{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:39:43Z","timestamp":1785451183452,"version":"3.56.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","thrombosisresearch.com","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.thromres.2025.109333","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T17:08:42Z","timestamp":1745514522000},"page":"109333","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Haemostatic changes detected by thromboelastography in chronic kidney disease: A systematic review and meta-analysis"],"prefix":"10.1016","volume":"250","author":[{"given":"Nao Shimada","family":"Ramos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise E.","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.thromres.2025.109333_bb0005","first-page":"1","article-title":"Kidney disease: improving global outcomes (KDIGO) CKD Work Group. KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease","volume":"3","author":"Levin","year":"2013","journal-title":"Kidney Int. Suppl."},{"issue":"9888","key":"10.1016\/j.thromres.2025.109333_bb0010","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S0140-6736(13)60687-X","article-title":"Chronic kidney disease: global dimension and perspectives","volume":"382","author":"Jha","year":"2013","journal-title":"Lancet"},{"issue":"10225","key":"10.1016\/j.thromres.2025.109333_bb0015","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0140-6736(20)30045-3","article-title":"Global, regional, and national burden of chronic kidney disease, 1990\u20132017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"395","author":"Bikbov","year":"2020","journal-title":"Lancet"},{"issue":"10159","key":"10.1016\/j.thromres.2025.109333_bb0020","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1016\/S0140-6736(18)31694-5","article-title":"Forecasting life expectancy, years of life lost, and all-cause and cause-specific mortality for 250 causes of death: reference and alternative scenarios for 2016\u201340 for 195 countries and territories","volume":"392","author":"Foreman","year":"2018","journal-title":"Lancet"},{"issue":"12","key":"10.1016\/j.thromres.2025.109333_bb0025","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1038\/ki.2011.368","article-title":"The contribution of chronic kidney disease to the global burden of major noncommunicable diseases","volume":"80","author":"Couser","year":"2011","journal-title":"Kidney Int."},{"issue":"12","key":"10.1016\/j.thromres.2025.109333_bb0030","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1038\/ki.2010.550","article-title":"Lower estimated glomerular filtration rate and higher albuminuria are associated with mortality and end-stage renal disease. A collaborative meta-analysis of kidney disease population cohorts","volume":"79","author":"Astor","year":"2011","journal-title":"Kidney Int."},{"issue":"1","key":"10.1016\/j.thromres.2025.109333_bb0035","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1055\/s-0030-1248722","article-title":"Disorders of hemostasis associated with chronic kidney disease","volume":"36","author":"Jalal","year":"2010","journal-title":"Semin. Thromb. Hemost."},{"issue":"16","key":"10.1016\/j.thromres.2025.109333_bb0040","doi-asserted-by":"crossref","first-page":"8705","DOI":"10.3390\/ijms25168705","article-title":"Hallmarks for thrombotic and hemorrhagic risks in chronic kidney disease patients","volume":"25","author":"Saeed","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.thromres.2025.109333_bb0045","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.blre.2011.07.001","article-title":"Bleeding and thrombotic complications of kidney disease","volume":"25","author":"Pavord","year":"2011","journal-title":"Blood Rev."},{"issue":"5","key":"10.1016\/j.thromres.2025.109333_bb0050","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1055\/s-2004-835678","article-title":"Platelet dysfunction in renal failure","volume":"30","author":"Boccardo","year":"2004","journal-title":"Semin. Thromb. Hemost."},{"issue":"9","key":"10.1016\/j.thromres.2025.109333_bb0055","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.3390\/biom11091309","article-title":"Coagulation abnormalities in renal pathology of chronic kidney disease: the interplay between blood cells and soluble factors","volume":"11","author":"Pavlou","year":"2021","journal-title":"Biomolecules"},{"issue":"2","key":"10.1016\/j.thromres.2025.109333_bb0060","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0212237","article-title":"Evaluation of hemostasis in patients with end-stage renal disease","volume":"14","author":"G\u00e4ckler","year":"2019","journal-title":"PLoS One"},{"issue":"253","key":"10.1016\/j.thromres.2025.109333_bb0065","article-title":"Biobased chitosan-derived self-nitrogen-doped porous carbon nanofibers containing nitrogen-doped zeolites for efficient removal of uremic toxins during hemodialysis","author":"Yang","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"issue":"10","key":"10.1016\/j.thromres.2025.109333_bb0070","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1007\/s11255-022-03184-7","article-title":"Platelet thrombus formation in patients with end-stage renal disease before and after hemodialysis as measured by the total thrombus-formation analysis system","volume":"54","author":"Mitic","year":"2022","journal-title":"Int. Urol. Nephrol."},{"issue":"4","key":"10.1016\/j.thromres.2025.109333_bb0075","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/0049-3848(86)90320-8","article-title":"Effect on platelet function of hypoalbuminemia in peritoneal dialysis","volume":"44","author":"Sloand","year":"1986","journal-title":"Thromb. Res."},{"issue":"2","key":"10.1016\/j.thromres.2025.109333_bb0080","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/ajh.23599","article-title":"TEG and ROTEM: technology and clinical applications","volume":"89","author":"Whiting","year":"2014","journal-title":"Am. J. Hematol."},{"issue":"3","key":"10.1016\/j.thromres.2025.109333_bb0085","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/bja\/69.3.307","article-title":"Thrombelastography","volume":"69","author":"Mallett","year":"1992","journal-title":"Br. J. Anaesth."},{"issue":"1","key":"10.1016\/j.thromres.2025.109333_bb0090","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/bjh.13930","article-title":"The place of viscoelastic testing in clinical practice","volume":"173","author":"Hans","year":"2016","journal-title":"Br. J. Haematol."},{"issue":"6","key":"10.1016\/j.thromres.2025.109333_bb0095","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1080\/00365513.2016.1200136","article-title":"Is viscoelastic coagulation monitoring with ROTEM or TEG validated?","volume":"76","author":"Solomon","year":"2016","journal-title":"Scand. J. Clin. Lab. Invest."},{"issue":"3","key":"10.1016\/j.thromres.2025.109333_bb0100","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1097\/ALN.0b013e318264c644","article-title":"Point-of-care testing: a prospective, randomized clinical trial of efficacy in coagulopathic cardiac surgery patients","volume":"117","author":"Weber","year":"2012","journal-title":"Anesthesiology"},{"issue":"83","key":"10.1016\/j.thromres.2025.109333_bb0105","first-page":"1","article-title":"Trauma-induced coagulopathy: impact of the early coagulation support protocol on blood product consumption, mortality and costs","volume":"19","author":"Nardi","year":"2015","journal-title":"Crit. Care"},{"issue":"17","key":"10.1016\/j.thromres.2025.109333_bb0110","first-page":"1","article-title":"Review of thromboelastography (TEG): medical and surgical applications","author":"Whitton","year":"2023","journal-title":"Ther. Adv. Pulm. Crit. Care Med."},{"issue":"4","key":"10.1016\/j.thromres.2025.109333_bb0115","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1111\/jth.15653","article-title":"Evaluation of novel coagulation and platelet function assays in patients with chronic kidney disease","volume":"20","author":"Abdelmaguid","year":"2022","journal-title":"J. Thromb. Haemost."},{"issue":"229","key":"10.1016\/j.thromres.2025.109333_bb0120","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.thromres.2023.06.027","article-title":"Safety and efficacy of apixaban versus low-molecular weight heparin or vitamin-K antagonists for venous thromboembolism treatment in patients with severe renal failure: a systematic review and meta-analysis","author":"Almajdi","year":"2023","journal-title":"Thromb. Res."},{"issue":"21","key":"10.1016\/j.thromres.2025.109333_bb0125","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1161\/CIRCULATIONAHA.111.084996","article-title":"Antithrombotic therapy in patients with chronic kidney disease","volume":"125","author":"Capodanno","year":"2012","journal-title":"Circulation"},{"issue":"226","key":"10.1016\/j.thromres.2025.109333_bb0130","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.thromres.2023.04.016","article-title":"Global coagulation assays in patients with chronic kidney disease and their role in predicting thrombotic risk","author":"Lim","year":"2023","journal-title":"Thromb. Res."},{"issue":"4","key":"10.1016\/j.thromres.2025.109333_bb0135","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1309\/LM2KBXKISKD9B1EA","article-title":"Comparison of prolonged prothrombin and activated partial thromboplastin time results with thrombelastograph parameters","volume":"44","author":"Kim","year":"2013","journal-title":"Lab. Med."},{"issue":"4","key":"10.1016\/j.thromres.2025.109333_bb0140","first-page":"153","article-title":"Evolution of viscoelastic haemostatic assays","volume":"44","author":"Gore","year":"2023","journal-title":"Aust. J. Med. Sci."},{"issue":"4","key":"10.1016\/j.thromres.2025.109333_bb0145","first-page":"278","article-title":"Research questions, hypotheses and objectives","volume":"53","author":"Farrugia","year":"2010","journal-title":"Can. J. Surg."},{"key":"10.1016\/j.thromres.2025.109333_bb0150","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"bmj"},{"issue":"4","key":"10.1016\/j.thromres.2025.109333_bb0155","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.jclinepi.2007.11.008","article-title":"The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies","volume":"61","author":"Von Elm","year":"2008","journal-title":"J. Clin. Epidemiol."},{"issue":"1","key":"10.1016\/j.thromres.2025.109333_bb0160","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3747\/pdi.2013.00036","article-title":"Differences in coagulation between hemodialysis and peritoneal dialysis","volume":"34","author":"Brophy","year":"2014","journal-title":"Perit. Dial. Int."},{"issue":"6","key":"10.1016\/j.thromres.2025.109333_bb0165","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/0049-3848(87)90091-0","article-title":"Thrombelastography of blood from subjects with chronic renal failure","volume":"45","author":"Holloway","year":"1987","journal-title":"Thromb. Res."},{"issue":"6","key":"10.1016\/j.thromres.2025.109333_bb0170","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.amjsurg.2023.06.025","article-title":"The in-vitro influence of urea concentration on thromboelastrography in patients with and without end stage renal disease","volume":"226","author":"Kukreja","year":"2023","journal-title":"Am. J. Surg."},{"issue":"6","key":"10.1016\/j.thromres.2025.109333_bb0175","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/j.amjsurg.2017.08.039","article-title":"The hypercoagulability paradox of chronic kidney disease: the role of fibrinogen","volume":"214","author":"Nunns","year":"2017","journal-title":"Am. J. Surg."},{"issue":"4","key":"10.1016\/j.thromres.2025.109333_bb0180","first-page":"34","article-title":"Detection of coagulopathy in chronic renal disease using thromboelastography and its comparison with conventional tests","volume":"67","author":"Pandey","year":"2019","journal-title":"J. Assoc. Physicians India"},{"issue":"6","key":"10.1016\/j.thromres.2025.109333_bb0185","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/S0952-8180(97)00097-4","article-title":"Perioperative hypercoagulability in uremic patients: a viscoelastic study","volume":"9","author":"Pivalizza","year":"1997","journal-title":"J. Clin. Anesth."},{"issue":"4","key":"10.1016\/j.thromres.2025.109333_bb0190","doi-asserted-by":"crossref","first-page":"274","DOI":"10.5114\/ait.2020.100568","article-title":"Assessment of haemostasis and impact of fibrinogen supplementation on clot properties using global haemostasis assays in patients on chronic dialysis","volume":"52","author":"Pluta","year":"2020","journal-title":"Anaesthesiol. Intensive Ther."},{"issue":"4","key":"10.1016\/j.thromres.2025.109333_bb0195","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/dat.20285","article-title":"Sequential changes in coagulation after renal transplantation: a thromboelastogram study","volume":"38","author":"Timmermans","year":"2009","journal-title":"Dial. Transplant."},{"key":"10.1016\/j.thromres.2025.109333_bb0200","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2288-14-135","article-title":"Estimating the sample mean and standard deviation from the sample size, median, range and\/or interquartile range","volume":"14","author":"Wan","year":"2014","journal-title":"BMC Med. Res. Methodol."},{"key":"10.1016\/j.thromres.2025.109333_bb0205","series-title":"Cochrane Handbook for Systematic Reviews of Interventions","author":"Chandler","year":"2019"},{"key":"10.1016\/j.thromres.2025.109333_bb0215","series-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 6.5. Cochrane","article-title":"Chapter 10: chapter 10: analysing data and undertaking meta-analyses [last updated November 2024, cited 27 January 2025]","author":"Deeks","year":"2024"},{"issue":"2","key":"10.1016\/j.thromres.2025.109333_bb0220","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.annepidem.2005.06.052","article-title":"Platelet counts differ by sex, ethnicity, and age in the United States","volume":"16","author":"Segal","year":"2006","journal-title":"Ann. Epidemiol."},{"issue":"1","key":"10.1016\/j.thromres.2025.109333_bb0225","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.41633","article-title":"Analysis of platelet count and new cancer diagnosis over a 10-year period","volume":"5","author":"Giannakeas","year":"2022","journal-title":"JAMA Netw. Open"},{"issue":"6","key":"10.1016\/j.thromres.2025.109333_bb0230","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1213\/ANE.0000000000001413","article-title":"A novel device for the evaluation of hemostatic function in critical care settings","volume":"123","author":"Ferrante","year":"2016","journal-title":"Anesth. Analg."},{"issue":"8","key":"10.1016\/j.thromres.2025.109333_bb0235","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.1007\/s00261-022-03539-9","article-title":"Thromboelastography: a review for radiologists and implications on periprocedural bleeding risk","volume":"47","author":"Willis","year":"2022","journal-title":"Abdom. Radiol."},{"key":"10.1016\/j.thromres.2025.109333_bb0240","series-title":"TEG\u00ae 5000 Thrombelastograph\u00ae Hemostasis System TEG Analytical Software (TAS) Version 4.2.3 User Manual","author":"Haemoscope Corporation","year":"2007"},{"issue":"1","key":"10.1016\/j.thromres.2025.109333_bb0245","doi-asserted-by":"crossref","first-page":"189","DOI":"10.3390\/jcm9010189","article-title":"Sensitivity of viscoelastic tests to platelet function","volume":"9","author":"Ranucci","year":"2020","journal-title":"J. Clin. Med."},{"issue":"6","key":"10.1016\/j.thromres.2025.109333_bb0250","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1053\/j.jvca.2023.02.022","article-title":"Interaction between platelet and fibrinogen on clot strength in healthy patients","volume":"37","author":"Maslow","year":"2023","journal-title":"J. Cardiothorac. Vasc. Anesth."},{"issue":"5","key":"10.1016\/j.thromres.2025.109333_bb0255","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1111\/ijlh.14144","article-title":"Viscoelastic testing: critical appraisal of new methodologies and current literature","volume":"45","author":"Wool","year":"2023","journal-title":"Int. J. Lab. Hematol."}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384825000829?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384825000829?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T16:58:41Z","timestamp":1747414721000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049384825000829"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":50,"alternative-id":["S0049384825000829"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2025.109333","relation":{},"ISSN":["0049-3848"],"issn-type":[{"value":"0049-3848","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Haemostatic changes detected by thromboelastography in chronic kidney disease: A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Thrombosis Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.thromres.2025.109333","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"109333"}}