{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T19:20:41Z","timestamp":1788808841914,"version":"build-2803163510"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thrombosisresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.thromres.2020.02.013","type":"journal-article","created":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T21:48:12Z","timestamp":1582062492000},"page":"24-34","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Do asymptomatic clots in children matter?"],"prefix":"10.1016","volume":"189","author":[{"given":"Sophie","family":"Jones","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Monagle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Newall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.thromres.2020.02.013_bb0005","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1542\/peds.2007-3852","article-title":"Incidence and diagnosis of thrombosis in children with short-term central venous lines of the upper venous system","volume":"122","author":"Hanslik","year":"2008","journal-title":"Pediatrics"},{"issue":"2","key":"10.1016\/j.thromres.2020.02.013_bb0010","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1002\/cncr.11042","article-title":"A prospective cohort study determining the prevalence of thrombotic events in children with acute lymphoblastic leukemia and a central venous line who are treated with L-asparaginase","volume":"97","author":"Mitchell","year":"2003","journal-title":"Cancer"},{"issue":"6","key":"10.1016\/j.thromres.2020.02.013_bb0015","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1002\/mpo.10062","article-title":"Prevalence of thrombophilia and central venous catheter-associated neck vein thrombosis in 41 children with cancer\u2014a prospective study","volume":"38","author":"Ruud","year":"2002","journal-title":"Medical And Pediatric Oncology"},{"issue":"2","key":"10.1016\/j.thromres.2020.02.013_bb0020","doi-asserted-by":"crossref","first-page":"e737S","DOI":"10.1378\/chest.11-2308","article-title":"Antithrombotic therapy in neonates and children","volume":"141","author":"Monagle","year":"2012","journal-title":"Chest"},{"issue":"10","key":"10.1016\/j.thromres.2020.02.013_bb0025","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1111\/j.1469-8749.2004.tb00987.x","article-title":"Paradoxical embolism in a preterm infant","volume":"46","author":"Filippi","year":"2004","journal-title":"Developmental Medicine & Child Neurology"},{"issue":"1","key":"10.1016\/j.thromres.2020.02.013_bb0030","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1182\/blood-2006-12-061234","article-title":"A thrombolytic regimen for high-risk deep venous thrombosis may substantially reduce the risk of postthrombotic syndrome in children","volume":"110","author":"Goldenberg","year":"2007","journal-title":"Blood"},{"issue":"11","key":"10.1016\/j.thromres.2020.02.013_bb0035","doi-asserted-by":"crossref","first-page":"4273","DOI":"10.1182\/blood-2002-09-2731","article-title":"Central venous line\u2013related thrombosis in children: association with central venous line location and insertion technique","volume":"101","author":"Male","year":"2003","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.thromres.2020.02.013_bb0040","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1016\/j.jpeds.2013.06.076","article-title":"Port-A-Cath\u2013related thrombosis and postthrombotic syndrome in pediatric oncology patients","volume":"163","author":"Albisetti","year":"2013","journal-title":"The Journal of Pediatrics"},{"issue":"22","key":"10.1016\/j.thromres.2020.02.013_bb0045","doi-asserted-by":"crossref","first-page":"3292","DOI":"10.1182\/bloodadvances.2018024786","article-title":"American Society of Hematology 2018 guidelines for management of venous thromboembolism: treatment of pediatric venous thromboembolism","volume":"2","author":"Monagle","year":"2018","journal-title":"Blood Advances"},{"issue":"7","key":"10.1016\/j.thromres.2020.02.013_bb0050","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1046\/j.1538-7836.2003.00308.x","article-title":"Venous thrombosis in children","volume":"1","author":"Chan","year":"2003","journal-title":"Journal of Thrombosis & Haemostasis"},{"issue":"8","key":"10.1016\/j.thromres.2020.02.013_bb0055","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1182\/blood-2018-05-849737","article-title":"The natural history of asymptomatic central venous catheter\u2013related thrombosis in critically ill children","volume":"133","author":"Jones","year":"2019","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.thromres.2020.02.013_bb0060","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s00247-015-3467-9","article-title":"Diagnostic accuracy of point-of-care ultrasound for catheter-related thrombosis in children","volume":"46","author":"Li","year":"2016","journal-title":"Pediatr Radiol"},{"issue":"1","key":"10.1016\/j.thromres.2020.02.013_bb0065","doi-asserted-by":"crossref","first-page":"e25","DOI":"10.1542\/peds.2005-1880","article-title":"A randomized trial comparing long-term and short-term use of umbilical venous catheters in premature infants with birth weights of less than 1251 grams","volume":"118","author":"Butler-O\u2019Hara","year":"2006","journal-title":"Pediatrics"},{"issue":"2","key":"10.1016\/j.thromres.2020.02.013_bb0070","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1097\/MPH.0b013e3181c09b0c","article-title":"Thrombotic complications of tunneled central lines in children with malignancy","volume":"32","author":"Ociepa","year":"2010","journal-title":"Journal of Pediatric Hematology\/Oncology"},{"issue":"7","key":"10.1016\/j.thromres.2020.02.013_bb0075","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.26378","article-title":"Evaluation of the need for chest X-rays in the management of asymptomatic, intraluminal vascular access device occlusion in childhood cancer","volume":"64","author":"Stammers","year":"2017","journal-title":"Pediatric Blood & Cancer"},{"issue":"5","key":"10.1016\/j.thromres.2020.02.013_bb0080","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1097\/PCC.0b013e31824fbdb4","article-title":"Central venous catheter-associated complications in infants with single ventricle: comparison of umbilical and femoral venous access routes","volume":"13","author":"Aiyagari","year":"2012","journal-title":"Pediatric Critical Care Medicine"},{"issue":"8","key":"10.1016\/j.thromres.2020.02.013_bb0085","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1002\/pbc.26036","article-title":"Prevalence of symptomatic and asymptomatic thrombosis in pediatric oncology patients with tunneled central venous catheters","volume":"63","author":"Schoot","year":"2016","journal-title":"Pediatric Blood & Cancer"},{"issue":"5","key":"10.1016\/j.thromres.2020.02.013_bb0090","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1111\/j.1538-7836.2004.00653.x","article-title":"A prospective, longitudinal study of central venous catheter-related deep venous thrombosis in boys with hemophilia","volume":"2","author":"Price","year":"2004","journal-title":"Journal of Thrombosis & Haemostasis"},{"issue":"1","key":"10.1016\/j.thromres.2020.02.013_bb0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0268-960X(02)00007-3","article-title":"Thromboembolic diseases of childhood","volume":"17","author":"Revel-Vilk","year":"2003","journal-title":"Blood Reviews"},{"issue":"5","key":"10.1016\/j.thromres.2020.02.013_bb0100","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1002\/pbc.20875","article-title":"Evaluation of pediatric oncology patients with previous multiple central catheters for vascular access: is Doppler ultrasound needed?","volume":"48","author":"Gupta","year":"2007","journal-title":"Pediatric Blood & Cancer"},{"issue":"4","key":"10.1016\/j.thromres.2020.02.013_bb0105","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1055\/s-0037-1613054","article-title":"Comparison of venography and ultrasound for the diagnosis of asymptomatic deep vein thrombosis in the upper body in children: results of the PARKAA study. Prophylactic Antithrombin Replacement in Kids with ALL treated with Asparaginase","volume":"87","author":"Male","year":"2002","journal-title":"Thrombosis Haemostasis"},{"key":"10.1016\/j.thromres.2020.02.013_bb0110","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1111\/j.1538-7836.2011.04433.x","article-title":"Definition of clinical efficacy and safety outcomes for clinical trials in deep venous thrombosis and pulmonary embolism in children","volume":"9","author":"Mitchell","year":"2011","journal-title":"Journal of Thrombosis & Haemostasis"},{"key":"10.1016\/j.thromres.2020.02.013_bb0115","series-title":"Pediatric Critical Care","first-page":"1140","article-title":"Chapter 80 - thrombosis in pediatric intensive care","author":"Roy","year":"2011"},{"key":"10.1016\/j.thromres.2020.02.013_bb0120","series-title":"Andrew's Pediatric Thromboembolism and Stroke","author":"Monagle","year":"2006"},{"issue":"4","key":"10.1016\/j.thromres.2020.02.013_bb0125","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1055\/s-2008-1043788","article-title":"Bleeding and thrombosis in children with acute lymphoblastic leukaemia, treated according to the ALL-BFM-90 protocol","volume":"211","author":"Sutor","year":"1999","journal-title":"Klinische Padiatrie"},{"issue":"7","key":"10.1016\/j.thromres.2020.02.013_bb0130","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1111\/j.1538-7836.2004.00755.x","article-title":"Screening for thrombophilia in children: a puzzling decision with unclear implications","volume":"2","author":"Tormene","year":"2004","journal-title":"Journal of Thrombosis and Haemostasis"},{"issue":"Suppl. 1","key":"10.1016\/j.thromres.2020.02.013_bb0135","first-page":"S68","article-title":"Current and future management of pediatric venous thromboembolism","volume":"87","author":"Kerlin","year":"2012","journal-title":"American Journal of Hematology"},{"issue":"2","key":"10.1016\/j.thromres.2020.02.013_bb0140","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1002\/ppul.20158","article-title":"Prevalence of thrombophilia and catheter-related thrombosis in cystic fibrosis","volume":"39","author":"Barker","year":"2005","journal-title":"Pediatric Pulmonology"},{"issue":"5","key":"10.1016\/j.thromres.2020.02.013_bb0145","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1182\/blood.V83.5.1251.1251","article-title":"Venous thromboembolic complications (VTE) in children: first analyses of the Canadian Registry of VTE","volume":"83","author":"Andrew","year":"1994","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.thromres.2020.02.013_bb0150","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/S0022-3476(95)70448-5","article-title":"A cross-sectional study of catheter-related thrombosis in children receiving total parenteral nutrition at home","volume":"126","author":"Andrew","year":"1995","journal-title":"The Journal of Pediatrics"},{"issue":"1","key":"10.1016\/j.thromres.2020.02.013_bb0155","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/S0022-3476(95)70499-X","article-title":"Catheterrelated thrombosis in critically ill children: comparison of catheters with and without heparin bonding","volume":"126","author":"Krafte-Jacobs","year":"1995","journal-title":"Journal of Pediatrics"},{"issue":"6","key":"10.1016\/j.thromres.2020.02.013_bb0160","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/S0022-3476(98)70149-0","article-title":"Central venous catheter related thrombosis in children: analysis of the Canadian Registry of Venous Thromboembolic Complications","volume":"133","author":"Massicotte","year":"1998","journal-title":"The Journal of Pediatrics"},{"issue":"5","key":"10.1016\/j.thromres.2020.02.013_bb0165","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1067\/mpd.2001.118192","article-title":"Venous thromboembolism in childhood: a prospective two-year registry in The Netherlands","volume":"139","author":"van Ommen","year":"2001","journal-title":"The Journal of Pediatrics"},{"issue":"9","key":"10.1016\/j.thromres.2020.02.013_bb0170","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1080\/08035250500499457","article-title":"Central line-associated venous late effects in children without prior history of thrombosis","volume":"95","author":"Ruud","year":"2006","journal-title":"Acta Paediatrica"},{"issue":"28","key":"10.1016\/j.thromres.2020.02.013_bb0175","doi-asserted-by":"crossref","first-page":"4575","DOI":"10.1200\/JCO.2005.05.5343","article-title":"Catheter-related deep venous thrombosis and other catheter complications in children with cancer","volume":"24","author":"Journeycake","year":"2006","journal-title":"Journal of Clinical Oncology"},{"issue":"2\u20133","key":"10.1016\/j.thromres.2020.02.013_bb0180","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0049-3848(03)00099-9","article-title":"An open-label randomized controlled trial of low molecular weight heparin for the prevention of central venous line-related thrombotic complications in children: the PROTEKT trial","volume":"109","author":"Massicotte","year":"2003","journal-title":"Thrombosis Research"},{"issue":"6","key":"10.1016\/j.thromres.2020.02.013_bb0185","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1097\/MPH.0000000000000370","article-title":"Chronic complications after femoral central venous catheter-related thrombosis in critically ill children","volume":"37","author":"Sol","year":"2015","journal-title":"Journal of Pediatric Hematology\/Oncology"},{"issue":"2","key":"10.1016\/j.thromres.2020.02.013_bb0190","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.jpeds.2012.06.059","article-title":"Incidence and acute complications of asymptomatic central venous catheter\u2013related deep venous thrombosis in critically ill children","volume":"162","author":"Faustino","year":"2013","journal-title":"Journal of Pediatrics"},{"issue":"4","key":"10.1016\/j.thromres.2020.02.013_bb0195","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1179\/027249309X12547917868961","article-title":"Neonatal thrombo-embolism: risk factors, clinical features and outcome","volume":"29","author":"Demirel","year":"2009","journal-title":"Annals of Tropical Paediatrics"},{"issue":"9","key":"10.1016\/j.thromres.2020.02.013_bb0200","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1016\/0022-3468(94)90805-2","article-title":"Thrombotic complications of saphenous central venous lines","volume":"29","author":"Pippus","year":"1994","journal-title":"Journal of Pediatric Surgery"},{"key":"10.1016\/j.thromres.2020.02.013_bb0205","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1155\/2011\/217564","article-title":"Management and outcome in 32 neonates with thrombotic events","volume":"2011","author":"van Elteren","year":"2011","journal-title":"International Journal of Pediatrics"},{"issue":"4","key":"10.1016\/j.thromres.2020.02.013_bb0210","first-page":"489","article-title":"A continuous heparin infusion does not prevent catheter-related thrombosis in infants after cardiac surgery","volume":"11","author":"Schroeder","year":"2010","journal-title":"Pediatric Critical Care Medicine"},{"issue":"7","key":"10.1016\/j.thromres.2020.02.013_bb0215","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1182\/blood-2014-04-570531","article-title":"Postthrombotic syndrome following upper extremity deep vein thrombosis in children","volume":"124","author":"Avila","year":"2014","journal-title":"Blood"},{"issue":"14","key":"10.1016\/j.thromres.2020.02.013_bb0220","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1182\/blood-2016-03-704585","article-title":"Postthrombotic syndrome and other outcomes of lower extremity deep vein thrombosis in children","volume":"128","author":"Avila","year":"2016","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.thromres.2020.02.013_bb0225","first-page":"988","article-title":"A new technique for transumbilical insertion of central venous silicone catheters in newborn infants","volume":"97","author":"Haumont","year":"2008"},{"issue":"1","key":"10.1016\/j.thromres.2020.02.013_bb0230","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1067\/mpd.2002.119591","article-title":"Accuracy of Doppler echocardiography for the diagnosis of thrombosis associated with umbilical venous catheters","volume":"140","author":"Roy","year":"2002","journal-title":"Journal of Pediatrics"},{"issue":"2","key":"10.1016\/j.thromres.2020.02.013_bb0235","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0022-3476(98)70226-4","article-title":"Incidence and risk factors of catheter-related deep vein thrombosis in a pediatric intensive care unit: a prospective study","volume":"133","author":"Beck","year":"1998","journal-title":"The Journal of Pediatrics"},{"issue":"6","key":"10.1016\/j.thromres.2020.02.013_bb0240","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1097\/PCC.0000000000000409","article-title":"Factor VIII may predict catheter-related thrombosis in critically ill children: a preliminary study","volume":"16","author":"Faustino","year":"2015","journal-title":"Pediatr Crit Care Med"},{"issue":"3","key":"10.1016\/j.thromres.2020.02.013_bb0245","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1001\/archpedi.1995.02170150068012","article-title":"A prospective study of femoral catheter-related thrombosis in children","volume":"149","author":"Talbott","year":"1995","journal-title":"Archives of Pediatrics & Adolescent Medicine"},{"issue":"6","key":"10.1016\/j.thromres.2020.02.013_bb0250","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/j.jpedsurg.2012.03.043","article-title":"Characterization of central venous catheter-associated deep venous thrombosis in infants","volume":"47","author":"Gray","year":"2012","journal-title":"Journal of Pediatric Surgery"},{"issue":"3","key":"10.1016\/j.thromres.2020.02.013_bb0255","doi-asserted-by":"crossref","first-page":"e453","DOI":"10.1542\/peds.2008-1508","article-title":"Heparin-bonded central venous catheters do not reduce thrombosis in infants with congenital heart disease: a blinded randomized, controlled trial","volume":"123","author":"Anton","year":"2009","journal-title":"Pediatrics"},{"issue":"4","key":"10.1016\/j.thromres.2020.02.013_bb0260","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1067\/mpd.2002.127276","article-title":"The risk of postthrombotic syndrome in children with congenital heart disease","volume":"141","author":"van Ommen","year":"2002","journal-title":"The Journal of Pediatrics"},{"issue":"5","key":"10.1016\/j.thromres.2020.02.013_bb0265","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1046\/j.1538-7836.2003.00158.x","article-title":"Prothrombotic conditions in an unselected cohort of children with venous thromboembolic disease","volume":"1","author":"Revel-Vilk","year":"2003","journal-title":"Journal of Thrombosis & Haemostasis"},{"issue":"5","key":"10.1016\/j.thromres.2020.02.013_bb0270","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1097\/00000542-198505000-00018","article-title":"Clinically silent venous thrombosis following internal and external jugular central venous cannulation in pediatric cardiac patients","volume":"62","author":"Moore","year":"1985","journal-title":"Anesthesiology"},{"issue":"4","key":"10.1016\/j.thromres.2020.02.013_bb0275","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/S0022-5223(96)70087-9","article-title":"Central venous thrombosis after cardiac operations in children","volume":"112","author":"Pet\u00e4j\u00e4","year":"1996","journal-title":"The Journal of Thoracic and Cardiovascular Surgery"},{"key":"10.1016\/j.thromres.2020.02.013_bb0280","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jpeds.2015.10.046","article-title":"Management and outcomes of patients with occlusive thrombosis after pediatric cardiac surgery","volume":"169","author":"Manlhiot","year":"2016","journal-title":"The Journal Of Pediatrics"},{"issue":"2","key":"10.1016\/j.thromres.2020.02.013_bb0285","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1053\/jpsu.2002.30249","article-title":"Magnetic resonance venography in assessing venous patency after multiple venous catheters","volume":"37","author":"Shankar","year":"2002","journal-title":"Journal of Pediatric Surgery"},{"issue":"9","key":"10.1016\/j.thromres.2020.02.013_bb0290","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1080\/08035250600729092","article-title":"Low-dose warfarin for the prevention of central line-associated thromboses in children with malignancies\u2014a randomized, controlled study","volume":"95","author":"Ruud","year":"2006","journal-title":"Acta Paediatrica"},{"issue":"3","key":"10.1016\/j.thromres.2020.02.013_bb0295","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/sj.leu.2404560","article-title":"Risk factors of central venous lines-related thrombosis in children with acute lymphoblastic leukemia during induction therapy: a prospective study","volume":"21","author":"Farinasso","year":"2007","journal-title":"Leukemia"},{"issue":"Suppl. 3","key":"10.1016\/j.thromres.2020.02.013_bb0300","doi-asserted-by":"crossref","first-page":"S147","DOI":"10.1007\/PL00014342","article-title":"Clinical importance of prothrombotic risk factors in pediatric patients with malignancy\u2014impact of central venous lines","volume":"158","author":"Knofler","year":"1999","journal-title":"European Journal of Pediatrics"},{"issue":"2","key":"10.1016\/j.thromres.2020.02.013_bb0305","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1097\/MPH.0b013e31815f88b7","article-title":"Venous thrombosis in children with solid tumors","volume":"30","author":"Schiavetti","year":"2008","journal-title":"Journal of Pediatric Hematology\/Oncology"},{"issue":"2","key":"10.1016\/j.thromres.2020.02.013_bb0310","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.1542\/peds.101.2.e7","article-title":"Late vascular occlusion of central lines in pediatric malignancies","volume":"101","author":"Wilimas","year":"1998","journal-title":"Pediatrics"},{"issue":"2","key":"10.1016\/j.thromres.2020.02.013_bb0315","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1067\/mpd.2001.111272","article-title":"Catheter-related thrombosis in children with cancer","volume":"138","author":"Glaser","year":"2001","journal-title":"The Journal of Pediatrics"},{"issue":"8929","key":"10.1016\/j.thromres.2020.02.013_bb0320","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/S0140-6736(94)91707-8","article-title":"Thrombosis and embolism in long-term central venous access for parenteral nutrition","volume":"344","author":"Dollery","year":"1994","journal-title":"The Lancet"},{"issue":"11","key":"10.1016\/j.thromres.2020.02.013_bb0325","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.3324\/haematol.2010.026989","article-title":"Post thrombotic syndrome in children: a systematic review of frequency of occurrence, validity of outcome measures, and prognostic factors","volume":"95","author":"Goldenberg","year":"2010","journal-title":"Haematologica"},{"issue":"6","key":"10.1016\/j.thromres.2020.02.013_bb0330","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.siny.2011.08.005","article-title":"Neonatal portal vein thrombosis: diagnosis and management","volume":"16","author":"Williams","year":"2011","journal-title":"Seminars in Fetal & Neonatal Medicine"},{"issue":"3","key":"10.1016\/j.thromres.2020.02.013_bb0335","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1136\/adc.85.3.228","article-title":"Long term complications of inferior vena cava thrombosis","volume":"85","author":"H\u00e4usler","year":"2001","journal-title":"Archives of Disease in Childhood"},{"issue":"10","key":"10.1016\/j.thromres.2020.02.013_bb0340","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1111\/j.1538-7836.2012.04885.x","article-title":"Standardization of post-thrombotic syndrome definition and outcome assessment following upper venous system thrombosis in pediatric practice","volume":"10","author":"Revel-Vilk","year":"2012","journal-title":"Journal of Thrombosis & Haemostasis"},{"issue":"7","key":"10.1016\/j.thromres.2020.02.013_bb0345","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1002\/pbc.25438","article-title":"Prevalence of post-thrombotic syndrome after cardiac catheterization","volume":"62","author":"Luceri","year":"2015","journal-title":"Pediatric Blood & Cancer"},{"issue":"4","key":"10.1016\/j.thromres.2020.02.013_bb0350","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1111\/j.1538-7836.2008.02901.x","article-title":"Prevalence of post-thrombotic syndrome following asymptomatic thrombosis in survivors of acute lymphoblastic leukemia","volume":"6","author":"Kuhle","year":"2008","journal-title":"Journal of Thrombosis Haemostasis"},{"issue":"2","key":"10.1016\/j.thromres.2020.02.013_bb0355","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/pbc.25302","article-title":"Post-thrombotic syndrome after central venous catheter removal in childhood cancer survivors: a prospective cohort study","volume":"62","author":"Polen","year":"2015","journal-title":"Pediatric Blood & Cancer"},{"issue":"5","key":"10.1016\/j.thromres.2020.02.013_bb0360","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1097\/CCM.0b013e31820eb8a1","article-title":"Mortality-adjusted duration of mechanical ventilation in critically ill children with symptomatic central venous line-related deep venous thrombosis","volume":"39","author":"Faustino","year":"2011","journal-title":"Critical Care Medicine"},{"key":"10.1016\/j.thromres.2020.02.013_bb0365","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.thromres.2018.07.016","article-title":"Slow progress. How do we shift the paradigm of thinking in pediatric thrombosis and anticoagulation?","volume":"173","author":"Monagle","year":"2019","journal-title":"Thrombosis Research"},{"issue":"12","key":"10.1016\/j.thromres.2020.02.013_bb0370","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1046\/j.1538-7836.2003.00465.x","article-title":"Pediatric venous thromboembolic disease in one single center: congenital prothrombotic disorders and the clinical outcome","volume":"1","author":"Van Ommen","year":"2003","journal-title":"Journal of Thrombosis & Haemostasis"},{"issue":"5","key":"10.1016\/j.thromres.2020.02.013_bb0375","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1080\/08880010490457042","article-title":"Central venous line thrombosis in children and young adults with thalassemia major","volume":"21","author":"Finkelstein","year":"2004","journal-title":"Pediatric Hematology & Oncology"},{"issue":"10","key":"10.1016\/j.thromres.2020.02.013_bb0380","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1503\/cmaj.070316","article-title":"Incidence of deep vein thrombosis related to peripherally inserted central catheters in children and adolescents","volume":"177","author":"Dubois","year":"2007","journal-title":"CMAJ Canadian Medical Association Journal"},{"issue":"6","key":"10.1016\/j.thromres.2020.02.013_bb0385","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1111\/j.1365-2516.2011.02515.x","article-title":"Deep venous thrombosis screening in patients with inherited bleeding disorders and central venous catheters","volume":"17","author":"Cost","year":"2011","journal-title":"Haemophilia"},{"issue":"4","key":"10.1016\/j.thromres.2020.02.013_bb0390","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1177\/0148607111416482","article-title":"Prophylactic anticoagulation decreases catheter-related thrombosis and occlusion in children with home parenteral nutrition","volume":"36","author":"Vegting","year":"2012","journal-title":"Journal of Parenteral and Enteral Nutrition"},{"issue":"4","key":"10.1016\/j.thromres.2020.02.013_bb0395","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/j.1365-2516.2011.02719.x","article-title":"MRI after removal of central venous access device reveals a high number of asymptomatic thromboses in children with haemophilia","volume":"18","author":"Ranta","year":"2012","journal-title":"Haemophilia"}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004938482030058X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004938482030058X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T17:40:51Z","timestamp":1758735651000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004938482030058X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":79,"alternative-id":["S004938482030058X"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2020.02.013","relation":{},"ISSN":["0049-3848"],"issn-type":[{"value":"0049-3848","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Do asymptomatic clots in children matter?","name":"articletitle","label":"Article Title"},{"value":"Thrombosis Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.thromres.2020.02.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}