{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:50:21Z","timestamp":1792453821044,"version":"4.5.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thrombosisresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.thromres.2019.11.019","type":"journal-article","created":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T21:18:15Z","timestamp":1574198295000},"page":"102-108","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"special_numbering":"C","title":["Association between polycystic ovary syndrome and venous thromboembolism: A systematic review and meta-analysis"],"prefix":"10.1016","volume":"185","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4455-4032","authenticated-orcid":false,"given":"Karim","family":"Gariani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine","family":"Hugon-Rodin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Philippe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Righini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7032-9491","authenticated-orcid":false,"given":"Marc","family":"Blondon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.thromres.2019.11.019_bb0005","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1056\/NEJMra041536","article-title":"Polycystic ovary syndrome","volume":"352","author":"Ehrmann","year":"2005","journal-title":"N Engl J Med."},{"issue":"4","key":"10.1016\/j.thromres.2019.11.019_bb0010","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1093\/humrep\/det469","article-title":"The prevalence of polycystic ovary syndrome in a normal population according to the Rotterdam criteria versus revised criteria including anti-Mullerian hormone","volume":"29","author":"Lauritsen","year":"2014","journal-title":"Hum Reprod."},{"issue":"5","key":"10.1016\/j.thromres.2019.11.019_bb0015","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1210\/jc.2009-2724","article-title":"Assessment of cardiovascular risk and prevention of cardiovascular disease in women with the polycystic ovary syndrome: a consensus statement by the Androgen Excess and Polycystic Ovary Syndrome (AE-PCOS) Society","volume":"95","author":"Wild","year":"2010","journal-title":"J Clin Endocrinol Metab."},{"issue":"6","key":"10.1016\/j.thromres.2019.11.019_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.fertnstert.2016.07.1121","article-title":"Phenotypes and body mass in women with polycystic ovary syndrome identified in referral versus unselected populations: systematic review and meta-analysis","volume":"106","author":"Lizneva","year":"2016","journal-title":"Fertil Steril."},{"issue":"5","key":"10.1016\/j.thromres.2019.11.019_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2012.08.007","article-title":"Is polycystic ovary syndrome another risk factor for venous thromboembolism? United States, 2003\u20132008","volume":"207","author":"Okoroh","year":"2012","journal-title":"Am J Obstet Gynecol."},{"issue":"1","key":"10.1016\/j.thromres.2019.11.019_bb0030","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1055\/s-0035-1564837","article-title":"Comprehensive assessment of the hemostatic system in polycystic ovarian syndrome","volume":"42","author":"Burchall","year":"2016","journal-title":"Semin Thromb Hemost."},{"issue":"5","key":"10.1016\/j.thromres.2019.11.019_bb0035","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nrendo.2018.24","article-title":"Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment","volume":"14","author":"Escobar-Morreale","year":"2018","journal-title":"Nat Rev Endocrinol."},{"issue":"6","key":"10.1016\/j.thromres.2019.11.019_bb0040","doi-asserted-by":"crossref","first-page":"R221","DOI":"10.1530\/EJE-14-0527","article-title":"Epidemiology of hormonal contraceptives-related venous thromboembolism","volume":"171","author":"Hugon-Rodin","year":"2014","journal-title":"Eur J Endocrinol."},{"key":"10.1016\/j.thromres.2019.11.019_bb0045","doi-asserted-by":"crossref","first-page":"b2535","DOI":"10.1136\/bmj.b2535","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"339","author":"Moher","year":"2009","journal-title":"BMJ."},{"issue":"9","key":"10.1016\/j.thromres.2019.11.019_bb0050","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s10654-010-9491-z","article-title":"Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses","volume":"25","author":"Stang","year":"2010","journal-title":"Eur J Epidemiol."},{"issue":"2","key":"10.1016\/j.thromres.2019.11.019_bb0055","doi-asserted-by":"crossref","first-page":"E115","DOI":"10.1503\/cmaj.120677","article-title":"Risk of venous thromboembolism in women with polycystic ovary syndrome: a population-based matched cohort analysis","volume":"185","author":"Bird","year":"2013","journal-title":"CMAJ."},{"issue":"1","key":"10.1016\/j.thromres.2019.11.019_bb0060","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12933-018-0680-5","article-title":"Cardiovascular disease in a nationwide population of Danish women with polycystic ovary syndrome","volume":"17","author":"Glintborg","year":"2018","journal-title":"Cardiovasc Diabetol."},{"issue":"7","key":"10.1016\/j.thromres.2019.11.019_bb0065","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/pds.896","article-title":"Venous thromboembolism associated with cyproterone acetate in combination with ethinyloestradiol (Dianette): observational studies using the UK General Practice Research Database","volume":"13","author":"Seaman","year":"2004","journal-title":"Pharmacoepidemiol Drug Saf."},{"key":"10.1016\/j.thromres.2019.11.019_bb0070","first-page":"S231","article-title":"Hormonal contraception, polycystic ovary syndrome, and venous thrombosis","volume":"19","author":"Thranov","year":"2014","journal-title":"Eur J Contraceptive and Reproductive Health Car."},{"issue":"8","key":"10.1016\/j.thromres.2019.11.019_bb0075","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1111\/jth.14474","article-title":"Endogenous sex hormones and risk of venous thromboembolism in young women","volume":"17","author":"Scheres","year":"2019","journal-title":"J Thromb Haemost."},{"issue":"4","key":"10.1016\/j.thromres.2019.11.019_bb0080","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1210\/jc.2010-2279","article-title":"Coagulation and fibrinolytic disturbances in women with polycystic ovary syndrome","volume":"96","author":"Manneras-Holm","year":"2011","journal-title":"J Clin Endocrinol Metab."},{"issue":"2","key":"10.1016\/j.thromres.2019.11.019_bb0085","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1080\/09513590802549874","article-title":"Thrombin activatable fibrinolysis inhibitor and other hemostatic parameters in patients with polycystic ovary syndrome","volume":"25","author":"Oral","year":"2009","journal-title":"Gynecol Endocrinol."},{"issue":"9","key":"10.1016\/j.thromres.2019.11.019_bb0090","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1080\/09513590802291824","article-title":"Increased thrombin-activatable fibrinolysis inhibitor antigen levels as a clue for prothrombotic state in polycystic ovary syndrome","volume":"24","author":"Karakurt","year":"2008","journal-title":"Gynecol Endocrinol."},{"issue":"6","key":"10.1016\/j.thromres.2019.11.019_bb0095","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1016\/j.fertnstert.2013.01.105","article-title":"Faster thrombin generation in women with polycystic ovary syndrome compared with healthy controls matched for age and body mass index","volume":"99","author":"de Mendonca-Louzeiro","year":"2013","journal-title":"Fertil Steril."},{"issue":"1","key":"10.1016\/j.thromres.2019.11.019_bb0100","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1182\/blood-2010-02-267740","article-title":"Venous thrombosis risk associated with plasma hypofibrinolysis is explained by elevated plasma levels of TAFI and PAI-1","volume":"116","author":"Meltzer","year":"2010","journal-title":"Blood."},{"issue":"6","key":"10.1016\/j.thromres.2019.11.019_bb0105","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.2337\/db05-1543","article-title":"Hyperglycemia stimulates coagulation, whereas hyperinsulinemia impairs fibrinolysis in healthy humans","volume":"55","author":"Stegenga","year":"2006","journal-title":"Diabetes"},{"issue":"10","key":"10.1016\/j.thromres.2019.11.019_bb0110","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1016\/j.metabol.2015.06.011","article-title":"Increased thrombin generation in women with polycystic ovary syndrome: a pilot study on the effect of metformin and oral contraceptives","volume":"64","author":"Glintborg","year":"2015","journal-title":"Metabolism."},{"issue":"9","key":"10.1016\/j.thromres.2019.11.019_bb0115","doi-asserted-by":"crossref","first-page":"720","DOI":"10.3109\/09513590.2015.1032930","article-title":"Endogenous thrombin potential in polycystic ovary syndrome: the association to body mass index, insulin resistance, and inflammation","volume":"31","author":"Aziz","year":"2015","journal-title":"Gynecol Endocrinol."},{"issue":"6","key":"10.1016\/j.thromres.2019.11.019_bb0120","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1111\/j.1538-7836.2012.04707.x","article-title":"Insulin resistance and risk of venous thromboembolism: results of a population-based cohort study","volume":"10","author":"Van Schouwenburg","year":"2012","journal-title":"J Thromb Haemost."},{"issue":"11","key":"10.1016\/j.thromres.2019.11.019_bb0125","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1161\/ATVBAHA.114.304085","article-title":"Association between the metabolic syndrome, its individual components, and unprovoked venous thromboembolism: results of a patient-level meta-analysis","volume":"34","author":"Ageno","year":"2014","journal-title":"Arterioscler Thromb Vasc Biol."},{"issue":"10","key":"10.1016\/j.thromres.2019.11.019_bb0130","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1111\/aogs.12706","article-title":"Polycystic ovary syndrome: cardiovascular risk factors according to specific phenotypes","volume":"94","author":"Aziz","year":"2015","journal-title":"Acta Obstet Gynecol Scand."},{"issue":"3","key":"10.1016\/j.thromres.2019.11.019_bb0135","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1210\/jc.2014-3886","article-title":"The potential implications of a PCOS diagnosis on a woman\u2019s long-term health using data linkage","volume":"100","author":"Hart","year":"2015","journal-title":"J Clin Endocrinol Metab."},{"issue":"2","key":"10.1016\/j.thromres.2019.11.019_bb0140","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.rbmo.2019.03.203","article-title":"A meta-analysis of pregnancy-related outcomes and complications in women with polycystic ovary syndrome undergoing IVF","volume":"39","author":"Sha","year":"2019","journal-title":"Reprod Biomed Online."},{"issue":"12","key":"10.1016\/j.thromres.2019.11.019_bb0145","doi-asserted-by":"crossref","first-page":"4565","DOI":"10.1210\/jc.2013-2350","article-title":"Diagnosis and treatment of polycystic ovary syndrome: an Endocrine Society clinical practice guideline","volume":"98","author":"Legro","year":"2013","journal-title":"J Clin Endocrinol Metab."},{"issue":"3","key":"10.1016\/j.thromres.2019.11.019_bb0150","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.fertnstert.2018.05.004","article-title":"Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome","volume":"110","author":"Teede","year":"2018","journal-title":"Fertil Steril."},{"key":"10.1016\/j.thromres.2019.11.019_bb0155","doi-asserted-by":"crossref","first-page":"b2890","DOI":"10.1136\/bmj.b2890","article-title":"Hormonal contraception and risk of venous thromboembolism: national follow-up study","volume":"339","author":"Lidegaard","year":"2009","journal-title":"BMJ."},{"issue":"2","key":"10.1016\/j.thromres.2019.11.019_bb0160","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.1365-2141.2007.06780.x","article-title":"Risk of venous thrombosis: obesity and its joint effect with oral contraceptive use and prothrombotic mutations","volume":"139","author":"Pomp","year":"2007","journal-title":"Br J Haematol."},{"key":"10.1016\/j.thromres.2019.11.019_bb0165","doi-asserted-by":"crossref","first-page":"b2921","DOI":"10.1136\/bmj.b2921","article-title":"The venous thrombotic risk of oral contraceptives, effects of oestrogen dose and progestogen type: results of the MEGA case-control study","volume":"339","author":"van Hylckama Vlieg","year":"2009","journal-title":"BMJ."},{"key":"10.1016\/j.thromres.2019.11.019_bb0170","article-title":"Low dose oestrogen combined oral contraception and risk of pulmonary embolism, stroke, and myocardial infarction in five million French women: cohort study","volume":"353","author":"Weill","year":"2016","journal-title":"BMJ."},{"key":"10.1016\/j.thromres.2019.11.019_bb0175","series-title":"The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonran-domized Studies on Meta-analysis","author":"Wells","year":"2009"}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384819305055?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384819305055?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T17:40:12Z","timestamp":1758735612000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049384819305055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":35,"alternative-id":["S0049384819305055"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2019.11.019","relation":{},"ISSN":["0049-3848"],"issn-type":[{"value":"0049-3848","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between polycystic ovary syndrome and venous thromboembolism: A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Thrombosis Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.thromres.2019.11.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}