{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T03:32:58Z","timestamp":1788492778594,"version":"build-2803163510"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T00:00:00Z","timestamp":1708905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007452","name":"Wu Jieping Medical Foundation","doi-asserted-by":"publisher","award":["320.6750.2020-4-36"],"award-info":[{"award-number":["320.6750.2020-4-36"]}],"id":[{"id":"10.13039\/100007452","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["kq2202391"],"award-info":[{"award-number":["kq2202391"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["kq2202394"],"award-info":[{"award-number":["kq2202394"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002822","name":"Central South University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002822","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001547","name":"China Medical Board Inc","doi-asserted-by":"publisher","award":["19-343"],"award-info":[{"award-number":["19-343"]}],"id":[{"id":"10.13039\/100001547","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","thrombosisresearch.com","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.thromres.2024.02.016","type":"journal-article","created":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T13:45:42Z","timestamp":1708091142000},"page":"22-29","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Pregnancy outcomes in Chinese women with mechanical heart valves receiving warfarin treatment throughout pregnancy: 14-year experience"],"prefix":"10.1016","volume":"236","author":[{"given":"Tianyu","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guobao","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyun","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenglan","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.thromres.2024.02.016_bb0005","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nrcardio.2012.69","article-title":"Anticoagulation during pregnancy in patients with a prosthetic heart valve","volume":"9","author":"Castellano","year":"2012","journal-title":"Nat. Rev. Cardiol."},{"issue":"10","key":"10.1016\/j.thromres.2024.02.016_bb0010","doi-asserted-by":"crossref","first-page":"1248.e1","DOI":"10.1016\/j.cjca.2015.11.005","article-title":"Anticoagulation regimens during pregnancy in patients with mechanical heart valves: a systematic review and meta-analysis","volume":"32","author":"Xu","year":"2016","journal-title":"Can. J. Cardiol."},{"issue":"Suppl. 1","key":"10.1016\/j.thromres.2024.02.016_bb0015","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1016\/S0049-3848(13)70010-0","article-title":"Anticoagulant choices in pregnant women with mechanical heart valves: balancing maternal and fetal risks\u2014the difference the dose makes","volume":"131","author":"McLintock","year":"2013","journal-title":"Thromb. Res."},{"key":"10.1016\/j.thromres.2024.02.016_bb0020","article-title":"Pregnancy, thrombophilia, and the risk of a first venous thrombosis: systematic review and bayesian meta-analysis","volume":"359","author":"Croles","year":"2017","journal-title":"BMJ"},{"issue":"2","key":"10.1016\/j.thromres.2024.02.016_bb0025","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1055\/s-2003-38897","article-title":"Hemostasis during normal pregnancy and puerperium","volume":"29","author":"Hellgren","year":"2003","journal-title":"Semin. Thromb. Hemost."},{"issue":"6","key":"10.1016\/j.thromres.2024.02.016_bb0030","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1515\/cclm-2017-0804","article-title":"Reference intervals for biochemical, haemostatic and haematological parameters in healthy Chinese women during early and late pregnancy","volume":"56","author":"Jin","year":"2018","journal-title":"Clin. Chem. Lab. Med."},{"issue":"4","key":"10.1016\/j.thromres.2024.02.016_bb0035","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.jacc.2020.11.035","article-title":"2020 ACC\/AHA guideline for the management of patients with valvular heart disease: executive summary: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"77","author":"Otto","year":"2021","journal-title":"J. Am. Coll. Cardiol."},{"issue":"1","key":"10.1016\/j.thromres.2024.02.016_bb0040","first-page":"35","article-title":"Risk of warfarin during pregnancy with mechanical valve prostheses","volume":"99","author":"Cotrufo","year":"2002","journal-title":"Obstet. Gynecol."},{"issue":"3","key":"10.1016\/j.thromres.2024.02.016_bb0045","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0020-7292(02)00186-8","article-title":"The risk of fetal loss associated with warfarin anticoagulation","volume":"78","author":"Blickstein","year":"2002","journal-title":"Int. J. Gynaecol. Obstet."},{"issue":"19","key":"10.1016\/j.thromres.2024.02.016_bb0050","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1093\/eurheartj\/ehx032","article-title":"Anticoagulation for pregnant women with mechanical heart valves: a systematic review and meta-analysis","volume":"38","author":"D\u2019Souza","year":"2017","journal-title":"Eur. Heart J."},{"issue":"2","key":"10.1016\/j.thromres.2024.02.016_bb0055","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0306-3356(21)00018-2","article-title":"Anticoagulants in pregnancy","volume":"13","author":"Howie","year":"1986","journal-title":"Clin. Obstet. Gynaecol."},{"issue":"22","key":"10.1016\/j.thromres.2024.02.016_bb0060","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1016\/j.jacc.2017.03.605","article-title":"Maternal and fetal outcomes of anticoagulation in pregnant women with mechanical heart valves","volume":"69","author":"Steinberg","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"issue":"5","key":"10.1016\/j.thromres.2024.02.016_bb0065","first-page":"e35","article-title":"2020 ACC\/AHA guideline for the management of patients with valvular heart disease: executive summary: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"143","author":"Otto","year":"2021","journal-title":"Circulation"},{"issue":"7","key":"10.1016\/j.thromres.2024.02.016_bb0070","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/eurheartj\/ehab395","article-title":"2021 ESC\/EACTS guidelines for the management of valvular heart disease","volume":"43","author":"Vahanian","year":"2022","journal-title":"Eur. Heart J."},{"issue":"2","key":"10.1016\/j.thromres.2024.02.016_bb0075","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1471-0528.2000.tb11696.x","article-title":"Pregnancy outcomes and cardiac complications in women with mechanical, bioprosthetic and homograft valves","volume":"107","author":"Sadler","year":"2000","journal-title":"BJOG"},{"issue":"2","key":"10.1016\/j.thromres.2024.02.016_bb0080","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.015563","article-title":"Long-term survival of patients with left ventricular noncompaction","volume":"10","author":"Vaidya","year":"2021","journal-title":"J. Am. Heart Assoc."},{"issue":"8154","key":"10.1016\/j.thromres.2024.02.016_bb0085","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/S0140-6736(79)92343-2","article-title":"Prematurity","volume":"2","author":"Ritchie","year":"1979","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.thromres.2024.02.016_bb0090","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1161\/CIRCULATIONAHA.115.015242","article-title":"Pregnancy in women with a mechanical heart valve: data of the European Society of Cardiology Registry of Pregnancy and Cardiac Disease (ROPAC)","volume":"132","author":"van Hagen","year":"2015","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.thromres.2024.02.016_bb0095","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/qjmed\/89.2.127","article-title":"Factors determining the maintenance dose of warfarin in Chinese patients","volume":"89","author":"Yu","year":"1996","journal-title":"QJM"},{"issue":"4","key":"10.1016\/j.thromres.2024.02.016_bb0100","doi-asserted-by":"crossref","first-page":"505","DOI":"10.2165\/00003495-198836040-00007","article-title":"Optimum use of anticoagulants in pregnancy","volume":"36","author":"Ginsberg","year":"1988","journal-title":"Drugs"},{"issue":"6","key":"10.1016\/j.thromres.2024.02.016_bb0105","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1016\/S0735-1097(99)00044-3","article-title":"Dose-dependent fetal complications of warfarin in pregnant women with mechanical heart valves","volume":"33","author":"Vitale","year":"1999","journal-title":"J. Am. Coll. Cardiol."},{"issue":"22","key":"10.1016\/j.thromres.2024.02.016_bb0110","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1056\/NEJM198611273152205","article-title":"Risks of anticoagulant therapy in pregnant women with artificial heart valves","volume":"315","author":"Iturbe-Alessio","year":"1986","journal-title":"N. Engl. J. Med."},{"issue":"8","key":"10.1016\/j.thromres.2024.02.016_bb0115","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1007\/s40262-019-00745-5","article-title":"Differences in warfarin pharmacodynamics and predictors of response among three racial populations","volume":"58","author":"Ohara","year":"2019","journal-title":"Clin. Pharmacokinet."},{"issue":"1","key":"10.1016\/j.thromres.2024.02.016_bb0120","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s12013-011-9275-4","article-title":"Low-intensity international normalized ratio (INR) oral anticoagulant therapy in Chinese patients with mechanical heart valve prostheses","volume":"62","author":"Haibo","year":"2012","journal-title":"Cell Biochem. Biophys."},{"issue":"5","key":"10.1016\/j.thromres.2024.02.016_bb0125","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1111\/j.1365-2125.2005.02361.x","article-title":"Is INR between 2.0 and 3.0 the optimal level for Chinese patients on warfarin therapy for moderate-intensity anticoagulation?","volume":"59","author":"You","year":"2005","journal-title":"Br. J. Clin. Pharmacol."},{"issue":"8","key":"10.1016\/j.thromres.2024.02.016_bb0130","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1056\/NEJMoa0809329","article-title":"Estimation of the warfarin dose with clinical and pharmacogenetic data","volume":"360","author":"Klein","year":"2009","journal-title":"N. Engl. J. Med."},{"issue":"9","key":"10.1016\/j.thromres.2024.02.016_bb0135","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1016\/j.amjcard.2017.07.050","article-title":"Meta-analysis of efficacy and safety of low-intensity warfarin therapy for East Asian patients with nonvalvular atrial fibrillation","volume":"120","author":"Liu","year":"2017","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.thromres.2024.02.016_bb0140","article-title":"Optimal oral anticoagulant therapy in Chinese patients with mechanical heart valves, European Journal of Pharmaceutical Sciences: Official Journal of the European Federation for","volume":"144","author":"Zhang","year":"2020","journal-title":"Pharmaceutical Sciences"},{"issue":"18","key":"10.1016\/j.thromres.2024.02.016_bb0145","doi-asserted-by":"crossref","first-page":"3827","DOI":"10.1182\/blood-2009-12-255992","article-title":"Warfarin pharmacogenetics: a single VKORC1 polymorphism is predictive of dose across 3 racial groups","volume":"115","author":"Limdi","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.thromres.2024.02.016_bb0150","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.ecoenv.2019.06.042","article-title":"Warfarin-exposed zebrafish embryos resembles human warfarin embryopathy in a dose and developmental-time dependent manner - from molecular mechanisms to environmental concerns","volume":"181","author":"Granadeiro","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"1","key":"10.1016\/j.thromres.2024.02.016_bb0155","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/0002-9343(80)90181-3","article-title":"Maternal and fetal sequelae of anticoagulation during pregnancy","volume":"68","author":"Hall","year":"1980","journal-title":"Am. J. Med."},{"issue":"9956","key":"10.1016\/j.thromres.2024.02.016_bb0160","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1016\/S0140-6736(14)61135-1","article-title":"Apgar score and the risk of cause-specific infant mortality: a population-based cohort study","volume":"384","author":"Iliodromiti","year":"2014","journal-title":"Lancet (London, England)"},{"issue":"16","key":"10.1016\/j.thromres.2024.02.016_bb0165","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1056\/NEJM199904223401603","article-title":"Birth weight in relation to morbidity and mortality among newborn infants","volume":"340","author":"McIntire","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.thromres.2024.02.016_bb0170","article-title":"Association between Apgar scores of 7 to 9 and neonatal mortality and morbidity: population based cohort study of term infants in Sweden","volume":"365","author":"Razaz","year":"2019","journal-title":"BMJ (Clinical Research Ed.)"},{"issue":"6","key":"10.1016\/j.thromres.2024.02.016_bb0175","first-page":"949","article-title":"Vitamin K antagonists and pregnancy outcome","volume":"95","author":"Schaefer","year":"2006","journal-title":"A multi-centre prospective study, Thromb Haemost"},{"issue":"11","key":"10.1016\/j.thromres.2024.02.016_bb0180","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1111\/j.1471-0528.1984.tb15077.x","article-title":"Follow-up study of children whose mothers were treated with warfarin during pregnancy","volume":"91","author":"Chong","year":"1984","journal-title":"Br. J. Obstet. Gynaecol."},{"issue":"1","key":"10.1016\/j.thromres.2024.02.016_bb0185","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/ajmg.1320450107","article-title":"Fetal and neonatal outcome of exposure to anticoagulants during pregnancy","volume":"45","author":"Wong","year":"1993","journal-title":"Am. J. Med. Genet."},{"issue":"8","key":"10.1016\/j.thromres.2024.02.016_bb0190","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1056\/NEJMoa1603693","article-title":"Global, regional, and national burden of rheumatic heart disease, 1990-2015","volume":"377","author":"Watkins","year":"2017","journal-title":"N. Engl. J. Med."},{"issue":"20","key":"10.1016\/j.thromres.2024.02.016_bb0195","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1136\/heartjnl-2016-310644","article-title":"Incidence and predictors of obstetric and fetal complications in women with structural heart disease","volume":"103","author":"van Hagen","year":"2017","journal-title":"Heart"},{"issue":"5","key":"10.1016\/j.thromres.2024.02.016_bb0200","doi-asserted-by":"crossref","first-page":"e91","DOI":"10.1016\/j.thromres.2011.07.006","article-title":"Anticoagulation therapy with combined low dose aspirin and warfarin following mechanical heart valve replacement","volume":"128","author":"Dong","year":"2011","journal-title":"Thromb. Res."},{"issue":"10","key":"10.1016\/j.thromres.2024.02.016_bb0205","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1161\/01.CIR.0000157737.92938.D8","article-title":"Relationship between race and mortality and morbidity after valve replacement surgery","volume":"111","author":"Taylor","year":"2005","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.thromres.2024.02.016_bb0210","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1002\/jbm.b.31151","article-title":"Current developments and future prospects for heart valve replacement therapy","volume":"88","author":"Kidane","year":"2009","journal-title":"J Biomed Mater Res B Appl Biomater"}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384824000513?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384824000513?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T14:18:28Z","timestamp":1717251508000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049384824000513"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":42,"alternative-id":["S0049384824000513"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2024.02.016","relation":{},"ISSN":["0049-3848"],"issn-type":[{"value":"0049-3848","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pregnancy outcomes in Chinese women with mechanical heart valves receiving warfarin treatment throughout pregnancy: 14-year experience","name":"articletitle","label":"Article Title"},{"value":"Thrombosis Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.thromres.2024.02.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}