{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T19:45:26Z","timestamp":1766087126005,"version":"3.48.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000780","name":"Commission europ\u00e9enne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thrombosisresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.thromres.2025.109356","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T10:54:22Z","timestamp":1747652062000},"page":"109356","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Selected cell receptor genotypes differentially modulate the ABO blood group influence on Factor VIII levels in severe aortic stenosis"],"prefix":"10.1016","volume":"251","author":[{"given":"Barbara","family":"Lunghi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annalisa","family":"Castagna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessio","family":"Branchini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcello","family":"Baroni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Marchetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianni","family":"Mazzoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Legnani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianna","family":"Spizzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"Mango","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simonetta","family":"Friso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Martinelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Bernardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.thromres.2025.109356_bb0005","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2016.6","article-title":"Calcific aortic stenosis","volume":"2","author":"Lindman","year":"2016","journal-title":"Nat. Rev. Dis. Primers."},{"key":"10.1016\/j.thromres.2025.109356_bb0010","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.thromres.2016.01.016","article-title":"Increased bleeding risk in patients with aortic valvular stenosis: from new mechanisms to new therapies","volume":"139","author":"Natorska","year":"2016","journal-title":"Thromb. Res."},{"key":"10.1016\/j.thromres.2025.109356_bb0015","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1093\/cvr\/cvac192","article-title":"Aortic stenosis and the haemostatic system","volume":"119","author":"Trimaille","year":"2023","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.thromres.2025.109356_bb0020","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1161\/ATVBAHA.119.312814","article-title":"Turbulent flow promotes cleavage of VWF (von Willebrand Factor) by ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type-1 motif, member 13)","volume":"39","author":"Bortot","year":"2019","journal-title":"ATVB"},{"key":"10.1016\/j.thromres.2025.109356_bb0025","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1056\/NEJMoa022831","article-title":"Acquired von Willebrand syndrome in aortic stenosis","volume":"349","author":"Vincentelli","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.thromres.2025.109356_bb0030","doi-asserted-by":"crossref","first-page":"3150","DOI":"10.1182\/blood.V85.11.3150.bloodjournal85113150","article-title":"The affinity and stoichiometry of binding of human factor VIII to von Willebrand factor","volume":"85","author":"Vlot","year":"1995","journal-title":"Blood"},{"key":"10.1016\/j.thromres.2025.109356_bb0035","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/hae.14078","article-title":"Biological mechanisms underlying inter-individual variation in factor VIII clearance in haemophilia","volume":"26","author":"Turecek","year":"2020","journal-title":"Haemophilia"},{"key":"10.1016\/j.thromres.2025.109356_bb0040","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1172\/JCI108788","article-title":"Stabilization of factor VIII in plasma by the von Willebrand factor","volume":"60","author":"Weiss","year":"1977","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.thromres.2025.109356_bb0045","doi-asserted-by":"crossref","first-page":"10299","DOI":"10.1021\/acs.analchem.5b02078","article-title":"Shear-dependent interactions of von Willebrand factor with factor VIII and protease ADAMTS 13 demonstrated at a single molecule level by atomic force microscopy","volume":"87","author":"Bonazza","year":"2015","journal-title":"Anal. Chem."},{"key":"10.1016\/j.thromres.2025.109356_bb0050","doi-asserted-by":"crossref","first-page":"32459","DOI":"10.1074\/jbc.M112.390690","article-title":"Light chain of factor VIII is sufficient for accelerating cleavage of von Willebrand factor by ADAMTS13 metalloprotease","volume":"287","author":"Cao","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.thromres.2025.109356_bb0055","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1111\/jth.15793","article-title":"Structural insights into blood coagulation factor VIII: procoagulant complexes, membrane binding, and antibody inhibition","volume":"20","author":"Childers","year":"2022","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2025.109356_bb0060","doi-asserted-by":"crossref","first-page":"3477","DOI":"10.1016\/j.jtha.2023.09.004","article-title":"Coagulation factor VIII regulates von Willebrand factor homeostasis in vivo","volume":"21","author":"Cao","year":"2023","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2025.109356_bb0065","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1093\/bja\/aer512","article-title":"Impact of loss of high-molecular-weight von Willebrand factor multimers on blood loss after aortic valve replacement","volume":"108","author":"Bolliger","year":"2012","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.thromres.2025.109356_bb0070","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1161\/01.CIR.102.11.1290","article-title":"Proteolysis of von willebrand factor and shear stress\u2013induced platelet aggregation in patients with aortic valve stenosis","volume":"102","author":"Pareti","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.thromres.2025.109356_bb0075","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1111\/jth.14715","article-title":"Patients with aortic stenosis have von Willebrand factor abnormalities and increased proliferation of endothelial colony forming cells","volume":"18","author":"Selvam","year":"2020","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2025.109356_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.rpth.2023.102284","article-title":"von Willebrand factor Ristocetin co-factor activity to von Willebrand factor antigen level ratio for diagnosis of acquired von Willebrand syndrome caused by aortic stenosis","volume":"8","author":"Okubo","year":"2024","journal-title":"Res. Pract. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2025.109356_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.rpth.2024.102431","article-title":"Mitral regurgitation is associated with similar loss of von Willebrand factor large multimers but lower frequency of anemia compared with aortic stenosis","volume":"8","author":"Takiguchi","year":"2024","journal-title":"Res. Pract. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2025.109356_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.thromres.2024.109094","article-title":"Investigation of von Willebrand factor multimer abnormalities before and after aortic valve replacement using the Hydragel-5 assay","volume":"241","author":"Hamiko","year":"2024","journal-title":"Thromb. Res."},{"key":"10.1016\/j.thromres.2025.109356_bb0095","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.thromres.2020.05.003","article-title":"The potential roles of von willebrand factor and neutrophil extracellular traps in the natural history of hypertrophic and hypertensive cardiomyopathy","volume":"192","author":"Becker","year":"2020","journal-title":"Thromb. Res."},{"key":"10.1016\/j.thromres.2025.109356_bb0100","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1177\/1076029616660759","article-title":"Severe aortic valve stenosis: sustained cure of acquired von Willebrand syndrome after surgical valve replacement","volume":"23","author":"Frank","year":"2017","journal-title":"Clin. Appl. Thromb. Hemost."},{"key":"10.1016\/j.thromres.2025.109356_bb0105","article-title":"Quantitative influence of ABO blood groups on factor VIII and its ratio to von Willebrand factor, novel observations from an ARIC study of 11,673 subjects","volume":"10","author":"Song","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.thromres.2025.109356_bb0110","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.jtha.2023.01.013","article-title":"Heterogeneity in the half-life of factor VIII concentrate in patients with hemophilia a is due to variability in the clearance of endogenous von willebrand factor","volume":"21","author":"Elsheikh","year":"2023","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2025.109356_bb0115","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1182\/blood-2014-06-528406","article-title":"von Willebrand factor biosynthesis, secretion, and clearance: connecting the far ends","volume":"125","author":"Lenting","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.thromres.2025.109356_bb0120","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1182\/blood.2020005843","article-title":"The relationship between ABO blood group, von Willebrand factor, and primary hemostasis","volume":"136","author":"Ward","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.thromres.2025.109356_bb0125","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1002\/ajh.24005","article-title":"Gene-centric approach identifies new and known loci for FVIII activity and VWF antigen levels in European Americans and African Americans","volume":"90","author":"Tang","year":"2015","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.thromres.2025.109356_bb0130","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1111\/jth.14741","article-title":"Coagulation factor VIII: relationship to cardiovascular disease risk and whole genome sequence and epigenome-wide analysis in African Americans","volume":"18","author":"Raffield","year":"2020","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2025.109356_bb0135","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.thromres.2020.05.051","article-title":"ABO blood group, glycosyltransferase activity and risk of venous thromboembolism","volume":"193","author":"Ibrahim-Kosta","year":"2020","journal-title":"Thromb. Res."},{"key":"10.1016\/j.thromres.2025.109356_bb0140","doi-asserted-by":"crossref","first-page":"239","DOI":"10.2147\/PGPM.S383221","article-title":"Current understanding of inherited modifiers of FVIII pharmacokinetic variation","volume":"16","author":"Swystun","year":"2023","journal-title":"PGPM"},{"key":"10.1016\/j.thromres.2025.109356_bb0145","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1016\/j.jtha.2023.04.014","article-title":"The contribution of the sinusoidal endothelial cell receptors CLEC4M, stabilin-2, and SCARA5 to VWF\u2013FVIII clearance in thrombosis and hemostasis","volume":"21","author":"Swystun","year":"2023","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2025.109356_bb0150","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1161\/CIRCULATIONAHA.109.869156","article-title":"Novel associations of multiple genetic loci with plasma levels of factor VII, factor VIII, and von willebrand factor: the CHARGE (cohorts for heart and aging research in genome epidemiology) consortium","volume":"121","author":"Smith","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.thromres.2025.109356_bb0155","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/1471-2350-12-102","article-title":"Combined analysis of three genome-wide association studies on vWF and FVIII plasma levels","volume":"12","author":"Antoni","year":"2011","journal-title":"BMC Med. Genet."},{"key":"10.1016\/j.thromres.2025.109356_bb0160","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1161\/CIRCULATIONAHA.118.034532","article-title":"Genome-wide association transethnic meta-analyses identifies novel associations regulating coagulation Factor VIII and von Willebrand Factor plasma levels","volume":"139","author":"Sabater-Lleal","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.thromres.2025.109356_bb0165","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1182\/blood.2023021452","article-title":"A genetic association study of circulating coagulation factor VIII and von Willebrand factor levels","volume":"143","author":"De Vries","year":"2024","journal-title":"Blood"},{"key":"10.1016\/j.thromres.2025.109356_bb0170","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/hae.12592","article-title":"Parameters influencing FVIII pharmacokinetics in patients with severe and moderate haemophilia A","volume":"21","author":"Kepa","year":"2015","journal-title":"Haemophilia"},{"key":"10.1016\/j.thromres.2025.109356_bb0175","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1182\/blood.2019000190","article-title":"Genetic determinants of VWF clearance and FVIII binding modify FVIII pharmacokinetics in pediatric hemophilia A patients","volume":"134","author":"Swystun","year":"2019","journal-title":"Blood"},{"key":"10.1016\/j.thromres.2025.109356_bb0180","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1111\/jth.14473","article-title":"Functional polymorphisms in the LDLR and pharmacokinetics of Factor VIII concentrates","volume":"17","author":"Lunghi","year":"2019","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2025.109356_bb0185","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1055\/s-0040-1714214","article-title":"Common genetic variants in ABO and CLEC4M modulate the pharmacokinetics of recombinant FVIII in severe hemophilia A patients","volume":"120","author":"Garcia-Mart\u00ednez","year":"2020","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.thromres.2025.109356_bb0190","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1111\/jth.15183","article-title":"Factor VIII pharmacokinetics associates with genetic modifiers of VWF and FVIII clearance in an adult hemophilia A population","volume":"19","author":"Ogiwara","year":"2021","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2025.109356_bb0195","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1055\/a-1591-7869","article-title":"The asialoglycoprotein receptor minor subunit gene contributes to pharmacokinetics of factor VIII concentrates in hemophilia A","volume":"122","author":"Lunghi","year":"2022","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.thromres.2025.109356_bb0200","doi-asserted-by":"crossref","first-page":"733","DOI":"10.3390\/jcm11030733","article-title":"Combination of CLEC4M rs868875 G-carriership and ABO O genotypes may predict faster decay of FVIII infused in hemophilia A patients","volume":"11","author":"Lunghi","year":"2022","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.thromres.2025.109356_bb0205","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/hae.14722","article-title":"Modulation of factor VIII pharmacokinetics by genetic components in factor VIII receptors","volume":"29","author":"Lunghi","year":"2023","journal-title":"Haemophilia"},{"key":"10.1016\/j.thromres.2025.109356_bb0210","series-title":"Methods in Enzymology","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0076-6879(10)79013-3","article-title":"The Ashwell\u2013Morell receptor","author":"Grewal","year":"2010"},{"key":"10.1016\/j.thromres.2025.109356_bb0215","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1007\/s00109-008-0350-2","article-title":"DC-SIGN and L-SIGN: the SIGNs for infection","volume":"86","author":"Khoo","year":"2008","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.thromres.2025.109356_bb0220","doi-asserted-by":"crossref","first-page":"22033","DOI":"10.1074\/jbc.M113.468108","article-title":"Mapping the binding region on the low density lipoprotein receptor for blood coagulation factor VIII","volume":"288","author":"Kurasawa","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.thromres.2025.109356_bb0225","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1042\/bj3620155","article-title":"Stabilin-1 and -2 constitute a novel family of fasciclin-like hyaluronan receptor homologues","volume":"362","author":"Politz","year":"2002","journal-title":"Biochem. J."},{"key":"10.1016\/j.thromres.2025.109356_bb0230","doi-asserted-by":"crossref","first-page":"4057","DOI":"10.1172\/JCI96400","article-title":"The endothelial cell receptor stabilin-2 regulates VWF-FVIII complex half-life and immunogenicity","volume":"128","author":"Swystun","year":"2018","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.thromres.2025.109356_bb0235","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1111\/jth.14521","article-title":"The scavenger receptor SCARA5 is an endocytic receptor for von Willebrand factor expressed by littoral cells in the human spleen","volume":"17","author":"Swystun","year":"2019","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2025.109356_bb0240","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.echo.2017.02.009","article-title":"Recommendations on the echocardiographic assessment of aortic valve stenosis: a focused update from the European Association of Cardiovascular Imaging and the American Society of Echocardiography","volume":"30","author":"Baumgartner","year":"2017","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"10.1016\/j.thromres.2025.109356_bb0245","doi-asserted-by":"crossref","first-page":"5688","DOI":"10.1182\/blood-2010-03-277079","article-title":"Polymorphisms at LDLR locus may be associated with coronary artery disease through modulation of coagulation factor VIII activity and independently from lipid profile","volume":"116","author":"Martinelli","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.thromres.2025.109356_bb0250","doi-asserted-by":"crossref","first-page":"12102","DOI":"10.1074\/jbc.M310436200","article-title":"An experimental model to study the in vivo survival of von Willebrand factor","volume":"279","author":"Lenting","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.thromres.2025.109356_bb0255","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/jth.15131","article-title":"In vivo modulation of a dominant-negative variant in mouse models of von Willebrand disease type 2A","volume":"19","author":"Campioni","year":"2021","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2025.109356_bb0260","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1365-2141.2004.05275.x","article-title":"Biological and genetic factors influencing plasma factor VIII levels in a healthy family population: results from the Stanislas cohort","volume":"128","author":"Morange","year":"2005","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.thromres.2025.109356_bb0265","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.thromres.2020.11.016","article-title":"Rise of levels of von Willebrand factor and factor VIII with age: role of genetic and acquired risk factors","volume":"197","author":"Biguzzi","year":"2021","journal-title":"Thromb. Res."},{"key":"10.1016\/j.thromres.2025.109356_bb0270","doi-asserted-by":"crossref","first-page":"f101","DOI":"10.1093\/ehjcvp\/pvaa008","article-title":"Thromboembolism and bleeding complications in anticoagulated patients with atrial fibrillation and native aortic or mitral valvular heart disease: a descriptive nationwide cohort study","volume":"7","author":"Melgaard","year":"2021","journal-title":"Eur. Heart J. \u2013 Cardiovasc. Pharmacother."},{"key":"10.1016\/j.thromres.2025.109356_bb0275","doi-asserted-by":"crossref","first-page":"5228","DOI":"10.1182\/blood-2012-10-457507","article-title":"The C-type lectin receptor CLEC4M binds, internalizes, and clears von Willebrand factor and contributes to the variation in plasma von Willebrand factor levels","volume":"121","author":"Rydz","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.thromres.2025.109356_bb0280","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0192024","article-title":"Genetic variation in the C-type lectin receptor CLEC4M in type 1 von Willebrand disease patients","volume":"13","author":"Manderstedt","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.thromres.2025.109356_bb0285","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1074\/jbc.M409925200","article-title":"Extended neck regions stabilize tetramers of the receptors DC-SIGN and DC-SIGNR","volume":"280","author":"Feinberg","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.thromres.2025.109356_bb0290","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1038\/s41467-024-46639-4","article-title":"Integrative genomic analyses identify candidate causal genes for calcific aortic valve stenosis involving tissue-specific regulation","volume":"15","author":"Th\u00e9riault","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.thromres.2025.109356_bb0295","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1161\/CIRCRESAHA.120.317979","article-title":"Multi-omics approaches to define calcific aortic valve disease pathogenesis","volume":"128","author":"Blaser","year":"2021","journal-title":"Circ. Res."},{"key":"10.1016\/j.thromres.2025.109356_bb0300","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1007\/s12471-016-0804-z","article-title":"Prevalence of blood type A and risk of vascular complications following transcatheter aortic valve implantation","volume":"24","author":"Rofe","year":"2016","journal-title":"Neth. Hear. J."},{"key":"10.1016\/j.thromres.2025.109356_bb0305","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.015909","article-title":"Possible link between the ABO blood group of bioprosthesis recipients and specific types of structural degeneration","volume":"9","author":"Schussler","year":"2020","journal-title":"JAHA"},{"key":"10.1016\/j.thromres.2025.109356_bb0310","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1093\/eurheartj\/eht034","article-title":"Aortic stenosis, atherosclerosis, and skeletal bone: is there a common link with calcification and inflammation?","volume":"34","author":"Dweck","year":"2013","journal-title":"Eur. Heart J."}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384825001069?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384825001069?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T19:36:26Z","timestamp":1766086586000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049384825001069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":62,"alternative-id":["S0049384825001069"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2025.109356","relation":{},"ISSN":["0049-3848"],"issn-type":[{"type":"print","value":"0049-3848"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Selected cell receptor genotypes differentially modulate the ABO blood group influence on Factor VIII levels in severe aortic stenosis","name":"articletitle","label":"Article Title"},{"value":"Thrombosis Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.thromres.2025.109356","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109356"}}