{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T10:39:03Z","timestamp":1772275143033,"version":"3.50.1"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270133"],"award-info":[{"award-number":["82270133"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission, Adminitrative Commission of Zhongguancun Science Park","doi-asserted-by":"publisher","award":["Z221100007422067"],"award-info":[{"award-number":["Z221100007422067"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012425","name":"Beijing Children's Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012425","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thrombosisresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.thromres.2025.109305","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T12:08:57Z","timestamp":1741954137000},"page":"109305","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["A comparison of My Precise Dose and WAPPS-Hemo as dosing tools for optimizing prophylaxis in children with hemophilia A treated with BAY 81-8973"],"prefix":"10.1016","volume":"249","author":[{"given":"Yaohan","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di","family":"Ai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoling","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingzi","family":"Zhen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoqing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanru","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zekun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Runhui","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.thromres.2025.109305_bb0005","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41572-021-00278-x","article-title":"Haemophilia[J]","volume":"7","author":"Berntorp","year":"2021","journal-title":"Nat. Rev. Dis. Primers."},{"issue":"Suppl. 6","key":"10.1016\/j.thromres.2025.109305_bb0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/hae.14046","article-title":"WFH guidelines for the management of hemophilia, 3rd edition[J]","volume":"26","author":"Srivastava","year":"2020","journal-title":"Haemophilia"},{"issue":"2","key":"10.1016\/j.thromres.2025.109305_bb0015","doi-asserted-by":"crossref","DOI":"10.1002\/rth2.12686","article-title":"Enhanced pharmacokinetics and reduced bleeds in boys with hemophilia A after switching to Kovaltry from other standard half-life factor VIII concentrates[J]","volume":"6","author":"Huang","year":"2022","journal-title":"Res Pract Thromb Haemost"},{"issue":"4","key":"10.1016\/j.thromres.2025.109305_bb0020","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1159\/000521360","article-title":"Efficacy of individualized preventive treatment of patients with severe hemophilia a guided by multiple clinical parameters and pharmacokinetics[J]","volume":"145","author":"Wang","year":"2022","journal-title":"Acta Haematol."},{"issue":"1","key":"10.1016\/j.thromres.2025.109305_bb0025","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/hae.13882","article-title":"Clinical application of web accessible population pharmacokinetic service-hemophilia (WAPPS-Hemo): patterns of blood sampling and patient characteristics among clinician users[J]","volume":"26","author":"Mceneny-King","year":"2020","journal-title":"Haemophilia"},{"issue":"5","key":"10.1016\/j.thromres.2025.109305_bb0030","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.3324\/haematol.2019.217133","article-title":"Relationship between factor VIII activity, bleeds and individual characteristics in severe hemophilia A patients[J]","volume":"105","author":"Abrantes","year":"2020","journal-title":"Haematologica"},{"issue":"12","key":"10.1016\/j.thromres.2025.109305_bb0035","doi-asserted-by":"crossref","first-page":"3432","DOI":"10.1016\/j.jtha.2023.08.031","article-title":"Pharmacokinetic-guided versus standard prophylaxis in hemophilia: a systematic review and meta-analysis[J]","volume":"21","author":"Kraemmer","year":"2023","journal-title":"J. Thromb. Haemost."},{"issue":"7","key":"10.1016\/j.thromres.2025.109305_bb0040","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1111\/jth.14153","article-title":"Pharmacokinetics and the transition to extended half-life factor concentrates: communication from the SSC of the ISTH[J]","volume":"16","author":"Ragni","year":"2018","journal-title":"J. Thromb. Haemost."},{"issue":"7","key":"10.1016\/j.thromres.2025.109305_bb0045","doi-asserted-by":"crossref","DOI":"10.1002\/rth2.12599","article-title":"External qualification of the web-accessible population pharmacokinetic service-hemophilia (WAPPS-Hemo) models for octocog alfa using real patient data[J]","volume":"5","author":"Chelle","year":"2021","journal-title":"Res Pract Thromb Haemost"},{"issue":"4","key":"10.1016\/j.thromres.2025.109305_bb0050","doi-asserted-by":"crossref","DOI":"10.2196\/resprot.6558","article-title":"Development of a web-accessible population pharmacokinetic service-hemophilia (WAPPS-Hemo): study protocol[J]","volume":"5","author":"Iorio","year":"2016","journal-title":"JMIR Res Protoc"},{"key":"10.1016\/j.thromres.2025.109305_bb0055","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.thromres.2023.10.009","article-title":"Development and internal validation of a clinical prediction model for individualized dosing of BAY 81-8973, a full-length recombinant factor VIII, in pediatric patients with haemophilia A[J]","volume":"232","author":"He","year":"2023","journal-title":"Thromb. Res."},{"issue":"2","key":"10.1016\/j.thromres.2025.109305_bb0060","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1002\/rth2.12305","article-title":"Pharmacokinetic-tailored approach to hemophilia prophylaxis: medical decision making and outcomes[J]","volume":"4","author":"Croteau","year":"2020","journal-title":"Res Pract Thromb Haemost"},{"issue":"1","key":"10.1016\/j.thromres.2025.109305_bb0065","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1182\/asheducation-2017.1.595","article-title":"Using pharmacokinetics to individualize hemophilia therapy[J]","volume":"2017","author":"Iorio","year":"2017","journal-title":"Hematology Am. Soc. Hematol. Educ. Program"},{"issue":"11","key":"10.1016\/j.thromres.2025.109305_bb0070","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1038\/aps.2012.149","article-title":"Pharmacometrics: a quantitative tool of pharmacological research[J]","volume":"33","author":"Zheng","year":"2012","journal-title":"Acta Pharmacol. Sin."},{"issue":"6","key":"10.1016\/j.thromres.2025.109305_bb0075","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1111\/hae.12253","article-title":"Comparative pharmacokinetics of factor VIII and recombinant factor IX: for which coagulation factors should half-life change with age?[J]","volume":"19","author":"Bj\u00f6rkman","year":"2013","journal-title":"Haemophilia"},{"issue":"2","key":"10.1016\/j.thromres.2025.109305_bb0080","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1182\/blood-2011-07-360594","article-title":"Population pharmacokinetics of recombinant factor VIII: the relationships of pharmacokinetics to age and body weight[J]","volume":"119","author":"Bj\u00f6rkman","year":"2012","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.thromres.2025.109305_bb0085","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1055\/s-0039-3400745","article-title":"Body mass index best predicts recovery of recombinant factor VIII in underweight to obese patients with severe haemophilia A[J]","volume":"120","author":"Tiede","year":"2020","journal-title":"Thromb. Haemost."},{"issue":"15","key":"10.1016\/j.thromres.2025.109305_bb0090","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.4103\/0366-6999.233604","article-title":"Pharmacokinetic studies of factor VIII in Chinese boys with severe hemophilia A: a single-center study[J]","volume":"131","author":"Chen","year":"2018","journal-title":"Chin Med J (Engl)"},{"key":"10.1016\/j.thromres.2025.109305_bb0095","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.thromres.2020.05.043","article-title":"Bleeds and imaging scoring scales in relation to pharmacokinetics of coagulation factor VIII in Chinese pediatric patients with severe hemophilia A[J]","volume":"193","author":"Huang","year":"2020","journal-title":"Thromb. Res."},{"issue":"5","key":"10.1016\/j.thromres.2025.109305_bb0100","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1055\/s-0040-1709522","article-title":"A novel, enriched population pharmacokinetic model for recombinant factor VIII-Fc fusion protein concentrate in hemophilia A patients[J]","volume":"120","author":"Bukkems","year":"2020","journal-title":"Thromb. Haemost."},{"issue":"5","key":"10.1016\/j.thromres.2025.109305_bb0105","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s10928-019-09634-7","article-title":"Development and evaluation of a generic population pharmacokinetic model for standard half-life factor VIII for use in dose individualization[J]","volume":"46","author":"Mceneny-King","year":"2019","journal-title":"J. Pharmacokinet. Pharmacodyn."}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384825000544?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384825000544?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T03:59:47Z","timestamp":1762228787000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049384825000544"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":21,"alternative-id":["S0049384825000544"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2025.109305","relation":{},"ISSN":["0049-3848"],"issn-type":[{"value":"0049-3848","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A comparison of My Precise Dose and WAPPS-Hemo as dosing tools for optimizing prophylaxis in children with hemophilia A treated with BAY 81-8973","name":"articletitle","label":"Article Title"},{"value":"Thrombosis Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.thromres.2025.109305","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109305"}}