{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T18:51:42Z","timestamp":1793904702077,"version":"4.8.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","thrombosisresearch.com","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.thromres.2024.109061","type":"journal-article","created":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T16:55:38Z","timestamp":1717779338000},"page":"109061","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Hemoglobin concentration and body mass index are determinants of plasma von Willebrand factor and factor VIII levels"],"prefix":"10.1016","volume":"240","author":[{"given":"Maria","family":"Carter-Febres","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Fenchel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Pomales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Tarango","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric S.","family":"Mullins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.thromres.2024.109061_bb0005","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1182\/blood.V69.2.454.454","article-title":"Epidemiological investigation of the prevalence of von Willebrand\u2019s disease","volume":"69","author":"Rodeghiero","year":"1987","journal-title":"Blood."},{"issue":"6","key":"10.1016\/j.thromres.2024.109061_bb0010","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.hoc.2021.07.004","article-title":"Von Willebrand disease: current status of diagnosis and management","volume":"35","author":"Weyand","year":"2021","journal-title":"Hematol. Oncol. Clin. North Am."},{"issue":"3","key":"10.1016\/j.thromres.2024.109061_bb0015","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1080\/10739680590925484","article-title":"Interactions of platelets with subendothelium and endothelium","volume":"12","author":"Chen","year":"2005","journal-title":"Microcirculation."},{"issue":"2","key":"10.1016\/j.thromres.2024.109061_bb0020","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1182\/blood-2006-05-022756","article-title":"VWF protects FVIII from endocytosis by dendritic cells and subsequent presentation to immune effectors","volume":"109","author":"Dasgupta","year":"2007","journal-title":"Blood."},{"issue":"4","key":"10.1016\/j.thromres.2024.109061_bb0025","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/hae.12116","article-title":"von Willebrand factor contributes to longer half-life of PEGylated factor VIII in vivo","volume":"19","author":"Tang","year":"2013","journal-title":"Haemophilia."},{"issue":"5","key":"10.1016\/j.thromres.2024.109061_bb0030","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1073\/pnas.71.5.1906","article-title":"Synthesis of von Willebrand factor by cultured human endothelial cells","volume":"71","author":"Jaffe","year":"1974","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"24","key":"10.1016\/j.thromres.2024.109061_bb0035","doi-asserted-by":"crossref","first-page":"3697","DOI":"10.1182\/blood-2014-02-554501","article-title":"Murine coagulation factor VIII is synthesized in endothelial cells","volume":"123","author":"Everett","year":"2014","journal-title":"Blood."},{"issue":"24","key":"10.1016\/j.thromres.2024.109061_bb0040","doi-asserted-by":"crossref","first-page":"3706","DOI":"10.1182\/blood-2014-02-555151","article-title":"A conditional knockout mouse model reveals endothelial cells as the principal and possibly exclusive source of plasma factor VIII","volume":"123","author":"Fahs","year":"2014","journal-title":"Blood."},{"issue":"21","key":"10.1016\/j.thromres.2024.109061_bb0045","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1056\/NEJMra1601561","article-title":"Von Willebrand\u2019s disease","volume":"375","author":"Leebeek","year":"2016","journal-title":"N. Engl. J. Med."},{"issue":"7","key":"10.1016\/j.thromres.2024.109061_bb0050","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1111\/j.1471-0528.2004.00176.x","article-title":"von Willebrand disease in women with menorrhagia: a systematic review","volume":"111","author":"Shankar","year":"2004","journal-title":"BJOG."},{"issue":"6","key":"10.1016\/j.thromres.2024.109061_bb0055","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1097\/AOG.0000000000002620","article-title":"Patterns of von Willebrand disease screening in girls and adolescents with heavy menstrual bleeding","volume":"131","author":"Jacobson","year":"2018","journal-title":"Obstet. Gynecol."},{"issue":"4","key":"10.1016\/j.thromres.2024.109061_bb0060","doi-asserted-by":"crossref","DOI":"10.1002\/rth2.12513","article-title":"Elevated von Willebrand factor levels during heavy menstrual bleeding episodes limit the diagnostic utility for von Willebrand disease","volume":"5","author":"Brown","year":"2021","journal-title":"Res Pract Thromb Haemost."},{"issue":"1 Pt 2","key":"10.1016\/j.thromres.2024.109061_bb0065","first-page":"R49","article-title":"Acute-phase behavior of factor VIII procoagulant and other acute-phase reactants in rabbits","volume":"257","author":"Noe","year":"1989","journal-title":"Am. J. Phys."},{"issue":"4","key":"10.1016\/j.thromres.2024.109061_bb0070","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/0049-3848(89)90317-4","article-title":"von Willebrand factor is an acute phase reactant in man","volume":"53","author":"Pottinger","year":"1989","journal-title":"Thromb. Res."},{"issue":"4","key":"10.1016\/j.thromres.2024.109061_bb0075","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1097\/01.psy.0000221229.43272.9d","article-title":"Altered blood coagulation in patients with posttraumatic stress disorder","volume":"68","author":"von Kanel","year":"2006","journal-title":"Psychosom. Med."},{"issue":"8017","key":"10.1016\/j.thromres.2024.109061_bb0080","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/S0140-6736(77)91197-7","article-title":"1-Deamino-8-d-arginine vasopressin: a new pharmacological approach to the management of haemophilia and von Willebrands\u2019 diseases","volume":"1","author":"Mannucci","year":"1977","journal-title":"Lancet."},{"issue":"21","key":"10.1016\/j.thromres.2024.109061_bb0085","doi-asserted-by":"crossref","first-page":"13329","DOI":"10.1016\/S0021-9258(18)90698-8","article-title":"Thrombin-induced release of von Willebrand factor from endothelial cells is mediated by phospholipid methylation. Prostacyclin synthesis is independent of phospholipid methylation","volume":"259","author":"de Groot","year":"1984","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.thromres.2024.109061_bb0090","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/0167-4889(83)90039-3","article-title":"The effect of calcium on the secretion of factor VIII-related antigen by cultured human endothelial cells","volume":"763","author":"Loesberg","year":"1983","journal-title":"Biochim. Biophys. Acta"},{"issue":"3","key":"10.1016\/j.thromres.2024.109061_bb0095","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1365-2141.1979.tb01155.x","article-title":"Coagulation activation and hyperviscosity in infection","volume":"42","author":"Richardson","year":"1979","journal-title":"Br. J. Haematol."},{"issue":"4","key":"10.1016\/j.thromres.2024.109061_bb0100","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1111\/j.1365-2141.1980.tb07188.x","article-title":"Hyperviscosity and thrombotic changes in idiopathic and secondary Raynaud\u2019s syndrome","volume":"45","author":"Blunt","year":"1980","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.thromres.2024.109061_bb0105","doi-asserted-by":"crossref","unstructured":"Sapp RM, Evans WS, Eagan LE, et al. The effects of moderate and high-intensity exercise on circulating markers of endothelial integrity and activation in young, healthy men. J. Appl. Physiol. (1985). 2019;127(5):1245\u20131256.","DOI":"10.1152\/japplphysiol.00477.2019"},{"issue":"1","key":"10.1016\/j.thromres.2024.109061_bb0110","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1182\/bloodadvances.2020003264","article-title":"ASH ISTH NHF WFH 2021 guidelines on the management of von Willebrand disease","volume":"5","author":"Connell","year":"2021","journal-title":"Blood Adv."},{"issue":"2","key":"10.1016\/j.thromres.2024.109061_bb0115","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1002\/rth2.12077","article-title":"Common VWF sequence variants associated with higher VWF and FVIII are less frequent in subjects diagnosed with type 1 VWD","volume":"2","author":"Flood","year":"2018","journal-title":"Res Pract Thromb Haemost."},{"issue":"6","key":"10.1016\/j.thromres.2024.109061_bb0120","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1182\/blood.V69.6.1691.1691","article-title":"The effect of ABO blood group on the diagnosis of von Willebrand disease","volume":"69","author":"Gill","year":"1987","journal-title":"Blood."},{"issue":"1","key":"10.1016\/j.thromres.2024.109061_bb0125","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1365-2141.1981.tb07197.x","article-title":"Alterations of factor VIII von Willebrand factor in clinical conditions associated with an increase in its plasma concentration","volume":"49","author":"Lombardi","year":"1981","journal-title":"Br. J. Haematol."},{"issue":"3","key":"10.1016\/j.thromres.2024.109061_bb0130","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.thromres.2004.08.022","article-title":"Relationship between hemoconcentration and blood coagulation responses to acute mental stress","volume":"115","author":"Zgraggen","year":"2005","journal-title":"Thromb. Res."},{"issue":"4","key":"10.1016\/j.thromres.2024.109061_bb0135","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1161\/01.CIR.39.4.503","article-title":"The hemodynamic response to chronic anemia","volume":"39","author":"Duke","year":"1969","journal-title":"Circulation."},{"issue":"1","key":"10.1016\/j.thromres.2024.109061_bb0140","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1046\/j.1442-200x.1999.01013.x","article-title":"Cardiovascular function before and after iron therapy by echocardiography in patients with iron deficiency anemia","volume":"41","author":"Hayashi","year":"1999","journal-title":"Pediatr. Int."},{"key":"10.1016\/j.thromres.2024.109061_bb0145","doi-asserted-by":"crossref","first-page":"617","DOI":"10.7326\/0003-4819-58-4-617","article-title":"A correlation of clinical and hemodynamic studies in patients with mild and severe anemia with and without congestive failure","volume":"58","author":"Graettinger","year":"1963","journal-title":"Ann. Intern. Med."},{"issue":"3","key":"10.1016\/j.thromres.2024.109061_bb0150","doi-asserted-by":"crossref","first-page":"e71","DOI":"10.1097\/AOG.0000000000003411","article-title":"Screening and Management of Bleeding Disorders in adolescents with heavy menstrual bleeding: ACOG COMMITTEE OPINION, number 785","volume":"134","year":"2019","journal-title":"Obstet. Gynecol."},{"issue":"1","key":"10.1016\/j.thromres.2024.109061_bb0155","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1182\/bloodadvances.2020003265","article-title":"ASH ISTH NHF WFH 2021 guidelines on the diagnosis of von Willebrand disease","volume":"5","author":"James","year":"2021","journal-title":"Blood Adv."},{"issue":"11","key":"10.1016\/j.thromres.2024.109061_bb0160","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1111\/jth.14591","article-title":"Utility of repeat testing in the evaluation for von Willebrand disease in pediatric patients","volume":"17","author":"Doshi","year":"2019","journal-title":"J. Thromb. Haemost."},{"issue":"3","key":"10.1016\/j.thromres.2024.109061_bb0165","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1182\/blood.V67.3.758.758","article-title":"Loss of the largest von Willebrand factor multimers from the plasma of patients with congenital cardiac defects","volume":"67","author":"Gill","year":"1986","journal-title":"Blood."},{"issue":"6","key":"10.1016\/j.thromres.2024.109061_bb0170","doi-asserted-by":"crossref","first-page":"e67","DOI":"10.1182\/blood-2010-08-299016","article-title":"Gain-of-function GPIb ELISA assay for VWF activity in the Zimmerman program for the molecular and clinical biology of VWD","volume":"117","author":"Flood","year":"2011","journal-title":"Blood."},{"issue":"2","key":"10.1016\/j.thromres.2024.109061_bb0175","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1182\/blood-2009-10-249102","article-title":"Common VWF exon 28 polymorphisms in African Americans affecting the VWF activity assay by ristocetin cofactor","volume":"116","author":"Flood","year":"2010","journal-title":"Blood."},{"issue":"1","key":"10.1016\/j.thromres.2024.109061_bb0180","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/hae.14467","article-title":"Impact of obesity on factor VIII and von Willebrand factor levels in patients with type 1 von Willebrand disease and low von Willebrand factor: an analysis of the ATHNdataset","volume":"28","author":"Schaefer","year":"2022","journal-title":"Haemophilia."},{"issue":"8","key":"10.1016\/j.thromres.2024.109061_bb0185","doi-asserted-by":"crossref","first-page":"E201","DOI":"10.1002\/ajh.25499","article-title":"BMI is an important determinant of VWF and FVIII levels and bleeding phenotype in patients with von Willebrand disease","volume":"94","author":"Atiq","year":"2019","journal-title":"Am. J. Hematol."},{"issue":"11","key":"10.1016\/j.thromres.2024.109061_bb0190","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1111\/j.1538-7836.2009.03594.x","article-title":"Limitations of the ristocetin cofactor assay in measurement of von Willebrand factor function","volume":"7","author":"Flood","year":"2009","journal-title":"J. Thromb. Haemost."}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384824001932?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384824001932?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T21:41:39Z","timestamp":1720042899000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049384824001932"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":38,"alternative-id":["S0049384824001932"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2024.109061","relation":{},"ISSN":["0049-3848"],"issn-type":[{"value":"0049-3848","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hemoglobin concentration and body mass index are determinants of plasma von Willebrand factor and factor VIII levels","name":"articletitle","label":"Article Title"},{"value":"Thrombosis Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.thromres.2024.109061","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"109061"}}