{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T21:11:07Z","timestamp":1762809067436,"version":"3.44.0"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T00:00:00Z","timestamp":1618790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur Forderung der wissenschaftlichen Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thrombosisresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.thromres.2021.04.017","type":"journal-article","created":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T19:22:12Z","timestamp":1618860132000},"page":"22-26","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Accuracy of the functional, flow cytometer-based Emo-Test HIT Confirm\u00ae for the diagnosis of heparin-induced thrombocytopenia"],"prefix":"10.1016","volume":"203","author":[{"given":"Justine","family":"Brodard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Benites","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise","family":"Stalder Zeerleder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Nagler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.thromres.2021.04.017_bb0005","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1056\/NEJMcp1411910","article-title":"Clinical practice. Heparin-Induced Thrombocytopenia","volume":"373","author":"Greinacher","year":"2015","journal-title":"N. Engl. J. Med."},{"issue":"12","key":"10.1016\/j.thromres.2021.04.017_bb0010","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1182\/blood-2018-04-847483","article-title":"High sensitivity and specificity of an automated IgG-specific chemiluminescence immunoassay for diagnosis of HIT","volume":"132","author":"Warkentin","year":"2018","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.thromres.2021.04.017_bb0015","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1160\/TH16-03-0240","article-title":"Clinical and laboratory tests for the diagnosis of heparin-induced thrombocytopenia","volume":"116","author":"Nagler","year":"2016","journal-title":"Thromb. Haemost."},{"issue":"4","key":"10.1016\/j.thromres.2021.04.017_bb0020","doi-asserted-by":"crossref","DOI":"10.3390\/molecules22040617","article-title":"Functional assays in the diagnosis of heparin-induced thrombocytopenia: a review","volume":"22","author":"Minet","year":"2017","journal-title":"Molecules"},{"issue":"6","key":"10.1016\/j.thromres.2021.04.017_bb0025","first-page":"993","article-title":"Heparin-induced thrombocytopenia (HIT) in 2011: an epidemic of overdiagnosis","volume":"106","author":"Cuker","year":"2011","journal-title":"Thromb. Haemost."},{"issue":"8","key":"10.1016\/j.thromres.2021.04.017_bb0030","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1111\/j.1538-7836.2009.03489.x","article-title":"Immunoassays are not created equal","volume":"7","author":"Warkentin","year":"2009","journal-title":"J. Thromb. Haemost."},{"issue":"5","key":"10.1016\/j.thromres.2021.04.017_bb0035","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1182\/blood-2015-07-661215","article-title":"Diagnostic value of immunoassays for heparin-induced thrombocytopenia: a systematic review and meta-analysis","volume":"127","author":"Nagler","year":"2016","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.thromres.2021.04.017_bb0040","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9041226","article-title":"Detection of platelet-activating antibodies associated with heparin-induced thrombocytopenia","volume":"9","author":"Tardy","year":"2020","journal-title":"J. Clin. Med."},{"issue":"5","key":"10.1016\/j.thromres.2021.04.017_bb0045","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1046\/j.1537-2995.1994.34594249047.x","article-title":"Laboratory diagnosis of heparin-associated thrombocytopenia and comparison of platelet aggregation test, heparin-induced platelet activation test, and platelet factor 4\/heparin enzyme-linked immunosorbent assay","volume":"34","author":"Greinacher","year":"1994","journal-title":"Transfusion"},{"issue":"4","key":"10.1016\/j.thromres.2021.04.017_bb0050","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1111\/jth.14749","article-title":"Evaluation of functional assays for the diagnosis of heparin induced thrombocytopenia using 5B9, a monoclonal IgG that mimics human antibodies","volume":"18","author":"Vayne","year":"2020","journal-title":"J. Thromb. Haemostasis"},{"issue":"8","key":"10.1016\/j.thromres.2021.04.017_bb0055","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1111\/j.1538-7836.2007.02617.x","article-title":"Heparin-induced thrombocytopenia: a prospective study on the incidence, platelet-activating capacity and clinical significance of antiplatelet factor 4\/heparin antibodies of the IgG, IgM, and IgA classes","volume":"5","author":"Greinacher","year":"2007","journal-title":"J. Thromb. Haemost."},{"issue":"6","key":"10.1016\/j.thromres.2021.04.017_bb0060","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1002\/ajh.24006","article-title":"The platelet serotonin-release assay","volume":"90","author":"Warkentin","year":"2015","journal-title":"Am. J. Hematol."},{"issue":"3","key":"10.1016\/j.thromres.2021.04.017_bb0065","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/ijlh.12236","article-title":"Current insights into the laboratory diagnosis of HIT","volume":"36","author":"Bakchoul","year":"2014","journal-title":"Int. J. Lab. Hematol."},{"key":"10.1016\/j.thromres.2021.04.017_bb0070","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.thromres.2019.11.004","article-title":"Accuracy of heparin-induced platelet aggregation test for the diagnosis of heparin-induced thrombocytopenia","volume":"185","author":"Brodard","year":"2020","journal-title":"Thromb. Res."},{"issue":"4","key":"10.1016\/j.thromres.2021.04.017_bb0075","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.pathol.2017.11.089","article-title":"HIT or miss? A comprehensive contemporary investigation of laboratory tests for heparin induced thrombocytopenia","volume":"50","author":"Favaloro","year":"2018","journal-title":"Pathology"},{"key":"10.1016\/j.thromres.2021.04.017_bb0080","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.thromres.2019.05.016","article-title":"Evaluation of a flow cytometer-based functional assay using platelet-rich plasma in the diagnosis of heparin-induced thrombocytopenia","volume":"180","author":"Althaus","year":"2019","journal-title":"Thromb. Res."},{"issue":"6","key":"10.1016\/j.thromres.2021.04.017_bb0085","first-page":"804","article-title":"An update on evidence based diagnostic and confirmatory testing strategies for heparin induced thrombocytopenia using combined immunological and functional assays, transfusion and apheresis science","volume":"57","author":"Amiral","year":"2018","journal-title":"Off. J. World Apheresis Assoc. Off. J. Eur. Soc. Haemapheresis"},{"key":"10.1016\/j.thromres.2021.04.017_bb0090","unstructured":"A.M. B. Tardy-Poncet, M. Piot, F. Alkhalfioui, H. Maes, B. Tardy, G.-H.S. Group, A standardized functional assay for routine reliable HIT diagnosis: a potential alternative to the serotonin release assay , Journal of Thrombosis and Haemostasis (2017)."},{"issue":"1","key":"10.1016\/j.thromres.2021.04.017_bb0095","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3324\/haematol.2011.048074","article-title":"Rapid exclusion or confirmation of heparin-induced thrombocytopenia: a single-center experience with 1,291 patients","volume":"97","author":"Nellen","year":"2012","journal-title":"Haematologica"},{"issue":"12","key":"10.1016\/j.thromres.2021.04.017_bb0100","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1055\/s-0039-1696712","article-title":"Rapid centrifugation in the routine hemostasis laboratory","volume":"119","author":"Wolfensberger","year":"2019","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.thromres.2021.04.017_bb0105","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.e6717","article-title":"Use of 3x2 tables with an intention to diagnose approach to assess clinical performance of diagnostic tests: meta-analytical evaluation of coronary CT angiography studies","volume":"345","author":"Schuetz","year":"2012","journal-title":"Bmj"}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384821003029?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384821003029?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T17:45:16Z","timestamp":1758735916000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049384821003029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":21,"alternative-id":["S0049384821003029"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2021.04.017","relation":{},"ISSN":["0049-3848"],"issn-type":[{"type":"print","value":"0049-3848"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Accuracy of the functional, flow cytometer-based Emo-Test HIT Confirm\u00ae for the diagnosis of heparin-induced thrombocytopenia","name":"articletitle","label":"Article Title"},{"value":"Thrombosis Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.thromres.2021.04.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}