{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T12:05:35Z","timestamp":1774008335058,"version":"3.50.1"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004569","name":"Ministerstwo Nauki i Szkolnictwa Wy\u017cszego","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004569","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thrombosisresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.thromres.2020.12.005","type":"journal-article","created":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T17:28:26Z","timestamp":1608139706000},"page":"190-195","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Von Willebrand factor in aortic or mitral valve stenosis and bleeding after heart valve surgery"],"prefix":"10.1016","volume":"198","author":[{"given":"Piotr","family":"Mazur","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Natorska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micha\u0142","family":"Z\u0105bczyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0141ukasz","family":"Krzych","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rados\u0142aw","family":"Litwinowicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"K\u0119dziora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bogus\u0142aw","family":"Kapelak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anetta","family":"Undas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.thromres.2020.12.005_bb0005","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/S0140-6736(09)60211-7","article-title":"Aortic stenosis","volume":"373","author":"Carabello","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.thromres.2020.12.005_bb0010","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1056\/NEJMoa022831","article-title":"Acquired von Willebrand syndrome in aortic stenosis","volume":"349","author":"Vincentelli","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.thromres.2020.12.005_bb0015","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1093\/ejcts\/ezx324","article-title":"2017 ESC\/EACTS guidelines for the management of valvular heart disease","volume":"52","author":"Falk","year":"2017","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"10.1016\/j.thromres.2020.12.005_bb0020","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1053\/j.jvca.2011.09.021","article-title":"Increased chest tube drainage is independently associated with adverse outcome after cardiac surgery","volume":"26","author":"Christensen","year":"2012","journal-title":"J. Cardiothorac. Vasc. Anesth."},{"key":"10.1016\/j.thromres.2020.12.005_bb0025","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1093\/ejcts\/ezx325","article-title":"2017 EACTS\/EACTA guidelines on patient blood management for adult cardiac surgery","volume":"53","author":"Pagano","year":"2018","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"10.1016\/j.thromres.2020.12.005_bb0030","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.ejcts.2010.10.003","article-title":"The Papworth Bleeding Risk Score: a stratification scheme for identifying cardiac surgery patients at risk of excessive early postoperative bleeding","volume":"39","author":"Vuylsteke","year":"2011","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"10.1016\/j.thromres.2020.12.005_bb0035","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1160\/TH04-12-0799","article-title":"Relationship between factor XIII activity, fibrinogen, haemostasis screening tests and postoperative bleeding in cardiopulmonary bypass surgery","volume":"93","author":"Blome","year":"2005","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.thromres.2020.12.005_bb0040","doi-asserted-by":"crossref","first-page":"e26","DOI":"10.1093\/ejcts\/ezt527","article-title":"Decreased von Willebrand factor ristocetin cofactor activity and increased ADAMTS13 antigen increase postoperative drainage after coronary artery bypass grafting","volume":"45","author":"Mazur","year":"2014","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"10.1016\/j.thromres.2020.12.005_bb0045","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1093\/ejcts\/ezy226","article-title":"Plasma fibrin clot properties affect blood loss after surgical aortic valve replacement for aortic stenosis","volume":"55","author":"Mazur","year":"2019","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"10.1016\/j.thromres.2020.12.005_bb0050","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.thromres.2016.01.016","article-title":"Increased bleeding risk in patients with aortic valvular stenosis: from new mechanisms to new therapies","volume":"139","author":"Natorska","year":"2016","journal-title":"Thromb. Res."},{"key":"10.1016\/j.thromres.2020.12.005_bb0055","doi-asserted-by":"crossref","first-page":"6306","DOI":"10.1073\/pnas.87.16.6306","article-title":"Identification of a cleavage site directing the immunochemical detection of molecular abnormalities in type IIA von Willebrand factor","volume":"87","author":"Dent","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.thromres.2020.12.005_bb0060","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1161\/01.CIR.102.11.1290","article-title":"Proteolysis of von Willebrand factor and shear stress-induced platelet aggregation in patients with aortic valve stenosis","volume":"102","author":"Pareti","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.thromres.2020.12.005_bb0065","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.thromres.2014.04.033","article-title":"Comparison of Von Willebrand factor (VWF) activity VWF:Ac with VWF ristocetin cofactor activity VWF:RCo","volume":"134","author":"Geisen","year":"2014","journal-title":"Thromb. Res."},{"key":"10.1016\/j.thromres.2020.12.005_bb0070","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1136\/hrt.2010.217273","article-title":"Increased thrombin generation and platelet activation are associated with deficiency in high molecular weight multimers of von Willebrand factor in patients with moderate-to-severe aortic stenosis","volume":"97","author":"Natorska","year":"2011","journal-title":"Heart"},{"key":"10.1016\/j.thromres.2020.12.005_bb0075","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/S0140-6736(16)00558-4","article-title":"Mitral valve disease\u2014current management and future challenges","volume":"387","author":"Nishimura","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.thromres.2020.12.005_bb0080","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.atherosclerosis.2010.08.072","article-title":"Relationships of mitral annular calcification to cardiovascular risk factors: the Multi-Ethnic Study of Atherosclerosis (MESA)","volume":"213","author":"Kanjanauthai","year":"2010","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.thromres.2020.12.005_bb0085","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1161\/01.CIR.83.5.1630","article-title":"Correlation of circulating von Willebrand factor levels with cardiovascular hemodynamics","volume":"83","author":"Penny","year":"1991","journal-title":"Circulation"},{"key":"10.1016\/j.thromres.2020.12.005_bb0090","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s11239-018-1687-1","article-title":"Impaired fibrinolysis in degenerative mitral and aortic valve stenosis","volume":"46","author":"Mazur","year":"2018","journal-title":"J. Thromb. Thrombolysis"},{"key":"10.1016\/j.thromres.2020.12.005_bb0095","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1093\/ejcts\/ezs455","article-title":"Guidelines on the management of valvular heart disease (version 2012): the Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)","volume":"42","author":"Vahanian","year":"2012","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"10.1016\/j.thromres.2020.12.005_bb0100","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1093\/bja\/aer512","article-title":"Impact of loss of high-molecular-weight von Willebrand factor multimers on blood loss after aortic valve replacement","volume":"108","author":"Bolliger","year":"2012","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.thromres.2020.12.005_bb0105","doi-asserted-by":"crossref","first-page":"120","DOI":"10.3109\/14017431.2010.545143","article-title":"No excess surgical blood loss in patients with acquired type 2A von Willebrand disease","volume":"45","author":"Mikkelsen","year":"2011","journal-title":"Scand. Cardiovasc. J."},{"key":"10.1016\/j.thromres.2020.12.005_bb0110","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1007\/s11239-019-01917-7","article-title":"Pre-procedural abnormal function of von Willebrand factor is predictive of bleeding after surgical but not transcatheter aortic valve replacement","volume":"48","author":"Grodecki","year":"2019","journal-title":"J. Thromb. Thrombolysis"},{"key":"10.1016\/j.thromres.2020.12.005_bb0115","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1016\/j.jtcvs.2013.10.070","article-title":"Universal definition of perioperative bleeding in adult cardiac surgery","volume":"147","author":"Dyke","year":"2014","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"10.1016\/j.thromres.2020.12.005_bb0120","doi-asserted-by":"crossref","first-page":"154","DOI":"10.23736\/S0021-9509.18.10209-6","article-title":"The von Willebrand factor ratio and perioperative bleeding in patients with aortic valve stenosis","volume":"60","author":"Brandenburger","year":"2019","journal-title":"J. Cardiovasc. Surg."},{"key":"10.1016\/j.thromres.2020.12.005_bb0125","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1172\/JCI119219","article-title":"Shear stress induction of the tissue factor gene","volume":"99","author":"Lin","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.thromres.2020.12.005_bb0130","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1177\/0003319706297917","article-title":"Coagulation, fibrinolytic system activation and endothelial dysfunction in patients with mitral stenosis and sinus rhythm","volume":"58","author":"Topaloglu","year":"2007","journal-title":"Angiology"},{"key":"10.1016\/j.thromres.2020.12.005_bb0135","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1177\/1076029607305115","article-title":"Alterations of von Willebrand factor and ristocetin cofactor activity during atrial fibrillation","volume":"15","author":"Kalyoncu","year":"2009","journal-title":"Clin. Appl. Thromb. Hemost."},{"key":"10.1016\/j.thromres.2020.12.005_bb0140","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1471-2253-12-27","article-title":"PAI-1 and t-PA\/PAI-1 complex potential markers of fibrinolytic bleeding after cardiac surgery employing cardiopulmonary bypass","volume":"12","author":"Ozolina","year":"2012","journal-title":"BMC Anesthesiol."},{"key":"10.1016\/j.thromres.2020.12.005_bb0145","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1365-2141.1986.tb07497.x","article-title":"Abnormalities of von Willebrand factor in myeloproliferative disease: a relationship with bleeding diathesis","volume":"63","author":"Fabris","year":"1986","journal-title":"Br. J. Haematol."}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384820306526?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384820306526?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T17:44:58Z","timestamp":1758735898000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049384820306526"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":29,"alternative-id":["S0049384820306526"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2020.12.005","relation":{},"ISSN":["0049-3848"],"issn-type":[{"value":"0049-3848","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Von Willebrand factor in aortic or mitral valve stenosis and bleeding after heart valve surgery","name":"articletitle","label":"Article Title"},{"value":"Thrombosis Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.thromres.2020.12.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}