j.thromres.2009.09.017","article-title":"Bolus tenecteplase for right ventricular dysfunction in hemodynamically stable patients with pulmonary embolism","volume":"125","author":"Becattini","year":"2010","journal-title":"Thromb. Res."},{"key":"10.1016\/j.thromres.2017.12.002_bb0075","first-page":"307","article-title":"Measurement in medicine: the analysis of method comparison studies","volume":"32","author":"Altman","year":"1983","journal-title":"Underst. Stat."},{"key":"10.1016\/j.thromres.2017.12.002_bb0080","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.2174\/138945006778559102","article-title":"Cyclooxygenase inhibition and atherothrombosis","volume":"7","author":"Sohn","year":"2006","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.thromres.2017.12.002_bb0085","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1001\/archinternmed.2008.525","article-title":"Increased mortality and cardiovascular morbidity associated with use of nonsteroidal antiinflammatory drugs in chronic heart failure","volume":"169","author":"Gislason","year":"2009","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.thromres.2017.12.002_bb0090","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1161\/CIRCOUTCOMES.108.805689","article-title":"Cardiovascular risks of nonsteroidal antiinflammatory drugs in patients after hospitalization for serious coronary heart disease","volume":"2","author":"Ray","year":"2009","journal-title":"Circ. Cardiovasc. Qual. Outcomes"},{"key":"10.1016\/j.thromres.2017.12.002_bb0095","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1185\/03007995.2010.486301","article-title":"Diclofenac: an update on its mechanism of action and safety profile","volume":"26","author":"Gan","year":"2010","journal-title":"Curr. Med. Res. Opin."},{"key":"10.1016\/j.thromres.2017.12.002_bb0100","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1111\/j.1365-2044.1990.tb14450.x","article-title":"Intravenous diclofenac sodium. Does its administration before operation suppress postoperative pain?","volume":"45","author":"Campbell","year":"1990","journal-title":"Anaesthesia"},{"key":"10.1016\/j.thromres.2017.12.002_bb0105","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1111\/j.1399-6576.1993.tb03776.x","article-title":"Effect of intravenous diclofenac or indomethacin on the emergence from anaesthesia for tonsillectomy","volume":"37","author":"Rorarius","year":"1993","journal-title":"Acta Anaesthesiol. Scand."},{"key":"10.1016\/j.thromres.2017.12.002_bb0110","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1001\/jamainternmed.2014.946","article-title":"Bleeding risk of patients with acute venous thromboembolism taking nonsteroidal anti-inflammatory drugs or aspirin","volume":"174","author":"Davidson","year":"2014","journal-title":"JAMA Intern. Med."},{"key":"10.1016\/j.thromres.2017.12.002_bb0115","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1093\/eurheartj\/ehn208","article-title":"Prognostic value of right ventricular dysfunction in patients with haemodynamically stable pulmonary embolism: a systematic review","volume":"29","author":"Sanchez","year":"2008","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.thromres.2017.12.002_bb0120","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1161\/CIRCULATIONAHA.113.005544","article-title":"Randomized, controlled trial of ultrasound-assisted catheter-directed thrombolysis for acute intermediate-risk pulmonary embolism","volume":"129","author":"Kucher","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.thromres.2017.12.002_bb0125","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.1001\/archinte.1997.00440430026003","article-title":"Thrombolytic therapy for pulmonary embolism: is it effective? Is it safe? When is it indicated?","volume":"157","author":"Dalen","year":"1997","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.thromres.2017.12.002_bb0130","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.echo.2010.05.010","volume":"23","author":"Rudski","year":"2010","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"10.1016\/j.thromres.2017.12.002_bb0135","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1164\/rccm.201311-2040OC","article-title":"On behalf of the protect investigators. Derivation and validation of multimarker prognostication for normotensive patients with acute symptomatic pulmonary embolism","volume":"189","author":"Jim\u00e9nez","year":"2014","journal-title":"Am. J. Respir. Crit. Care Med."}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384817305881?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384817305881?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T10:51:53Z","timestamp":1620816713000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049384817305881"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":27,"alternative-id":["S0049384817305881"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2017.12.002","relation":{},"ISSN":["0049-3848"],"issn-type":[{"value":"0049-3848","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diclofenac for reversal of right ventricular dysfunction in acute normotensive pulmonary embolism: A pilot study","name":"articletitle","label":"Article Title"},{"value":"Thrombosis Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.thromres.2017.12.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}