{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:15:10Z","timestamp":1790010910664,"version":"4.0.1"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thrombosisresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.thromres.2023.05.009","type":"journal-article","created":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T20:38:40Z","timestamp":1683664720000},"page":"165-172","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Efficacy and safety of recombinant human soluble thrombomodulin in patients with sepsis-induced disseminated intravascular coagulation - A meta-analysis"],"prefix":"10.1016","volume":"226","author":[{"given":"Hideo","family":"Kato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mao","family":"Hagihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiro","family":"Asai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takumi","family":"Umemura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Hirai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuaki","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Yamagishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Iwamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshige","family":"Mikamo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.thromres.2023.05.009_bb0005","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/j.1538-7836.2011.04319.x","article-title":"Thrombomodulin: protectorate god of the vasculature in thrombosis and inflammation","volume":"9","author":"Ito","year":"2011","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2023.05.009_bb0010","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1136\/bmj.327.7421.974","article-title":"Disseminated intravascular coagulation: old disease, new hope","volume":"327","author":"Toh","year":"2003","journal-title":"BMJ"},{"key":"10.1016\/j.thromres.2023.05.009_bb0015","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.thromres.2019.04.025","article-title":"Role of disseminated intravascular coagulation in severe sepsis","volume":"178","author":"Gando","year":"2019","journal-title":"Thromb. Res."},{"key":"10.1016\/j.thromres.2023.05.009_bb0020","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1007\/s11239-014-1068-3","article-title":"The recent time trend of outcomes of disseminated intravascular coagulation in Japan: an observational study based on a national administrative database","volume":"38","author":"Murata","year":"2014","journal-title":"J. Thromb. Thrombolysis"},{"key":"10.1016\/j.thromres.2023.05.009_bb0025","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/2052-0492-2-15","article-title":"Diagnosis and treatment of disseminated intravascular coagulation (DIC) according to four DIC guidelines","volume":"2","author":"Wada","year":"2014","journal-title":"J. Intensive Care"},{"key":"10.1016\/j.thromres.2023.05.009_bb0030","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/j.1538-7836.2011.04319.x","article-title":"Thrombomodulin: protectorate god of the vasculature in thrombosis and inflammation","volume":"9","author":"Ito","year":"2011","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2023.05.009_bb0035","first-page":"313","article-title":"Time trends of the outcomes and treatment options for disseminated intravascular coagulation: a nationwide observational study in Japan","volume":"3","author":"Yamakawa","year":"2020","journal-title":"JMA J."},{"key":"10.1016\/j.thromres.2023.05.009_bb0040","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1001\/jama.2019.5358","article-title":"Effect of a recombinant human soluble thrombomodulin on mortality in patients with sepsis-associated coagulopathy the SCARLET randomized clinical trial","volume":"321","author":"Vincent","year":"2019","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.thromres.2023.05.009_bb0045","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s40560-020-00512-w","article-title":"The effect of recombinant human soluble thrombomodulin on renal function and mortality in septic disseminated intravascular coagulation patients with acute kidney injury: a retrospective study","volume":"8","author":"Akatsuka","year":"2020","journal-title":"J. Intensive Care"},{"key":"10.1016\/j.thromres.2023.05.009_bb0050","first-page":"85","article-title":"The comparison between two single-drug treatment of recombinant human soluble thrombomodulin (rhTM) and anti-thrombin (AT) on septic disseminated intravascular coagulation (DIC)","volume":"44","author":"Ohashi","year":"2020","journal-title":"Acta Med. Hyog."},{"key":"10.1016\/j.thromres.2023.05.009_bb0055","article-title":"Clinical impact of recombinant thrombomodulin administration on disseminated intravascular coagulation due to severe acute cholangitis (Recover- AC study)","author":"Ogura","year":"2021","journal-title":"J. Hepatobiliary Pancreat Sci."},{"key":"10.1016\/j.thromres.2023.05.009_bb0060","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1055\/s-0038-1676345","article-title":"Recombinant human soluble thrombomodulin in sepsis-induced coagulopathy: an updated systematic review and meta-analysis","volume":"119","author":"Yamakawa","year":"2019","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.thromres.2023.05.009_bb0065","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1111\/jth.14812","article-title":"Efficacy and safety of recombinant human soluble thrombomodulin in patients with sepsis-associated coagulopathy: a systematic review and meta-analysis","volume":"18","author":"Valeriani","year":"2020","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2023.05.009_bb0070","unstructured":"The guidelines of preferred reporting items for systematic review and meta-analysis (PRISMA) statement (http:\/\/prisma-statement.org)."},{"key":"10.1016\/j.thromres.2023.05.009_bb0075","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and me-ta-analyses: the PRISMA statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLoS Med."},{"key":"10.1016\/j.thromres.2023.05.009_bb0080","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1016\/j.jiac.2021.06.017","article-title":"Comparison of mortality between echinocandins and polyenes for an initial treatment of candidemia: a systematic review and meta-analysis","volume":"27","author":"Kato","year":"2021","journal-title":"J. Infect. Chemother."},{"key":"10.1016\/j.thromres.2023.05.009_bb0085","first-page":"71","article-title":"Effectiveness of healthy lifestyle-based interventions in lung cancer survivors: a systematic review and meta-analysis","volume":"31","author":"Heredia-ciuro","year":"2022","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.thromres.2023.05.009_bb0090","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1136\/jech.52.6.377","article-title":"The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions","volume":"52","author":"Downs","year":"1998","journal-title":"J. Epidemiol. Community Health"},{"key":"10.1016\/j.thromres.2023.05.009_bb0095","article-title":"A systematic review and meta-analysis on possible role of vitamin c in sepsis","volume":"14","author":"Brown","year":"2022","journal-title":"Cureus"},{"key":"10.1016\/j.thromres.2023.05.009_bb0100","unstructured":"Jalili M, Barzegari H, Pourtabatabaei N, Honarmand AR, Boreiri M, Mehrvarz A, Ahmadinejad Z. Effect of door-to-antibiotic time on mortality of patients with sepsis in emergency department: a prospective cohort study. Acta Med Iran. 213;51:454-60."},{"key":"10.1016\/j.thromres.2023.05.009_bb0105","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1097\/00003246-198510000-00009","article-title":"APACHE II: a severity of disease classification system","volume":"13","author":"Knaus","year":"1985","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.thromres.2023.05.009_bb0110","first-page":"359","article-title":"Treatment effect of thrombomodulin-a on septic disseminated intravascular coagulation (DIC): a historical cohort study","volume":"19","author":"Kudo","year":"2012","journal-title":"J. Jpn. Soc. Intens. Care Med."},{"key":"10.1016\/j.thromres.2023.05.009_bb0115","first-page":"603","article-title":"Effects of recombinant human soluble thrombomodulin and danaparoid sodium for sepsis-induced disseminated intravascular coagulation","volume":"19","author":"Umegaki","year":"2012","journal-title":"J. Jpn. Soc. Intens. Care Med."},{"key":"10.1016\/j.thromres.2023.05.009_bb0120","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1477-9560-11-3","article-title":"Recombinant human soluble thrombomodulin administration improves sepsis-induced disseminated intravascular coagulation and mortality: a retrospective cohort study","volume":"11","author":"Kato","year":"2013","journal-title":"Thromb. J."},{"key":"10.1016\/j.thromres.2023.05.009_bb0125","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1007\/s00134-013-2822-2","article-title":"Recombinant human soluble thrombomodulin in sepsis-induced disseminated intravascular coagulation: a multicenter propensity score analysis","volume":"39","author":"Tamakawa","year":"2013","journal-title":"Intens. Care Med."},{"key":"10.1016\/j.thromres.2023.05.009_bb0130","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1111\/1744-9987.12112","article-title":"Effective combination therapy of polymyxin-B direct hemoperfusion and recombinant thrombomodulin for septic shock accompanied by disseminated intravascular coagulation: a historical controlled trial","volume":"17","author":"Yamato","year":"2013","journal-title":"Ther. Apher. Dial."},{"key":"10.1016\/j.thromres.2023.05.009_bb0135","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.jiac.2014.04.010","article-title":"A retrospective comparative study of recombinant human thrombomodulin and gabexate mesilate in sepsis-induced disseminated intravascular coagulation patients","volume":"20","author":"Takazono","year":"2014","journal-title":"J. Infect. Chemother."},{"key":"10.1016\/j.thromres.2023.05.009_bb0140","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.jss.2015.04.048","article-title":"Recombinant soluble thrombomodulin for postoperative disseminated intravascular coagulation","volume":"197","author":"Hashimoto","year":"2015","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.thromres.2023.05.009_bb0145","article-title":"Can recombinant human thrombomodulin increase survival among patients with severe septicinduced disseminated intravascular coagulation: a single-centre, open-label","volume":"6","author":"Hagiwara","year":"2016","journal-title":"Randomised Control. Trial"},{"key":"10.1016\/j.thromres.2023.05.009_bb0150","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1160\/TH15-12-0987","article-title":"Recombinant human soluble thrombomodulin and mortality in sepsis-induced disseminated intravascular coagulation a multicentre retrospective study","volume":"115","author":"Hayakawa","year":"2016","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.thromres.2023.05.009_bb0155","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jcrc.2016.06.008","article-title":"The efficacy and safety of antithrombin and recombinant human thrombomodulin combination therapy in patients with severe sepsis and disseminated intravascular coagulation","volume":"36","author":"Yasuda","year":"2016","journal-title":"J. Crit. Care"},{"key":"10.1016\/j.thromres.2023.05.009_bb0160","first-page":"717","article-title":"Efficiency of recombinant human soluble thrombomodulin in disseminated intravascular coagulation","volume":"37","author":"Katayama","year":"2017","journal-title":"J. Abdom. Emerg. Med."},{"key":"10.1016\/j.thromres.2023.05.009_bb0165","doi-asserted-by":"crossref","first-page":"471","DOI":"10.5009\/gnl17489","article-title":"Clinical impact of recombinant soluble thrombomodulin for disseminated intravascular coagulation associated with severe acute cholangitis","volume":"12","author":"Okuda","year":"2018","journal-title":"Gut Liver."},{"key":"10.1016\/j.thromres.2023.05.009_bb0170","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.3390\/jcm8101553","article-title":"Human soluble recombinant thrombomodulin, ART-123, resolved early phase coagulopathies, but did not significantly Alter the 28 day outcome in the treatment of DIC associated with infectious systemic inflammatory response syndromes","volume":"8","author":"Mori","year":"2019","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.thromres.2023.05.009_bb0175","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.thromres.2018.12.025","article-title":"Multicenter clinical experience with recombinant soluble thrombomodulin for disseminated intravascular coagulation associated with severe acute cholecystitis","volume":"176","author":"Ogura","year":"2019","journal-title":"Thromb. Res."},{"key":"10.1016\/j.thromres.2023.05.009_bb0180","volume":"34625\u2013631","author":"Gando","year":"2006","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.thromres.2023.05.009_bb0185","doi-asserted-by":"crossref","DOI":"10.1002\/ams2.659","article-title":"The Japanese clinical practice guidelines for management of sepsis and septic shock 2020 (J-SSCG 20209","volume":"8","author":"Egi","year":"2021","journal-title":"Acute Med. Surg."},{"key":"10.1016\/j.thromres.2023.05.009_bb0190","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/s00134-021-06506-y","article-title":"Surviving sepsis campaign; international guidelines for management of sepsis and septic shock 2021","volume":"47","author":"Evans","year":"2021","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.thromres.2023.05.009_bb0195","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1056\/NEJM199908193410807","article-title":"Disseminated intravascular coagulation","volume":"341","author":"Levi","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.thromres.2023.05.009_bb0200","first-page":"1","article-title":"Lipopolysaccharide (LPS), LPS-immune complexes and cytokines as inducers of pulmonary inflammation in patients with cystic fibrosis and chronic Pseudomonas aeruginosa lung infection","volume":"50","author":"Kronborg","year":"1995","journal-title":"APMIS Suppl."},{"key":"10.1016\/j.thromres.2023.05.009_bb0205","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1182\/blood.V95.5.1714.005k40_1714_1720","article-title":"Regulation of factor VIIIa by human activated protein C and protein S: inactivation of cofactor in the intrinsic factor xase","volume":"95","author":"O\u2019Brien","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.thromres.2023.05.009_bb0210","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.thromres.2016.09.011","article-title":"Anti-inflammatory and anti-fibrinolytic effects of thrombomodulin alfa through carboxypeptidase B2 in the presence of thrombin","volume":"147","author":"Tawara","year":"2016","journal-title":"Thromb. Res."},{"key":"10.1016\/j.thromres.2023.05.009_bb0215","doi-asserted-by":"crossref","first-page":"3361","DOI":"10.1182\/blood-2008-03-142760","article-title":"Lectin-like domain of thrombomodulin binds to its specific ligand Lewis Y antigen and neutralizes lipopolysaccharide-induced inflammatory response","volume":"112","author":"Shi","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.thromres.2023.05.009_bb0220","doi-asserted-by":"crossref","first-page":"2969","DOI":"10.3892\/etm.2017.4308","article-title":"Evaluation of the effect of recombinant thrombomodulin on a lipopolysaccharide-induced murine sepsis model","volume":"13","author":"Takehara","year":"2017","journal-title":"Exp Ther Med."},{"key":"10.1016\/j.thromres.2023.05.009_bb0225","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s13054-015-0810-3","article-title":"Benefit profile of recombinant human soluble thrombomodulin in sepsis-induced disseminated intravascular coagulation: a multicenter propensity score analysis","volume":"19","author":"Yoshimura","year":"2015","journal-title":"Crit. Care"},{"key":"10.1016\/j.thromres.2023.05.009_bb0230","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1182\/blood.V95.5.1714.005k40_1714_1720","article-title":"Regulation of factor VIIIa by human activated protein C and protein S: inactivation of cofactor in the intrinsic factor xase","volume":"95","author":"O\u2019Brien","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.thromres.2023.05.009_bb0235","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1002\/cpdd.163","article-title":"Population pharmacokinetic analysis of thrombomodulin alfa to support dosing rational in patient with renal impairment","volume":"4","author":"Mouksassi","year":"2015","journal-title":"Clin. Pharmacol. Drug Dev."},{"key":"10.1016\/j.thromres.2023.05.009_bb0240","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1097\/SHK.0000000000001477","article-title":"Therapeutic and adverse effects of thrombomodulin alfa to treat sepsis-induced disseminated intravascular coagulation","volume":"54","author":"Imaura","year":"2020","journal-title":"Shock"}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384823001354?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384823001354?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T17:52:00Z","timestamp":1758736320000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049384823001354"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":48,"alternative-id":["S0049384823001354"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2023.05.009","relation":{},"ISSN":["0049-3848"],"issn-type":[{"value":"0049-3848","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy and safety of recombinant human soluble thrombomodulin in patients with sepsis-induced disseminated intravascular coagulation - A meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Thrombosis Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.thromres.2023.05.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}