{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:59:02Z","timestamp":1791388742315,"version":"4.3.3"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971508"],"award-info":[{"award-number":["81971508"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471589"],"award-info":[{"award-number":["81471589"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thrombosisresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.thromres.2021.12.020","type":"journal-article","created":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T02:56:01Z","timestamp":1640746561000},"page":"33-41","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Predictive factors for differentiating thrombohemorrhagic disorders in high-risk acute promyelocytic leukemia"],"prefix":"10.1016","volume":"210","author":[{"given":"Mengyu","family":"Xiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengjie","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiya","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaona","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junwei","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinyin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijie","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanliang","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.thromres.2021.12.020_bb0005","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1182\/blood-2007-07-102798","article-title":"Acute promyelocytic leukemia: from highly fatal to highly curable","volume":"111","author":"Wang","year":"2008","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.thromres.2021.12.020_bb0010","first-page":"1247","article-title":"Definition of relapse risk and role of nonanthracycline drugs for consolidation in patients with acute promyelocytic leukemia: a joint study of the PETHEMA and GIMEMA cooperative groups","volume":"96","author":"Sanz","year":"2000","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.thromres.2021.12.020_bb0015","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1182\/bloodadvances.2019001278","article-title":"A phase 2 study of ATRA, arsenic trioxide, and gemtuzumab ozogamicin in patients with high-risk APL (SWOG 0535)","volume":"4","author":"Lancet","year":"2020","journal-title":"Blood Adv."},{"issue":"14","key":"10.1016\/j.thromres.2021.12.020_bb0020","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.1182\/bloodadvances.2021004789","article-title":"Characteristics and predictors of early hospital deaths in newly diagnosed APL: a 13-year population-wide study","volume":"5","author":"Gill","year":"2021","journal-title":"Blood Adv."},{"issue":"1","key":"10.1016\/j.thromres.2021.12.020_bb0025","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/bjh.17018","article-title":"Early intracranial haemorrhages in acute promyelocytic leukaemia: analysis of neuroradiological and clinico-biological parameters","volume":"193","author":"Gurnari","year":"2021","journal-title":"Br. J. Haematol."},{"issue":"7","key":"10.1016\/j.thromres.2021.12.020_bb0030","doi-asserted-by":"crossref","first-page":"3395","DOI":"10.1182\/blood-2007-07-100669","article-title":"Causes and prognostic factors of remission induction failure in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and idarubicin","volume":"111","author":"de la Serna","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.thromres.2021.12.020_bb0035","article-title":"Coagulopathy in acute promyelocytic leukemia: can we go beyond supportive care?","volume":"8","author":"Hambley","year":"2021","journal-title":"Front. Med. (Lausanne)"},{"issue":"4","key":"10.1016\/j.thromres.2021.12.020_bb0040","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.thromres.2012.11.024","article-title":"Thrombosis in acute promyelocytic leukemia","volume":"131","author":"Rashidi","year":"2013","journal-title":"Thromb. Res."},{"key":"10.1016\/j.thromres.2021.12.020_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.leukres.2020.106356","article-title":"Hemorrhage in acute promyelocytic leukemia: can it be predicted and prevented?","volume":"94","author":"Naymagon","year":"2020","journal-title":"Leuk. Res."},{"issue":"1","key":"10.1016\/j.thromres.2021.12.020_bb0050","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/sj.leu.2404377","article-title":"Occurrence of thrombotic events in acute promyelocytic leukemia correlates with consistent immunophenotypic and molecular features","volume":"21","author":"Breccia","year":"2007","journal-title":"Leukemia"},{"key":"10.1016\/j.thromres.2021.12.020_bb0055","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.leukres.2019.02.007","article-title":"The value of FDP\/FIB and D-dimer\/FIB ratios in predicting high-risk APL-related thrombosis","volume":"79","author":"Bai","year":"2019","journal-title":"Leuk. Res."},{"issue":"4","key":"10.1016\/j.thromres.2021.12.020_bb0060","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/j.1600-0609.2011.01747.x","article-title":"Clinical bleeding events and laboratory coagulation profiles in acute promyelocytic leukemia","volume":"88","author":"Chang","year":"2012","journal-title":"Eur. J. Haematol."},{"issue":"9850","key":"10.1016\/j.thromres.2021.12.020_bb0065","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/S0140-6736(12)60689-8","article-title":"Therapeutic platelet transfusion versus routine prophylactic transfusion in patients with haematological malignancies: an open-label, multicentre, randomised study","volume":"380","author":"Wandt","year":"2012","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.thromres.2021.12.020_bb0070","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/1097-0142(19810101)47:1<207::AID-CNCR2820470134>3.0.CO;2-6","article-title":"Reporting results of cancer treatment","volume":"47","author":"Miller","year":"1981","journal-title":"Cancer"},{"key":"10.1016\/j.thromres.2021.12.020_bb0075","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.thromres.2018.11.022","article-title":"A multicenter, prospective evaluation of the chinese Society of Thrombosis and Hemostasis Scoring System for disseminated intravascular coagulation","volume":"173","author":"Luo","year":"2019","journal-title":"Thromb. Res."},{"issue":"5","key":"10.1016\/j.thromres.2021.12.020_bb0080","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1080\/09537104.2020.1799969","article-title":"Investigation of fibrinogen in early bleeding of patients with newly diagnosed acute promyelocytic leukemia","volume":"32","author":"Chu","year":"2021","journal-title":"Platelets"},{"issue":"20","key":"10.1016\/j.thromres.2021.12.020_bb0085","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1182\/blood-2016-03-643544","article-title":"The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia","volume":"127","author":"Arber","year":"2016","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.thromres.2021.12.020_bb0090","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1055\/s-0034-1370792","article-title":"The unique hemostatic dysfunction in acute promyelocytic leukemia","volume":"40","author":"Kwaan","year":"2014","journal-title":"Semin. Thromb. Hemost."},{"key":"10.1016\/j.thromres.2021.12.020_bb0095","doi-asserted-by":"crossref","DOI":"10.1038\/bcj.2015.25","article-title":"Acute promyelocytic leukemia: where did we start, where are we now, and the future","volume":"5","author":"Coombs","year":"2015","journal-title":"Blood Cancer J."},{"issue":"9","key":"10.1016\/j.thromres.2021.12.020_bb0100","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/j.leukres.2013.05.007","article-title":"Administration of ATRA to newly diagnosed patients with acute promyelocytic leukemia is delayed contributing to early hemorrhagic death","volume":"37","author":"Altman","year":"2013","journal-title":"Leuk. Res."},{"issue":"2","key":"10.1016\/j.thromres.2021.12.020_bb0105","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s00432-019-03076-x","article-title":"Comparative analysis of causes and predictors of early death in elderly and young patients with acute promyelocytic leukemia treated with arsenic trioxide","volume":"146","author":"Jin","year":"2020","journal-title":"J. Cancer Res. Clin. Oncol."},{"issue":"7","key":"10.1016\/j.thromres.2021.12.020_bb0110","doi-asserted-by":"crossref","first-page":"e641","DOI":"10.1097\/MPH.0000000000001601","article-title":"Early mortality in children and adolescents with acute promyelocytic leukemia: experience of the boldrini Children's center","volume":"42","author":"de Azevedo","year":"2020","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"10.1016\/j.thromres.2021.12.020_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcmd.2019.102351","article-title":"Factors affecting thrombohemorrhagic early death in patients with acute promyelocytic leukemia treated with arsenic trioxide alone","volume":"79","author":"Hou","year":"2019","journal-title":"Blood Cells Mol. Dis."},{"issue":"9","key":"10.1016\/j.thromres.2021.12.020_bb0120","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1007\/s00277-017-3042-6","article-title":"Predictors of thrombohemorrhagic early death in children and adolescents with t(15;17)-positive acute promyelocytic leukemia treated with ATRA and chemotherapy","volume":"96","author":"Abla","year":"2017","journal-title":"Ann. Hematol."},{"issue":"10","key":"10.1016\/j.thromres.2021.12.020_bb0125","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1080\/10428194.2019.1581187","article-title":"Predictors of early hemorrhage in acute promyelocytic leukemia","volume":"60","author":"Naymagon","year":"2019","journal-title":"Leuk Lymphoma"},{"issue":"2","key":"10.1016\/j.thromres.2021.12.020_bb0130","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.thromres.2004.11.001","article-title":"Predictive factors of bleeding and thrombosis during induction therapy in acute promyelocytic leukemia-a single center experience in 34 patients","volume":"116","author":"Dally","year":"2005","journal-title":"Thromb. Res."},{"issue":"1","key":"10.1016\/j.thromres.2021.12.020_bb0135","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s12959-021-00294-7","article-title":"Risk factors of thrombosis in chinese subjects with acute promyelocytic leukemia","volume":"19","author":"Zhang","year":"2021","journal-title":"Thromb. J."},{"issue":"2","key":"10.1016\/j.thromres.2021.12.020_bb0140","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1046\/j.1365-2141.1996.4911029.x","article-title":"All-trans-retinoic acid increases adhesion to endothelium of the human promyelocytic leukaemia cell line NB4","volume":"93","author":"Marchetti","year":"1996","journal-title":"Br. J. Haematol."},{"issue":"8","key":"10.1016\/j.thromres.2021.12.020_bb0145","first-page":"14210","article-title":"Acute myocardial\/cerebral infarction as first\/relapse manifestation in one acute promyelocytic leukemia patient","volume":"8","author":"Li","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"issue":"10","key":"10.1016\/j.thromres.2021.12.020_bb0150","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1055\/s-0039-1693737","article-title":"All-trans retinoic acid impairs platelet function and thrombus formation and inhibits protein kinase CssI\/delta phosphorylation","volume":"119","author":"Luo","year":"2019","journal-title":"Thromb. Haemost."},{"issue":"4","key":"10.1016\/j.thromres.2021.12.020_bb0155","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.thromres.2014.11.026","article-title":"Thrombotic events in acute promyelocytic leukemia","volume":"135","author":"Mitrovic","year":"2015","journal-title":"Thromb. Res."},{"issue":"10294","key":"10.1016\/j.thromres.2021.12.020_bb0160","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0140-6736(20)32658-1","article-title":"Venous thromboembolism","volume":"398","author":"Khan","year":"2021","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.thromres.2021.12.020_bb0165","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1186\/s12885-017-3588-7","article-title":"D-dimer levels and cerebral infarction in critically ill cancer patients","volume":"17","author":"Ryu","year":"2017","journal-title":"BMC Cancer"},{"issue":"15","key":"10.1016\/j.thromres.2021.12.020_bb0170","doi-asserted-by":"crossref","first-page":"3408","DOI":"10.3390\/jcm10153408","article-title":"Soluble C-type lectin-like receptor 2 elevation in patients with acute cerebral infarction","volume":"10","author":"Nishigaki","year":"2021","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.thromres.2021.12.020_bb0175","first-page":"130","article-title":"Blood parameters in treatment with arsenic trioxide in acute promyelocytic leukemia: a systematic review","volume":"14","author":"Kanesbi","year":"2020","journal-title":"Int. J. Hematol. Oncol. Stem Cell Res."},{"issue":"6","key":"10.1016\/j.thromres.2021.12.020_bb0180","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.blre.2006.04.001","article-title":"Haemostatic problems in acute promyelocytic leukaemia","volume":"20","author":"Arbuthnot","year":"2006","journal-title":"Blood Rev."}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004938482100579X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004938482100579X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:23:28Z","timestamp":1777397008000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004938482100579X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":36,"alternative-id":["S004938482100579X"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2021.12.020","relation":{},"ISSN":["0049-3848"],"issn-type":[{"value":"0049-3848","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Predictive factors for differentiating thrombohemorrhagic disorders in high-risk acute promyelocytic leukemia","name":"articletitle","label":"Article Title"},{"value":"Thrombosis Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.thromres.2021.12.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}