{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T14:14:28Z","timestamp":1776608068400,"version":"3.51.2"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2016-ZQN-86"],"award-info":[{"award-number":["2016-ZQN-86"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2016J01622"],"award-info":[{"award-number":["2016J01622"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thrombosisresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.thromres.2020.02.001","type":"journal-article","created":{"date-parts":[[2020,2,4]],"date-time":"2020-02-04T03:38:55Z","timestamp":1580787535000},"page":"39-43","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Comparison of hemocoagulase atrox versus tranexamic acid used in primary total knee arthroplasty: A randomized controlled trial"],"prefix":"10.1016","volume":"188","author":[{"given":"Ji-zheng","family":"Qin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shao-jie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin-peng","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-hai","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.thromres.2020.02.001_bb0005","doi-asserted-by":"crossref","first-page":"2","DOI":"10.2106\/00004623-199901000-00002","article-title":"An analysis of blood management in patients having a total hip or knee arthroplasty","volume":"81","author":"Bierbaum","year":"1999","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.thromres.2020.02.001_bb0010","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.arth.2003.10.013","article-title":"Risks associated with blood transfusion after total knee arthroplasty","volume":"19","author":"Bong","year":"2004","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.thromres.2020.02.001_bb0015","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.transci.2005.07.011","article-title":"A provincial program of blood conservation: the Ontario Transfusion Coordinators (ONTraC)","volume":"33","author":"Freedman","year":"2005","journal-title":"Transfus Apher Sci"},{"key":"10.1016\/j.thromres.2020.02.001_bb0020","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1093\/bja\/aeg111","article-title":"Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement","volume":"90","author":"Good","year":"2003","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.thromres.2020.02.001_bb0025","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.tmrv.2005.05.002","article-title":"Bacterial detection of platelets: current problems and possible resolutions","volume":"19","author":"Blajchman","year":"2005","journal-title":"Transfus Med Rev"},{"key":"10.1016\/j.thromres.2020.02.001_bb0030","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1111\/j.1537-2995.2009.02348.x","article-title":"Bacterial culture reduces but does not eliminate the risk of septic transfusion reactions to single donor platelets","volume":"49","author":"Fuller","year":"2009","journal-title":"Transfusion"},{"key":"10.1016\/j.thromres.2020.02.001_bb0035","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1213\/ANE.0b013e31825b6824","article-title":"Trends in in-hospital major morbidity and mortality after total joint arthroplasty: United States 1998\u20132008","volume":"115","author":"Kirksey","year":"2012","journal-title":"Anesth Analg"},{"key":"10.1016\/j.thromres.2020.02.001_bb0040","first-page":"6","article-title":"Postoperative blood salvage versus allogeneic blood transfusion in total knee and hip arthroplasty: a literature review","volume":"87","author":"Leigheb","year":"2016","journal-title":"Acta Biomed"},{"key":"10.1016\/j.thromres.2020.02.001_bb0045","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/NOR.0b013e318205749a","article-title":"The use of cryotherapy after a total knee replacement: a literature review","volume":"30","author":"Markert","year":"2011","journal-title":"Orthop Nurs"},{"key":"10.1016\/j.thromres.2020.02.001_bb0050","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3109\/17453679608995620","article-title":"Hypotensive epidural anesthesia for total hip arthroplasty: a review","volume":"67","author":"Sharrock","year":"1996","journal-title":"Acta Orthop Scand"},{"key":"10.1016\/j.thromres.2020.02.001_bb0055","doi-asserted-by":"crossref","first-page":"441","DOI":"10.5312\/wjo.v8.i6.441","article-title":"Perioperative blood management strategies for patients undergoing total knee replacement: where do we stand now?","volume":"8","author":"Themistoklis","year":"2017","journal-title":"World J Orthop"},{"key":"10.1016\/j.thromres.2020.02.001_bb0060","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3109\/00365528709089756","article-title":"Clinical pharmacology of tranexamic acid","volume":"137","author":"Astedt","year":"1987","journal-title":"Scand J Gastroenterol Suppl"},{"key":"10.1016\/j.thromres.2020.02.001_bb0065","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1055\/s-2007-996127","article-title":"Enzyme-controlling medicines: introduction","volume":"23","author":"Okamoto","year":"1997","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.thromres.2020.02.001_bb0070","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.transci.2013.09.005","article-title":"Effectiveness of oral tranexamic acid administration on blood loss after knee artroplasty: a randomized clinical trial","volume":"49","author":"Alipour","year":"2013","journal-title":"Transfus Apher Sci"},{"key":"10.1016\/j.thromres.2020.02.001_bb0075","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1213\/01.ANE.0000136770.75805.19","article-title":"The postoperative blood-sparing efficacy of oral versus intravenous tranexamic acid after total knee replacement","volume":"99","author":"Zohar","year":"2004","journal-title":"Anesth Analg"},{"key":"10.1016\/j.thromres.2020.02.001_bb0080","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.arth.2016.07.004","article-title":"Intravenous vs intra-articular tranexamic acid in total knee arthroplasty: a randomized, double-blind trial","volume":"32","author":"Goyal","year":"2017","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.thromres.2020.02.001_bb0085","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1016\/j.arth.2016.04.036","article-title":"Intravenous vs topical tranexamic acid in total knee arthroplasty without tourniquet application: a randomized controlled study","volume":"31","author":"Tzatzairis","year":"2016","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.thromres.2020.02.001_bb0090","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ijsu.2016.05.064","article-title":"Intravenous versus topical tranexamic acid in primary total hip replacement: a systemic review and meta-analysis","volume":"32","author":"Sun","year":"2016","journal-title":"Int J Surg"},{"key":"10.1016\/j.thromres.2020.02.001_bb0095","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.injury.2016.11.028","article-title":"The impact of hemocoagulase for improvement of coagulation and reduction of bleeding in fracture-related hip hemiarthroplasty geriatric patients: a prospective, single-blinded, randomized, controlled study","volume":"48","author":"Qiu","year":"2017","journal-title":"Injury"},{"key":"10.1016\/j.thromres.2020.02.001_bb0100","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1159\/000085826","article-title":"New treatment of neonatal pulmonary hemorrhage with hemocoagulase in addition to mechanical ventilation","volume":"88","author":"Shi","year":"2005","journal-title":"Biol Neonate"},{"key":"10.1016\/j.thromres.2020.02.001_bb0105","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s00264-017-3537-8","article-title":"The efficacy and safety of two low-dose peri-operative dexamethasone on pain and recovery following total hip arthroplasty: a randomized controlled trial","volume":"42","author":"Lei","year":"2017","journal-title":"Int Orthop"},{"key":"10.1016\/j.thromres.2020.02.001_bb0110","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1007\/s00264-015-2998-x","article-title":"Adductor canal block provides better performance after total knee arthroplasty compared with femoral nerve block: a systematic review and meta-analysis","volume":"40","author":"Li","year":"2015","journal-title":"Int Orthop"},{"key":"10.1016\/j.thromres.2020.02.001_bb0115","first-page":"169","article-title":"Two doses of low-dose perioperative dexamethasone improve the clinical outcome after total knee arthroplasty: a randomized controlled study","volume":"472","author":"Xu","year":"2017","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"10.1016\/j.thromres.2020.02.001_bb0120","doi-asserted-by":"crossref","DOI":"10.1186\/s13018-014-0116-1","article-title":"Blood management of staged bilateral total knee arthroplasty in a single hospitalization period","volume":"9","author":"Ma","year":"2014","journal-title":"J Orthop Surg Res"},{"key":"10.1016\/j.thromres.2020.02.001_bb0125","article-title":"Adductor canal block versus femoral nerve block for total knee arthroplasty: a meta-analysis of randomized controlled trials","volume":"7","author":"Wang","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.thromres.2020.02.001_bb0130","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/os.12092","article-title":"Comparison between drainage and non-drainage after total hip arthroplasty in Chinese subjects","volume":"6","author":"Zeng","year":"2014","journal-title":"Orthop Surg"},{"issue":"3","key":"10.1016\/j.thromres.2020.02.001_bb0135","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1097\/00000542-198303000-00016","article-title":"Estimating allowable blood loss: corrected for dilution","volume":"58","author":"Gross","year":"1983","journal-title":"Anesthesiology"},{"key":"10.1016\/j.thromres.2020.02.001_bb0140","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.clinthera.2009.01.005","article-title":"A review of three stand-alone topical thrombins for surgical hemostasis","volume":"31","author":"Cheng","year":"2009","journal-title":"Clin Ther"},{"key":"10.1016\/j.thromres.2020.02.001_bb0145","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1302\/0301-620X.78B3.0780434","article-title":"Fibrinolytic inhibition with tranexamic acid reduces blood loss and blood transfusion after knee arthroplasty: a prospective, randomized, double-blind study of 86 patients","volume":"78","author":"Benoni","year":"1996","journal-title":"J Bone Joint Surg Br"},{"key":"10.1016\/j.thromres.2020.02.001_bb0150","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0968-0160(00)00047-8","article-title":"How much blood is really lost in total knee arthroplasty? Correct blood loss management should take hidden loss into account","volume":"7","author":"Sehat","year":"2000","journal-title":"Knee"},{"key":"10.1016\/j.thromres.2020.02.001_bb0155","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.2106\/00004623-199173070-00011","article-title":"Blood loss after total knee replacement: effects of tourniquet release and continuous passivemotion","volume":"73","author":"Lotke","year":"1991","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.thromres.2020.02.001_bb0160","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.arth.2011.10.008","article-title":"Predicting need for allogeneic transfusion after total knee arthroplasty","volume":"27","author":"Noticewala","year":"2012","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.thromres.2020.02.001_bb0165","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1182\/blood-2008-07-077370","article-title":"The hazards of blood transfusion in historical perspective","volume":"112","author":"Alter","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.thromres.2020.02.001_bb0170","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1007\/s00264-012-1538-1","article-title":"Factors associated with prolonged length of stay following a total knee replacement in patients aged over 75","volume":"36","author":"Raut","year":"2012","journal-title":"Int Orthod"},{"key":"10.1016\/j.thromres.2020.02.001_bb0175","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.arth.2005.09.006","article-title":"Influence of hemoglobin levels on inpatient rehabilitation outcomes after total knee arthroplasty","volume":"21","author":"Diamond","year":"2006","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.thromres.2020.02.001_bb0180","doi-asserted-by":"crossref","DOI":"10.1186\/1756-0500-6-184","article-title":"Tranexamic acid and the reduction of blood loss in total knee and hip arthroplasty: a meta-analysis","volume":"6","author":"Gandhi","year":"2013","journal-title":"BMC Res Notes"},{"key":"10.1016\/j.thromres.2020.02.001_bb0185","doi-asserted-by":"crossref","first-page":"5831","DOI":"10.3748\/wjg.v22.i25.5831","article-title":"Hemostatic effect of topical hemocoagulase spray in digestive endoscopy","volume":"22","author":"Wang","year":"2016","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.thromres.2020.02.001_bb0190","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s00402-015-2183-0","article-title":"The beneficial effect of Batroxobin on blood loss reduction in spinal fusion surgery: a prospective, randomized, double-blind, placebo-controlled study","volume":"135","author":"Hu","year":"2015","journal-title":"Arch Orthop Trauma Surg"},{"key":"10.1016\/j.thromres.2020.02.001_bb0195","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00402-011-1390-6","article-title":"Which is more effective in adolescent idiopathic scoliosis surgery: batroxobin, tranexamic acid or a combination?","volume":"132","author":"Xu","year":"2012","journal-title":"Arch Orthop Trauma Surg"},{"key":"10.1016\/j.thromres.2020.02.001_bb0200","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S1665-2681(19)31031-2","article-title":"A comparison study of local injection and radiofrequency ablation therapy for traumatic portal vein injure guided by contrast-enhanced ultrasonography","volume":"11","author":"Luo","year":"2012","journal-title":"Ann Hepatol"},{"key":"10.1016\/j.thromres.2020.02.001_bb0205","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.thromres.2018.02.007","article-title":"The effect of oral versus intravenous tranexamic acid in reducing blood loss after primary total hip arthroplasty: a randomized clinical trial","volume":"164","author":"Cao","year":"2018","journal-title":"Thromb Res"},{"key":"10.1016\/j.thromres.2020.02.001_bb0210","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.thromres.2018.09.054","article-title":"Efficacy and safety of multiple boluses of oral versus intravenous tranexamic acid at reducing blood loss after primary total knee arthroplasty without a tourniquet: a prospective randomized clinical trial","volume":"171","author":"Cao","year":"2018","journal-title":"Thromb Res"},{"key":"10.1016\/j.thromres.2020.02.001_bb0215","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.thromres.2018.04.026","article-title":"Oral tranexamic acid is equivalent to topical tranexamic acid without drainage in primary total hip arthroplasty: a double-blind randomized clinical trial","volume":"167","author":"Luo","year":"2018","journal-title":"Thromb Res"},{"key":"10.1016\/j.thromres.2020.02.001_bb0220","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.thromres.2018.10.006","article-title":"Blood loss and cost-effectiveness of oral vs intravenous tranexamic acid in primary total hip arthroplasty: a randomized clinical trial","volume":"171","author":"Wu","year":"2018","journal-title":"Thromb Res"},{"key":"10.1016\/j.thromres.2020.02.001_bb0225","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.thromres.2019.05.003","article-title":"Risk of venous and arterial thrombosis in non-surgical patients receiving systemic tranexamic acid: a systematic review and meta-analysis","volume":"179","author":"Chornenki","year":"2019","journal-title":"Thromb Res"},{"key":"10.1016\/j.thromres.2020.02.001_bb0230","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.thromres.2019.02.006","article-title":"The safest and most efficacious route of tranexamic acid administration in total joint arthroplasty: a systematic review and network meta-analysis","volume":"176","author":"Xu","year":"2019","journal-title":"Thromb Res"},{"key":"10.1016\/j.thromres.2020.02.001_bb0235","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.thromres.2018.11.025","article-title":"Comparison of three routes of administration of tranexamic acid in primary unilateral total knee arthroplasty: analysis of a national database","volume":"173","author":"Xie","year":"2019","journal-title":"Thromb Res"},{"key":"10.1016\/j.thromres.2020.02.001_bb0240","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1080\/17453670510045444","article-title":"Tranexamic acid reduces blood loss in cemented hip arthroplasty: a randomized, double-blind study of 39 patients with osteoarthritis","volume":"76","author":"Niskanen","year":"2005","journal-title":"Acta Orthop"},{"key":"10.1016\/j.thromres.2020.02.001_bb0245","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.2106\/JBJS.K.00873","article-title":"Effectiveness and safety of tranexamic acid in reducing blood loss in total knee arthroplasty: a meta-analysis","volume":"94","author":"Yang","year":"2012","journal-title":"J Bone Joint Surg Am"}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384820300396?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384820300396?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T17:40:51Z","timestamp":1758735651000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049384820300396"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":49,"alternative-id":["S0049384820300396"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2020.02.001","relation":{},"ISSN":["0049-3848"],"issn-type":[{"value":"0049-3848","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparison of hemocoagulase atrox versus tranexamic acid used in primary total knee arthroplasty: A randomized controlled trial","name":"articletitle","label":"Article Title"},{"value":"Thrombosis Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.thromres.2020.02.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}