{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T03:28:02Z","timestamp":1784863682514,"version":"3.55.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thrombosisresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.thromres.2025.109378","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T15:51:45Z","timestamp":1749052305000},"page":"109378","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Neutrophil extracellular traps-related markers in chronic limb threatening ischemia - a relation with progression and prognosis"],"prefix":"10.1016","volume":"252","author":[{"given":"Tomasz","family":"Nowakowski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Malinowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Natorska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anetta","family":"Undas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.thromres.2025.109378_bb0005","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1161\/CIRCRESAHA.116.303849","article-title":"Epidemiology of peripheral artery disease","volume":"116","author":"Criqui","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.thromres.2025.109378_bb0010","doi-asserted-by":"crossref","first-page":"e875","DOI":"10.1161\/CIR.0000000000000967","article-title":"Reducing nontraumatic lower-extremity amputations by 20% by 2030: time to get to our feet: a policy statement from the American Heart Association","volume":"143","author":"Creager","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.thromres.2025.109378_bb0015","doi-asserted-by":"crossref","first-page":"e171","DOI":"10.1161\/CIR.0000000000001005","article-title":"Lower extremity peripheral artery disease: contemporary epidemiology, management gaps, and future directions: a scientific statement from the American Heart Association","volume":"144","author":"Criqui","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.thromres.2025.109378_bb0020","doi-asserted-by":"crossref","first-page":"2682","DOI":"10.3390\/jcm12072682","article-title":"Chronic limb-threatening ischemia and the need for revascularization","volume":"12","author":"Berchiolli","year":"2023","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.thromres.2025.109378_bb0025","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1056\/NEJMoa2207899","article-title":"Surgery or endovascular therapy for chronic limb-threatening ischemia","volume":"387","author":"Farber","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.thromres.2025.109378_bb0030","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1126\/science.1092385","article-title":"Neutrophil extracellular traps kill bacteria","volume":"303","author":"Brinkmann","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.thromres.2025.109378_bb0035","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nature10146","article-title":"Progress and challenges in translating the biology of atherosclerosis","volume":"473","author":"Libby","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.thromres.2025.109378_bb0040","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1126\/science.aaa8064","article-title":"Inflammation. Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis","volume":"349","author":"Warnatsch","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.thromres.2025.109378_bb0045","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1160\/TH11-09-0650","article-title":"Presence of luminal neutrophil extracellular traps in atherosclerosis","volume":"107","author":"Megens","year":"2012","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.thromres.2025.109378_bb0050","first-page":"1205","article-title":"Neutrophil extracellular traps (NETs) in cardiovascular diseases: from molecular mechanisms to therapeutic interventions","volume":"81","author":"Natorska","year":"2023","journal-title":"Kardiol. Pol."},{"key":"10.1016\/j.thromres.2025.109378_bb0055","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1161\/CIRCRESAHA.120.315931","article-title":"Neutrophil extracellular traps participate in cardiovascular diseases: recent experimental and clinical insights","volume":"126","author":"Doring","year":"2020","journal-title":"Circ. Res."},{"key":"10.1016\/j.thromres.2025.109378_bb0060","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1161\/CIRCRESAHA.116.304944","article-title":"Coronary neutrophil extracellular trap burden and deoxyribonuclease activity in ST-elevation acute coronary syndrome are predictors of ST-segment resolution and infarct size","volume":"116","author":"Mangold","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.thromres.2025.109378_bb0065","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1093\/eurheartj\/ehv007","article-title":"Expression of functional tissue factor by neutrophil extracellular traps in culprit artery of acute myocardial infarction","volume":"36","author":"Stakos","year":"2015","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.thromres.2025.109378_bb0070","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1093\/eurheartj\/ehv419","article-title":"Histopathological evaluation of thrombus in patients presenting with stent thrombosis. A multicenter European study: a report of the prevention of late stent thrombosis by an interdisciplinary global European effort consortium","volume":"37","author":"Riegger","year":"2016","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.thromres.2025.109378_bb0075","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.thromres.2019.01.006","article-title":"Neutrophil extracellular traps in thrombi retrieved during interventional treatment of ischemic arterial diseases","volume":"175","author":"Farkas","year":"2019","journal-title":"Thromb. Res."},{"key":"10.1016\/j.thromres.2025.109378_bb0080","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1161\/ATVBAHA.113.301627","article-title":"Elevated levels of circulating DNA and chromatin are independently associated with severe coronary atherosclerosis and a prothrombotic state","volume":"33","author":"Borissoff","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.thromres.2025.109378_bb0085","doi-asserted-by":"crossref","first-page":"866","DOI":"10.3390\/biomedicines11030866","article-title":"Biomarkers of neutrophil activation in patients with symptomatic chronic peripheral artery disease predict worse cardiovascular outcome","volume":"11","author":"Buso","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.thromres.2025.109378_bb0090","doi-asserted-by":"crossref","first-page":"304","DOI":"10.3390\/jcm9020304","article-title":"Surrogate markers of neutrophil extracellular trap formation are associated with ischemic outcomes and platelet activation after peripheral angioplasty and stenting","volume":"9","author":"Demyanets","year":"2020","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.thromres.2025.109378_bb0095","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1007\/s11239-019-01826-9","article-title":"Restenosis is associated with prothrombotic plasma fibrin clot characteristics in endovascularly treated patients with critical limb ischemia","volume":"47","author":"Nowakowski","year":"2019","journal-title":"J. Thromb. Thrombolysis"},{"key":"10.1016\/j.thromres.2025.109378_bb0100","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1159\/000071636","article-title":"Calibrated automated thrombin generation measurement in clotting plasma","volume":"33","author":"Hemker","year":"2003","journal-title":"Pathophysiol. Haemost. Thromb."},{"key":"10.1016\/j.thromres.2025.109378_bb0105","first-page":"163","article-title":"Neutrophil extracellular traps (NETs) in aortic stenosis: comparison of methods for assessment of NETs formation","volume":"77","author":"Kopi\u0144ski","year":"2023","journal-title":"Advances in Hygiene and Experimental Medicine"},{"key":"10.1016\/j.thromres.2025.109378_bb0110","doi-asserted-by":"crossref","first-page":"4272","DOI":"10.1182\/blood-2009-05-222380","article-title":"Altered fibrin clot structure\/function in patients with idiopathic venous thromboembolism and their relatives","volume":"114","author":"Undas","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.thromres.2025.109378_bb0115","article-title":"High-dose atorvastatin and rosuvastatin reduce neutrophil extracellular traps-related proteins in coronary artery disease: association with prothrombotic state","volume":"134","author":"St\u0119pie\u0144","year":"2024","journal-title":"Pol Arch Intern Med"},{"key":"10.1016\/j.thromres.2025.109378_bb0120","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/2896380","article-title":"Neutrophil extracellular traps and microcrystals","volume":"2017","author":"Rada","year":"2017","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.thromres.2025.109378_bb0130","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-68375-7","article-title":"Prothrombotic clot properties associated with NETs formation characterize acute pulmonary embolism patients with higher mortality risk","volume":"10","author":"Z\u0105bczyk","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.thromres.2025.109378_bb0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.thromres.2022.02.025","article-title":"Markers of NET formation and stroke risk in patients with atrial fibrillation: association with prothrombotic state","volume":"213","author":"Mo\u0142ek","year":"2022","journal-title":"Thromb. Res."},{"key":"10.1016\/j.thromres.2025.109378_bb0140","doi-asserted-by":"crossref","first-page":"6946","DOI":"10.1074\/jbc.M112.404301","article-title":"Mechanical stability and fibrinolytic resistance of clots containing fibrin, DNA, and histones","volume":"288","author":"Longstaff","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.thromres.2025.109378_bb0145","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.thromres.2015.10.012","article-title":"Extracellular histones induce tissue factor expression in vascular endothelial cells via TLR and activation of NF-\u03baB and AP-1","volume":"137","author":"Yang","year":"2016","journal-title":"Thromb. Res."},{"key":"10.1016\/j.thromres.2025.109378_bb0150","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-68375-7","article-title":"Prothrombotic fibrin clot properties associated with NETs formation characterize acute pulmonary embolism patients with higher mortality risk","volume":"10","author":"Z\u0105bczyk","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.thromres.2025.109378_bb0155","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.rinim.2014.03.001","article-title":"Evidence for simvastatin anti-inflammatory actions based on quantitative analyses of NETosis and other inflammation\/oxidation markers","volume":"4","author":"Al-Ghoul","year":"2014","journal-title":"Results Immunol"},{"key":"10.1016\/j.thromres.2025.109378_bb0160","doi-asserted-by":"crossref","first-page":"3538","DOI":"10.1093\/eurheartj\/ehae179","article-title":"2024 ESC guidelines for the management of peripheral arterial and aortic diseases","volume":"45","author":"Mazzolai","year":"2024","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.thromres.2025.109378_bb0165","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ejvs.2023.08.067","article-title":"2024 clinical practice guidelines on the management of asymptomatic lower limb peripheral arterial disease and intermittent claudication","volume":"67","author":"Nordasting","year":"2024","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"key":"10.1016\/j.thromres.2025.109378_bb0170","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1016\/j.jacc.2018.03.008","article-title":"Major adverse limb events and mortality in patients with peripheral artery disease: the COMPASS trial","volume":"71","author":"Anand","year":"2018","journal-title":"J. Am. Coll. Cardiol."}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384825001288?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384825001288?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:17:04Z","timestamp":1751415424000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049384825001288"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":33,"alternative-id":["S0049384825001288"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2025.109378","relation":{},"ISSN":["0049-3848"],"issn-type":[{"value":"0049-3848","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neutrophil extracellular traps-related markers in chronic limb threatening ischemia - a relation with progression and prognosis","name":"articletitle","label":"Article Title"},{"value":"Thrombosis Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.thromres.2025.109378","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109378"}}