{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T18:47:34Z","timestamp":1776797254980,"version":"3.51.2"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004541","name":"Ministry of Education, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004541","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["CRG\/2019\/001211"],"award-info":[{"award-number":["CRG\/2019\/001211"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thrombosisresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.thromres.2023.09.008","type":"journal-article","created":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T09:25:14Z","timestamp":1694942714000},"page":"8-16","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Targeted delivery of miR125a-5p and human Factor VIII attenuates molecular mediators of hemophilic arthropathy"],"prefix":"10.1016","volume":"231","author":[{"given":"Mohankumar B.","family":"Senthilkumar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pratiksha","family":"Sarangi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonal","family":"Amit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Senthilnathan","family":"Senguttuvan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narendra","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giridhara R.","family":"Jayandharan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.thromres.2023.09.008_bb0005","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1111\/jth.15444","article-title":"Hemophilic arthropathy: current knowledge and future perspectives","volume":"19","author":"Gualtierotti","year":"2021","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2023.09.008_bb0010","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1111\/j.1538-7836.2010.03962.x","article-title":"Haemostasis, blood-induced joint disease: the pathophysiology of hemophilic arthropathy","volume":"8","author":"Valentino","year":"2010","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2023.09.008_bb0015","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1097\/00008480-200202000-00008","article-title":"Current treatment of hemophilic arthropathy","author":"Hilgartner","year":"2002","journal-title":"Curr. Opin. Pediatr."},{"key":"10.1016\/j.thromres.2023.09.008_bb0020","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1182\/blood-2010-05-284653","article-title":"Neoangiogenesis contributes to the development of hemophilic synovitis","volume":"117","author":"Acharya","year":"2011","journal-title":"Blood."},{"key":"10.1016\/j.thromres.2023.09.008_bb0025","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/hae.14200","article-title":"Biomarkers and immunological parameters in haemophilia and rheumatoid arthritis patients: a comparative multiplexing laboratory study","volume":"27","author":"Toenges","year":"2021","journal-title":"Haemophilia."},{"key":"10.1016\/j.thromres.2023.09.008_bb0030","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1046\/j.1365-2559.1999.00608.x","article-title":"Haemophilic arthropathy resembles degenerative rather than inflammatory joint disease","volume":"34","author":"Roosendaal","year":"1999","journal-title":"Histopathology."},{"key":"10.1016\/j.thromres.2023.09.008_bb0035","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1038\/s41590-023-01527-9","article-title":"Drivers of heterogeneity in synovial fibroblasts in rheumatoid arthritis","volume":"24","author":"Smith","year":"2023","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.thromres.2023.09.008_bb0040","first-page":"3669","article-title":"Unique inflammatory signature in hemophilic arthropathy: epigenetic changes due to interaction between blood and fibroblast-like Synoviocytes","volume":"130","author":"Mignot","year":"2017","journal-title":"Blood."},{"key":"10.1016\/j.thromres.2023.09.008_bb0045","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/jth.12101","article-title":"Nuclear factor (NF)-\u03baB and its associated pathways are major molecular regulators of blood-induced joint damage in a murine model of hemophilia","volume":"11","author":"Sen","year":"2013","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2023.09.008_bb0050","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3389\/fendo.2018.00402","article-title":"Overview of microRNA biogenesis, mechanisms of actions, and circulation","volume":"9","author":"O'Brien","year":"2018","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.thromres.2023.09.008_bb0055","doi-asserted-by":"crossref","first-page":"14453","DOI":"10.1111\/jcmm.16068","article-title":"Unique inflammatory signature in haemophilic arthropathy: miRNA changes due to interaction between blood and fibroblast-like synoviocytes","volume":"24","author":"Mignot","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.thromres.2023.09.008_bb0060","doi-asserted-by":"crossref","first-page":"492","DOI":"10.3390\/ijms17040492","article-title":"MicroRNA-15b modulates molecular mediators of blood induced arthropathy in hemophilia mice","volume":"17","author":"Sen","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.thromres.2023.09.008_bb0065","doi-asserted-by":"crossref","first-page":"376","DOI":"10.3389\/fmed.2020.00376","article-title":"MicroRNAs in synovial pathology associated with osteoarthritis","volume":"7","author":"Tavallaee","year":"2020","journal-title":"Front. Med."},{"key":"10.1016\/j.thromres.2023.09.008_bb0070","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1136\/annrheumdis-2011-200803","article-title":"Identification of microRNA-221\/222 and microRNA-323-3p association with rheumatoid arthritis via predictions using the human tumour necrosis factor transgenic mouse model","volume":"10","author":"Pandis","year":"2012","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.thromres.2023.09.008_bb0075","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.autrev.2015.07.005","article-title":"MicroRNAs in rheumatoid arthritis: altered expression and diagnostic potential","volume":"14","author":"Churov","year":"2015","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.thromres.2023.09.008_bb0080","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s00296-013-2754-8","article-title":"The inflammatory circuitry of miR-149 as a pathological mechanism in osteoarthritis","volume":"34","author":"Santini","year":"2014","journal-title":"Rheumatol. Int."},{"key":"10.1016\/j.thromres.2023.09.008_bb0085","doi-asserted-by":"crossref","first-page":"106328","DOI":"10.1016\/j.intimp.2020.106328","article-title":"MiR-145-5p mitigates dysregulated Wnt1\/\u03b2-catenin signaling pathway in rheumatoid arthritis","volume":"82","author":"Dinesh","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.thromres.2023.09.008_bb0090","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1302\/2046-3758.611.BJR-2017-0090.R1","article-title":"Dysregulation of both miR-140-3p and miR-140-5p in synovial fluid correlate with osteoarthritis severity","volume":"6","author":"Yin","year":"2017","journal-title":"Bone. Joint. Res."},{"key":"10.1016\/j.thromres.2023.09.008_bb0095","doi-asserted-by":"crossref","first-page":"69351","DOI":"10.18632\/oncotarget.20615","article-title":"HIF-1\u03b1: CRAT: miR-144-3p axis dysregulation promotes osteoarthritis chondrocyte apoptosis and VLCFA accumulation","volume":"8","author":"Song","year":"2017","journal-title":"Oncotarget."},{"key":"10.1016\/j.thromres.2023.09.008_bb0100","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.12659\/MSM.899228","article-title":"miR-181a modulates chondrocyte apoptosis by targeting glycerol-3-phosphate dehydrogenase 1-like protein (GPD1L) in osteoarthritis","volume":"23","author":"Zhai","year":"2017","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.thromres.2023.09.008_bb0105","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1101\/gad.1915510","article-title":"MicroRNA-140 plays dual roles in both cartilage development and homeostasis","volume":"24","author":"Miyaki","year":"2010","journal-title":"Genes Dev."},{"key":"10.1016\/j.thromres.2023.09.008_bb0110","doi-asserted-by":"crossref","first-page":"611","DOI":"10.14348\/molcells.2016.0103","article-title":"MicroRNA-27a inhibits cell migration and invasion of fibroblast-like synoviocytes by targeting follistatin-like protein 1 in rheumatoid arthritis","volume":"39","author":"Shi","year":"2016","journal-title":"Mol. Cells"},{"key":"10.1016\/j.thromres.2023.09.008_bb0115","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.3389\/fimmu.2018.02037","article-title":"Multi-step regulation of the TLR4 pathway by the miR-125a~99b~let-7e cluster","volume":"9","author":"Curtale","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.thromres.2023.09.008_bb0120","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jaut.2019.04.014","article-title":"MicroRNA-125a suppresses intestinal mucosal inflammation through targeting ETS-1 in patients with inflammatory bowel diseases","volume":"101","author":"Ge","year":"2019","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.thromres.2023.09.008_bb0125","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.120798","article-title":"IL-16\/miR-125a axis controls neutrophil recruitment in pristane-induced lung inflammation","volume":"3","author":"Smith","year":"2018","journal-title":"JCI. Insight."},{"key":"10.1016\/j.thromres.2023.09.008_bb0130","doi-asserted-by":"crossref","first-page":"7096","DOI":"10.1038\/ncomms8096","article-title":"MiR-125a targets effector programs to stabilize Treg-mediated immune homeostasis","volume":"6","author":"Pan","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.thromres.2023.09.008_bb0135","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1038\/s41418-021-00911-y","article-title":"miR-125a-5p attenuates macrophage-mediated vascular dysfunction by targeting Ninjurin1","volume":"29","author":"Hwang","year":"2022","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.thromres.2023.09.008_bb0140","doi-asserted-by":"crossref","DOI":"10.1002\/jcla.24076","article-title":"Long non-coding RNA NEAT1 and its targets (microRNA-21 and microRNA-125a) in rheumatoid arthritis: altered expression and potential to monitor disease activity and treatment outcome","volume":"35","author":"Yang","year":"2021","journal-title":"J. Clin. Lab. Anal."},{"key":"10.1016\/j.thromres.2023.09.008_bb0145","doi-asserted-by":"crossref","first-page":"11225","DOI":"10.1080\/21655979.2021.1995580","article-title":"miR-125a-5p-abundant exosomes derived from mesenchymal stem cells suppress chondrocyte degeneration via targeting E2F2 in traumatic osteoarthritis","volume":"12","author":"Xia","year":"2021","journal-title":"Bioengineered"},{"key":"10.1016\/j.thromres.2023.09.008_bb0150","first-page":"A69","article-title":"A8. 12 Decreased expression of MIR-125A in psoriatic arthritis. Implications for joint pathogenesis","volume":"75","author":"Wade","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.thromres.2023.09.008_bb0155","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1111\/j.1365-2516.2008.01689.x","article-title":"Experimental haemophilic arthropathy in a mouse model of a massive haemarthrosis: gross, radiological and histological changes","volume":"14","author":"Hakobyan","year":"2008","journal-title":"Haemophilia."},{"key":"10.1016\/j.thromres.2023.09.008_bb0160","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/j.joca.2009.03.010","article-title":"Optical imaging of mouse articular cartilage using the glycosaminoglycans binding property of fluorescent-labeled octaarginine","volume":"9","author":"Inagawa","year":"2009","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.thromres.2023.09.008_bb0165","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1089\/hum.2019.164","article-title":"Rational engineering and preclinical evaluation of neddylation and SUMOylation site modified adeno-associated virus vectors in murine models of hemophilia B and leber congenital amaurosis","volume":"30","author":"Maurya","year":"2019","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.thromres.2023.09.008_bb0170","doi-asserted-by":"crossref","first-page":"4738","DOI":"10.1021\/acs.molpharmaceut.9b00959","article-title":"Molecular engineering of adeno-associated virus capsid improves its therapeutic gene transfer in murine models of hemophilia and retinal degeneration","volume":"16","author":"Mary","year":"2019","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.thromres.2023.09.008_bb0175","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1111\/jcmm.17770","article-title":"Potential role of long non-coding RNA H19 and Neat1 in haemophilic arthropathy","volume":"27","author":"Sarangi","year":"2023","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.thromres.2023.09.008_bb0180","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1111\/j.1538-7836.2010.03930.x","article-title":"17\u03b1-Ethinylestradiol rapidly alters transcript levels of murine coagulation genes via estrogen receptor \u03b1","volume":"8","author":"Cleuren","year":"2010","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2023.09.008_bb0185","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1111\/j.1365-2516.2006.01348.x","article-title":"Histological changes in murine haemophilic synovitis: a quantitative grading system to assess blood-induced synovitis","volume":"12","author":"Valentino","year":"2006","journal-title":"Haemophilia."},{"key":"10.1016\/j.thromres.2023.09.008_bb0190","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1111\/hae.13672","article-title":"Bleed volume of experimental knee haemarthrosis correlates with the subsequent degree of haemophilic arthropathy","volume":"25","author":"V\u00f8ls","year":"2019","journal-title":"Haemophilia."},{"key":"10.1016\/j.thromres.2023.09.008_bb0195","doi-asserted-by":"crossref","first-page":"119657","DOI":"10.1016\/j.lfs.2021.119657","article-title":"Reduced expression of MiR-125a-5p aggravates LPS-induced experimental acute kidney injury pathology by targeting TRAF6","volume":"288","author":"Yang","year":"2022","journal-title":"Life Sci."},{"key":"10.1016\/j.thromres.2023.09.008_bb0200","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.3892\/mmr.2014.3104","article-title":"Tumor necrosis factor receptor-associated factor 6 promotes migration of rheumatoid arthritis fibroblast-like synoviocytes","volume":"11","author":"Wang","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.thromres.2023.09.008_bb0205","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1136\/ard-2022-222605","article-title":"Age-associated B cells contribute to the pathogenesis of rheumatoid arthritis by inducing activation of fibroblast-like synoviocytes via TNF-\u03b1-mediated ERK1\/2 and JAK-STAT1 pathways","volume":"81","author":"Qin","year":"2022","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.thromres.2023.09.008_bb0210","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1111\/jth.12176","article-title":"IL-6 receptor antagonist as adjunctive therapy with clotting factor replacement to protect against bleeding-induced arthropathy in hemophilia","volume":"11","author":"Narkbunnam","year":"2013","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2023.09.008_bb0215","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1089\/hum.2019.355","article-title":"Exploring the potential feasibility of intra-articular adeno-associated virus-mediated gene therapy for hemophilia arthropathy","volume":"31","author":"Zhang","year":"2020","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.thromres.2023.09.008_bb0220","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1056\/NEJMoa1908490","article-title":"Multiyear follow-up of AAV5-hFVIII-SQ gene therapy for hemophilia A","volume":"382","author":"Pasi","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.thromres.2023.09.008_bb0225","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3390\/jcm6070063","article-title":"Pathophysiology of hemophilic arthropathy","volume":"6","author":"Melchiorre","year":"2017","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.thromres.2023.09.008_bb0230","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1302\/0301-620X.80B3.0800540","article-title":"Iron deposits and catabolic properties of synovial tissue from patients with haemophilia","volume":"80","author":"Roosendaal","year":"1998","journal-title":"J. Bone Joint Surg. Br."},{"key":"10.1016\/j.thromres.2023.09.008_bb0235","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/hae.13236","article-title":"Differential effects of bleeds on the development of arthropathy \u2013 basic and applied issues","volume":"23","author":"van Vulpen","year":"2017","journal-title":"Haemophilia."},{"key":"10.1016\/j.thromres.2023.09.008_bb0240","doi-asserted-by":"crossref","first-page":"R133","DOI":"10.1186\/ar3866","article-title":"Upregulation of tumor necrosis factor receptor-associated factor 6 correlated with synovitis severity in rheumatoid arthritis","volume":"14","author":"Zhu","year":"2012","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.thromres.2023.09.008_bb0245","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1136\/ard.2005.037929","article-title":"Expression of Jak3, STAT1, STAT4, and STAT6 in inflammatory arthritis: unique Jak3 and STAT4 expression in dendritic cells in seropositive rheumatoid arthritis","volume":"65","author":"Walker","year":"2006","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.thromres.2023.09.008_bb0250","doi-asserted-by":"crossref","first-page":"14262","DOI":"10.1021\/acsnano.0c03850","article-title":"Synthetically engineered adeno-associated virus for efficient, safe, and versatile gene therapy applications","volume":"14","author":"Lugin","year":"2020","journal-title":"ACS Nano."},{"key":"10.1016\/j.thromres.2023.09.008_bb0255","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1089\/hum.2017.181","article-title":"Gene delivery to joints by intra-articular injection","volume":"29","author":"Evans","year":"2018","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.thromres.2023.09.008_bb0260","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1002\/jgm.1053","article-title":"Inflammation-inducible anti-TNF gene expression mediated by intra-articular injection of serotype 5 adeno-associated virus reduces arthritis","volume":"9","author":"Khoury","year":"2007","journal-title":"J. Gene Med."},{"key":"10.1016\/j.thromres.2023.09.008_bb0265","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1016\/j.joca.2012.08.011","article-title":"In vivo reduction or blockade of interleukin-1\u03b2 in primary osteoarthritis influences expression of mediators implicated in pathogenesis","volume":"20","author":"Santangelo","year":"2012","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.thromres.2023.09.008_bb0270","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1080\/15548627.2018.1474995","article-title":"Inhibition of TRAF6 ubiquitin-ligase activity by PRDX1 leads to inhibition of NFKB activation and autophagy activation","volume":"14","author":"Min","year":"2018","journal-title":"Autophagy."},{"key":"10.1016\/j.thromres.2023.09.008_bb0275","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1146\/annurev-biophys-083012-130338","article-title":"Molecular basis of NF-\u03baB signaling","volume":"42","author":"Napetschnig","year":"2013","journal-title":"Annu. Rev. Biophys."},{"key":"10.1016\/j.thromres.2023.09.008_bb0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113553","article-title":"Kaempferol attenuates streptozotocin-induced diabetic nephropathy by downregulating TRAF6 expression: the role of TRAF6 in diabetic nephropathy","volume":"268","author":"Luo","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.thromres.2023.09.008_bb0285","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/icb.2014.51","article-title":"STAT1 plays a role in TLR signal transduction and inflammatory responses","volume":"92","author":"Luu","year":"2014","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.thromres.2023.09.008_bb0290","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1186\/s13287-022-02855-7","article-title":"MicroRNA-146a-5p-modified human umbilical cord mesenchymal stem cells enhance protection against diabetic nephropathy in rats through facilitating M2 macrophage polarization","volume":"13","author":"Zhang","year":"2022","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.thromres.2023.09.008_bb0295","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.cyto.2017.05.001","article-title":"Tumor necrosis factor receptor-associated factor (TRAF) 6 inhibition mitigates the pro-inflammatory roles and proliferation of rheumatoid arthritis fibroblast-like synoviocytes","volume":"93","author":"Zhu","year":"2017","journal-title":"Cytokine."},{"key":"10.1016\/j.thromres.2023.09.008_bb0300","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1177\/0022034520901710","article-title":"DPSCs attenuate experimental progressive TMJ arthritis by inhibiting the STAT1 pathway","volume":"99","author":"Cui","year":"2020","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.thromres.2023.09.008_bb0305","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s11658-019-0146-0","article-title":"MiR-125a-5p promotes osteoclastogenesis by targeting TNFRSF1B","volume":"24","author":"Sun","year":"2019","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.thromres.2023.09.008_bb0310","first-page":"3498","article-title":"JAK\/STAT pathway in pathology of rheumatoid arthritis (review)","volume":"20","author":"Ciobanu","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.thromres.2023.09.008_bb0315","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/boneres.2015.5","article-title":"TGF-\u03b2\/BMP signaling and other molecular events: regulation of osteoblastogenesis and bone formation","volume":"3","author":"Rahman","year":"2015","journal-title":"Bone. Res."},{"key":"10.1016\/j.thromres.2023.09.008_bb0320","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1182\/blood-2003-08-2954","article-title":"Total correction of hemophilia a mice with canine FVIII using an AAV 8 serotype","volume":"103","author":"Sarkar","year":"2004","journal-title":"Blood."}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384823002608?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384823002608?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T17:51:05Z","timestamp":1758736265000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049384823002608"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":64,"alternative-id":["S0049384823002608"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2023.09.008","relation":{},"ISSN":["0049-3848"],"issn-type":[{"value":"0049-3848","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeted delivery of miR125a-5p and human Factor VIII attenuates molecular mediators of hemophilic arthropathy","name":"articletitle","label":"Article Title"},{"value":"Thrombosis Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.thromres.2023.09.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}