{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:32:10Z","timestamp":1791909130875,"version":"4.3.4"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","thrombosisresearch.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.thromres.2018.04.015","type":"journal-article","created":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T02:11:34Z","timestamp":1524103894000},"page":"96-105","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Differential sensitivity of von Willebrand factor activity assays to reduced VWF molecular weight forms: A large international cross-laboratory study"],"prefix":"10.1016","volume":"166","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2103-1661","authenticated-orcid":false,"given":"Emmanuel J.","family":"Favaloro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roslyn","family":"Bonar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine J.","family":"Hollestelle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Jennings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soma","family":"Mohammed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piet","family":"Meijer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Woods","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel","family":"Meiring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.thromres.2018.04.015_bb0005","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/bjh.13064","article-title":"The diagnosis and management of von Willebrand disease: a United Kingdom Haemophilia Centre Doctors Organization guideline approved by the British Committee for Standards in Haematology","volume":"167","author":"Laffan","year":"2014","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.thromres.2018.04.015_bb0010","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1111\/j.1538-7836.2006.02146.x","article-title":"Update on the pathophysiology and classification of von Willebrand disease: a report of the Subcommittee on von Willebrand Factor","volume":"4","author":"Sadler","year":"2006","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2018.04.015_bb0015","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1365-2516.2007.01643.x","article-title":"von Willebrand disease (VWD): evidence-based diagnosis and management guidelines, the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel report (USA)","volume":"14","author":"Nichols","year":"2008","journal-title":"Haemophilia"},{"key":"10.1016\/j.thromres.2018.04.015_bb0020","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.pathol.2016.03.001","article-title":"Laboratory tests used to help diagnose von Willebrand disease: an update","volume":"48","author":"Favaloro","year":"2016","journal-title":"Pathology"},{"key":"10.1016\/j.thromres.2018.04.015_bb0025","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1055\/s-0038-1653684","article-title":"Ristocetin: a new tool in the investigation of platelet aggregation","volume":"26","author":"Howard","year":"1971","journal-title":"Thromb. Diath. Haemorrh."},{"key":"10.1016\/j.thromres.2018.04.015_bb0030","first-page":"75","article-title":"Laboratory testing for von Willebrand disease: the past, present, and future state of play for von Willebrand factor assays that measure platelet binding activity, with or without ristocetin","volume":"43","author":"Just","year":"2017","journal-title":"Semin. Thromb. Hemost."},{"key":"10.1016\/j.thromres.2018.04.015_bb0035","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1111\/jth.12964","article-title":"Platelet dependent von Willebrand factor activity. Nomenclature and methodology: communication from the SSC of the ISTH","volume":"13","author":"Bodo","year":"2015","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2018.04.015_bb0040","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.1182\/blood-2015-10-636480","article-title":"Acquired von Willebrand syndrome associated with left ventricular assist device","volume":"127","author":"Nascimbene","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.thromres.2018.04.015_bb0045","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1111\/j.1538-7836.2012.04729.x","article-title":"Differential sensitivity of von Willebrand factor \u2018activity\u2019 assays to large and small VWF molecular weight forms: a cross-laboratory study comparing ristocetin cofactor, collagen binding and monoclonal antibody based assays","volume":"10","author":"Favaloro","year":"2012","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2018.04.015_bb0050","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1172\/JCI41062","article-title":"N\u2011acetylcysteine reduces the size and activity of von Willebrand factor in human plasma and mice","volume":"121","author":"Chen","year":"2011","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.thromres.2018.04.015_bb0055","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/hae.13396","article-title":"Pre-analytical issues that may cause misdiagnosis in haemophilia and von Willebrand disease","volume":"24","author":"Favaloro","year":"2018","journal-title":"Haemophilia"},{"key":"10.1016\/j.thromres.2018.04.015_bb0060","doi-asserted-by":"crossref","DOI":"10.4084\/mjhid.2013.052","article-title":"Changes of von Willebrand factor during pregnancy in women with and without von Willebrand disease","volume":"5","author":"Castaman","year":"2013","journal-title":"Mediterr. J. Hematol. Infect. Dis."},{"key":"10.1016\/j.thromres.2018.04.015_bb0065","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1055\/s-0037-1616109","article-title":"Recommended abbreviations for von Willebrand Factor and its activities","volume":"86","author":"Mazurier","year":"2001","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.thromres.2018.04.015_bb0070","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0049-3848(86)90150-7","article-title":"An ELISA test for the binding of von Willebrand antigen to collagen","volume":"43","author":"Brown","year":"1986","journal-title":"Thromb. Res."},{"key":"10.1016\/j.thromres.2018.04.015_bb0075","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1160\/TH10-06-0360","article-title":"Evaluation of commercial von Willebrand factor collagen binding assays to assist the discrimination of types 1 and 2 von Willebrand disease","volume":"104","author":"Favaloro","year":"2010","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.thromres.2018.04.015_bb0080","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.thromres.2014.05.020","article-title":"Evaluating errors in the laboratory identification of von Willebrand disease in the real world","volume":"134","author":"Favaloro","year":"2014","journal-title":"Thromb. Res."},{"key":"10.1016\/j.thromres.2018.04.015_bb0085","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1055\/s-2006-947862","article-title":"An external quality assessment program for von Willebrand factor laboratory analysis: an overview from the European concerted action on thrombosis and disabilities foundation","volume":"32","author":"Meijer","year":"2006","journal-title":"Semin. Thromb. Hemost."},{"key":"10.1016\/j.thromres.2018.04.015_bb0090","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1309\/AJCPH5JK4ONENPAE","article-title":"The North American specialized coagulation laboratory association experience","volume":"135","author":"Chandler","year":"2011","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.thromres.2018.04.015_bb0095","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1055\/s-2006-947863","article-title":"Laboratory tests for measurement of von Willebrand factor show poor agreement among different centers: results from the UK NEQA Scheme for Blood Coagulation","volume":"32","author":"Kitchen","year":"2006","journal-title":"Semin. Thromb. Hemost."},{"key":"10.1016\/j.thromres.2018.04.015_bb0100","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/jth.13243","article-title":"Developments in the diagnostic procedures for von Willebrand disease","volume":"14","author":"De Jong","year":"2016","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2018.04.015_bb0105","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1055\/s-0031-1300950","article-title":"Generation and breakdown of soluble ultra-large von Willebrand factor multimers","volume":"38","author":"Turner","year":"2012","journal-title":"Semin. Thromb. Hemost."},{"key":"10.1016\/j.thromres.2018.04.015_bb0110","doi-asserted-by":"crossref","first-page":"5312","DOI":"10.1182\/blood-2011-06-360297","article-title":"Lateral self-association of VWF involves the Cys2431-Cys2453 disulfide\/dithiol in the C2 domain","volume":"118","author":"Ganderton","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.thromres.2018.04.015_bb0115","doi-asserted-by":"crossref","first-page":"e1277","DOI":"10.1097\/MJT.0000000000000386","article-title":"N\u2011acetylcysteine for relapsing thrombotic thrombocytopenic purpura: more evidence of a promising drug","volume":"23","author":"Cabanillas","year":"2016","journal-title":"Am. J. Ther."},{"key":"10.1016\/j.thromres.2018.04.015_bb0120","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1007\/s11239-015-1259-6","article-title":"The role of N\u2011acetylcysteine in the treatment of thrombotic thrombocytopenic purpura","volume":"41","author":"Rottenstreich","year":"2016","journal-title":"J. Thromb. Thrombolysis"},{"key":"10.1016\/j.thromres.2018.04.015_bb0125","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1111\/trf.12440","article-title":"Treatment of refractory thrombotic thrombocytopenic purpura with N\u2011acetylcysteine: a case report","volume":"54","author":"Li","year":"2014","journal-title":"Transfusion"},{"key":"10.1016\/j.thromres.2018.04.015_bb0130","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/j.1538-7836.2010.04102.x","article-title":"Diagnostic repertoire for laboratory diagnosis of von Willebrand disease: results of a blind study in 32 centres worldwide. A scientific standardization committee communication","volume":"9","author":"Lee","year":"2011","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2018.04.015_bb0135","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1055\/s-0037-1608798","article-title":"Complications of implanted nonbiologic devices-an overview","volume":"44","author":"Kwaan","year":"2018","journal-title":"Semin. Thromb. Hemost."}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384818303207?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384818303207?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,10,16]],"date-time":"2019-10-16T01:17:37Z","timestamp":1571188657000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049384818303207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":27,"alternative-id":["S0049384818303207"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2018.04.015","relation":{},"ISSN":["0049-3848"],"issn-type":[{"value":"0049-3848","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differential sensitivity of von Willebrand factor activity assays to reduced VWF molecular weight forms: A large international cross-laboratory study","name":"articletitle","label":"Article Title"},{"value":"Thrombosis Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.thromres.2018.04.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2018 Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}