{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T03:26:44Z","timestamp":1792466804993,"version":"4.5.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thrombosisresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.thromres.2022.01.026","type":"journal-article","created":{"date-parts":[[2022,1,29]],"date-time":"2022-01-29T18:27:27Z","timestamp":1643480847000},"page":"98-105","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Association of whole blood microRNA expression with platelet function and turnover in patients with coronary artery disease"],"prefix":"10.1016","volume":"211","author":[{"given":"Oliver Buchhave","family":"Pedersen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Mette","family":"Hvas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik Lerkevang","family":"Grove","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanne B\u00f8jet","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Pasalic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steen Dalby","family":"Kristensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter H.","family":"Nissen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.thromres.2022.01.026_bb0005","doi-asserted-by":"crossref","first-page":"5197","DOI":"10.2174\/138161212803251899","article-title":"The role of platelets in athero-thrombotic events","volume":"18","author":"Freynhofer","year":"2012","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.thromres.2022.01.026_bb0010","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1016\/j.jacc.2017.08.037","article-title":"Antiplatelet agents for the treatment and prevention of coronary atherothrombosis","volume":"70","author":"Patrono","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.thromres.2022.01.026_bb0015","doi-asserted-by":"crossref","first-page":"5344","DOI":"10.2174\/138161212803251925","article-title":"Interindividual variability in the efficacy of oral antiplatelet drugs: definitions, mechanisms and clinical importance","volume":"18","author":"Wurtz","year":"2012","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.thromres.2022.01.026_bb0020","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1055\/s-0040-1721386","article-title":"Immature platelets and risk of cardiovascular events among patients with ischemic heart disease: a systematic review","volume":"121","author":"Faber","year":"2021","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.thromres.2022.01.026_bb0025","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21103598","article-title":"Role of microRNAs in hemophilia and thrombosis in humans","volume":"21","author":"Jankowska","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.thromres.2022.01.026_bb0030","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1161\/CIRCRESAHA.109.215566","article-title":"Circulating microRNAs in patients with coronary artery disease","volume":"107","author":"Fichtlscherer","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.thromres.2022.01.026_bb0035","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1055\/s-0035-1570077","article-title":"MicroRNAs in platelet physiology and function","volume":"42","author":"Lindsay","year":"2016","journal-title":"Semin. Thromb. Hemost."},{"key":"10.1016\/j.thromres.2022.01.026_bb0040","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1182\/blood.2020005230","article-title":"miR-125a-5p regulates megakaryocyte proplatelet formation via the actin-bundling protein L-plastin","volume":"136","author":"Bhatlekar","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.thromres.2022.01.026_bb0045","article-title":"MicroRNA as biomarkers for platelet function and maturity in patients with cardiovascular disease","author":"Pedersen","year":"2021","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.thromres.2022.01.026_bb0050","article-title":"Determinants of reduced antiplatelet effect of aspirin in patients with stable coronary artery disease","volume":"10","author":"Larsen","year":"2015","journal-title":"PloS One"},{"key":"10.1016\/j.thromres.2022.01.026_bb0055","series-title":"MicroRNA Biomarker Discovery and Validation Using the nCounter Platform","author":"Dennis","year":"2016"},{"key":"10.1016\/j.thromres.2022.01.026_bb0060","doi-asserted-by":"crossref","first-page":"3853","DOI":"10.1096\/fj.15-271312","article-title":"Normalization panels for the reliable quantification of circulating microRNAs by RT-qPCR","volume":"29","author":"Kok","year":"2015","journal-title":"FASEB J."},{"key":"10.1016\/j.thromres.2022.01.026_bb0065","doi-asserted-by":"crossref","first-page":"749","DOI":"10.3858\/emm.2010.42.11.076","article-title":"Suitable reference genes for relative quantification of miRNA expression in prostate cancer","volume":"42","author":"Schaefer","year":"2010","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.thromres.2022.01.026_bb0070","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.thromres.2022.01.026_bb0075","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/1471-2164-12-144","article-title":"Quantitative miRNA expression analysis using fluidigm microfluidics dynamic arrays","volume":"12","author":"Jang","year":"2011","journal-title":"BMC Genomics"},{"key":"10.1016\/j.thromres.2022.01.026_bb0080","first-page":"511","article-title":"miR-15a-5p regulates expression of multiple proteins in the megakaryocyte GPVI signaling pathway","volume":"17","author":"Basak","year":"2019"},{"key":"10.1016\/j.thromres.2022.01.026_bb0085","article-title":"Inhibition of profibrotic microRNA-21 affects platelets and their releasate","volume":"3","author":"Barwari","year":"2018","journal-title":"JCIInsight"},{"key":"10.1016\/j.thromres.2022.01.026_bb0090","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1161\/ATVBAHA.113.302339","article-title":"Role for platelet glycoprotein ib-IX and effects of its inhibition in endotoxemia-induced thrombosis, thrombocytopenia, and mortality","volume":"33","author":"Yin","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.thromres.2022.01.026_bb0095","doi-asserted-by":"crossref","first-page":"611","DOI":"10.2459\/JCM.0000000000000691","article-title":"Platelet miRNA-26b down-regulates multidrug resistance protein 4 in patients on chronic aspirin treatment","volume":"19","author":"La Rosa","year":"2018","journal-title":"J. Cardiovasc. Med. (Hagerstown)"},{"key":"10.1016\/j.thromres.2022.01.026_bb0100","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1002\/rth2.12104","article-title":"MiR-21 role in aspirin-dependent PPARalpha and multidrug resistance protein 4 upregulation","volume":"2","author":"Massimi","year":"2018","journal-title":"Res. Pract. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2022.01.026_bb0105","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1160\/TH16-04-0322","article-title":"Hyperglycaemia suppresses microRNA expression in platelets to increase P2RY12 and SELP levels in type 2 diabetes mellitus","volume":"117","author":"Fejes","year":"2017","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.thromres.2022.01.026_bb0110","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1023\/A:1016611230747","article-title":"Platelets and vascular endothelial growth factor (VEGF): a morphological and functional study","volume":"4","author":"Salgado","year":"2001","journal-title":"Angiogenesis"},{"key":"10.1016\/j.thromres.2022.01.026_bb0115","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1172\/JCI5028","article-title":"Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal","volume":"103","author":"Benjamin","year":"1999","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.thromres.2022.01.026_bb0120","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.biochi.2009.05.012","article-title":"Inhibition of platelets and tumor cell adhesion by the disintegrin domain of human ADAM9 to collagen I under dynamic flow conditions","volume":"91","author":"Cominetti","year":"2009","journal-title":"Biochimie"},{"key":"10.1016\/j.thromres.2022.01.026_bb0125","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1055\/s-0038-1676802","article-title":"Functional validation of microRNA-126-3p as a platelet reactivity regulator using human haematopoietic stem cells","volume":"119","author":"Garcia","year":"2019","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.thromres.2022.01.026_bb0130","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.devcel.2008.03.012","article-title":"MicroRNA-mediated control of cell fate in megakaryocyte-erythrocyte progenitors","volume":"14","author":"Lu","year":"2008","journal-title":"Dev. Cell"},{"key":"10.1016\/j.thromres.2022.01.026_bb0135","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.thromres.2017.04.016","article-title":"Thrombin-activated platelet-derived exosomes regulate endothelial cell expression of ICAM-1 via microRNA-223 during the thrombosis-inflammation response","volume":"154","author":"Li","year":"2017","journal-title":"Thromb. Res."},{"key":"10.1016\/j.thromres.2022.01.026_bb0140","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1093\/oxfordjournals.jbchem.a003164","article-title":"Platelet-activating factor receptor","volume":"131","author":"Honda","year":"2002","journal-title":"J. Biochem."},{"key":"10.1016\/j.thromres.2022.01.026_bb0145","series-title":"Biochemistry of Platelet Activating Factor","author":"Ashraf","year":"2021"},{"key":"10.1016\/j.thromres.2022.01.026_bb0150","doi-asserted-by":"crossref","first-page":"6169","DOI":"10.1038\/s41598-020-63263-6","article-title":"Circulating MicroRNA profiling in non-ST elevated coronary artery syndrome highlights genomic associations with serial platelet reactivity measurements","volume":"10","author":"Becker","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.thromres.2022.01.026_bb0155","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1161\/CIRCRESAHA.114.305663","article-title":"Association of microRNAs and YRNAs with platelet function","volume":"118","author":"Kaudewitz","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.thromres.2022.01.026_bb0160","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s00439-016-1642-1","article-title":"New molecular insights into modulation of platelet reactivity in aspirin-treated patients using a network-based approach","volume":"135","author":"Zufferey","year":"2016","journal-title":"Hum. Genet."},{"key":"10.1016\/j.thromres.2022.01.026_bb0165","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1007\/s11239-017-1537-6","article-title":"Platelet microRNA for predicting acute myocardial infarction","volume":"44","author":"Li","year":"2017","journal-title":"J. Thromb. Thrombolysis"},{"key":"10.1016\/j.thromres.2022.01.026_bb0170","doi-asserted-by":"crossref","DOI":"10.1111\/eci.13149","article-title":"Course of platelet miRNAs after cessation of P2Y12 antagonists","volume":"49","author":"Jager","year":"2019","journal-title":"Eur. J. Clin. Investig."},{"key":"10.1016\/j.thromres.2022.01.026_bb0175","doi-asserted-by":"crossref","first-page":"3451","DOI":"10.1093\/eurheartj\/eht007","article-title":"Aspirin treatment hampers the use of plasma microRNA-126 as a biomarker for the progression of vascular disease","volume":"34","author":"de Boer","year":"2013","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.thromres.2022.01.026_bb0180","doi-asserted-by":"crossref","DOI":"10.1002\/prp2.751","article-title":"The expression profile of platelet-derived miRNA in coronary artery disease patients with clopidogrel resistance","volume":"9","author":"Lin","year":"2021","journal-title":"Pharmacol. Res. Perspect."},{"key":"10.1016\/j.thromres.2022.01.026_bb0185","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/s41401-018-0041-7","article-title":"Plasma miR-142 predicts major adverse cardiovascular events as an intermediate biomarker of dual antiplatelet therapy","volume":"40","author":"Tang","year":"2019","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.thromres.2022.01.026_bb0190","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1161\/CIRCRESAHA.111.300539","article-title":"Circulating microRNAs as novel biomarkers for platelet activation","volume":"112","author":"Willeit","year":"2013","journal-title":"Circ. Res."},{"key":"10.1016\/j.thromres.2022.01.026_bb0195","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1080\/09537104.2016.1265924","article-title":"Platelet microvesicles in health and disease","volume":"28","author":"Melki","year":"2017","journal-title":"Platelets"}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384822000329?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384822000329?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T17:47:39Z","timestamp":1758736059000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049384822000329"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":39,"alternative-id":["S0049384822000329"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2022.01.026","relation":{},"ISSN":["0049-3848"],"issn-type":[{"value":"0049-3848","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of whole blood microRNA expression with platelet function and turnover in patients with coronary artery disease","name":"articletitle","label":"Article Title"},{"value":"Thrombosis Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.thromres.2022.01.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}