{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:33:22Z","timestamp":1792632802727,"version":"4.5.0"},"reference-count":175,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007496","name":"Biomedical Laboratory Research and Development, VA Office of Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007496","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thrombosisresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.thromres.2020.10.041","type":"journal-article","created":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T22:34:13Z","timestamp":1606257253000},"page":"62-71","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"special_numbering":"C","title":["Links between thrombosis and inflammation in traumatic brain injury"],"prefix":"10.1016","volume":"198","author":[{"given":"W. Brad","family":"Hubbard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-fei","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel A.","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolando E.","family":"Rumbaut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.thromres.2020.10.041_bb0005","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1182\/blood-2009-05-199208","article-title":"Coagulation and innate immune responses: can we view them separately?","volume":"114","author":"Delvaeye","year":"2009","journal-title":"Blood"},{"issue":"9","key":"10.1016\/j.thromres.2020.10.041_bb0010","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1182\/blood-2018-11-882993","article-title":"Thromboinflammation: challenges of therapeutically targeting coagulation and other host defense mechanisms","volume":"133","author":"Jackson","year":"2019","journal-title":"Blood"},{"key":"10.1016\/j.thromres.2020.10.041_bb0015","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jneuroim.2018.10.011","article-title":"How is the formation of microthrombi after traumatic brain injury linked to inflammation?","volume":"326","author":"Albert-Weissenberger","year":"2019","journal-title":"J. Neuroimmunol."},{"issue":"4","key":"10.1016\/j.thromres.2020.10.041_bb0020","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1161\/STROKEAHA.115.011238","article-title":"Thromboinflammation in stroke brain damage","volume":"47","author":"Meyer","year":"2016","journal-title":"Stroke"},{"issue":"8","key":"10.1016\/j.thromres.2020.10.041_bb0025","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/s41582-019-0221-1","article-title":"Thrombo-inflammation in acute ischaemic stroke \u2014 implications for treatment","volume":"15","author":"Stoll","year":"2019","journal-title":"Nat. Rev. Neurol."},{"issue":"5","key":"10.1016\/j.thromres.2020.10.041_bb0030","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1097\/SHK.0000000000001056","article-title":"Platelet function changes in a time-dependent manner following traumatic brain injury in a murine model","volume":"50","author":"Martin","year":"2018","journal-title":"Shock"},{"issue":"7","key":"10.1016\/j.thromres.2020.10.041_bb0035","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1089\/neu.2008.0586","article-title":"Classification of traumatic brain injury for targeted therapies","volume":"25","author":"Saatman","year":"2008","journal-title":"J. Neurotrauma"},{"issue":"12","key":"10.1016\/j.thromres.2020.10.041_bb0040","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1176\/appi.ajp.2012.12050600","article-title":"White matter abnormalities in veterans with mild traumatic brain injury","volume":"169","author":"Jorge","year":"2012","journal-title":"Am. J. Psychiatry"},{"issue":"Pt 8","key":"10.1016\/j.thromres.2020.10.041_bb0045","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1093\/brain\/awv139","article-title":"Military blast exposure, ageing and white matter integrity","volume":"138","author":"Trotter","year":"2015","journal-title":"Brain: a journal of neurology"},{"issue":"2","key":"10.1016\/j.thromres.2020.10.041_bb0050","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1602\/neurorx.2.2.372","article-title":"Neuroimaging in traumatic brain imaging","volume":"2","author":"Lee","year":"2005","journal-title":"NeuroRx: the journal of the American Society for Experimental NeuroTherapeutics"},{"issue":"22","key":"10.1016\/j.thromres.2020.10.041_bb0055","doi-asserted-by":"crossref","first-page":"3107","DOI":"10.1089\/neu.2017.5022","article-title":"Accelerated changes in cortical thickness measurements with age in military service members with traumatic brain injury","volume":"34","author":"Savjani","year":"2017","journal-title":"J. Neurotrauma"},{"issue":"2","key":"10.1016\/j.thromres.2020.10.041_bb0060","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1176\/appi.neuropsych.15050106","article-title":"Preliminary investigation of cerebral blood flow and amyloid burden in veterans with and without combat-related traumatic brain injury","volume":"28","author":"Ponto","year":"2016","journal-title":"J Neuropsychiatry Clin Neurosci"},{"issue":"Pt 3","key":"10.1016\/j.thromres.2020.10.041_bb0065","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.expneurol.2015.05.019","article-title":"Cerebral vascular injury in traumatic brain injury","volume":"275","author":"Kenney","year":"2016","journal-title":"Exp. Neurol."},{"issue":"7","key":"10.1016\/j.thromres.2020.10.041_bb0070","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1002\/jnr.23732","article-title":"Chronic cerebrovascular dysfunction after traumatic brain injury","volume":"94","author":"Jullienne","year":"2016","journal-title":"J. Neurosci. Res."},{"issue":"2","key":"10.1016\/j.thromres.2020.10.041_bb0075","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1093\/brain\/awx350","article-title":"Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model","volume":"141","author":"Tagge","year":"2018","journal-title":"Brain"},{"issue":"13","key":"10.1016\/j.thromres.2020.10.041_bb0080","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1089\/neu.2013.3080","article-title":"Delayed increases in microvascular pathology after experimental traumatic brain injury are associated with prolonged inflammation, blood\u2013brain barrier disruption, and progressive white matter damage","volume":"31","author":"Glushakova","year":"2014","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.thromres.2020.10.041_bb0085","doi-asserted-by":"crossref","first-page":"5175249","DOI":"10.1155\/2017\/5175249","article-title":"Distinguishing the unique neuropathological profile of blast polytrauma","volume":"2017","author":"Hubbard","year":"2017","journal-title":"Oxidative Med. Cell. Longev."},{"issue":"5","key":"10.1016\/j.thromres.2020.10.041_bb0090","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s00401-018-1824-0","article-title":"Mechanical disruption of the blood\u2013brain barrier following experimental concussion","volume":"135","author":"Johnson","year":"2018","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.thromres.2020.10.041_bb0095","doi-asserted-by":"crossref","DOI":"10.1177\/2059700216684518","article-title":"Effects of concussion on the blood-brain barrier in humans and rodents","volume":"1","author":"Sahyouni","year":"2017","journal-title":"J Concussion"},{"issue":"10","key":"10.1016\/j.thromres.2020.10.041_bb0100","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1007\/s10439-013-0805-7","article-title":"Distribution of blood-brain barrier disruption in primary blast injury","volume":"41","author":"Yeoh","year":"2013","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.thromres.2020.10.041_bb0105","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1146\/annurev-cellbio-100617-062608","article-title":"Development and cell biology of the blood-brain barrier","volume":"35","author":"Langen","year":"2019","journal-title":"Annu. Rev. Cell Dev. Biol."},{"issue":"21","key":"10.1016\/j.thromres.2020.10.041_bb0110","doi-asserted-by":"crossref","first-page":"4067","DOI":"10.1111\/febs.13412","article-title":"The dynamic blood-brain barrier","volume":"282","author":"Keaney","year":"2015","journal-title":"FEBS J."},{"key":"10.1016\/j.thromres.2020.10.041_bb0115","doi-asserted-by":"crossref","first-page":"282","DOI":"10.3389\/fncel.2019.00282","article-title":"Pericytes and neurovascular function in the healthy and diseased brain","volume":"13","author":"Brown","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.thromres.2020.10.041_bb0120","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3389\/fncel.2014.00231","article-title":"Protection after stroke: cellular effectors of neurovascular unit integrity","volume":"8","author":"Posada-Duque","year":"2014","journal-title":"Front. Cell. Neurosci."},{"issue":"3","key":"10.1016\/j.thromres.2020.10.041_bb0125","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s10545-013-9608-0","article-title":"Blood-brain barrier structure and function and the challenges for CNS drug delivery","volume":"36","author":"Abbott","year":"2013","journal-title":"J. Inherit. Metab. Dis."},{"issue":"1","key":"10.1016\/j.thromres.2020.10.041_bb0130","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/jcbfm.2012.153","article-title":"Immunologic privilege in the central nervous system and the blood-brain barrier","volume":"33","author":"Muldoon","year":"2013","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"22","key":"10.1016\/j.thromres.2020.10.041_bb0135","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.1182\/blood-2015-12-688838","article-title":"Cardiolipin-mediated procoagulant activity of mitochondria contributes to traumatic brain injury-associated coagulopathy in mice","volume":"127","author":"Zhao","year":"2016","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.thromres.2020.10.041_bb0140","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/s41423-019-0213-5","article-title":"Dissemination of brain inflammation in traumatic brain injury","volume":"16","author":"Shi","year":"2019","journal-title":"Cell Mol Immunol"},{"issue":"1","key":"10.1016\/j.thromres.2020.10.041_bb0145","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1365-2990.2010.01138.x","article-title":"Review: molecular pathogenesis of blood-brain barrier breakdown in acute brain injury","volume":"37","author":"Nag","year":"2011","journal-title":"Neuropathol. Appl. Neurobiol."},{"issue":"13","key":"10.1016\/j.thromres.2020.10.041_bb0150","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1182\/blood-2014-09-598805","article-title":"Brain-derived microparticles induce systemic coagulation in a murine model of traumatic brain injury","volume":"125","author":"Tian","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.thromres.2020.10.041_bb0155","doi-asserted-by":"crossref","unstructured":"Zhao Z; Zhou Y; Hilton T, L.F., Han C, Liu L, Yuan HJ, Li Y, Xu X, Cap A, Wu XP, Zhang FY, Shi FD, Zhang JN, Dong JF, Extracellular mitochondria released from traumatized brains induced platelet procoagulant activity. Haematologica, 2019: p. ZZin press.","DOI":"10.3324\/haematol.2018.214932"},{"issue":"18","key":"10.1016\/j.thromres.2020.10.041_bb0160","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1182\/blood-2017-11-784108","article-title":"Coagulopathy induced by traumatic brain injury: systemic manifestation of a localized injury","volume":"131","author":"Zhang","year":"2018","journal-title":"Blood"},{"issue":"20","key":"10.1016\/j.thromres.2020.10.041_bb0165","doi-asserted-by":"crossref","first-page":"2850","DOI":"10.1089\/neu.2019.6375","article-title":"A serum protein biomarker panel improves outcome prediction in human traumatic brain injury","volume":"36","author":"Thelin","year":"2019","journal-title":"J. Neurotrauma"},{"issue":"4","key":"10.1016\/j.thromres.2020.10.041_bb0170","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1007\/s12975-011-0125-x","article-title":"Blood-brain barrier pathophysiology in traumatic brain injury","volume":"2","author":"Chodobski","year":"2011","journal-title":"Transl. Stroke Res."},{"key":"10.1016\/j.thromres.2020.10.041_bb0175","doi-asserted-by":"crossref","first-page":"351","DOI":"10.3389\/fneur.2017.00351","article-title":"Monitoring the neuroinflammatory response following acute brain injury","volume":"8","author":"Thelin","year":"2017","journal-title":"Front. Neurol."},{"issue":"10","key":"10.1016\/j.thromres.2020.10.041_bb0180","doi-asserted-by":"crossref","first-page":"3583","DOI":"10.4049\/jimmunol.1700896","article-title":"Nonclassical monocytes mediate secondary injury, neurocognitive outcome, and neutrophil infiltration after traumatic brain injury","volume":"199","author":"Makinde","year":"2017","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.thromres.2020.10.041_bb0185","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/jcbfm.2009.262","article-title":"Role of CCL2 (MCP-1) in traumatic brain injury (TBI): evidence from severe TBI patients and CCL2-\/- mice","volume":"30","author":"Semple","year":"2010","journal-title":"Journal of cerebral blood flow and metabolism: official journal of the International Society of Cerebral Blood Flow and Metabolism"},{"issue":"6","key":"10.1016\/j.thromres.2020.10.041_bb0190","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.3390\/ijms19061616","article-title":"Persistent infiltration and impaired response of peripherally-derived monocytes after traumatic brain injury in the aged brain","volume":"19","author":"Chou","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.thromres.2020.10.041_bb0195","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1089\/neu.2009.1114","article-title":"Temporal profile of thrombogenesis in the cerebral microcirculation after traumatic brain injury in mice","volume":"27","author":"Schwarzmaier","year":"2009","journal-title":"J. Neurotrauma"},{"issue":"12","key":"10.1016\/j.thromres.2020.10.041_bb0200","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1089\/neu.2004.21.1756","article-title":"Delayed thrombosis after traumatic brain injury in rats","volume":"21","author":"Lu","year":"2004","journal-title":"J. Neurotrauma"},{"issue":"1","key":"10.1016\/j.thromres.2020.10.041_bb0205","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1186\/1742-2094-10-32","article-title":"In vivo temporal and spatial profile of leukocyte adhesion and migration after experimental traumatic brain injury in mice","volume":"10","author":"Schwarzmaier","year":"2013","journal-title":"J. Neuroinflammation"},{"issue":"3","key":"10.1016\/j.thromres.2020.10.041_bb0210","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1001\/jamaneurol.2014.3558","article-title":"Inflammation and neuroprotection in traumatic brain injury","volume":"72","author":"Corps","year":"2015","journal-title":"JAMA Neurol"},{"issue":"6","key":"10.1016\/j.thromres.2020.10.041_bb0215","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/j.neuron.2017.07.010","article-title":"Neuroimmunology of traumatic brain injury: time for a paradigm shift","volume":"95","author":"Jassam","year":"2017","journal-title":"Neuron"},{"issue":"5","key":"10.1016\/j.thromres.2020.10.041_bb0220","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.celrep.2019.09.046","article-title":"Activated CD8+ T cells cause long-term neurological impairment after traumatic brain injury in mice","volume":"29","author":"Daglas","year":"2019","journal-title":"Cell Reports"},{"issue":"1","key":"10.1016\/j.thromres.2020.10.041_bb0225","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1186\/s12974-019-1550-0","article-title":"Depletion of regulatory T cells increases T cell brain infiltration, reactive astrogliosis, and interferon-\u03b3 gene expression in acute experimental traumatic brain injury","volume":"16","author":"Kr\u00e4mer","year":"2019","journal-title":"J. Neuroinflammation"},{"issue":"1","key":"10.1016\/j.thromres.2020.10.041_bb0230","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1186\/s12974-017-0917-3","article-title":"Omega-3 polyunsaturated fatty acid supplementation attenuates microglial-induced inflammation by inhibiting the HMGB1\/TLR4\/NF-kappaB pathway following experimental traumatic brain injury","volume":"14","author":"Chen","year":"2017","journal-title":"J. Neuroinflammation"},{"issue":"7482","key":"10.1016\/j.thromres.2020.10.041_bb0235","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/nature12808","article-title":"Transcranial amelioration of inflammation and cell death after brain injury","volume":"505","author":"Roth","year":"2014","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.thromres.2020.10.041_bb0240","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s12974-017-0867-9","article-title":"Exercise attenuates neurological deficits by stimulating a critical HSP70\/NF-kappaB\/IL-6\/synapsin I axis in traumatic brain injury rats","volume":"14","author":"Chio","year":"2017","journal-title":"J. Neuroinflammation"},{"issue":"10","key":"10.1016\/j.thromres.2020.10.041_bb0245","doi-asserted-by":"crossref","first-page":"2718","DOI":"10.1002\/eji.200838437","article-title":"IFN-beta regulates CD73 and adenosine expression at the blood-brain barrier","volume":"38","author":"Niemela","year":"2008","journal-title":"Eur. J. Immunol."},{"issue":"3","key":"10.1016\/j.thromres.2020.10.041_bb0250","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nri.2016.4","article-title":"Purinergic regulation of the immune system","volume":"16","author":"Cekic","year":"2016","journal-title":"Nat Rev Immunol"},{"issue":"10","key":"10.1016\/j.thromres.2020.10.041_bb0255","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1182\/blood-2012-06-437772","article-title":"Tissue factor-positive neutrophils bind to injured endothelial wall and initiate thrombus formation","volume":"120","author":"Darbousset","year":"2012","journal-title":"Blood"},{"issue":"22","key":"10.1016\/j.thromres.2020.10.041_bb0260","doi-asserted-by":"crossref","first-page":"eaax8847","DOI":"10.1126\/sciadv.aax8847","article-title":"Neutrophil extracellular traps exacerbate neurological deficits after traumatic brain injury","volume":"6","author":"Vaibhav","year":"2020","journal-title":"Science Advances"},{"issue":"4","key":"10.1016\/j.thromres.2020.10.041_bb0265","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.cell.2019.10.001","article-title":"Stress-induced metabolic disorder in peripheral CD4(+) T cells leads to anxiety-like behavior","volume":"179","author":"Fan","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.thromres.2020.10.041_bb0270","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.bbi.2020.03.029","article-title":"Chemokine signaling mediated monocyte infiltration affects anxiety-like behavior following blast injury","volume":"88","author":"Murugan","year":"2020","journal-title":"Brain Behav. Immun."},{"issue":"2","key":"10.1016\/j.thromres.2020.10.041_bb0275","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1523\/JNEUROSCI.2405-14.2015","article-title":"CCR2 antagonism alters brain macrophage polarization and ameliorates cognitive dysfunction induced by traumatic brain injury","volume":"35","author":"Morganti","year":"2015","journal-title":"J. Neurosci."},{"issue":"6","key":"10.1016\/j.thromres.2020.10.041_bb0280","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1002\/ana.24655","article-title":"Targeting coagulation factor XII as a novel therapeutic option in brain trauma","volume":"79","author":"Hopp","year":"2016","journal-title":"Ann. Neurol."},{"issue":"17","key":"10.1016\/j.thromres.2020.10.041_bb0285","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1089\/neu.2012.2348","article-title":"Traumatic brain injury-associated coagulopathy","volume":"29","author":"Zhang","year":"2012","journal-title":"J. Neurotrauma"},{"issue":"4","key":"10.1016\/j.thromres.2020.10.041_bb0290","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1002\/rth2.12254","article-title":"Blood platelets: circulating mirrors of neurons?","volume":"3","author":"Canobbio","year":"2019","journal-title":"Research and practice in thrombosis and haemostasis"},{"key":"10.1016\/j.thromres.2020.10.041_bb0295","doi-asserted-by":"crossref","first-page":"747","DOI":"10.3389\/fimmu.2020.00747","article-title":"Platelets in neurodegenerative conditions-friend or foe?","volume":"11","author":"Leiter","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.thromres.2020.10.041_bb0300","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.expneurol.2015.03.018","article-title":"Lesion-induced accumulation of platelets promotes survival of adult neural stem \/ progenitor cells","volume":"269","author":"Kazanis","year":"2015","journal-title":"Exp. Neurol."},{"issue":"11","key":"10.1016\/j.thromres.2020.10.041_bb0305","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/S0301-472X(01)00733-0","article-title":"Of mice and men: comparison of the ultrastructure of megakaryocytes and platelets","volume":"29","author":"Schmitt","year":"2001","journal-title":"Exp. Hematol."},{"issue":"24","key":"10.1016\/j.thromres.2020.10.041_bb0310","doi-asserted-by":"crossref","first-page":"1901725","DOI":"10.1002\/advs.201901725","article-title":"Transforming endothelium with platelet-rich plasma in engineered microvessels","volume":"6","author":"Nagao","year":"2019","journal-title":"Adv Sci (Weinh)"},{"issue":"3","key":"10.1016\/j.thromres.2020.10.041_bb0315","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.neuron.2019.06.002","article-title":"Cerebral microvascular injury: a potentially treatable endophenotype of traumatic brain injury-induced neurodegeneration","volume":"103","author":"Sandsmark","year":"2019","journal-title":"Neuron"},{"issue":"7","key":"10.1016\/j.thromres.2020.10.041_bb0320","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1177\/0271678X17701460","article-title":"Response of the cerebral vasculature following traumatic brain injury","volume":"37","author":"Salehi","year":"2017","journal-title":"Journal of cerebral blood flow and metabolism: official journal of the International Society of Cerebral Blood Flow and Metabolism"},{"issue":"13\u201314","key":"10.1016\/j.thromres.2020.10.041_bb0325","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.3109\/02699052.2013.823562","article-title":"Role of fibrinogen in cerebrovascular dysfunction after traumatic brain injury","volume":"27","author":"Muradashvili","year":"2013","journal-title":"Brain Inj."},{"key":"10.1016\/j.thromres.2020.10.041_bb0330","series-title":"Fibrinogen and Fibrin, in Advances in Protein Chemistry","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0065-3233(05)70008-5","author":"Weisel","year":"2005"},{"issue":"9","key":"10.1016\/j.thromres.2020.10.041_bb0335","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1007\/s00701-019-04010-3","article-title":"A retrospective study of the effect of fibrinogen levels during fresh frozen plasma transfusion in patients with traumatic brain injury","volume":"161","author":"Nakae","year":"2019","journal-title":"Acta Neurochir."},{"issue":"2","key":"10.1016\/j.thromres.2020.10.041_bb0340","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s11011-014-9550-3","article-title":"Ablation of matrix metalloproteinase-9 gene decreases cerebrovascular permeability and fibrinogen deposition post traumatic brain injury in mice","volume":"30","author":"Muradashvili","year":"2015","journal-title":"Metab. Brain Dis."},{"issue":"7","key":"10.1016\/j.thromres.2020.10.041_bb0345","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1021\/acs.bioconjchem.9b00360","article-title":"Biomimetic strategies to treat traumatic brain injury by leveraging fibrinogen","volume":"30","author":"Brown","year":"2019","journal-title":"Bioconjug. Chem."},{"issue":"19","key":"10.1016\/j.thromres.2020.10.041_bb0350","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1089\/neu.2017.5291","article-title":"Contribution of fibrinogen to inflammation and neuronal density in human traumatic brain injury","volume":"35","author":"Jenkins","year":"2018","journal-title":"J. Neurotrauma"},{"issue":"6","key":"10.1016\/j.thromres.2020.10.041_bb0355","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1089\/neu.2006.23.976","article-title":"Impaired fibrinolysis and traumatic brain injury in mice","volume":"23","author":"Morales","year":"2006","journal-title":"J. Neurotrauma"},{"issue":"16","key":"10.1016\/j.thromres.2020.10.041_bb0360","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1182\/blood-2014-08-588442","article-title":"Endogenous plasminogen activators mediate progressive intracerebral hemorrhage after traumatic brain injury in mice","volume":"125","author":"Hijazi","year":"2015","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.thromres.2020.10.041_bb0365","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1227\/NEU.0b013e31824d179b","article-title":"Coagulopathy after traumatic brain injury","volume":"70","author":"Laroche","year":"2012","journal-title":"Neurosurgery"},{"issue":"10210","key":"10.1016\/j.thromres.2020.10.041_bb0370","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1016\/S0140-6736(19)32233-0","volume":"394","year":"2019","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.thromres.2020.10.041_bb0375","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1097\/TA.0000000000002173","article-title":"Severe traumatic brain injury is associated with a unique coagulopathy phenotype","volume":"86","author":"Samuels","year":"2019","journal-title":"The journal of trauma and acute care surgery"},{"issue":"1","key":"10.1016\/j.thromres.2020.10.041_bb0380","doi-asserted-by":"crossref","first-page":"10622","DOI":"10.1038\/s41598-018-28848-2","article-title":"Hemostatic nanoparticles increase survival, mitigate neuropathology and alleviate anxiety in a rodent blast trauma model","volume":"8","author":"Hubbard","year":"2018","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.thromres.2020.10.041_bb0385","doi-asserted-by":"crossref","first-page":"5260","DOI":"10.1073\/pnas.74.12.5260","article-title":"Activation of factor IX by the reaction product of tissue factor and factor VII: additional pathway for initiating blood coagulation","volume":"74","author":"Osterud","year":"1977","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.thromres.2020.10.041_bb0390","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1172\/JCI116573","article-title":"Astrocytes are the primary source of tissue factor in the murine central nervous system. A role for astrocytes in cerebral hemostasis","volume":"92","author":"Eddleston","year":"1993","journal-title":"J. Clin. Invest."},{"issue":"24","key":"10.1016\/j.thromres.2020.10.041_bb0395","doi-asserted-by":"crossref","first-page":"16256","DOI":"10.1016\/S0021-9258(18)98544-3","article-title":"Phospholipid-independent and -dependent interactions required for tissue factor receptor and cofactor function","volume":"266","author":"Ruf","year":"1991","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.thromres.2020.10.041_bb0400","doi-asserted-by":"crossref","first-page":"4227","DOI":"10.1021\/bi00412a004","article-title":"Human tissue factor contains thioester-linked palmitate and stearate on the cytoplasmic half-cystine","volume":"27","author":"Bach","year":"1988","journal-title":"Biochemistry"},{"issue":"8","key":"10.1016\/j.thromres.2020.10.041_bb0405","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1055\/s-0030-1267039","article-title":"Tissue factor, lipid rafts, and microparticles","volume":"36","author":"Davizon","year":"2010","journal-title":"Semin. Thromb. Hemost."},{"issue":"5","key":"10.1016\/j.thromres.2020.10.041_bb0410","first-page":"1087","article-title":"Selective cellular expression of tissue factor in human tissues. Implications for disorders of hemostasis and thrombosis","volume":"134","author":"Drake","year":"1989","journal-title":"Am. J. Pathol."},{"issue":"2","key":"10.1016\/j.thromres.2020.10.041_bb0415","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/0049-3848(90)90148-6","article-title":"Localization of human tissue factor antigen by immunostaining with monospecific, polyclonal anti-human tissue factor antibody","volume":"59","author":"Fleck","year":"1990","journal-title":"Thromb. Res."},{"issue":"7","key":"10.1016\/j.thromres.2020.10.041_bb0420","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1182\/blood.V90.7.2615","article-title":"Collagen but not fibrinogen surfaces induce bleb formation, exposure of phosphatidylserine, and procoagulant activity of adherent platelets: evidence for regulation by protein tyrosine kinase-dependent Ca2+ responses","volume":"90","author":"Heemskerk","year":"1997","journal-title":"Blood"},{"issue":"12","key":"10.1016\/j.thromres.2020.10.041_bb0425","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.1111\/j.1538-7836.2006.02211.x","article-title":"Bax activators potentiate coated-platelet formation","volume":"4","author":"Dale","year":"2006","journal-title":"J. Thromb. Haemost."},{"issue":"8","key":"10.1016\/j.thromres.2020.10.041_bb0430","doi-asserted-by":"crossref","first-page":"5987","DOI":"10.1074\/jbc.275.8.5987","article-title":"Constitutive death of platelets leading to scavenger receptor-mediated phagocytosis. A caspase-independent cell clearance program","volume":"275","author":"Brown","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"20","key":"10.1016\/j.thromres.2020.10.041_bb0435","doi-asserted-by":"crossref","first-page":"13289","DOI":"10.1016\/S0021-9258(18)98837-X","article-title":"Evidence that agonist-induced activation of calpain causes the shedding of procoagulant-containing microvesicles from the membrane of aggregating platelets","volume":"266","author":"Fox","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.thromres.2020.10.041_bb0440","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1146\/annurev.bb.21.060192.002221","article-title":"Protein involvement in transmembrane lipid asymmetry","volume":"21","author":"Devaux","year":"1992","journal-title":"Annu. Rev. Biophys. Biomol. Struct."},{"issue":"7325","key":"10.1016\/j.thromres.2020.10.041_bb0445","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/nature09583","article-title":"Calcium-dependent phospholipid scrambling by TMEM16F","volume":"468","author":"Suzuki","year":"2010","journal-title":"Nature"},{"issue":"5618","key":"10.1016\/j.thromres.2020.10.041_bb0450","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/268358a0","article-title":"Membrane asymmetry and blood coagulation","volume":"268","author":"Zwaal","year":"1977","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.thromres.2020.10.041_bb0455","doi-asserted-by":"crossref","first-page":"5386","DOI":"10.1016\/S0021-9258(20)81901-2","article-title":"The kinetics and cofactor dependence of the two cleavages involved in prothrombin activation","volume":"258","author":"Nesheim","year":"1983","journal-title":"J. Biol. Chem."},{"issue":"11","key":"10.1016\/j.thromres.2020.10.041_bb0460","doi-asserted-by":"crossref","first-page":"7268","DOI":"10.4049\/jimmunol.174.11.7268","article-title":"Astrocyte-derived ATP induces vesicle shedding and IL-1 beta release from microglia","volume":"174","author":"Bianco","year":"2005","journal-title":"J. Immunol."},{"issue":"9","key":"10.1016\/j.thromres.2020.10.041_bb0465","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/S0028-3908(97)00137-8","article-title":"ATP-mediated cytotoxicity in microglial cells","volume":"36","author":"Ferrari","year":"1997","journal-title":"Neuropharmacology"},{"issue":"7","key":"10.1016\/j.thromres.2020.10.041_bb0470","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1002\/glia.20397","article-title":"P2X(7) receptors: properties and relevance to CNS function","volume":"54","author":"Duan","year":"2006","journal-title":"Glia"},{"issue":"2","key":"10.1016\/j.thromres.2020.10.041_bb0475","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/0006-8993(72)90652-X","article-title":"The distribution of lipids in the human nervous system. II. Lipid composition of human fetal and infant brain","volume":"47","author":"Svennerholm","year":"1972","journal-title":"Brain Res."},{"issue":"5","key":"10.1016\/j.thromres.2020.10.041_bb0480","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/S0022-2275(20)42702-6","article-title":"Distribution and fatty acid composition of phosphoglycerides in normal human brain","volume":"9","author":"Svennerholm","year":"1968","journal-title":"J. Lipid Res."},{"issue":"2","key":"10.1016\/j.thromres.2020.10.041_bb0485","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.brainresrev.2006.02.002","article-title":"Cyclooxygenases, lipoxygenases, and epoxygenases in CNS: their role and involvement in neurological disorders","volume":"52","author":"Phillis","year":"2006","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.thromres.2020.10.041_bb0490","doi-asserted-by":"crossref","DOI":"10.1111\/jth.15096","article-title":"Diverse activities of von Willebrand factor in traumatic brain injury and associated coagulopathy","author":"Xu","year":"2020","journal-title":"J. Thromb. Haemost."},{"issue":"1","key":"10.1016\/j.thromres.2020.10.041_bb0495","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3324\/haematol.2018.214932","article-title":"Extracellular mitochondria released from traumatized brains induced platelet procoagulant activity","volume":"105","author":"Zhao","year":"2019","journal-title":"Haematologica"},{"issue":"10","key":"10.1016\/j.thromres.2020.10.041_bb0500","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1002\/jnr.24271","article-title":"Mitochondrial uncoupling prodrug improves tissue sparing, cognitive outcome, and mitochondrial bioenergetics after traumatic brain injury in male mice","volume":"96","author":"Hubbard","year":"2018","journal-title":"J. Neurosci. Res."},{"issue":"8","key":"10.1016\/j.thromres.2020.10.041_bb0505","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1089\/neu.2018.5990","article-title":"Acute mitochondrial impairment underlies prolonged cellular dysfunction after repeated mild traumatic brain injuries","volume":"36","author":"Hubbard","year":"2019","journal-title":"J. Neurotrauma"},{"issue":"2","key":"10.1016\/j.thromres.2020.10.041_bb0510","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0005-2736(90)90036-N","article-title":"Improved methods to isolate and subfractionate rat liver mitochondria. Lipid composition of the inner and outer membrane","volume":"1021","author":"Hovius","year":"1990","journal-title":"Biochim. Biophys. Acta"},{"issue":"1","key":"10.1016\/j.thromres.2020.10.041_bb0515","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/S0005-2736(96)00240-4","article-title":"Phospholipid composition of highly purified mitochondrial outer membranes of rat liver and Neurospora crassa. Is cardiolipin present in the mitochondrial outer membrane?","volume":"1325","author":"de Kroon","year":"1997","journal-title":"Biochim. Biophys. Acta"},{"issue":"3","key":"10.1016\/j.thromres.2020.10.041_bb0520","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1097\/00005373-199703000-00023","article-title":"Evidence for early supply independent mitochondrial dysfunction in patients developing multiple organ failure after trauma","volume":"42","author":"Cairns","year":"1997","journal-title":"J. Trauma"},{"issue":"5","key":"10.1016\/j.thromres.2020.10.041_bb0525","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1097\/SHK.0b013e31824c3238","article-title":"Structural changes of the heart during severe sepsis or septic shock","volume":"37","author":"Smeding","year":"2012","journal-title":"Shock"},{"issue":"7","key":"10.1016\/j.thromres.2020.10.041_bb0530","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1089\/neu.1998.15.531","article-title":"Mitochondrial dysfunction after experimental traumatic brain injury: combined efficacy of SNX-111 and U-101033E","volume":"15","author":"Xiong","year":"1998","journal-title":"J. Neurotrauma"},{"issue":"2","key":"10.1016\/j.thromres.2020.10.041_bb0535","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0006-8993(97)00573-8","article-title":"Impaired mitochondrial function, oxidative stress and altered antioxidant enzyme activities following traumatic spinal cord injury","volume":"765","author":"Azbill","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/j.thromres.2020.10.041_bb0540","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.redox.2015.12.011","article-title":"Cellular and subcellular oxidative stress parameters following severe spinal cord injury","volume":"8","author":"Visavadiya","year":"2016","journal-title":"Redox Biol."},{"issue":"2","key":"10.1016\/j.thromres.2020.10.041_bb0545","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1097\/MAJ.0000000000000506","article-title":"Traumatic brain injury and mitochondrial dysfunction","volume":"350","author":"Hiebert","year":"2015","journal-title":"Am J Med Sci"},{"key":"10.1016\/j.thromres.2020.10.041_bb0550","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.511","article-title":"Acute focal brain damage alters mitochondrial dynamics and autophagy in axotomized neurons","volume":"5","author":"Cavallucci","year":"2014","journal-title":"Cell Death Dis."},{"issue":"7285","key":"10.1016\/j.thromres.2020.10.041_bb0555","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nature08780","article-title":"Circulating mitochondrial DAMPs cause inflammatory responses to injury","volume":"464","author":"Zhang","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.thromres.2020.10.041_bb0560","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1146\/annurev.iy.12.040194.005015","article-title":"Tolerance, danger, and the extended family","volume":"12","author":"Matzinger","year":"1994","journal-title":"Annu. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.thromres.2020.10.041_bb0565","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/09537100701817224","article-title":"Platelet receptor redox regulation","volume":"19","author":"Arthur","year":"2008","journal-title":"Platelets"},{"issue":"8","key":"10.1016\/j.thromres.2020.10.041_bb0570","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1182\/blood-2005-03-1047","article-title":"Platelet NAD(P)H-oxidase-generated ROS production regulates alphaIIbbeta3-integrin activation independent of the NO\/cGMP pathway","volume":"106","author":"Begonja","year":"2005","journal-title":"Blood."},{"issue":"4","key":"10.1016\/j.thromres.2020.10.041_bb0575","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1161\/01.ATV.0000012262.76205.6A","article-title":"Role of mitochondrial oxidant generation in endothelial cell responses to hypoxia","volume":"22","author":"Pearlstein","year":"2002","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"4","key":"10.1016\/j.thromres.2020.10.041_bb0580","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1161\/01.RES.85.4.304","article-title":"A role for reactive oxygen species in endothelial cell anoikis","volume":"85","author":"Li","year":"1999","journal-title":"Circ. Res."},{"issue":"20","key":"10.1016\/j.thromres.2020.10.041_bb0585","doi-asserted-by":"crossref","first-page":"9530","DOI":"10.1016\/S0021-9258(18)43421-7","article-title":"Dynamic state of glutathione in blood plasma","volume":"255","author":"Anderson","year":"1980","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.thromres.2020.10.041_bb0590","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/0003-2697(92)90456-H","article-title":"Determination of the in vivo redox status of cysteine, cysteinylglycine, homocysteine, and glutathione in human plasma","volume":"200","author":"Mansoor","year":"1992","journal-title":"Anal.Biochem."},{"issue":"9\u201310","key":"10.1016\/j.thromres.2020.10.041_bb0595","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1089\/ars.2006.8.1865","article-title":"Redefining oxidative stress","volume":"8","author":"Jones","year":"2006","journal-title":"Antioxid.Redox.Signal."},{"issue":"2","key":"10.1016\/j.thromres.2020.10.041_bb0600","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/0003-9861(85)90065-7","article-title":"Distribution of oxidized and reduced forms of glutathione and cysteine in rat plasma","volume":"240","author":"Lash","year":"1985","journal-title":"Arch.Biochem.Biophys."},{"issue":"14","key":"10.1016\/j.thromres.2020.10.041_bb0605","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1182\/blood-2014-05-573543","article-title":"Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation","volume":"124","author":"Boudreau","year":"2014","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.thromres.2020.10.041_bb0610","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1182\/blood-2016-01-636423","article-title":"Advances in the understanding of trauma-induced coagulopathy","volume":"128","author":"Chang","year":"2016","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.thromres.2020.10.041_bb0615","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s12028-009-9281-1","article-title":"Acute coagulopathy in isolated blunt traumatic brain injury","volume":"12","author":"Wafaisade","year":"2010","journal-title":"Neurocrit. Care."},{"issue":"1","key":"10.1016\/j.thromres.2020.10.041_bb0620","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.ajem.2017.06.057","article-title":"Coagulopathy as a predictor of mortality after penetrating traumatic brain injury","volume":"36","author":"Folkerson","year":"2018","journal-title":"Am. J. Emerg. Med."},{"issue":"9","key":"10.1016\/j.thromres.2020.10.041_bb0625","doi-asserted-by":"crossref","first-page":"632","DOI":"10.4103\/ijccm.IJCCM_156_18","article-title":"Non- neurological complications after traumatic brain injury: a prospective observational study","volume":"22","author":"Goyal","year":"2018","journal-title":"Indian J Crit Care Med"},{"key":"10.1016\/j.thromres.2020.10.041_bb0630","first-page":"207247","article-title":"Pulmonary complications in patients with severe brain injury","volume":"2012","author":"Lee","year":"2012","journal-title":"Crit Care Res Pract"},{"issue":"4","key":"10.1016\/j.thromres.2020.10.041_bb0635","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1097\/TA.0000000000001584","article-title":"Outcomes after concomitant traumatic brain injury and hemorrhagic shock: a secondary analysis from the pragmatic, randomized optimal platelets and plasma ratios trial","volume":"83","author":"Galvagno","year":"2017","journal-title":"J. Trauma Acute Care Surg."},{"key":"10.1016\/j.thromres.2020.10.041_bb0640","first-page":"102","article-title":"Hemodynamic depression and microthrombosis in the peripheral areas of cortical contusion in the rat: role of platelet activating factor","volume":"70","author":"Maeda","year":"1997","journal-title":"Acta Neurochir Suppl"},{"issue":"3","key":"10.1016\/j.thromres.2020.10.041_bb0645","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.amjsurg.2006.12.004","article-title":"Incidence of venous thromboembolism in patients with traumatic brain injury","volume":"193","author":"Denson","year":"2007","journal-title":"Am. J. Surg."},{"issue":"5","key":"10.1016\/j.thromres.2020.10.041_bb0650","first-page":"1436","article-title":"Traumatic brain injury is associated with the development of deep vein thrombosis independent of pharmacological prophylaxis","volume":"66","author":"Reiff","year":"2009","journal-title":"J. Trauma"},{"key":"10.1016\/j.thromres.2020.10.041_bb0655","doi-asserted-by":"crossref","first-page":"81","DOI":"10.2147\/OAEM.S239881","article-title":"The safety of early thromboembolic prophylaxis in closed traumatic intracranial hemorrhage","volume":"12","author":"Jamous","year":"2020","journal-title":"Open Access Emerg Med"},{"issue":"3","key":"10.1016\/j.thromres.2020.10.041_bb0660","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s00134-016-4655-2","article-title":"Venous thromboembolic events in critically ill traumatic brain injury patients","volume":"43","author":"Skrifvars","year":"2017","journal-title":"Intensive Care Med."},{"issue":"1","key":"10.1016\/j.thromres.2020.10.041_bb0665","first-page":"10","article-title":"Deep vein thrombosis and pulmonary embolus in patients with traumatic brain injury: a prospective observational study","volume":"14","author":"Praeger","year":"2012","journal-title":"Crit Care Resusc"},{"issue":"8","key":"10.1016\/j.thromres.2020.10.041_bb0670","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1089\/neu.2006.0159","article-title":"Plasma von Willebrand factor levels correlate with clinical outcome of severe traumatic brain injury","volume":"24","author":"De Oliveira","year":"2007","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.thromres.2020.10.041_bb0675","article-title":"Von Willebrand factor contribution to pathophysiology outside of von Willebrand disease","volume":"26","author":"Mojiri","year":"2018","journal-title":"Microcirculation"},{"key":"10.1016\/j.thromres.2020.10.041_bb0680","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/978-3-030-41769-7_18","article-title":"Physiological roles of the von Willebrand factor-factor VIII interaction","volume":"94","author":"Kiouptsi","year":"2020","journal-title":"Subcell Biochem"},{"issue":"2","key":"10.1016\/j.thromres.2020.10.041_bb0685","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s00018-014-1743-8","article-title":"Of von Willebrand factor and platelets","volume":"72","author":"Bryckaert","year":"2015","journal-title":"Cell. Mol. Life Sci."},{"issue":"3","key":"10.1016\/j.thromres.2020.10.041_bb0690","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/bjh.15206","article-title":"Identification of novel diagnostic biomarkers for deep venous thrombosis","volume":"181","author":"Memon","year":"2018","journal-title":"Br. J. Haematol."},{"issue":"2","key":"10.1016\/j.thromres.2020.10.041_bb0695","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1089\/neu.2018.5696","article-title":"Relative deficiency of plasma a disintegrin and metalloprotease with thrombospondin type 1 repeats 13 activity and elevation of human neutrophil peptides in patients with traumatic brain injury","volume":"36","author":"Kumar","year":"2019","journal-title":"J. Neurotrauma"},{"issue":"10","key":"10.1016\/j.thromres.2020.10.041_bb0700","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1182\/blood-2018-03-841932","article-title":"von Willebrand factor enhances microvesicle-induced vascular leakage and coagulopathy in mice with traumatic brain injury","volume":"132","author":"Wu","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.thromres.2020.10.041_bb0705","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/978-3-7091-0693-8_11","article-title":"Intracranial hemorrhage: mechanisms of secondary brain injury","volume":"111","author":"Lok","year":"2011","journal-title":"Acta Neurochir. Suppl."},{"issue":"11","key":"10.1016\/j.thromres.2020.10.041_bb0710","doi-asserted-by":"crossref","first-page":"3199","DOI":"10.1182\/blood-2010-09-310706","article-title":"Factor VIIa bound to endothelial cell protein C receptor activates protease activated receptor-1 and mediates cell signaling and barrier protection","volume":"117","author":"Sen","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.thromres.2020.10.041_bb0715","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.neuroscience.2017.02.020","article-title":"FVIIa prevents the progressive hemorrhaging of a brain contusion by protecting microvessels via formation of the TF-FVIIa-FXa complex","volume":"348","author":"Yuan","year":"2017","journal-title":"Neuroscience"},{"issue":"5","key":"10.1016\/j.thromres.2020.10.041_bb0720","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1182\/blood-2017-08-801738","article-title":"Lactadherin promotes microvesicle clearance to prevent coagulopathy and improves survival of severe TBI mice","volume":"131","author":"Zhou","year":"2018","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.thromres.2020.10.041_bb0725","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1182\/blood-2002-07-1951","article-title":"Lactadherin inhibits enzyme complexes of blood coagulation by competing for phospholipid-binding sites","volume":"101","author":"Shi","year":"2003","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.thromres.2020.10.041_bb0730","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1111\/j.1538-7836.2008.03010.x","article-title":"Lactadherin blocks thrombosis and hemostasis in vivo: correlation with platelet phosphatidylserine exposure","volume":"6","author":"Shi","year":"2008","journal-title":"J. Thromb. Haemost."},{"issue":"7","key":"10.1016\/j.thromres.2020.10.041_bb0735","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1111\/j.1538-7836.2007.02536.x","article-title":"Purified A2 domain of von Willebrand factor binds to the active conformation of von Willebrand factor and blocks the interaction with platelet glycoprotein Ibalpha","volume":"5","author":"Martin","year":"2007","journal-title":"J. Thromb. Haemost."},{"issue":"10","key":"10.1016\/j.thromres.2020.10.041_bb0740","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1161\/STROKEAHA.118.022888","article-title":"Extracellular vimentin\/VWF (von Willebrand factor) interaction contributes to VWF string formation and stroke pathology","volume":"49","author":"Fasipe","year":"2018","journal-title":"Stroke"},{"issue":"7","key":"10.1016\/j.thromres.2020.10.041_bb0745","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1182\/bloodadvances.2020001500","article-title":"Modulating the rate of fibrin formation and clot structure attenuates microvascular thrombosis in systemic inflammation","volume":"4","author":"Valladolid","year":"2020","journal-title":"Blood Adv"},{"issue":"13","key":"10.1016\/j.thromres.2020.10.041_bb0750","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1089\/neu.2015.4072","article-title":"Cerebral blood flow alterations in acute sport-related concussion","volume":"33","author":"Wang","year":"2016","journal-title":"J. Neurotrauma"},{"issue":"2","key":"10.1016\/j.thromres.2020.10.041_bb0755","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1089\/neu.2017.5237","article-title":"Cerebral blood flow after mild traumatic brain injury: associations between symptoms and post-injury perfusion","volume":"35","author":"Stephens","year":"2018","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.thromres.2020.10.041_bb0760","doi-asserted-by":"crossref","first-page":"210","DOI":"10.3389\/fnins.2020.00210","article-title":"In vivo two-photon imaging reveals acute cerebral vascular spasm and microthrombosis after mild traumatic brain injury in mice","volume":"14","author":"Han","year":"2020","journal-title":"Front. Neurosci."},{"issue":"1","key":"10.1016\/j.thromres.2020.10.041_bb0765","doi-asserted-by":"crossref","first-page":"8681","DOI":"10.1038\/s41598-018-26813-7","article-title":"Temporal and spatial effects of blast overpressure on blood-brain barrier permeability in traumatic brain injury","volume":"8","author":"Kuriakose","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.thromres.2020.10.041_bb0770","doi-asserted-by":"crossref","first-page":"26992","DOI":"10.1038\/srep26992","article-title":"Primary blast causes mild, moderate, severe and lethal TBI with increasing blast overpressures: experimental rat injury model","volume":"6","author":"Mishra","year":"2016","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.thromres.2020.10.041_bb0775","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1089\/neu.2019.6483","article-title":"Dynamic blood\u2013brain barrier regulation in mild traumatic brain injury","volume":"37","author":"O\u2019Keeffe","year":"2019","journal-title":"J. Neurotrauma"},{"issue":"6","key":"10.1016\/j.thromres.2020.10.041_bb0780","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1093\/brain\/awaa140","article-title":"Slow blood-to-brain transport underlies enduring barrier dysfunction in American football players","volume":"143","author":"Veksler","year":"2020","journal-title":"Brain"},{"issue":"6","key":"10.1016\/j.thromres.2020.10.041_bb0785","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1093\/brain\/awaa166","article-title":"Unravelling the mechanisms of blood\u2013brain barrier dysfunction in repetitive mild head injury","volume":"143","author":"Ware","year":"2020","journal-title":"Brain"},{"issue":"19","key":"10.1016\/j.thromres.2020.10.041_bb0790","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1089\/neu.2013.3302","article-title":"Systemic platelet dysfunction is the result of local dysregulated coagulation and platelet activation in the brain in a rat model of isolated traumatic brain injury","volume":"31","author":"Ploplis","year":"2014","journal-title":"J. Neurotrauma"},{"issue":"Pt 1","key":"10.1016\/j.thromres.2020.10.041_bb0795","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1093\/brain\/aws307","article-title":"The spectrum of disease in chronic traumatic encephalopathy","volume":"136","author":"McKee","year":"2013","journal-title":"Brain"},{"issue":"1","key":"10.1016\/j.thromres.2020.10.041_bb0800","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s40478-016-0382-8","article-title":"Microglial neuroinflammation contributes to tau accumulation in chronic traumatic encephalopathy","volume":"4","author":"Cherry","year":"2016","journal-title":"Acta neuropathologica communications"},{"issue":"9","key":"10.1016\/j.thromres.2020.10.041_bb0805","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/S1474-4422(16)30057-6","article-title":"Characterisation of interface astroglial scarring in the human brain after blast exposure: a post-mortem case series","volume":"15","author":"Shively","year":"2016","journal-title":"Lancet Neurol."},{"issue":"3 Suppl","key":"10.1016\/j.thromres.2020.10.041_bb0810","first-page":"S242","article-title":"Military-related traumatic brain injury and neurodegeneration","volume":"10","author":"McKee","year":"2014","journal-title":"Alzheimer's & dementia: the journal of the Alzheimer's Association"},{"issue":"7","key":"10.1016\/j.thromres.2020.10.041_bb0815","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1093\/jnen\/nlw036","article-title":"Blood-brain barrier dysfunction as a Hallmark pathology in chronic traumatic encephalopathy","volume":"75","author":"Doherty","year":"2016","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"2","key":"10.1016\/j.thromres.2020.10.041_bb0820","doi-asserted-by":"crossref","first-page":"51","DOI":"10.5414\/NP301130","article-title":"Blood-brain barrier dysfunction in a boxer with chronic traumatic encephalopathy and schizophrenia","volume":"38","author":"Farrell","year":"2019","journal-title":"Clin. Neuropathol."},{"issue":"12","key":"10.1016\/j.thromres.2020.10.041_bb0825","first-page":"1147","article-title":"Blood-brain barrier disruption is an early event that may persist for many years after traumatic brain injury in humans","volume":"74","author":"Hay","year":"2015","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.thromres.2020.10.041_bb0830","doi-asserted-by":"crossref","first-page":"101695","DOI":"10.1016\/j.pneurobio.2019.101695","article-title":"Platelets: the missing link between the blood and brain?","author":"Leiter","year":"2019","journal-title":"Prog Neurobiol"},{"issue":"8","key":"10.1016\/j.thromres.2020.10.041_bb0835","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1089\/neu.2018.6096","article-title":"Experimental designs for repeated mild traumatic brain injury: challenges and considerations","volume":"36","author":"Bolton-Hall","year":"2019","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.thromres.2020.10.041_bb0840","first-page":"10(1015)","article-title":"A comprehensive review of experimental rodent models of repeated blast TBI","author":"Skotak","year":"2019","journal-title":"Front. Neurol."},{"key":"10.1016\/j.thromres.2020.10.041_bb0845","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/978-1-4939-3816-2_8","article-title":"Cellular mechanisms and behavioral outcomes in blast-induced neurotrauma: comparing experimental setups","volume":"1462","author":"Bailey","year":"2016","journal-title":"Methods Mol. Biol."},{"issue":"1","key":"10.1016\/j.thromres.2020.10.041_bb0850","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/s12974-018-1173-x","article-title":"Neutrophils in traumatic brain injury (TBI): friend or foe?","volume":"15","author":"Liu","year":"2018","journal-title":"J. Neuroinflammation"},{"issue":"1","key":"10.1016\/j.thromres.2020.10.041_bb0855","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12974-018-1066-z","article-title":"The role of the complement system in traumatic brain injury: a review","volume":"15","author":"Hammad","year":"2018","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.thromres.2020.10.041_bb0860","doi-asserted-by":"crossref","first-page":"721","DOI":"10.3389\/fimmu.2018.00721","article-title":"Extracellular vesicles: packages sent with complement","volume":"9","author":"Karasu","year":"2018","journal-title":"Front. Immunol."},{"issue":"269","key":"10.1016\/j.thromres.2020.10.041_bb0865","article-title":"C1-Inhibitor protects from focal brain trauma in a cortical cryolesion mice model by reducing thrombo-inflammation","volume":"8","author":"Albert-Weissenberger","year":"2014","journal-title":"Front. Cell. Neurosci."},{"issue":"11","key":"10.1016\/j.thromres.2020.10.041_bb0870","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1001\/jamaneurol.2018.2030","article-title":"Safety and efficacy of atorvastatin for chronic subdural hematoma in Chinese patients: a randomized ClinicalTrial","volume":"75","author":"Jiang","year":"2018","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.thromres.2020.10.041_bb0875","article-title":"Conformation-dependent blockage of activated VWF improved outcomes of traumatic brain injury in mice","author":"Xu","year":"2020","journal-title":"Blood"}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384820306022?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384820306022?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T17:43:36Z","timestamp":1758735816000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049384820306022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":175,"alternative-id":["S0049384820306022"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2020.10.041","relation":{},"ISSN":["0049-3848"],"issn-type":[{"value":"0049-3848","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Links between thrombosis and inflammation in traumatic brain injury","name":"articletitle","label":"Article Title"},{"value":"Thrombosis Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.thromres.2020.10.041","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}