{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:38:29Z","timestamp":1791434309574,"version":"4.3.3"},"reference-count":77,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["RG\/18\/11\/34036"],"award-info":[{"award-number":["RG\/18\/11\/34036"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["204951\/B\/16\/Z"],"award-info":[{"award-number":["204951\/B\/16\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thrombosisresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.thromres.2021.01.005","type":"journal-article","created":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T03:08:24Z","timestamp":1610939304000},"page":"1-8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":96,"special_numbering":"C","title":["Mechanisms of thrombosis and cardiovascular complications in COVID-19"],"prefix":"10.1016","volume":"200","author":[{"given":"Eden M.","family":"Page","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.S.","family":"Ari\u00ebns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.thromres.2021.01.005_bb0005","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.jacbts.2020.04.002","article-title":"COVID-19 for the cardiologist: a current review of the virology, clinical epidemiology, cardiac and other clinical manifestations and potential therapeutic strategies","volume":"5","author":"Atri","year":"2020","journal-title":"JACC Basic Transl Sci."},{"key":"10.1016\/j.thromres.2021.01.005_bb0010","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1002\/ajh.25829","article-title":"Hematological findings and complications of COVID-19","volume":"95","author":"Terpos","year":"2020","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.thromres.2021.01.005_bb0015","doi-asserted-by":"crossref","first-page":"104362","DOI":"10.1016\/j.jcv.2020.104362","article-title":"Coagulation disorders in coronavirus infected patients: COVID-19, SARS-CoV-1, MERS-CoV and lessons from the past","volume":"127","author":"Giannis","year":"2020","journal-title":"J. Clin. Virol."},{"key":"10.1016\/j.thromres.2021.01.005_bb0020","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.thromres.2020.04.013","article-title":"Incidence of thrombotic complications in critically ill ICU patients with COVID-19","volume":"191","author":"Klok","year":"2020","journal-title":"Thromb. Res."},{"key":"10.1016\/j.thromres.2021.01.005_bb0025","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1111\/jth.14888","article-title":"Incidence of venous thromboembolism in hospitalized patients with COVID-19","volume":"18","author":"Middeldorp","year":"2020","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2021.01.005_bb0030","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1111\/bjh.16727","article-title":"Thromboembolic risk and anticoagulant therapy in COVID-19 patients: emerging evidence and call for action","volume":"189","author":"Kollias","year":"2020","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.thromres.2021.01.005_bb0035","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1111\/jth.14830","article-title":"Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia","volume":"18","author":"Cui","year":"2020","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2021.01.005_bb0040","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.thromres.2020.06.027","article-title":"Is COVID-19 associated thrombosis caused by overactivation of the complement cascade? A literature review","volume":"194","author":"Fletcher-Sandersj\u00f6\u00f6","year":"2020","journal-title":"Thromb. Res."},{"key":"10.1016\/j.thromres.2021.01.005_bb0045","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1111\/jth.14844","article-title":"Pathological evidence of pulmonary thrombotic phenomena in severe COVID-19","volume":"18","author":"Dolhnikoff","year":"2020","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2021.01.005_bb0050","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1111\/jth.14879","article-title":"What do monitoring platelet counts in COVID-19 teach us?","volume":"18","author":"Thachil","year":"2020","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2021.01.005_bb0055","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.thromres.2020.06.014","article-title":"COVID-19 and thrombotic complications: pulmonary thrombosis rather than embolism?","volume":"193","author":"Gabrielli","year":"2020","journal-title":"Thromb. Res."},{"key":"10.1016\/j.thromres.2021.01.005_bb0060","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.thromres.2020.04.042","article-title":"COVID-19 associated pulmonary thrombosis","volume":"191","author":"van Nieuwkoop","year":"2020","journal-title":"Thromb. Res."},{"key":"10.1016\/j.thromres.2021.01.005_bb0065","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1055\/s-0040-1712097","article-title":"Pulmonary embolism or pulmonary thrombosis in COVID-19? Is the recommendation to use high-dose heparin for thromboprophylaxis justified?","volume":"120","author":"Cattaneo","year":"2020","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.thromres.2021.01.005_bb0070","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.thromres.2020.04.032","article-title":"Thrombotic complications in critically ill patients with COVID 19","volume":"191","author":"Rosen","year":"2020","journal-title":"Thromb. Res."},{"key":"10.1016\/j.thromres.2021.01.005_bb0075","first-page":"M20","article-title":"Autopsy findings and venous thromboembolism in patients with COVID-19","author":"Wichmann","year":"2020","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.thromres.2021.01.005_bb0080","doi-asserted-by":"crossref","DOI":"10.1007\/s11239-020-02172-x","article-title":"Potential role for tissue factor in the pathogenesis of hypercoagulability associated with in COVID-19","author":"Bautista-Vargas","year":"2020","journal-title":"J. Thromb. Thrombolysis"},{"key":"10.1016\/j.thromres.2021.01.005_bb0085","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1182\/blood.2020006000","article-title":"COVID-19 and its implications for thrombosis and anticoagulation","volume":"135","author":"Connors","year":"2020","journal-title":"Blood."},{"key":"10.1016\/j.thromres.2021.01.005_bb0090","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.1172\/JCI137244","article-title":"Clinical and immunological features of severe and moderate coronavirus disease 2019","volume":"130","author":"Chen","year":"2020","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.thromres.2021.01.005_bb0095","doi-asserted-by":"crossref","first-page":"142","DOI":"10.3389\/fped.2018.00142","article-title":"The role of inflammation in venous thromboembolism","volume":"6","author":"Branchford","year":"2018","journal-title":"Front. Pediatr."},{"key":"10.1016\/j.thromres.2021.01.005_bb0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1469-1809.2009.00551.x","article-title":"Interaction between fibrinogen and IL-6 genetic variants and associations with cardiovascular disease risk in the cardiovascular health study","volume":"74","author":"Carty","year":"2010","journal-title":"Ann. Hum. Genet."},{"key":"10.1016\/j.thromres.2021.01.005_bb0105","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.3389\/fimmu.2020.01446","article-title":"The COVID-19 cytokine storm; what we know so far","volume":"11","author":"Ragab","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.thromres.2021.01.005_bb0110","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1161\/CIRCULATIONAHA.120.050089","article-title":"Established cardiovascular biomarkers provide limited prognostic information in unselected patients hospitalized with COVID-19","volume":"142","author":"Omland","year":"2020","journal-title":"Circulation."},{"key":"10.1016\/j.thromres.2021.01.005_bb0115","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.03006-2020","article-title":"Confronting the controversy: interleukin-6 and the COVID-19 cytokine storm syndrome","volume":"56","author":"Chen","year":"2020","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.thromres.2021.01.005_bb0120","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1161\/CIRCRESAHA.120.317703","article-title":"Platelets can associate with SARS-CoV-2 RNA and are hyperactivated in COVID-19","volume":"127","author":"Zaid","year":"2020","journal-title":"Circ. Res."},{"key":"10.1016\/j.thromres.2021.01.005_bb0125","doi-asserted-by":"crossref","DOI":"10.1182\/blood.2020007214","article-title":"Platelet gene expression and function in COVID-19 patients","author":"Manne","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.thromres.2021.01.005_bb0130","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12959-015-0048-y","article-title":"Contact pathway of coagulation and inflammation","volume":"13","author":"Wu","year":"2015","journal-title":"Thromb. J."},{"key":"10.1016\/j.thromres.2021.01.005_bb0135","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1038\/s41467-019-09607-x","article-title":"The role of platelets in mediating a response to human influenza infection","volume":"10","author":"Koupenova","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.thromres.2021.01.005_bb0140","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1182\/bloodadvances.2020001640","article-title":"Influenza-induced thrombocytopenia is dependent on the subtype and sialoglycan receptor and increases with virus pathogenicity","volume":"4","author":"Jansen","year":"2020","journal-title":"Blood Adv."},{"key":"10.1016\/j.thromres.2021.01.005_bb0145","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/s41594-019-0233-y","article-title":"Structural basis for human coronavirus attachment to sialic acid receptors","volume":"26","author":"Tortorici","year":"2019","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.thromres.2021.01.005_bb0150","doi-asserted-by":"crossref","first-page":"4549","DOI":"10.3390\/ijms21124549","article-title":"SARS-CoV-2 evolutionary adaptation toward host entry and recognition of receptor O-acetyl sialylation in virus-host interaction","volume":"21","author":"Kim","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.thromres.2021.01.005_bb0155","article-title":"Neutrophil extracellular traps (NETs) in COVID-19","volume":"5","author":"Zuo","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.thromres.2021.01.005_bb0160","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.thromres.2020.04.031","article-title":"The role of neutrophil extracellular traps in Covid-19: only an hypothesis or a potential new field of research?","volume":"191","author":"Mozzini","year":"2020","journal-title":"Thromb. Res."},{"key":"10.1016\/j.thromres.2021.01.005_bb0165","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.cca.2020.04.027","article-title":"Hyperinflammation and derangement of renin-angiotensin-aldosterone system in COVID-19: a novel hypothesis for clinically suspected hypercoagulopathy and microvascular immunothrombosis","volume":"507","author":"Henry","year":"2020","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.thromres.2021.01.005_bb0170","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1161\/STROKEAHA.117.019896","article-title":"Thrombus neutrophil extracellular traps content impair tPA-induced thrombolysis in acute ischemic stroke","volume":"49","author":"Ducroux","year":"2018","journal-title":"Stroke."},{"key":"10.1016\/j.thromres.2021.01.005_bb0175","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1160\/TH14-08-0669","article-title":"DNA, histones and neutrophil extracellular traps exert anti-fibrinolytic effects in a plasma environment","volume":"113","author":"Varj\u00fa","year":"2015","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.thromres.2021.01.005_bb0180","article-title":"2020, Plasma tissue plasminogen activator and plasminogen activator inhibitor-1 in hospitalized COVID-19 patients","author":"Zuo","year":"2020","journal-title":"medRxiv"},{"key":"10.1016\/j.thromres.2021.01.005_bb0185","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jamcollsurg.2020.05.021","article-title":"Fibrinolysis shutdown and thrombosis in severe COVID-19","volume":"231","author":"Seheult","year":"2020","journal-title":"J. Am. Coll. Surg."},{"key":"10.1016\/j.thromres.2021.01.005_bb0190","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1111\/jth.14578","article-title":"Diagnosis and management of sepsis-induced coagulopathy and disseminated intravascular coagulation","volume":"17","author":"Iba","year":"2019","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2021.01.005_bb0195","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.thromres.2020.04.024","article-title":"Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Milan, Italy","volume":"191","author":"Lodigiani","year":"2020","journal-title":"Thromb. Res."},{"key":"10.1016\/j.thromres.2021.01.005_bb0200","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1111\/jth.14768","article-title":"Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia","volume":"18","author":"Tang","year":"2020","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2021.01.005_bb0205","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1007\/s00134-020-06062-x","article-title":"High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study","volume":"46","author":"Helms","year":"2020","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.thromres.2021.01.005_bb0210","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1111\/jth.14818","article-title":"Pulmonary thrombosis in 2019-nCoV pneumonia?","volume":"18","author":"Marongiu","year":"2020","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2021.01.005_bb0215","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1111\/jth.14843","article-title":"Response to \u2018Pulmonary thrombosis in 2019-nCoV pneumonia?\u2019","volume":"18","author":"Tang","year":"2020","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2021.01.005_bb0220","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1007\/s11239-020-02129-0","article-title":"Pulmonary intravascular coagulation in COVID-19: possible pathogenesis and recommendations on anticoagulant\/thrombolytic therapy","volume":"50","author":"Belen-Apak","year":"2020","journal-title":"J. Thromb. Thrombolysis"},{"key":"10.1016\/j.thromres.2021.01.005_bb0225","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/bjh.16783","article-title":"Severe COVID-19 infection and thrombotic microangiopathy: success doesn\u2019t come easily","volume":"189","author":"Gavriilaki","year":"2020","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.thromres.2021.01.005_bb0230","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0035690","article-title":"Effects of MASP-1 of the complement system on activation of coagulation factors and plasma clot formation","volume":"7","author":"Hess","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.thromres.2021.01.005_bb0235","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0000623","article-title":"Simultaneous activation of complement and coagulation by MBL-associated serine protease 2","volume":"2","author":"Krarup","year":"2007","journal-title":"PLoS One"},{"key":"10.1016\/j.thromres.2021.01.005_bb0240","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.molimm.2014.05.013","article-title":"Multiple roles of complement MASP-1 at the interface of innate immune response and coagulation","volume":"61","author":"Dob\u00f3","year":"2014","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.thromres.2021.01.005_bb0245","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1093\/cvr\/cvaa106","article-title":"COVID-19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options","volume":"116","author":"Guzik","year":"2020","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.thromres.2021.01.005_bb0250","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.cardfail.2020.04.009","article-title":"Elevated troponin in patients with coronavirus disease 2019: possible mechanisms","volume":"26","author":"Tersalvi","year":"2020","journal-title":"J. Card. Fail."},{"key":"10.1016\/j.thromres.2021.01.005_bb0255","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.dsx.2020.03.013","article-title":"Cardiovascular disease and COVID-19","volume":"14","author":"Bansal","year":"2020","journal-title":"Diabetes Metab. Syndr."},{"key":"10.1016\/j.thromres.2021.01.005_bb0260","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00912-2020","article-title":"Understanding the renin-angiotensin-aldosterone-SARS-CoV-axis: a comprehensive review","volume":"56","author":"Ingraham","year":"2020","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.thromres.2021.01.005_bb0265","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1136\/heartjnl-2020-317025","article-title":"COVID-19 and acute myocardial injury: the heart of the matter or an innocent bystander?","volume":"106","author":"Cheng","year":"2020","journal-title":"Heart."},{"key":"10.1016\/j.thromres.2021.01.005_bb0270","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1093\/cvr\/cvaa160","article-title":"Evidence of SARS-CoV-2 mRNA in endomyocardial biopsies of patients with clinically suspected myocarditis tested negative for COVID-19 in nasopharyngeal swab","volume":"116","author":"Wenzel","year":"2020","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.thromres.2021.01.005_bb0275","first-page":"30422","article-title":"Recognizing COVID-19-related myocarditis: the possible pathophysiology and proposed guideline for diagnosis and management","volume":"S1547-5271","author":"Siripanthong","year":"2020","journal-title":"Heart Rhythm."},{"key":"10.1016\/j.thromres.2021.01.005_bb0280","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1134\/S0006297916110134","article-title":"The role of cytokines in the development of atherosclerosis","volume":"81","author":"Fatkhullina","year":"2016","journal-title":"Biochemistry (Mosc)"},{"key":"10.1016\/j.thromres.2021.01.005_bb0285","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1111\/jth.14810","article-title":"ISTH interim guidance on recognition and management of coagulopathy in COVID-19","volume":"18","author":"Thachil","year":"2020","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2021.01.005_bb0290","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/S0140-6736(20)30566-3","article-title":"Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study","volume":"395","author":"Zhou","year":"2020","journal-title":"Lancet."},{"key":"10.1016\/j.thromres.2021.01.005_bb0295","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1111\/jth.14859","article-title":"D-dimer levels on admission to predict in-hospital mortality in patients with Covid-19","volume":"18","author":"Zhang","year":"2020","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2021.01.005_bb0300","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1111\/jth.14848","article-title":"Thrombocytopenia and its association with mortality in patients with COVID-19","volume":"18","author":"Yang","year":"2020","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2021.01.005_bb0305","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1111\/jth.14832","article-title":"Exploring possible mechanisms for COVID-19 induced: thrombocytopenia unanswered questions","volume":"18","author":"Amgalan","year":"2020","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2021.01.005_bb0310","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1159\/000507666","article-title":"The baffling case of ischemic stroke disappearance from the casualty department in the COVID-19 era","volume":"83","author":"Morelli","year":"2020","journal-title":"Eur. Neurol."},{"key":"10.1016\/j.thromres.2021.01.005_bb0315","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s11239-020-02130-7","article-title":"Evaluation of coagulation function by rotation thromboelastometry in critically ill patients with severe COVID-19 pneumonia","volume":"50","author":"Pavoni","year":"2020","journal-title":"J. Thromb. Thrombolysis"},{"key":"10.1016\/j.thromres.2021.01.005_bb0320","doi-asserted-by":"crossref","first-page":"2001028","DOI":"10.1183\/13993003.01028-2020","article-title":"Clinical phenotypes of SARS-CoV-2: implications for clinicians and researchers","volume":"55","author":"Rello","year":"2020","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.thromres.2021.01.005_bb0325","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1056\/NEJMoa2002032","article-title":"Clinical characteristics of coronavirus disease 2019 in China","volume":"382","author":"Guan","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.thromres.2021.01.005_bb0330","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1111\/jth.14850","article-title":"Hypercoagulability of COVID-19 patients in intensive care unit. A report of thromboelastography findings and other parameters of hemostasis","volume":"18","author":"Panigada","year":"2020","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2021.01.005_bb0335","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.thromres.2020.04.021","article-title":"Age-adjusted D-dimer cut-off levels to rule out venous thromboembolism in COVID-19 patients","volume":"190","author":"Roncon","year":"2020","journal-title":"Thromb. Res."},{"key":"10.1016\/j.thromres.2021.01.005_bb0340","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1001\/jamacardio.2020.1017","article-title":"Cardiovascular implications of fatal outcomes of patients with coronavirus disease 2019 (COVID-19)","volume":"5","author":"Guo","year":"2020","journal-title":"JAMA Cardiol."},{"key":"10.1016\/j.thromres.2021.01.005_bb0345","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.thromres.2020.04.023","article-title":"Where do we stand with antithrombotic prophylaxis in patients with COVID-19?","volume":"191","author":"Ciavarella","year":"2020","journal-title":"Thromb. Res."},{"key":"10.1016\/j.thromres.2021.01.005_bb0350","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1111\/jth.14869","article-title":"High incidence of venous thromboembolic events in anticoagulated severe COVID-19 patients","volume":"18","author":"Llitjos","year":"2020","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2021.01.005_bb0355","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1111\/jth.14860","article-title":"ISTH interim guidance on recognition and management of coagulopathy in COVID-19: a comment","volume":"18","author":"Barrett","year":"2020","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2021.01.005_bb0360","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1111\/jth.14870","article-title":"Type and dose of heparin in Covid-19: reply","volume":"18","author":"Thachil","year":"2020","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2021.01.005_bb0365","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1055\/s-0040-1710019","article-title":"Prevention and treatment of venous thromboembolism associated with coronavirus disease 2019 infection: a consensus statement before guidelines","volume":"120","author":"Zhai","year":"2020","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.thromres.2021.01.005_bb0370","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1111\/jth.14821","article-title":"The versatile heparin in COVID-19","volume":"18","author":"Thachil","year":"2020","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2021.01.005_bb0375","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1111\/jth.14817","article-title":"Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy","volume":"18","author":"Tang","year":"2020","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2021.01.005_bb0380","doi-asserted-by":"crossref","first-page":"108468","DOI":"10.1016\/j.clim.2020.108468","article-title":"Can ticagrelor be used to prevent sepsis-induced coagulopathy in COVID-19?","volume":"216","author":"Omarjee","year":"2020","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.thromres.2021.01.005_bb0385","first-page":"233","article-title":"Ticagrelor can be an important agent in the treatment of severe COVID-19 patients with myocardial infarction","volume":"37","author":"Ak\u015fit","year":"2020","journal-title":"Balkan Med. J."}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384821000141?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384821000141?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T17:44:06Z","timestamp":1758735846000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049384821000141"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":77,"alternative-id":["S0049384821000141"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2021.01.005","relation":{},"ISSN":["0049-3848"],"issn-type":[{"value":"0049-3848","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanisms of thrombosis and cardiovascular complications in COVID-19","name":"articletitle","label":"Article Title"},{"value":"Thrombosis Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.thromres.2021.01.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}