{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T21:31:17Z","timestamp":1784755877064,"version":"3.55.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission, Adminitrative Commission of Zhongguancun Science Park","doi-asserted-by":"publisher","award":["Z181100001718182"],"award-info":[{"award-number":["Z181100001718182"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission, Adminitrative Commission of Zhongguancun Science Park","doi-asserted-by":"publisher","award":["20006429"],"award-info":[{"award-number":["20006429"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thrombosisresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.thromres.2023.10.012","type":"journal-article","created":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T10:59:25Z","timestamp":1697885965000},"page":"43-53","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Machine learning model for predicting physical activity related bleeding risk in Chinese boys with haemophilia A"],"prefix":"10.1016","volume":"232","author":[{"given":"Di","family":"Ai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqiang","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningning","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingzi","family":"Zhen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wensheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runhui","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.thromres.2023.10.012_bb0005","series-title":"Haemophilia","first-page":"1","article-title":"WFH guidelines for the management of hemophilia","volume":"26(S6)","author":"Srivastava","year":"2020"},{"issue":"4","key":"10.1016\/j.thromres.2023.10.012_bb0010","doi-asserted-by":"crossref","first-page":"e267","DOI":"10.1111\/hae.13773","article-title":"Physical activity and its related factors in Japanese people with haemophilia","volume":"25","author":"Goto","year":"2019","journal-title":"Haemophilia"},{"issue":"3","key":"10.1016\/j.thromres.2023.10.012_bb0015","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1365-2516.2009.01990.x","article-title":"Physical activity participation and bleeding characteristics in young patients with severe haemophilia","volume":"15","author":"Tiktinsky","year":"2009","journal-title":"Haemophilia"},{"issue":"4","key":"10.1016\/j.thromres.2023.10.012_bb0020","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1111\/j.1365-2516.2010.02469.x","article-title":"Comparison of physical activity and sedentary behaviours between young haemophilia A patients and healthy adolescents","volume":"17","author":"Gonz\u00e1lez","year":"2011","journal-title":"Haemophilia"},{"issue":"19","key":"10.1016\/j.thromres.2023.10.012_bb0025","doi-asserted-by":"crossref","first-page":"3946","DOI":"10.1182\/blood-2012-11-469403","article-title":"Correlation between phenotype and genotype in a large unselected cohort of children with severe hemophilia A","volume":"121","author":"Carcao","year":"2013","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.thromres.2023.10.012_bb0030","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/hae.12912","article-title":"The impact of sport on health status, psychological well-being and physical performance of adults with haemophilia","volume":"22","author":"von Mackensen","year":"2016","journal-title":"Haemophilia"},{"issue":"3","key":"10.1016\/j.thromres.2023.10.012_bb0035","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/j.1365-2516.2009.02187.x","article-title":"Alarmingly high prevalence of obesity in haemophilia in the state of Mississippi","volume":"16","author":"Majumdar","year":"2010","journal-title":"Haemophilia"},{"key":"10.1016\/j.thromres.2023.10.012_bb0040","doi-asserted-by":"crossref","first-page":"S61","DOI":"10.1016\/j.thromres.2013.10.022","article-title":"Early orthopaedic challenges in haemophilia patients and therapeutic approach","volume":"134","author":"Seuser","year":"2014","journal-title":"Thromb. Res."},{"issue":"4","key":"10.1016\/j.thromres.2023.10.012_bb0045","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1111\/hae.13985","article-title":"Understanding minimum and ideal factor levels for participation in physical activities by people with haemophilia: an expert elicitation exercise","volume":"26","author":"Martin","year":"2020","journal-title":"Haemophilia"},{"issue":"6","key":"10.1016\/j.thromres.2023.10.012_bb0050","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1111\/j.1538-7836.2006.01953.x","article-title":"Tailored prophylaxis in severe hemophilia a: interim results from the first 5 years of the Canadian hemophilia primary prophylaxis study","volume":"4","author":"Feldman","year":"2006","journal-title":"J. Thromb. Haemost."},{"issue":"3","key":"10.1016\/j.thromres.2023.10.012_bb0055","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/j.1538-7836.2008.03270.x","article-title":"Break-through bleeding in relation to predicted factor VIII levels in patients receiving prophylactic treatment for severe hemophilia A","volume":"7","author":"Collins","year":"2009","journal-title":"J. Thromb. Haemost."},{"issue":"5","key":"10.1016\/j.thromres.2023.10.012_bb0060","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.3324\/haematol.2019.217133","article-title":"Relationship between factor VIII activity, bleeds and individual characteristics in severe hemophilia A patients","volume":"105","author":"Abrantes","year":"2020","journal-title":"Haematologica"},{"issue":"5","key":"10.1016\/j.thromres.2023.10.012_bb0065","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1542\/peds.2009-0072","article-title":"Athletic participation in severe hemophilia: bleeding and joint outcomes in children on prophylaxis","volume":"124","author":"Ross","year":"2009","journal-title":"Pediatrics"},{"issue":"4","key":"10.1016\/j.thromres.2023.10.012_bb0070","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.jtha.2022.12.019","article-title":"Machine learning in the coagulation and hemostasis arena: an overview and evaluation of methods, review of literature, and future directions","volume":"21","author":"Rashidi","year":"2023","journal-title":"J. Thromb. Haemost."},{"issue":"7","key":"10.1016\/j.thromres.2023.10.012_bb0075","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1111\/jth.15318","article-title":"Comparison of multivariate linear regression and a machine learning algorithm developed for prediction of precision warfarin dosing in a Korean population","volume":"19","author":"Nguyen","year":"2021","journal-title":"J. Thromb. Haemost."},{"issue":"1","key":"10.1016\/j.thromres.2023.10.012_bb0080","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1007\/s10278-022-00724-6","article-title":"Automated multimodal machine learning for esophageal variceal bleeding prediction based on endoscopy and structured data","volume":"36","author":"Wang","year":"2023","journal-title":"J. Digit. Imaging"},{"issue":"4","key":"10.1016\/j.thromres.2023.10.012_bb0085","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1097\/AOG.0000000000003759","article-title":"Machine learning and statistical models to predict postpartum hemorrhage","volume":"135","author":"Venkatesh","year":"2020","journal-title":"Obstet. Gynecol."},{"issue":"6","key":"10.1016\/j.thromres.2023.10.012_bb0090","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1111\/jth.15723","article-title":"Risk factors for bleeding in people living with hemophilia A and B treated with regular prophylaxis: a systematic review of the literature","volume":"20","author":"Germini","year":"2022","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2023.10.012_bb0095","article-title":"Playing it safe","volume":"October","author":"Renner","year":"2018","journal-title":"Occup. Health Saf."},{"key":"10.1016\/j.thromres.2023.10.012_bb0100","doi-asserted-by":"crossref","unstructured":"Prentice RL, Zhao S. Regression models and multivariate life tables ABSTRACT. J. Am. Stat. Assoc. 2021;0(0):1\u201332. doi:https:\/\/doi.org\/10.1080\/01621459.2020.1713792.","DOI":"10.1080\/01621459.2020.1713792"},{"issue":"12","key":"10.1016\/j.thromres.2023.10.012_bb0105","first-page":"1974","article-title":"Random survival forests","volume":"6","author":"Taylor","year":"2011","journal-title":"JTO Acquis."},{"issue":"1","key":"10.1016\/j.thromres.2023.10.012_bb0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12874-018-0482-1","article-title":"DeepSurv: personalized treatment recommender system using a cox proportional hazards deep neural network","volume":"18","author":"Katzman","year":"2018","journal-title":"BMC Med. Res. Methodol."},{"issue":"18","key":"10.1016\/j.thromres.2023.10.012_bb0115","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1001\/jama.1982.03320430047030","article-title":"Evaluating the yield of medical tests","volume":"247","author":"Harrell","year":"1982","journal-title":"JAMA - J Am Med Assoc."},{"key":"10.1016\/j.thromres.2023.10.012_bb0120","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1002\/(SICI)1097-0258(19990915\/30)18:17\/18<2529::AID-SIM274>3.0.CO;2-5","article-title":"Assessment and comparison of prognostic classification schemes for survival data","volume":"2545","author":"Graf","year":"1999","journal-title":"Stat. Med."},{"issue":"10","key":"10.1016\/j.thromres.2023.10.012_bb0125","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1111\/jth.15424","article-title":"Health and treatment outcomes of patients with hemophilia in the Netherlands, 1972\u20132019","volume":"19","author":"Hassan","year":"2021","journal-title":"J. Thromb. Haemost."},{"issue":"2","key":"10.1016\/j.thromres.2023.10.012_bb0130","doi-asserted-by":"crossref","first-page":"107","DOI":"10.5482\/HAMO-15-02-0007","article-title":"Health promotion for young patients with haemophilia: counselling, adjuvant exercise therapy and school sports","volume":"37","author":"Sondermann","year":"2017","journal-title":"Hamostaseologie"},{"issue":"4","key":"10.1016\/j.thromres.2023.10.012_bb0135","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1097\/00004703-200308000-00002","article-title":"Social, emotional, and behavioral functioning of children with hemophilia","volume":"24","author":"Trzepacz","year":"2003","journal-title":"J. Dev. Behav. Pediatr."},{"issue":"6","key":"10.1016\/j.thromres.2023.10.012_bb0140","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1055\/s-0041-1739514","article-title":"Predictive modeling identifies total bleeds at 12-weeks Postswitch to N8-GP prophylaxis as a predictor of treatment response","volume":"122","author":"Chowdary","year":"2022","journal-title":"Thromb. Haemost."},{"issue":"1","key":"10.1016\/j.thromres.2023.10.012_bb0145","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1365-2516.2012.02904.x","article-title":"Patterns of physical activity in children with haemophilia","volume":"19","author":"Broderick","year":"2013","journal-title":"Haemophilia"},{"issue":"September","key":"10.1016\/j.thromres.2023.10.012_bb0150","doi-asserted-by":"crossref","first-page":"883","DOI":"10.2147\/JBM.S327180","article-title":"A prospective observational study of antihemophilic factor (recombinant) prophylaxis related to physical activity levels in patients with hemophilia a in the United States (space)","volume":"12","author":"Konkle","year":"2021","journal-title":"J. Blood Med."},{"issue":"3","key":"10.1016\/j.thromres.2023.10.012_bb0155","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1055\/a-1983-0594","article-title":"Association between sports participation, factor VIII levels and bleeding in hemophilia A","volume":"123","author":"Bukkems","year":"2023","journal-title":"Thromb. Haemost."},{"issue":"14","key":"10.1016\/j.thromres.2023.10.012_bb0160","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1001\/jama.2012.12727","article-title":"Association between physical activity and risk of bleeding in children with hemophilia","volume":"308","author":"Broderick","year":"2012","journal-title":"JAMA \u2013 J. Am. Med. Assoc."},{"issue":"4","key":"10.1016\/j.thromres.2023.10.012_bb0165","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1111\/bjh.15606","article-title":"Bleeding risk for patients with haemophilia under antithrombotic therapy. Results of the French multicentric study ERHEA","volume":"185","author":"Desjonqueres","year":"2019","journal-title":"Br. J. Haematol."},{"issue":"26","key":"10.1016\/j.thromres.2023.10.012_bb0170","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1182\/blood.2021011849","article-title":"Incidence and mortality rates of intracranial hemorrhage in hemophilia: a systematic review and meta-analysis","volume":"138","author":"Zwagemaker","year":"2021","journal-title":"Blood"}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004938482300289X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004938482300289X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T09:20:53Z","timestamp":1778664053000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004938482300289X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":34,"alternative-id":["S004938482300289X"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2023.10.012","relation":{},"ISSN":["0049-3848"],"issn-type":[{"value":"0049-3848","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Machine learning model for predicting physical activity related bleeding risk in Chinese boys with haemophilia A","name":"articletitle","label":"Article Title"},{"value":"Thrombosis Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.thromres.2023.10.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}