{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:26:42Z","timestamp":1792614402467,"version":"4.5.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T00:00:00Z","timestamp":1685059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thrombosisresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.thromres.2023.05.018","type":"journal-article","created":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T20:36:59Z","timestamp":1684960619000},"page":"10-20","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["Tissue factor expression in monocyte subsets during human immunothrombosis, endotoxemia and sepsis"],"prefix":"10.1016","volume":"228","author":[{"given":"Kathryn M.","family":"Musgrave","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wezi","family":"Sendama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron I.","family":"Gardner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Dewar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron J.","family":"Lake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henri M.H.","family":"Spronk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rene","family":"van Oerle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayken","family":"Visser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"ten Cate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Kesteven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Fuller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"McDonald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carly","family":"Knill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian","family":"Hulme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Filby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen E.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alistair I.","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-H\u00e9l\u00e8ne","family":"Ruchaud-Sparagano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. John","family":"Simpson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J.","family":"Rostron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.thromres.2023.05.018_bb0005","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1111\/jth.14578","article-title":"Diagnosis and management of sepsis-induced coagulopathy and disseminated intravascular coagulation","volume":"17","author":"Iba","year":"2019","journal-title":"J. Thromb. Haemost."},{"issue":"2","key":"10.1016\/j.thromres.2023.05.018_bb0010","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1097\/01.CCM.0000153520.31562.48","article-title":"Dynamic evolution of coagulopathy in the first day of severe sepsis: relationship with mortality and organ failure","volume":"33","author":"Dhainaut","year":"2005","journal-title":"Crit. Care Med."},{"issue":"1","key":"10.1016\/j.thromres.2023.05.018_bb0015","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/nri3345","article-title":"Thrombosis as an intravascular effector of innate immunity","volume":"13","author":"Engelmann","year":"2013","journal-title":"Nat. Rev. Immunol."},{"issue":"5","key":"10.1016\/j.thromres.2023.05.018_bb0020","first-page":"1087","article-title":"Selective cellular expression of tissue factor in human tissues. Implications for disorders of hemostasis and thrombosis","volume":"134","author":"Drake","year":"1989","journal-title":"Am. J. Pathol."},{"issue":"Suppl. 1","key":"10.1016\/j.thromres.2023.05.018_bb0025","doi-asserted-by":"crossref","first-page":"S70","DOI":"10.1016\/j.thromres.2010.01.042","article-title":"Cellular sources of tissue factor in endotoxemia and sepsis","volume":"125","author":"Pawlinski","year":"2010","journal-title":"Thromb. Res."},{"issue":"7","key":"10.1016\/j.thromres.2023.05.018_bb0030","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.4049\/jimmunol.153.7.3245","article-title":"Monocyte vesiculation is a possible mechanism for dissemination of membrane-associated procoagulant activities and adhesion molecules after stimulation by lipopolysaccharide","volume":"153","author":"Satta","year":"1994","journal-title":"J. Immunol."},{"key":"10.1016\/j.thromres.2023.05.018_bb0035","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.thromres.2016.11.007","article-title":"Coagulation and sepsis","volume":"149","author":"Levi","year":"2017","journal-title":"Thromb. Res."},{"issue":"Suppl. 1","key":"10.1016\/j.thromres.2023.05.018_bb0040","article-title":"Biological basis and pathological relevance of microvascular thrombosis","volume":"133","author":"Pfeiler","year":"2014","journal-title":"Thromb. Res."},{"issue":"3","key":"10.1016\/j.thromres.2023.05.018_bb0045","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1182\/blood.V95.3.930.003k46_930_935","article-title":"Cellular origin and procoagulant properties of microparticles in meningococcal sepsis","volume":"95","author":"Nieuwland","year":"2000","journal-title":"Blood."},{"issue":"1","key":"10.1016\/j.thromres.2023.05.018_bb0050","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1055\/s-0038-1657303","article-title":"Increased tissue thromboplastin activity in monocytes of patients with meningococcal infection: related to an unfavourable prognosis","volume":"49","author":"Osterud","year":"1983","journal-title":"Thromb. Haemost."},{"issue":"1","key":"10.1016\/j.thromres.2023.05.018_bb0055","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1097\/00003246-200101000-00003","article-title":"The activity of tissue factor pathway inhibitor in experimental models of superantigen-induced shock and polymicrobial intra-abdominal sepsis","volume":"29","author":"Opal","year":"2001","journal-title":"Crit. Care Med."},{"issue":"3","key":"10.1016\/j.thromres.2023.05.018_bb0060","first-page":"127","article-title":"Lethal E. coli septic shock is prevented by blocking tissue factor with monoclonal antibody","volume":"33","author":"Taylor","year":"1991","journal-title":"Circ. Shock."},{"issue":"5","key":"10.1016\/j.thromres.2023.05.018_bb0065","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1182\/blood-2009-12-259267","article-title":"Hematopoietic and nonhematopoietic cell tissue factor activates the coagulation cascade in endotoxemic mice","volume":"116","author":"Pawlinski","year":"2010","journal-title":"Blood."},{"issue":"16","key":"10.1016\/j.thromres.2023.05.018_bb0070","doi-asserted-by":"crossref","first-page":"e74","DOI":"10.1182\/blood-2010-02-258558","article-title":"Nomenclature of monocytes and dendritic cells in blood","volume":"116","author":"Ziegler-Heitbrock","year":"2010","journal-title":"Blood."},{"issue":"5","key":"10.1016\/j.thromres.2023.05.018_bb0075","doi-asserted-by":"crossref","first-page":"e16","DOI":"10.1182\/blood-2010-12-326355","article-title":"Gene expression profiling reveals the defining features of the classical, intermediate and nonclassical human monocyte subsets","volume":"118","author":"Wong","year":"2011","journal-title":"Blood."},{"issue":"6","key":"10.1016\/j.thromres.2023.05.018_bb0080","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s10753-007-9036-0","article-title":"Genetic evidence of a functional monocyte dichotomy","volume":"30","author":"Mobley","year":"2007","journal-title":"Inflammation."},{"issue":"8","key":"10.1016\/j.thromres.2023.05.018_bb0085","doi-asserted-by":"crossref","first-page":"4028","DOI":"10.1021\/pr900364p","article-title":"Identification of novel functional differences in monocyte subsets using proteomic and transcriptomic methods","volume":"8","author":"Zhao","year":"2009","journal-title":"J. Proteome Res."},{"issue":"3","key":"10.1016\/j.thromres.2023.05.018_bb0090","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3109\/09537109509013263","article-title":"The high responder phenomenon: enhancement of LPS induced tissue factor activity in monocytes by platelets and granulocytes","volume":"6","author":"Ossterud","year":"1995","journal-title":"Platelets."},{"issue":"7","key":"10.1016\/j.thromres.2023.05.018_bb0095","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1161\/01.ATV.0000168413.29874.d7","article-title":"Intracellular and surface distribution of monocyte tissue factor: application to intersubject variability","volume":"25","author":"Egorina","year":"2005","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"7","key":"10.1016\/j.thromres.2023.05.018_bb0100","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1160\/TH16-10-0784","article-title":"IL-33 stimulates the release of procoagulant microvesicles from human monocytes and differentially increases tissue factor in human monocyte subsets","volume":"117","author":"Stojkovic","year":"2017","journal-title":"Thromb. Haemost."},{"issue":"22","key":"10.1016\/j.thromres.2023.05.018_bb0105","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1056\/NEJMoa1202290","article-title":"Drotrecogin alfa (activated) in adults with septic shock","volume":"366","author":"Ranieri","year":"2012","journal-title":"N. Engl. J. Med."},{"issue":"9","key":"10.1016\/j.thromres.2023.05.018_bb0110","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1097\/CCM.0b013e31828e9b03","article-title":"A randomized, double-blind, placebo-controlled, Phase 2b study to evaluate the safety and efficacy of recombinant human soluble thrombomodulin, ART-123, in patients with sepsis and suspected disseminated intravascular coagulation","volume":"41","author":"Vincent","year":"2013","journal-title":"Crit. Care Med."},{"issue":"1","key":"10.1016\/j.thromres.2023.05.018_bb0115","doi-asserted-by":"crossref","first-page":"143","DOI":"10.4161\/viru.26083","article-title":"Animal models of sepsis","volume":"5","author":"Fink","year":"2014","journal-title":"Virulence."},{"issue":"15","key":"10.1016\/j.thromres.2023.05.018_bb0120","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1001\/jama.286.15.1869","article-title":"Caring for the critically ill patient. High-dose antithrombin III in severe sepsis: a randomized controlled trial","volume":"286","author":"Warren","year":"2001","journal-title":"JAMA."},{"issue":"2","key":"10.1016\/j.thromres.2023.05.018_bb0125","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1001\/jama.290.2.238","article-title":"Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: a randomized controlled trial","volume":"290","author":"Abraham","year":"2003","journal-title":"JAMA."},{"key":"10.1016\/j.thromres.2023.05.018_bb0130","article-title":"Human lipopolysaccharide models provide mechanistic and therapeutic insights into systemic and pulmonary inflammation","volume":"561","author":"Brooks","year":"2020","journal-title":"Eur. Respir. J."},{"issue":"18","key":"10.1016\/j.thromres.2023.05.018_bb0135","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1161\/CIRCULATIONAHA.120.050656","article-title":"Neutrophils and contact activation of coagulation as potential drivers of Covid-19","volume":"142","author":"Busch","year":"2020","journal-title":"Circulation"},{"issue":"8","key":"10.1016\/j.thromres.2023.05.018_bb0140","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA."},{"issue":"20","key":"10.1016\/j.thromres.2023.05.018_bb0145","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1001\/jama.2019.5358","article-title":"Effect of a recombinant human soluble thrombomodulin on mortality in patients with Sepsis-associated coagulopathy: the SCARLET randomized clinical trial","volume":"321","author":"Vincent","year":"2019","journal-title":"Jama."},{"issue":"5","key":"10.1016\/j.thromres.2023.05.018_bb0150","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1128\/iai.64.5.1762-1769.1996","article-title":"Human monocyte CD14 is upregulated by lipopolysaccharide","volume":"64","author":"Landmann","year":"1996","journal-title":"Infect. Immun."},{"issue":"5","key":"10.1016\/j.thromres.2023.05.018_bb0155","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1097\/00001721-200207000-00004","article-title":"Cellular activation responses in blood in relation to lipid pattern: healthy men and women in families with myocardial infarction or cancer","volume":"13","author":"\u00d8sterud","year":"2002","journal-title":"Blood Coagul. Fibrinolysis"},{"issue":"Suppl. 1","key":"10.1016\/j.thromres.2023.05.018_bb0160","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1097\/00001721-199506001-00004","article-title":"Cellular interactions in tissue factor expression by blood monocytes","volume":"6","author":"Osterud","year":"1995","journal-title":"Blood Coagul. Fibrinolysis"},{"issue":"12","key":"10.1016\/j.thromres.2023.05.018_bb0165","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1182\/blood.V76.12.2520.2520","article-title":"Experimental endotoxemia in humans: analysis of cytokine release and coagulation, fibrinolytic, and complement pathways","volume":"76","author":"van Deventer","year":"1990","journal-title":"Blood."},{"issue":"1","key":"10.1016\/j.thromres.2023.05.018_bb0170","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/s00134-018-5173-1","article-title":"Long-term impact of sepsis on cardiovascular health","volume":"45","author":"Mankowski","year":"2019","journal-title":"Intensive Care Med."},{"issue":"2","key":"10.1016\/j.thromres.2023.05.018_bb0175","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1182\/blood.V96.2.554.014k17_554_559","article-title":"The in vivo kinetics of tissue factor messenger RNA expression during human endotoxemia: relationship with activation of coagulation","volume":"96","author":"Franco","year":"2000","journal-title":"Blood."},{"issue":"1","key":"10.1016\/j.thromres.2023.05.018_bb0180","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1038\/s41467-019-09913-4","article-title":"Lipopolysaccharide inhalation recruits monocytes and dendritic cell subsets to the alveolar airspace","volume":"10","author":"Jardine","year":"2019","journal-title":"Nat. Commun."},{"issue":"7","key":"10.1016\/j.thromres.2023.05.018_bb0185","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1084\/jem.20170355","article-title":"The fate and lifespan of human monocyte subsets in steady state and systemic inflammation","volume":"214","author":"Patel","year":"2017","journal-title":"J. Exp. Med."},{"issue":"7","key":"10.1016\/j.thromres.2023.05.018_bb0190","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1182\/blood.V75.7.1481.1481","article-title":"Disseminated intravascular coagulation in rabbits induced by administration of endotoxin or tissue factor: effect of anti-tissue factor antibodies and measurement of plasma extrinsic pathway inhibitor activity","volume":"75","author":"Warr","year":"1990","journal-title":"Blood."},{"issue":"2","key":"10.1016\/j.thromres.2023.05.018_bb0195","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.bcmd.2003.12.002","article-title":"Blood cell-derived tissue factor influences host response during murine endotoxemia","volume":"32","author":"Schoenmakers","year":"2004","journal-title":"Blood Cells Mol. Dis."},{"issue":"12","key":"10.1016\/j.thromres.2023.05.018_bb0200","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1182\/blood.V81.12.3313.3313","article-title":"Activation of the kallikrein-kinin system after endotoxin administration to normal human volunteers","volume":"81","author":"DeLa","year":"1993","journal-title":"Blood."},{"issue":"16","key":"10.1016\/j.thromres.2023.05.018_bb0205","doi-asserted-by":"crossref","first-page":"10294","DOI":"10.1016\/S0021-9258(18)99224-0","article-title":"The integrity of the cysteine 186-cysteine 209 bond of the second disulfide loop of tissue factor is required for binding of factor VII","volume":"266","author":"Rehemtulla","year":"1991","journal-title":"J. Biol. Chem."},{"issue":"39","key":"10.1016\/j.thromres.2023.05.018_bb0210","doi-asserted-by":"crossref","first-page":"12020","DOI":"10.1021\/bi061271a","article-title":"Evidence for activation of tissue factor by an allosteric disulfide bond","volume":"45","author":"Chen","year":"2006","journal-title":"Biochemistry."},{"issue":"8","key":"10.1016\/j.thromres.2023.05.018_bb0215","doi-asserted-by":"crossref","first-page":"3038","DOI":"10.1182\/blood-2003-07-2399","article-title":"Lipid rafts are necessary for tonic inhibition of cellular tissue factor procoagulant activity","volume":"103","author":"Dietzen","year":"2004","journal-title":"Blood."},{"issue":"1","key":"10.1016\/j.thromres.2023.05.018_bb0220","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1182\/blood-2004-03-0990","article-title":"Acute cholesterol depletion impairs functional expression of tissue factor in fibroblasts: modulation of tissue factor activity by membrane cholesterol","volume":"105","author":"Mandal","year":"2005","journal-title":"Blood."},{"issue":"3","key":"10.1016\/j.thromres.2023.05.018_bb0225","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1161\/01.ATV.0000202656.53964.04","article-title":"Tissue factor encryption","volume":"26","author":"Bach","year":"2006","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"9","key":"10.1016\/j.thromres.2023.05.018_bb0230","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1007\/s00018-005-4527-3","article-title":"Surface exposure of phosphatidylserine in pathological cells","volume":"62","author":"Zwaal","year":"2005","journal-title":"Cell. Mol. Life Sci."},{"issue":"6335","key":"10.1016\/j.thromres.2023.05.018_bb0235","doi-asserted-by":"crossref","DOI":"10.1126\/science.aah4573","article-title":"Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors","volume":"356","author":"Villani","year":"2017","journal-title":"Science."},{"issue":"21","key":"10.1016\/j.thromres.2023.05.018_bb0240","first-page":"2063","article-title":"Severe sepsis and septic shock","volume":"369","author":"Angus","year":"2013","journal-title":"N. Engl. J. Med."}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384823001512?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384823001512?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T17:50:25Z","timestamp":1758736225000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049384823001512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":48,"alternative-id":["S0049384823001512"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2023.05.018","relation":{},"ISSN":["0049-3848"],"issn-type":[{"value":"0049-3848","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tissue factor expression in monocyte subsets during human immunothrombosis, endotoxemia and sepsis","name":"articletitle","label":"Article Title"},{"value":"Thrombosis Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.thromres.2023.05.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}