{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T04:04:47Z","timestamp":1793851487777,"version":"4.6.1"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","thrombosisresearch.com","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.thromres.2024.109196","type":"journal-article","created":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T06:01:05Z","timestamp":1729490465000},"page":"109196","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["CXCL13\/CXCR5 axis facilitates TFH expansion and correlates with disease severity in adults with immune thrombocytopenia"],"prefix":"10.1016","volume":"244","author":[{"given":"Zhenyu","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoyun","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yali","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimuye Kalayu","family":"Yirga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qizhen","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meijuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.thromres.2024.109196_bb0005","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1111\/jth.14809","article-title":"Management of major bleeds in patients with immune thrombocytopenia","volume":"18","author":"Mithoowani","year":"2020","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2024.109196_bb0010","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1056\/NEJMc1013806","article-title":"Guidelines for immune thrombocytopenia","volume":"364","author":"Provan","year":"2011","journal-title":"N. Engl. J. Med."},{"issue":"Suppl. 1","key":"10.1016\/j.thromres.2024.109196_bb0015","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1053\/j.seminhematol.2016.04.005","article-title":"T cells in the pathogenesis of immune thrombocytopenia","volume":"53","author":"Wei","year":"2016","journal-title":"Semin. Hematol."},{"key":"10.1016\/j.thromres.2024.109196_bb0020","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.immuni.2012.11.020","article-title":"Persistent antigen and germinal center B cells sustain T follicular helper cell responses and phenotype","volume":"38","author":"Baumjohann","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.thromres.2024.109196_bb0025","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1111\/jth.14419","article-title":"The sensitivity and specificity of platelet autoantibody testing in immune thrombocytopenia: a systematic review and meta-analysis of a diagnostic test","volume":"17","author":"Vrbensky","year":"2019","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2024.109196_bb0030","doi-asserted-by":"crossref","first-page":"2962","DOI":"10.1182\/bloodadvances.2020001846","article-title":"Platelet autoantibodies in the bone marrow of patients with immune thrombocytopenia","volume":"4","author":"Shrestha","year":"2020","journal-title":"Blood Adv."},{"key":"10.1016\/j.thromres.2024.109196_bb0035","doi-asserted-by":"crossref","first-page":"4553","DOI":"10.4049\/jimmunol.1101328","article-title":"Regulation of the germinal center reaction by Foxp3+ follicular regulatory T cells","volume":"187","author":"Wollenberg","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.thromres.2024.109196_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e20591","article-title":"Fecal microbiota transplantation regulates TFH\/TFR cell imbalance via TLR\/MyD88 pathway in experimental autoimmune hepatitis","volume":"9","author":"Ma","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.thromres.2024.109196_bb0045","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1002\/eji.202049093","article-title":"Altered follicular regulatory T (Tfr)- and helper T (Tfh)-cell subsets are associated with autoantibody levels in microscopic polyangiitis patients","volume":"51","author":"Long","year":"2021","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.thromres.2024.109196_bb0050","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.639975","article-title":"The imbalance of circulating follicular T helper cell subsets in primary Sjogren\u2019s syndrome associates with serological alterations and abnormal B-cell distribution","volume":"12","author":"Szabo","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.thromres.2024.109196_bb0055","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.lfs.2019.04.053","article-title":"CXCL13\/CXCR5 signaling axis in cancer","volume":"227","author":"Hussain","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.thromres.2024.109196_bb0060","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1002\/eji.202048831","article-title":"CXCR5-CXCL13 axis markers in full-term and preterm human neonates in the first weeks of life","volume":"51","author":"Pietrasanta","year":"2021","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.thromres.2024.109196_bb0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molimm.2020.06.003","article-title":"An imbalance between blood CD4(+)CXCR5(+)Foxp3(+) Tfr cells and CD4(+)CXCR5(+)Tfh cells may contribute to the immunopathogenesis of rheumatoid arthritis","volume":"125","author":"Cao","year":"2020","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.thromres.2024.109196_bb0070","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2105822118","article-title":"Single-cell profiling reveals the importance of CXCL13\/CXCR5 axis biology in lymphocyte-rich classic Hodgkin lymphoma","volume":"118","author":"Aoki","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.thromres.2024.109196_bb0075","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1182\/bloodadvances.2020001468","article-title":"Unexpected enhancement of FVIII immunogenicity by endothelial expression in lentivirus-transduced and transgenic mice","volume":"4","author":"Shi","year":"2020","journal-title":"Blood Adv."},{"key":"10.1016\/j.thromres.2024.109196_bb0080","article-title":"Association of platelet desialylation and circulating follicular helper T cells in patients with thrombocytopenia","volume":"13","author":"Chen","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.thromres.2024.109196_bb0085","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.bcmd.2016.06.006","article-title":"Differences in frequency and regulation of T follicular helper cells between newly diagnosed and chronic pediatric immune thrombocytopenia","volume":"61","author":"Yao","year":"2016","journal-title":"Blood Cells Mol. Dis."},{"key":"10.1016\/j.thromres.2024.109196_bb0090","doi-asserted-by":"crossref","first-page":"4087","DOI":"10.1182\/bloodadvances.2020003860","article-title":"Abnormalities of bone marrow B cells and plasma cells in primary immune thrombocytopenia","volume":"5","author":"Yu","year":"2021","journal-title":"Blood Adv."},{"key":"10.1016\/j.thromres.2024.109196_bb0095","doi-asserted-by":"crossref","first-page":"843","DOI":"10.3324\/haematol.2022.281557","article-title":"Enhancing regulatory T-cell function via inhibition of high mobility group box 1 protein signaling in immune thrombocytopenia","volume":"108","author":"Wang","year":"2023","journal-title":"Haematologica"},{"key":"10.1016\/j.thromres.2024.109196_bb0100","first-page":"0236","article-title":"Desialylated platelet clearance in the liver is a novel mechanism of systemic immunosuppression","volume":"6","author":"Li","year":"2023","journal-title":"Research (Wash D C)."},{"key":"10.1016\/j.thromres.2024.109196_bb0105","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s40164-021-00214-5","article-title":"Platelet desialylation and TFH cells-the novel pathway of immune thrombocytopenia","volume":"10","author":"Chen","year":"2021","journal-title":"Exp. Hematol. Oncol."},{"key":"10.1016\/j.thromres.2024.109196_bb0110","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1182\/blood-2008-07-162503","article-title":"Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group","volume":"113","author":"Rodeghiero","year":"2009","journal-title":"Blood"},{"issue":"2011","key":"10.1016\/j.thromres.2024.109196_bb0115","first-page":"4190","article-title":"Evidence-based practice guideline for immune thrombocytopenia","volume":"117","author":"C. Neunert, W. Lim, M. Crowther, A. Cohen, L. Solberg, Jr., M.A. Crowther, H. American Society of, The American Society of Hematology","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.thromres.2024.109196_bb0120","doi-asserted-by":"crossref","first-page":"8023","DOI":"10.1002\/jcp.29457","article-title":"E35 ablates acute leukemia stem and progenitor cells in vitro and in vivo","volume":"235","author":"Chen","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.thromres.2024.109196_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2023.113780","article-title":"Emodin derivative E35 and its combination with autophagy inhibitor against acute myeloid leukemia cells in vitro and in vivo","volume":"432","author":"Zhang","year":"2023","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.thromres.2024.109196_bb0130","doi-asserted-by":"crossref","first-page":"7737","DOI":"10.1038\/ncomms8737","article-title":"Desialylation is a mechanism of Fc-independent platelet clearance and a therapeutic target in immune thrombocytopenia","volume":"6","author":"Li","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.thromres.2024.109196_bb0135","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.3324\/haematol.2017.164137","article-title":"Amotosalen\/ultraviolet a pathogen inactivation technology reduces platelet activatability, induces apoptosis and accelerates clearance","volume":"102","author":"Stivala","year":"2017","journal-title":"Haematologica"},{"key":"10.1016\/j.thromres.2024.109196_bb0140","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/cei.13025","article-title":"Rheumatoid arthritis fibroblast-like synoviocytes co-cultured with PBMC increased peripheral CD4(+) CXCR5(+) ICOS(+) T cell numbers","volume":"190","author":"Tang","year":"2017","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.thromres.2024.109196_bb0145","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202304610","article-title":"Manganese-based immunomodulatory nanocomposite with catalase-like activity and microwave-enhanced ROS elimination ability for efficient rheumatoid arthritis therapy","volume":"19","author":"Chen","year":"2023","journal-title":"Small"},{"key":"10.1016\/j.thromres.2024.109196_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2023.109734","article-title":"The immune imbalance between follicular regulatory and helper T cells in myelin oligodendrocyte glycoprotein IgG-associated disease","volume":"255","author":"Chang","year":"2023","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.thromres.2024.109196_bb0155","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1177\/1352458518779951","article-title":"Peripheral imbalanced TFH\/TFR ratio correlates with intrathecal IgG synthesis in multiple sclerosis at clinical onset","volume":"25","author":"Puthenparampil","year":"2019","journal-title":"Mult. Scler."},{"key":"10.1016\/j.thromres.2024.109196_bb0160","doi-asserted-by":"crossref","first-page":"2858","DOI":"10.1182\/blood-2014-03-563445","article-title":"Splenic TFH expansion participates in B-cell differentiation and antiplatelet-antibody production during immune thrombocytopenia","volume":"124","author":"Audia","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.thromres.2024.109196_bb0165","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1177\/15353702231168142","article-title":"Imbalance of follicular regulatory T (Tfr) cells\/follicular helper T (Tfh) cells in adult patients with primary immune thrombocytopenia","volume":"248","author":"Sun","year":"2023","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.thromres.2024.109196_bb0170","first-page":"1284205","article-title":"Circulating T follicular helper 2 cells","volume":"14","author":"Shigehara","year":"2023","journal-title":"T follicular regulatory cells and regulatory B cells are effective biomarkers for predicting the response to house dust mite sublingual immunotherapy in patients with allergic respiratory diseases, Front Immunol."},{"key":"10.1016\/j.thromres.2024.109196_bb0175","first-page":"49","article-title":"Regulatory T cells in skin regeneration and wound healing","volume":"10","author":"Knoedler","year":"2023","journal-title":"Mil. Med. Res."},{"key":"10.1016\/j.thromres.2024.109196_bb0180","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.it.2015.05.005","article-title":"T follicular regulatory cells in the regulation of B cell responses","volume":"36","author":"Sage","year":"2015","journal-title":"Trends Immunol."},{"key":"10.1016\/j.thromres.2024.109196_bb0185","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1084\/jem.20190493","article-title":"Regulatory roles of IL-10-producing human follicular T cells","volume":"216","author":"Canete","year":"2019","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.thromres.2024.109196_bb0190","doi-asserted-by":"crossref","first-page":"1235937","DOI":"10.3389\/fimmu.2023.1235937","article-title":"BAFF system expression in double negative 2, activated naive and activated memory B cells in systemic lupus erythematosus","volume":"14","author":"Alvarez Gomez","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.thromres.2024.109196_bb0195","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.thromres.2022.02.021","article-title":"HMGB1 is increased in patients with immune thrombocytopenia and negatively associates with Tregs","volume":"213","author":"Zhang","year":"2022","journal-title":"Thromb. Res."},{"key":"10.1016\/j.thromres.2024.109196_bb0200","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.autrev.2017.04.012","article-title":"Pathogenesis of immune thrombocytopenia","volume":"16","author":"Audia","year":"2017","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.thromres.2024.109196_bb0205","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12014-023-09413-0","article-title":"Identification of ORM1, vWF, SPARC, and PPBP as immune-related proteins involved in immune thrombocytopenia by quantitative LC-MS\/MS, Clin","volume":"20","author":"Yin","year":"2023","journal-title":"Proteomics"},{"key":"10.1016\/j.thromres.2024.109196_bb0210","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.cyto.2019.05.014","article-title":"Evaluation of IVIG response in relation to Th1\/Th2 cytokines in pediatricm immune thrombocytopenia","volume":"120","author":"Chen","year":"2019","journal-title":"Cytokine"},{"key":"10.1016\/j.thromres.2024.109196_bb0215","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.exphem.2021.08.005","article-title":"Differential effects of Huaier aqueous extract on human CD4(+)T lymphocytes from patients with primary immune thrombocytopenia","volume":"101-102","author":"Yuan","year":"2021","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.thromres.2024.109196_bb0220","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jaut.2016.11.002","article-title":"B cell depleting therapy regulates splenic and circulating T follicular helper cells in immune thrombocytopenia","volume":"77","author":"Audia","year":"2017","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.thromres.2024.109196_bb0225","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.canlet.2021.09.026","article-title":"ETV4 promotes pancreatic ductal adenocarcinoma metastasis through activation of the CXCL13\/CXCR5 signaling axis","volume":"524","author":"Gao","year":"2022","journal-title":"Cancer Lett."},{"key":"10.1016\/j.thromres.2024.109196_bb0230","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/s41419-021-04136-2","article-title":"CXCL13\/CXCR5 axis facilitates endothelial progenitor cell homing and angiogenesis during rheumatoid arthritis progression","volume":"12","author":"Tsai","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.thromres.2024.109196_bb0235","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s40164-022-00304-y","article-title":"Impaired mitochondria of Tregs decreases OXPHOS-derived ATP in primary immune thrombocytopenia with positive plasma pathogens detected by metagenomic sequencing","volume":"11","author":"Zhan","year":"2022","journal-title":"Exp. Hematol. Oncol."},{"key":"10.1016\/j.thromres.2024.109196_bb0240","doi-asserted-by":"crossref","first-page":"1242454","DOI":"10.1126\/science.1242454","article-title":"Fueling immunity: insights into metabolism and lymphocyte function","volume":"342","author":"Pearce","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.thromres.2024.109196_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110597","article-title":"Mitochondrial ROS-dependent CD4(+)PD-1(+)T cells are pathological expansion in patients with primary immune thrombocytopenia","volume":"122","author":"Li","year":"2023","journal-title":"Int. Immunopharmacol."}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384824003281?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384824003281?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,19]],"date-time":"2025-01-19T14:42:48Z","timestamp":1737297768000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049384824003281"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":49,"alternative-id":["S0049384824003281"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2024.109196","relation":{},"ISSN":["0049-3848"],"issn-type":[{"value":"0049-3848","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CXCL13\/CXCR5 axis facilitates TFH expansion and correlates with disease severity in adults with immune thrombocytopenia","name":"articletitle","label":"Article Title"},{"value":"Thrombosis Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.thromres.2024.109196","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109196"}}