{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:22:09Z","timestamp":1792027329191,"version":"4.4.0"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100005881","name":"Hemostasis and Thrombosis Research Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005881","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013554","name":"Foundation for Women and Girls with Blood Disorders","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thrombosisresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.thromres.2021.06.006","type":"journal-article","created":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T04:29:52Z","timestamp":1623385792000},"page":"95-100","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Concomitant use of combined hormonal contraceptives and antifibrinolytic agents for the management of heavy menstrual bleeding: A practice pattern survey"],"prefix":"10.1016","volume":"204","author":[{"given":"Ming Y.","family":"Lim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenora","family":"Olson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhvi A.","family":"Rajpurkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela C.","family":"Weyand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.thromres.2021.06.006_bb0005","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/aogs.12292","article-title":"Heavy menstrual bleeding significantly affects quality of life","volume":"93","author":"Karlsson","year":"2014","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"10.1016\/j.thromres.2021.06.006_bb0010","series-title":"Lysteda [Package Insert]","author":"Ferring Pharmaceuticals Inc","year":"2013"},{"key":"10.1016\/j.thromres.2021.06.006_bb0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.contraception.2018.02.008","article-title":"Heavy menstrual bleeding: is tranexamic acid a safe adjunct to combined hormonal contraception?","volume":"98","author":"Thorne","year":"2018","journal-title":"Contraception"},{"key":"10.1016\/j.thromres.2021.06.006_bb0020","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1097\/AOG.0b013e3181f20177","article-title":"Tranexamic acid treatment for heavy menstrual bleeding: a randomized controlled trial","volume":"116","author":"Lukes","year":"2010","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.thromres.2021.06.006_bb0025","first-page":"1","article-title":"Tranexamic acid therapy: effective treatment in heavy menstrual bleeding. Clinical update on safety","volume":"4","author":"Rybo","year":"1991","journal-title":"Ther. Adv."},{"key":"10.1016\/j.thromres.2021.06.006_bb0030","first-page":"413","article-title":"Tranexamic acid for the treatment of heavy menstrual bleeding: efficacy and safety","volume":"4","author":"Leminen","year":"2012","journal-title":"Int. J. Women\u2019s Health"},{"key":"10.1016\/j.thromres.2021.06.006_bb0035","article-title":"Antifibrinolytics for heavy menstrual bleeding","volume":"4","author":"Bryant-Smith","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.thromres.2021.06.006_bb0040","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/ejh.13348","article-title":"The many roles of tranexamic acid: an overview of the clinical indications for TXA in medical and surgical patients","volume":"104","author":"Cai","year":"2020","journal-title":"Eur. J. Haematol."},{"key":"10.1016\/j.thromres.2021.06.006_bb0045","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1097\/AOG.0b013e318262e320","article-title":"Practice bulletin no. 128: diagnosis of abnormal uterine bleeding in reproductive-aged women","volume":"120","author":"Committee on Practice B-G","year":"2012","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.thromres.2021.06.006_bb0050","series-title":"Medical Eligibility Criteria for Contraceptive Use: A WHO Family Planning Cornerstone","author":"World Health Organization (WHO)","year":"2015"},{"key":"10.1016\/j.thromres.2021.06.006_bb0055","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1111\/j.1538-7836.2012.04662.x","article-title":"Duration of anticoagulant therapy after a first episode of an unprovoked pulmonary embolus or deep vein thrombosis: guidance from the SSC of the ISTH","volume":"10","author":"Baglin","year":"2012","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2021.06.006_bb0060","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1182\/blood-2015-08-665927","article-title":"Recurrent venous thromboembolism and abnormal uterine bleeding with anticoagulant and hormone therapy use","volume":"127","author":"Martinelli","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.thromres.2021.06.006_bb0065","doi-asserted-by":"crossref","first-page":"f5298","DOI":"10.1136\/bmj.f5298","article-title":"Different combined oral contraceptives and the risk of venous thrombosis: systematic review and network meta-analysis","volume":"347","author":"Stegeman","year":"2013","journal-title":"BMJ"},{"key":"10.1016\/j.thromres.2021.06.006_bb0070","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0140-6736(10)60835-5","article-title":"Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial","volume":"376","author":"Shakur","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.thromres.2021.06.006_bb0075","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/aogs.12798","article-title":"Tranexamic acid for preventing postpartum blood loss after cesarean delivery: a systematic review and meta-analysis of randomized controlled trials","volume":"95","author":"Simonazzi","year":"2016","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"10.1016\/j.thromres.2021.06.006_bb0080","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1093\/bja\/aep314","article-title":"Tranexamic acid in hip fracture surgery: a randomized controlled trial","volume":"104","author":"Zufferey","year":"2010","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.thromres.2021.06.006_bb0085","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1016\/S0140-6736(20)30848-5","article-title":"Effects of a high-dose 24-h infusion of tranexamic acid on death and thromboembolic events in patients with acute gastrointestinal bleeding (HALT-IT): an international randomised, double-blind, placebo-controlled trial","volume":"395","author":"Collaborators","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.thromres.2021.06.006_bb0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1182\/blood-2020-138920","article-title":"Effects of tranexamic acid prophylaxis on bleeding outcomes in hematologic malignancy: the a-TREAT trial","volume":"136","author":"Gernsheimer","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.thromres.2021.06.006_bb0095","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.thromres.2019.05.003","article-title":"Risk of venous and arterial thrombosis in non-surgical patients receiving systemic tranexamic acid: a systematic review and meta-analysis","volume":"179","author":"Chornenki","year":"2019","journal-title":"Thromb. Res."},{"key":"10.1016\/j.thromres.2021.06.006_bb0100","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1016\/S0140-6736(17)30638-4","article-title":"Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial","volume":"389","author":"Collaborators","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.thromres.2021.06.006_bb0105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0070310","article-title":"The incidence of first venous thromboembolism in and around pregnancy using linked primary and secondary care data: a population based cohort study from England and comparative meta-analysis","volume":"8","author":"Abdul Sultan","year":"2013","journal-title":"PLoS One"},{"issue":"Suppl. 1","key":"10.1016\/j.thromres.2021.06.006_bb0110","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/j.1365-2516.2011.02558.x","article-title":"Surveillance of female patients with inherited bleeding disorders in United States Haemophilia Treatment Centres","volume":"17","author":"Byams","year":"2011","journal-title":"Haemophilia"},{"key":"10.1016\/j.thromres.2021.06.006_bb0115","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1182\/bloodadvances.2020003264","article-title":"ASH ISTH NHF WFH 2021 guidelines on the management of von Willebrand disease","volume":"5","author":"Connell","year":"2021","journal-title":"Blood Adv."}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384821003662?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384821003662?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T17:46:01Z","timestamp":1758735961000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049384821003662"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":23,"alternative-id":["S0049384821003662"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2021.06.006","relation":{},"ISSN":["0049-3848"],"issn-type":[{"value":"0049-3848","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Concomitant use of combined hormonal contraceptives and antifibrinolytic agents for the management of heavy menstrual bleeding: A practice pattern survey","name":"articletitle","label":"Article Title"},{"value":"Thrombosis Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.thromres.2021.06.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}