{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T07:01:59Z","timestamp":1768114919203,"version":"3.49.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100005485","name":"American College of Cardiology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005485","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thrombosisresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.thromres.2021.06.012","type":"journal-article","created":{"date-parts":[[2021,6,19]],"date-time":"2021-06-19T00:37:14Z","timestamp":1624063034000},"page":"108-113","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Relations of arterial stiffness and endothelial dysfunction with incident venous thromboembolism"],"prefix":"10.1016","volume":"204","author":[{"given":"Darae","family":"Ko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah R.","family":"Preis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew D.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramachandran S.","family":"Vasan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emelia J.","family":"Benjamin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi M.","family":"Hamburg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary F.","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.thromres.2021.06.012_bb0005","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/nrcardio.2015.83","article-title":"Epidemiology of venous thromboembolism","volume":"12","author":"Heit","year":"2015","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.thromres.2021.06.012_bb0010","series-title":"The Surgeon General's Call to Action to Prevent Deep Vein Thrombosis and Pulmonary Embolism","author":"Office of the Surgeon General (US) and National Heart L, and Blood Institute (US)","year":"2008"},{"key":"10.1016\/j.thromres.2021.06.012_bb0015","first-page":"190","article-title":"CDC grand rounds: preventing hospital-associated venous thromboembolism","volume":"63","author":"Streiff","year":"2014","journal-title":"MMWR Morb. Mortal. Wkly Rep."},{"key":"10.1016\/j.thromres.2021.06.012_bb0020","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1161\/CIRCULATIONAHA.116.024507","article-title":"Association of traditional cardiovascular risk factors with venous thromboembolism: an individual participant data meta-analysis of prospective studies","volume":"135","author":"Mahmoodi","year":"2017","journal-title":"Circulation."},{"key":"10.1016\/j.thromres.2021.06.012_bb0025","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1056\/NEJMoa022157","article-title":"An association between atherosclerosis and venous thrombosis","volume":"348","author":"Prandoni","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.thromres.2021.06.012_bb0030","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.thromres.2015.12.024","article-title":"Coronary endothelial dysfunction is associated with increased risk of venous thromboembolism","volume":"139","author":"Prasad","year":"2016","journal-title":"Thromb. Res."},{"key":"10.1016\/j.thromres.2021.06.012_bb0035","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1177\/0268355516652033","article-title":"Assessment of arterial stiffness in patients with venous thromboembolism: separate or continuous circuits?","volume":"32","author":"Aykan","year":"2017","journal-title":"Phlebology."},{"key":"10.1016\/j.thromres.2021.06.012_bb0040","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1258\/phleb.2009.009040","article-title":"Aortic elastic properties in patients with venous thromboembolism","volume":"25","author":"Duran","year":"2010","journal-title":"Phlebology."},{"issue":"Suppl. 1","key":"10.1016\/j.thromres.2021.06.012_bb0045","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1111\/j.1538-7836.2007.02467.x","article-title":"Venous thromboembolism and atherosclerosis: is there a link?","volume":"5","author":"Prandoni","year":"2007","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2021.06.012_bb0050","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1161\/CIRCULATIONAHA.109.921460","article-title":"Risk factors for venous thromboembolism: results from the Copenhagen City heart study","volume":"121","author":"Holst","year":"2010","journal-title":"Circulation."},{"key":"10.1016\/j.thromres.2021.06.012_bb0055","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1161\/CIRCULATIONAHA.107.709204","article-title":"Cardiovascular risk factors and venous thromboembolism: a meta-analysis","volume":"117","author":"Ageno","year":"2008","journal-title":"Circulation."},{"key":"10.1016\/j.thromres.2021.06.012_bb0060","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1093\/ije\/dyv337","article-title":"Cohort profile: the Framingham heart study (FHS): overview of milestones in cardiovascular epidemiology","volume":"44","author":"Tsao","year":"2015","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.thromres.2021.06.012_bb0065","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1161\/01.CIR.0000112565.60887.1E","article-title":"Clinical correlates and heritability of flow-mediated dilation in the community: the Framingham heart study","volume":"109","author":"Benjamin","year":"2004","journal-title":"Circulation."},{"key":"10.1016\/j.thromres.2021.06.012_bb0070","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1161\/01.HYP.0000137305.77635.68","article-title":"Local shear stress and brachial artery flow-mediated dilation: the Framingham heart study","volume":"44","author":"Mitchell","year":"2004","journal-title":"Hypertension."},{"key":"10.1016\/j.thromres.2021.06.012_bb0075","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1161\/HYPERTENSIONAHA.110.160812","article-title":"Relation of brachial and digital measures of vascular function in the community: the Framingham heart study","volume":"57","author":"Hamburg","year":"2011","journal-title":"Hypertension."},{"key":"10.1016\/j.thromres.2021.06.012_bb0080","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1161\/CIRCULATIONAHA.107.748574","article-title":"Cross-sectional relations of digital vascular function to cardiovascular risk factors in the Framingham heart study","volume":"117","author":"Hamburg","year":"2008","journal-title":"Circulation."},{"key":"10.1016\/j.thromres.2021.06.012_bb0085","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.thromres.2016.06.033","article-title":"Epidemiology of venous thromboembolism in the Framingham heart study","volume":"145","author":"Puurunen","year":"2016","journal-title":"Thromb. Res."},{"key":"10.1016\/j.thromres.2021.06.012_bb0090","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1093\/biomet\/80.3.557","article-title":"Checking the cox model with cumulative sums of martingale-based residuals","volume":"80","author":"Lin","year":"1993","journal-title":"Biometrika."},{"key":"10.1016\/j.thromres.2021.06.012_bb0095","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1055\/s-0036-1598002","article-title":"Lipoprotein(a) as a risk factor for venous thromboembolism: a systematic review and meta-analysis of the literature","volume":"43","author":"Dentali","year":"2017","journal-title":"Semin. Thromb. Hemost."},{"key":"10.1016\/j.thromres.2021.06.012_bb0100","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1038\/s41588-019-0519-3","article-title":"Genome-wide association analysis of venous thromboembolism identifies new risk loci and genetic overlap with arterial vascular disease","volume":"51","author":"Klarin","year":"2019","journal-title":"Nat Genet"},{"key":"10.1016\/j.thromres.2021.06.012_bb0105","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1038\/s41588-019-0519-3","article-title":"Genome-wide association analysis of venous thromboembolism identifies new risk loci and genetic overlap with arterial vascular disease","volume":"51","author":"Klarin","year":"2019","journal-title":"Nat. Genet."},{"key":"10.1016\/j.thromres.2021.06.012_bb0110","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1056\/NEJMoa0900241","article-title":"A randomized trial of rosuvastatin in the prevention of venous thromboembolism","volume":"360","author":"Glynn","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.thromres.2021.06.012_bb0115","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1161\/CIRCULATIONAHA.120.046397","article-title":"The effect of PCSK9 (proprotein convertase subtilisin\/kexin type 9) inhibition on the risk of venous thromboembolism","volume":"141","author":"Marston","year":"2020","journal-title":"Circulation."},{"key":"10.1016\/j.thromres.2021.06.012_bb0120","doi-asserted-by":"crossref","first-page":"812","DOI":"10.3324\/haematol.10872","article-title":"Endothelial dysfunction in patients with spontaneous venous thromboembolism","volume":"92","author":"Migliacci","year":"2007","journal-title":"Haematologica."},{"key":"10.1016\/j.thromres.2021.06.012_bb0125","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1007\/s11357-011-9265-x","article-title":"Idiopathic deep venous thrombosis and arterial endothelial dysfunction in the elderly","volume":"34","author":"Mazzoccoli","year":"2012","journal-title":"Age (Dordr.)"},{"key":"10.1016\/j.thromres.2021.06.012_bb0130","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1253\/circj.CJ-13-1325","article-title":"Utility of noninvasive endothelial function test for prediction of deep vein thrombosis after total hip or knee arthroplasty","volume":"78","author":"Suzuki","year":"2014","journal-title":"Circ. J."},{"key":"10.1016\/j.thromres.2021.06.012_bb0135","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1024\/0301-1526\/a000695","article-title":"Deep vein thrombosis and properties of the arterial wall","volume":"47","author":"Jeraj","year":"2018","journal-title":"Vasa."},{"key":"10.1016\/j.thromres.2021.06.012_bb0140","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1161\/CIRCULATIONAHA.109.886655","article-title":"Arterial stiffness and cardiovascular events: the Framingham heart study","volume":"121","author":"Mitchell","year":"2010","journal-title":"Circulation."},{"key":"10.1016\/j.thromres.2021.06.012_bb0145","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.jacc.2013.09.063","article-title":"Aortic pulse wave velocity improves cardiovascular event prediction: an individual participant meta-analysis of prospective observational data from 17,635 subjects","volume":"63","author":"Ben-Shlomo","year":"2014","journal-title":"J. Am. Coll. Cardiol."}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384821003728?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384821003728?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T17:46:24Z","timestamp":1758735984000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049384821003728"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":29,"alternative-id":["S0049384821003728"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2021.06.012","relation":{},"ISSN":["0049-3848"],"issn-type":[{"value":"0049-3848","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Relations of arterial stiffness and endothelial dysfunction with incident venous thromboembolism","name":"articletitle","label":"Article Title"},{"value":"Thrombosis Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.thromres.2021.06.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}