{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:47:47Z","timestamp":1787507267140,"version":"build-2736575974"},"reference-count":102,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thrombosisresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.thromres.2025.109384","type":"journal-article","created":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T01:29:21Z","timestamp":1749950961000},"page":"109384","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Thrombin generation assay in venous thromboembolism: A scoping review"],"prefix":"10.1016","volume":"252","author":[{"given":"Maria Eduarda Machado","family":"Souza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Let\u00edcia Gon\u00e7alves Resende","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00e1dia Regina Oliveira","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livian Rabelo","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"das Gra\u00e7as Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6377-241X","authenticated-orcid":false,"given":"Danyelle Romana Alves","family":"Rios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.thromres.2025.109384_bb0005","doi-asserted-by":"crossref","DOI":"10.1161\/CIR.0000000000000818","article-title":"Venous thromboembolism research priorities: a scientific statement from the American Heart Association and the international society on thrombosis and Haemostasis","author":"Cushman","year":"2020","journal-title":"Circulation [Internet]."},{"key":"10.1016\/j.thromres.2025.109384_bb0010","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1016\/S0049-3848(11)70007-X","article-title":"Thrombin generation tests","volume":"127","author":"Castoldi","year":"2011","journal-title":"Thromb. Res."},{"key":"10.1016\/j.thromres.2025.109384_bb0015","doi-asserted-by":"crossref","DOI":"10.1111\/jth.15538","article-title":"Clinical use of thrombin generation assays","author":"Binder","year":"2021","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2025.109384_bb0020","doi-asserted-by":"crossref","DOI":"10.1111\/jth.15529","article-title":"Thrombin generation assays are versatile tools in blood coagulation analysis: a review of technical features, and applications from research to laboratory routine","volume":"19","author":"Depasse","year":"2021","journal-title":"J. Thromb. Haemost."},{"issue":"1","key":"10.1016\/j.thromres.2025.109384_bb0025","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1007\/s11239-021-02621-1","article-title":"Global coagulation assays in hypercoagulable states","volume":"54","author":"Lim","year":"2022","journal-title":"J. Thromb. Thrombolysis"},{"issue":"7","key":"10.1016\/j.thromres.2025.109384_bb0030","doi-asserted-by":"crossref","first-page":"467","DOI":"10.7326\/M18-0850","article-title":"PRISMA extension for scoping reviews (PRISMA-ScR): checklist and explanation","volume":"169","author":"Tricco","year":"2018","journal-title":"Ann. Intern. Med."},{"issue":"4","key":"10.1016\/j.thromres.2025.109384_bb0035","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1001\/jama.296.4.397","article-title":"Identification of patients at low risk for recurrent venous thromboembolism by measuring thrombin generation","volume":"296","author":"Hron","year":"2006","journal-title":"JAMA"},{"issue":"6","key":"10.1016\/j.thromres.2025.109384_bb0040","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1111\/j.1365-2141.2007.06738.x","article-title":"Elevated endogenous thrombin potential is associated with an increased risk of a first deep venous thrombosis but not with the risk of recurrence","volume":"138","author":"van Hylckama","year":"2007","journal-title":"Br. J. Haematol."},{"issue":"1","key":"10.1016\/j.thromres.2025.109384_bb0045","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1365-2141.2007.06732.x","article-title":"Thrombin generation: a comparison of assays using platelet-poor and -rich plasma and whole blood samples from healthy controls and patients with a history of venous thromboembolism","volume":"139","author":"Tappenden","year":"2007","journal-title":"Br. J. Haematol."},{"issue":"6","key":"10.1016\/j.thromres.2025.109384_bb0050","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1111\/j.1538-7836.2008.02963.x","article-title":"Microparticle-mediated thrombin generation assay: increased activity in patients with recurrent thrombosis","volume":"6","author":"Bidot","year":"2008","journal-title":"J. Thromb. Haemost."},{"issue":"12","key":"10.1016\/j.thromres.2025.109384_bb0055","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1373\/clinchem.2008.112243","article-title":"Prediction of recurrent venous thromboembolism by endogenous thrombin potential and D-dimer","volume":"54","author":"Eichinger","year":"2008","journal-title":"Clin. Chem."},{"issue":"10","key":"10.1016\/j.thromres.2025.109384_bb0060","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1111\/j.1538-7836.2008.03117.x","article-title":"High rate of unprovoked recurrent venous thrombosis is associated with high thrombin-generating potential in a prospective cohort study","volume":"6","author":"Besser","year":"2008","journal-title":"J. Thromb. Haemost."},{"issue":"8","key":"10.1016\/j.thromres.2025.109384_bb0065","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1111\/j.1538-7836.2008.03018.x","article-title":"High thrombin generation measured in the presence of thrombomodulin is associated with an increased risk of recurrent venous thromboembolism","volume":"6","author":"Tripodi","year":"2008","journal-title":"J. Thromb. Haemost."},{"issue":"8","key":"10.1016\/j.thromres.2025.109384_bb0070","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1111\/j.1538-7836.2008.02998.x","article-title":"Comparison between idiopathic deep vein thrombosis of the upper and lower extremity regarding risk factors and recurrence","volume":"6","author":"Lechner","year":"2008","journal-title":"J. Thromb. Haemost."},{"issue":"2","key":"10.1016\/j.thromres.2025.109384_bb0075","first-page":"240","article-title":"Thrombin generation in patients after acute deep-vein thrombosis","volume":"100","author":"ten Cate-Hoek","year":"2008","journal-title":"Thromb. Haemost."},{"issue":"10","key":"10.1016\/j.thromres.2025.109384_bb0080","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1111\/j.1538-7836.2009.03561.x","article-title":"Peak thrombin generation and subsequent venous thromboembolism: the longitudinal investigation of thromboembolism etiology (LITE) study","volume":"7","author":"Lutsey","year":"2009","journal-title":"J. Thromb. Haemost."},{"issue":"14","key":"10.1016\/j.thromres.2025.109384_bb0085","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1161\/CIRCULATIONAHA.109.925214","article-title":"Risk assessment of recurrence in patients with unprovoked deep vein thrombosis or pulmonary embolism: the Vienna prediction model","volume":"121","author":"Eichinger","year":"2010","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.thromres.2025.109384_bb0090","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3109\/00365513.2010.534173","article-title":"A thrombin generation assay may reduce the need for compression ultrasonography for the exclusion of deep venous thrombosis in the elderly","volume":"71","author":"Haas","year":"2011","journal-title":"Scand. J. Clin. Lab. Invest."},{"issue":"5","key":"10.1016\/j.thromres.2025.109384_bb0095","first-page":"901","article-title":"Thrombin generation and activated protein C resistance in the absence of factor V Leiden correlates with the risk of recurrent venous thromboembolism in women aged 18-65 years","volume":"106","author":"Sonnevi","year":"2011","journal-title":"Thromb. Haemost."},{"issue":"4","key":"10.1016\/j.thromres.2025.109384_bb0100","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.thromres.2011.07.020","article-title":"Persistent high factor VIII activity leading to increased thrombin generation - a prospective cohort study","volume":"129","author":"Ryland","year":"2012","journal-title":"Thromb. Res."},{"issue":"2","key":"10.1016\/j.thromres.2025.109384_bb0105","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.thromres.2012.11.015","article-title":"Is thrombin generation at the time of an acute thromboembolic episode a predictor of recurrence? The LInk\u00f6ping Study on Thrombosis (LIST)--a 7-year follow-up","volume":"131","author":"Chaireti","year":"2013","journal-title":"Thromb. Res."},{"issue":"1","key":"10.1016\/j.thromres.2025.109384_bb0110","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1097\/MBC.0b013e32835a07fa","article-title":"African-Caribbean ethnicity is associated with a hypercoagulable state as measured by thrombin generation","volume":"24","author":"Roberts","year":"2013","journal-title":"Blood Coagul. Fibrinolysis"},{"issue":"9","key":"10.1016\/j.thromres.2025.109384_bb0115","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1111\/jth.13043","article-title":"THE risk of a first and a recurrent venous thrombosis associated with an elevated D-dimer level and an elevated thrombin potential: results of THE THE-VTE study","volume":"13","author":"van Hylckama","year":"2015","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2025.109384_bb0120","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.thromres.2016.04.002","article-title":"Clinical and laboratory predictors of deep vein thrombosis after acute stroke","volume":"142","author":"Balogun","year":"2016","journal-title":"Thromb. Res."},{"issue":"6","key":"10.1016\/j.thromres.2025.109384_bb0125","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1111\/bjh.13911","article-title":"Prolonged clot lysis time increases the risk of a first but not recurrent venous thrombosis","volume":"172","author":"Karasu","year":"2016","journal-title":"Br. J. Haematol."},{"issue":"5","key":"10.1016\/j.thromres.2025.109384_bb0130","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1177\/1076029617700999","article-title":"Thrombin generation in patients with suspected venous thromboembolism","volume":"23","author":"Wexels","year":"2017","journal-title":"Clin. Appl. Thromb. Hemost."},{"issue":"2","key":"10.1016\/j.thromres.2025.109384_bb0135","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1161\/ATVBAHA.116.308253","article-title":"Prothrombotic fibrin clot phenotype is associated with recurrent pulmonary embolism after discontinuation of anticoagulant therapy","volume":"37","author":"Zabczyk","year":"2017","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.thromres.2025.109384_bb0140","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.thromres.2018.06.019","article-title":"Associations between complement pathways activity, mannose-binding lectin, and odds of unprovoked venous thromboembolism","volume":"169","author":"H\u00f8iland","year":"2018","journal-title":"Thromb. Res."},{"issue":"2","key":"10.1016\/j.thromres.2025.109384_bb0145","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/jth.14364","article-title":"Rosuvastatin use reduces thrombin generation potential in patients with venous thromboembolism: a randomized controlled trial","volume":"17","author":"Orsi","year":"2019","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2025.109384_bb0150","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3389\/fcvm.2019.00033","article-title":"Searching for a common Thrombo-inflammatory basis in patients with deep vein thrombosis or peripheral artery disease","volume":"6","author":"Kremers","year":"2019","journal-title":"Front Cardiovasc Med."},{"issue":"3","key":"10.1016\/j.thromres.2025.109384_bb0155","doi-asserted-by":"crossref","first-page":"e178","DOI":"10.1055\/s-0040-1714210","article-title":"Diagnostic accuracy in acute venous thromboembolism: comparing D-dimer, thrombin generation, overall hemostatic potential, and fibrin monomers","volume":"4","author":"Farm","year":"2020","journal-title":"TH Open."},{"key":"10.1016\/j.thromres.2025.109384_bb0160","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.thromres.2019.11.030","article-title":"Does cell-free DNA promote coagulation and inhibit fibrinolysis in patients with unprovoked venous thromboembolism?","volume":"186","author":"Medeiros","year":"2020","journal-title":"Thromb. Res."},{"issue":"9","key":"10.1016\/j.thromres.2025.109384_bb0165","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9092892","article-title":"Characterization of thrombin generation curve shape in presence of platelets from acute venous thromboembolism patients","volume":"9","author":"Lagrange","year":"2020","journal-title":"J. Clin. Med."},{"issue":"1","key":"10.1016\/j.thromres.2025.109384_bb0170","doi-asserted-by":"crossref","first-page":"11433","DOI":"10.1038\/s41598-020-68375-7","article-title":"Prothrombotic fibrin clot properties associated with NETs formation characterize acute pulmonary embolism patients with higher mortality risk","volume":"10","author":"Z\u0105bczyk","year":"2020","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.thromres.2025.109384_bb0175","article-title":"D-dimer, thrombin generation, and risk of a first venous thrombosis in the elderly","volume":"5","author":"Wang","year":"2021","journal-title":"Res Pr Thromb Haemost."},{"issue":"04","key":"10.1016\/j.thromres.2025.109384_bb0180","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1055\/s-0040-1718762","article-title":"Loose fibrin clot structure and increased susceptibility to lysis characterize patients with central acute pulmonary embolism: the impact of isolated embolism","volume":"121","author":"Z\u0105bczyk","year":"2021","journal-title":"Thromb. Haemost."},{"issue":"3","key":"10.1016\/j.thromres.2025.109384_bb0185","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1111\/jth.15595","article-title":"Variation of platelet function in clinical phenotypes of acute venous thromboembolism - results from the GMP-VTE project","volume":"20","author":"Panova-Noeva","year":"2022","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2025.109384_bb0190","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.thromres.2022.11.023","article-title":"Translational insights into mechanisms underlying residual venous obstruction and the role of factor XI, P-selectin and GPVI in recurrent venous thromboembolism","volume":"221","author":"Iding","year":"2023","journal-title":"Thromb. Res."},{"issue":"18","key":"10.1016\/j.thromres.2025.109384_bb0195","doi-asserted-by":"crossref","DOI":"10.3390\/jcm12186050","article-title":"Thrombin generation is associated with venous thromboembolism recurrence, but not with major bleeding and death in the elderly: a prospective multicenter cohort study","volume":"12","author":"Vrotniakaite-Bajerciene","year":"2023","journal-title":"J. Clin. Med."},{"issue":"9","key":"10.1016\/j.thromres.2025.109384_bb0200","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1161\/01.ATV.0000030186.66672.36","article-title":"Analysis of coagulation cascade and endothelial cell activation during inhibition of vascular endothelial growth factor\/vascular endothelial growth factor receptor pathway in cancer patients","volume":"22","author":"Kuenen","year":"2002","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"15","key":"10.1016\/j.thromres.2025.109384_bb0205","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1200\/JCO.2010.32.8294","article-title":"Prediction of venous thromboembolism in patients with cancer by measuring thrombin generation: results from the Vienna Cancer and thrombosis study","volume":"29","author":"Ay","year":"2011","journal-title":"J. Clin. Oncol."},{"issue":"12","key":"10.1016\/j.thromres.2025.109384_bb0210","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1007\/s00384-012-1493-8","article-title":"Association between increased tumor necrosis factor alpha levels and acquired activated protein C resistance in patients with metastatic colorectal cancer","volume":"27","author":"Ferroni","year":"2012","journal-title":"Int. J. Color. Dis."},{"issue":"11","key":"10.1016\/j.thromres.2025.109384_bb0215","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1007\/s00520-012-1391-1","article-title":"Early changes of a novel APC-dependent thrombin generation assay during chemotherapy independently predict venous thromboembolism in cancer patients--a pilot study","volume":"20","author":"Ferroni","year":"2012","journal-title":"Support Care Cancer"},{"issue":"2","key":"10.1016\/j.thromres.2025.109384_bb0220","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1097\/MBC.0b013e32834fb539","article-title":"Profile of thrombin generation in children with acute lymphoblastic leukemia treated by Berlin-Frankfurt-M\u00fcnster (BFM) protocols","volume":"23","author":"Lejhancova-Tousovska","year":"2012","journal-title":"Blood Coagul. Fibrinolysis"},{"issue":"2","key":"10.1016\/j.thromres.2025.109384_bb0225","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s11060-015-1840-z","article-title":"A prospective multicenter study of venous thromboembolism in patients with newly-diagnosed high-grade glioma: hazard rate and risk factors","volume":"124","author":"Streiff","year":"2015","journal-title":"J. Neuro-Oncol."},{"key":"10.1016\/j.thromres.2025.109384_bb0230","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.thromres.2016.01.027","article-title":"Procoagulant activity in gynaecological cancer patients; the effect of surgery and chemotherapy","volume":"139","author":"Abu Saadeh","year":"2016","journal-title":"Thromb. Res."},{"issue":"2","key":"10.1016\/j.thromres.2025.109384_bb0235","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1007\/s11239-016-1471-z","article-title":"Procoagulant activity of extracellular vesicles as a potential biomarker for risk of thrombosis and DIC in patients with acute leukaemia","volume":"43","author":"Gheldof","year":"2017","journal-title":"J. Thromb. Thrombolysis"},{"key":"10.1016\/j.thromres.2025.109384_bb0240","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bcmd.2017.03.010","article-title":"Thrombin generation as a predictor of thromboembolic events in multiple myeloma patients","volume":"65","author":"Leiba","year":"2017","journal-title":"Blood Cells Mol. Dis."},{"issue":"4","key":"10.1016\/j.thromres.2025.109384_bb0245","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1080\/10428194.2016.1219900","article-title":"Baseline and treatment-related changes in thrombin generation in patients with multiple myeloma","volume":"58","author":"Tiong","year":"2017","journal-title":"Leuk. Lymphoma"},{"issue":"11","key":"10.1016\/j.thromres.2025.109384_bb0250","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/s41408-018-0135-y","article-title":"Longer procoagulant phospholipid-dependent clotting time, lower endogenous thrombin potential and higher tissue factor pathway inhibitor concentrations are associated with increased VTE occurrence in patients with newly diagnosed multiple myeloma: results","volume":"8","author":"Fotiou","year":"2018","journal-title":"Blood Cancer J."},{"issue":"11","key":"10.1016\/j.thromres.2025.109384_bb0255","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0207387","article-title":"Coagulation biomarkers and prediction of venous thromboembolism and survival in small cell lung cancer: a sub-study of RASTEN - a randomized trial with low molecular weight heparin","volume":"13","author":"Gezelius","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.thromres.2025.109384_bb0260","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.trsl.2019.08.009","article-title":"Ex vivo properties of plasma clot formation and lysis in patients with cancer at risk for venous thromboembolism, arterial thrombosis, and death","volume":"215","author":"Posch","year":"2020","journal-title":"Transl. Res."},{"issue":"9","key":"10.1016\/j.thromres.2025.109384_bb0265","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1159\/000508271","article-title":"Evaluation of biomarkers for the prediction of venous thromboembolism in ambulatory Cancer patients","volume":"43","author":"Schorling","year":"2020","journal-title":"Oncol. Res. Treat."},{"issue":"5","key":"10.1016\/j.thromres.2025.109384_bb0270","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1002\/rth2.12342","article-title":"A risk score for prediction of venous thromboembolism in gynecologic cancer: the Thrombogyn score","volume":"4","author":"Norris","year":"2020","journal-title":"Res Pr Thromb Haemost."},{"issue":"8","key":"10.1016\/j.thromres.2025.109384_bb0275","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1007\/s42399-020-00352-7","article-title":"Pathogenic mechanisms of venous thromboembolism in ovarian tumor patients","volume":"2","author":"Takahashi","year":"2020","journal-title":"SN Compr Clin Med."},{"issue":"7","key":"10.1016\/j.thromres.2025.109384_bb0280","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0253613","article-title":"Increased activity of procoagulant factors in patients with small cell lung cancer","volume":"16","author":"Pedersen","year":"2021","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.thromres.2025.109384_bb0285","article-title":"Thrombotic potential during pediatric acute lymphoblastic leukemia induction: role of cell-free DNA","volume":"5","author":"Kumar","year":"2021","journal-title":"Res Pr Thromb Haemost."},{"issue":"11","key":"10.1016\/j.thromres.2025.109384_bb0290","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14112771","article-title":"Biomarkers of venous thromboembolism recurrence after discontinuation of low molecular weight heparin treatment for Cancer-associated thrombosis (HISPALIS-study)","volume":"14","author":"Otero","year":"2022","journal-title":"Cancers (Basel)"},{"issue":"4","key":"10.1016\/j.thromres.2025.109384_bb0295","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.jtha.2023.12.037","article-title":"Altered whole blood thrombin generation and hyperresponsive platelets in patients with pancreatic cancer","volume":"22","author":"Willems","year":"2024","journal-title":"J. Thromb. Haemost."},{"issue":"5","key":"10.1016\/j.thromres.2025.109384_bb0300","first-page":"562","article-title":"Use of calibrated automated thrombinography +\/\u2212 thrombomodulin to recognise the prothrombotic phenotype","volume":"96","author":"Dargaud","year":"2006","journal-title":"Thromb. Haemost."},{"issue":"6","key":"10.1016\/j.thromres.2025.109384_bb0305","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1159\/000102050","article-title":"Endogenous thrombin potential for predicting risk of venous thromboembolism in carriers of factor V Leiden","volume":"35","author":"Lincz","year":"2006","journal-title":"Pathophysiol. Haemost. Thromb."},{"issue":"5","key":"10.1016\/j.thromres.2025.109384_bb0310","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1111\/j.1538-7836.2007.02448.x","article-title":"Differential effects of high prothrombin levels on thrombin generation depending on the cause of the hyperprothrombinemia","volume":"5","author":"Castoldi","year":"2007","journal-title":"J. Thromb. Haemost."},{"issue":"9","key":"10.1016\/j.thromres.2025.109384_bb0315","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1111\/j.1538-7836.2008.03070.x","article-title":"Mild hyperhomocysteinemia is associated with increased TAFI levels and reduced plasma fibrinolytic potential","volume":"6","author":"Colucci","year":"2008","journal-title":"J. Thromb. Haemost."},{"issue":"2","key":"10.1016\/j.thromres.2025.109384_bb0320","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.thromres.2008.12.033","article-title":"Thrombin generation and D-dimer concentrations in a patient cohort investigated for venous thromboembolism. Relations to venous thrombosis, factor V Leiden and prothrombin G20210A. The LIST study","volume":"124","author":"Chaireti","year":"2009","journal-title":"Thromb. Res."},{"issue":"5","key":"10.1016\/j.thromres.2025.109384_bb0325","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1111\/j.1538-7836.2010.03773.x","article-title":"Prothrombin G20210A carriers the genetic mutation and a history of venous thrombosis contributes to thrombin generation independently of factor II plasma levels","volume":"8","author":"Lavigne-Lissalde","year":"2010","journal-title":"J. Thromb. Haemost."},{"issue":"6","key":"10.1016\/j.thromres.2025.109384_bb0330","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1097\/MBC.0b013e328347404d","article-title":"Patients with deep venous thrombosis and thrombophilia risk factors have a specific prolongation of the lag time in a chromogenic thrombin generation assay","volume":"22","author":"Haas","year":"2011","journal-title":"Blood Coagul. Fibrinolysis"},{"issue":"1","key":"10.1016\/j.thromres.2025.109384_bb0335","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.thromres.2010.10.018","article-title":"Procoagulant activity, but not number, of microparticles increases with age and in individuals after a single venous thromboembolism","volume":"127","author":"Owen","year":"2011","journal-title":"Thromb. Res."},{"issue":"9","key":"10.1016\/j.thromres.2025.109384_bb0340","article-title":"The Prothrombotic phenotypes in familial protein C deficiency are differentiated by computational modeling of thrombin generation","volume":"7","author":"Brummel-Ziedins","year":"2012","journal-title":"PLoS ONE [Internet]."},{"issue":"11","key":"10.1016\/j.thromres.2025.109384_bb0345","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1111\/jth.12722","article-title":"Anti-protein C antibodies are associated with resistance to endogenous protein C activation and a severe thrombotic phenotype in antiphospholipid syndrome","volume":"12","author":"Arachchillage","year":"2014","journal-title":"J. Thromb. Haemost."},{"issue":"3","key":"10.1016\/j.thromres.2025.109384_bb0350","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s11239-019-01821-0","article-title":"Thrombin generation profile in non-thrombotic factor V Leiden carriers","volume":"47","author":"Billoir","year":"2019","journal-title":"J. Thromb. Thrombolysis"},{"issue":"5","key":"10.1016\/j.thromres.2025.109384_bb0355","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1111\/hae.14579","article-title":"Clinical, biological, and genetic features in an afibrinogenemia patient series in Algeria","volume":"28","author":"Hadjali-Saichi","year":"2022","journal-title":"Haemophilia"},{"key":"10.1016\/j.thromres.2025.109384_bb0360","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.thromres.2016.09.024","article-title":"Early thrombin formation capacity in trauma patients and association with venous thromboembolism","volume":"147","author":"Voils","year":"2016","journal-title":"Thromb. Res."},{"issue":"3","key":"10.1016\/j.thromres.2025.109384_bb0365","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1097\/TA.0000000000001466","article-title":"Thrombin generation profiles as predictors of symptomatic venous thromboembolism after trauma: a prospective cohort study","volume":"83","author":"Park","year":"2017","journal-title":"J. Trauma Acute Care Surg."},{"issue":"4","key":"10.1016\/j.thromres.2025.109384_bb0370","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1055\/s-0038-1636535","article-title":"Altered plasma clot properties and trauma-related venous thromboembolism despite Thromboprophylaxis","volume":"118","author":"Goldman","year":"2018","journal-title":"Thromb. Haemost."},{"issue":"11","key":"10.1016\/j.thromres.2025.109384_bb0375","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1136\/jclinpath-2018-205293","article-title":"Biomarkers for the diagnosis of venous thromboembolism: D-dimer, thrombin generation, procoagulant phospholipid and soluble P-selectin","volume":"71","author":"Riva","year":"2018","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.thromres.2025.109384_bb0380","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.thromres.2019.08.010","article-title":"Prothrombotic fibrin clot properties are associated with post-discharge venous thromboembolism in acutely ill medical patients","volume":"182","author":"W\u00f3jcik","year":"2019","journal-title":"Thromb. Res."},{"issue":"3","key":"10.1016\/j.thromres.2025.109384_bb0385","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.surg.2019.04.014","article-title":"Early versus late venous thromboembolism: a secondary analysis of data from the PROPPR trial","volume":"166","author":"Myers","year":"2019","journal-title":"Surgery"},{"key":"10.1016\/j.thromres.2025.109384_bb0390","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.thromres.2020.01.014","article-title":"Supplementation with antithrombin III ex vivo optimizes enoxaparin responses in critically injured patients","volume":"187","author":"Cardenas","year":"2020","journal-title":"Thromb. Res."},{"issue":"4","key":"10.1016\/j.thromres.2025.109384_bb0395","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/aas.13748","article-title":"Utility of coagulation analyses to assess thromboprophylaxis with dalteparin in intensive care unit patients","volume":"65","author":"Andersen","year":"2021","journal-title":"Acta Anaesthesiol. Scand."},{"issue":"8","key":"10.1016\/j.thromres.2025.109384_bb0400","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1001\/jamasurg.2022.2214","article-title":"Association of Changes in Antithrombin activity over time with responsiveness to enoxaparin prophylaxis and risk of trauma-related venous thromboembolism","volume":"157","author":"Vincent","year":"2022","journal-title":"JAMA Surg."},{"issue":"9","key":"10.1016\/j.thromres.2025.109384_bb0405","doi-asserted-by":"crossref","DOI":"10.1002\/hsr2.1558","article-title":"Comparison of coagulation parameters associated with fibrinogen concentrate and cryoprecipitate for treatment of bleeding in patients undergoing cytoreductive surgery for pseudomyxoma peritonei: subanalysis from a randomized, controlled phase 2 study","volume":"6","author":"Roy","year":"2023","journal-title":"Health Sci Rep."},{"issue":"1","key":"10.1016\/j.thromres.2025.109384_bb0410","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-28474-7","article-title":"Age-dependent thrombin generation predicts 30-day mortality and symptomatic thromboembolism after multiple trauma","volume":"13","author":"Lesbo","year":"2023","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.thromres.2025.109384_bb0415","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1046\/j.1365-2141.2001.03111.x","article-title":"Hormone replacement therapy and acquired resistance to activated protein C: results of a randomized, double-blind, placebo-controlled trial","volume":"115","author":"H\u00f8ibraaten","year":"2001","journal-title":"Br. J. Haematol."},{"issue":"5","key":"10.1016\/j.thromres.2025.109384_bb0420","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.thromres.2013.09.006","article-title":"Enhanced thrombin generation in women with a history of oral contraception-related venous thrombosis","volume":"132","author":"An\u017eej Doma","year":"2013","journal-title":"Thromb. Res."},{"issue":"1","key":"10.1016\/j.thromres.2025.109384_bb0425","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1001\/jamainternmed.2013.11074","article-title":"Lower risk of cardiovascular events in postmenopausal women taking oral estradiol compared with oral conjugated equine estrogens","volume":"174","author":"Smith","year":"2014","journal-title":"JAMA Intern. Med."},{"issue":"10","key":"10.1016\/j.thromres.2025.109384_bb0430","first-page":"572","article-title":"Unfavorably altered plasma clot properties in women with a HERDOO2 score equal to or greater than 2 and prediction of recurrent venous thromboembolism","volume":"128","author":"Mrozi\u0144ska","year":"2018","journal-title":"Pol Arch Intern Med."},{"key":"10.1016\/j.thromres.2025.109384_bb0435","first-page":"4923535","article-title":"Plasma fibrin clot properties are unfavorably altered in women following venous thromboembolism associated with combined hormonal contraception","volume":"2019","author":"Pir\u00f3g","year":"2019","journal-title":"Markers"},{"key":"10.1016\/j.thromres.2025.109384_bb0440","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.thromres.2021.09.018","article-title":"Resistance to activated protein C and impaired TFPI activity in women with previous hormone-induced venous thromboembolism","volume":"207","author":"Tchaikovski","year":"2021","journal-title":"Thromb. Res."},{"issue":"2","key":"10.1016\/j.thromres.2025.109384_bb0445","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1160\/TH04-06-0372","article-title":"Venous thromboembolism during pregnancy is not associated with persistent elevated activated protein C (APC) sensitivity ratio based on the endogenous thrombin potential","volume":"93","author":"Zotz","year":"2005","journal-title":"Thromb. Haemost."},{"issue":"8","key":"10.1016\/j.thromres.2025.109384_bb0450","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1111\/j.0001-6349.2005.00762.x","article-title":"Sensitivity to activated protein C in patients with deep vein thrombosis during early puerperium period","volume":"84","author":"Ohashi","year":"2005","journal-title":"Acta Obstet. Gynecol. Scand."},{"issue":"6","key":"10.1016\/j.thromres.2025.109384_bb0455","first-page":"1165","article-title":"Differential haemostatic risk factors for pregnancy-related deep-vein thrombosis and pulmonary embolism: a population-based case-control study","volume":"108","author":"Bergrem","year":"2012","journal-title":"Thromb. Haemost."},{"issue":"5","key":"10.1016\/j.thromres.2025.109384_bb0460","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1111\/bjh.15102","article-title":"The DiPEP (diagnosis of PE in pregnancy) biomarker study: an observational cohort study augmented with additional cases to determine the diagnostic utility of biomarkers for suspected venous thromboembolism during pregnancy and puerperium","volume":"180","author":"Hunt","year":"2018","journal-title":"Br. J. Haematol."},{"issue":"6","key":"10.1016\/j.thromres.2025.109384_bb0465","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1182\/blood.V99.6.1965","article-title":"Randomized trial of different regimens of heparins and in vivo thrombin generation in acute deep vein thrombosis","volume":"99","author":"Kakkar","year":"2002","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.thromres.2025.109384_bb0470","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.thromres.2014.11.037","article-title":"Rivaroxaban and warfarin achieve effective anticoagulation, as assessed by inhibition of TG and in-vivo markers of coagulation activation, in patients with venous thromboembolism","volume":"135","author":"Arachchillage","year":"2015","journal-title":"Thromb. Res."},{"issue":"1","key":"10.1016\/j.thromres.2025.109384_bb0475","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s11239-018-1650-1","article-title":"Erythrocyte compression index is impaired in patients with residual vein obstruction","volume":"46","author":"Zabczyk","year":"2018","journal-title":"J. Thromb. Thrombolysis"},{"key":"10.1016\/j.thromres.2025.109384_bb0480","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.thromres.2019.03.022","article-title":"Correlation of thromboelastography and thrombin generation assays in warfarin-treated patients","volume":"178","author":"Schmidt","year":"2019","journal-title":"Thromb. Res."},{"issue":"1","key":"10.1016\/j.thromres.2025.109384_bb0485","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1477-9560-3-16","article-title":"Towards a standardization of thrombin generation assessment: the influence of tissue factor, platelets and phospholipids concentration on the normal values of Thrombogram-Thrombinoscope assay","volume":"3","author":"Gerotziafas","year":"2005","journal-title":"Thromb. J."},{"issue":"8","key":"10.1016\/j.thromres.2025.109384_bb0490","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1111\/jth.14863","article-title":"Towards standardization of thrombin generation assays: inventory of thrombin generation methods based on results of an International Society of Thrombosis and Haemostasis Scientific Standardization Committee survey","volume":"18","author":"De Laat-Kremers","year":"2020","journal-title":"J. Thromb. Haemost."},{"issue":"6","key":"10.1016\/j.thromres.2025.109384_bb0495","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.thromres.2012.07.017","article-title":"Evaluation of a standardized protocol for thrombin generation measurement using the calibrated automated thrombogram: an international multicentre study","volume":"130","author":"Dargaud","year":"2012","journal-title":"Thromb. Res."},{"issue":"1","key":"10.1016\/j.thromres.2025.109384_bb0500","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/rth2.12048","article-title":"A review of commercially available thrombin generation assays","volume":"2","author":"Kintigh","year":"2017","journal-title":"Res Pract Thromb Haemost."},{"issue":"2","key":"10.1016\/j.thromres.2025.109384_bb0505","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/hae.13640","article-title":"Evaluation of a standardized protocol for thrombin generation using the calibrated automated thrombogram: a Nordic study","volume":"25","author":"Ljungkvist","year":"2019","journal-title":"Haemoph Off J World Fed Hemoph."},{"issue":"5","key":"10.1016\/j.thromres.2025.109384_bb0510","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1111\/jth.15287","article-title":"Recommendations for the measurement of thrombin generation: communication from the ISTH SSC subcommittee on lupus anticoagulant\/antiphospholipid antibodies","volume":"19","author":"Ninivaggi","year":"2021","journal-title":"J. Thromb. Haemost."}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384825001343?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384825001343?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T20:17:43Z","timestamp":1751401063000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049384825001343"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":102,"alternative-id":["S0049384825001343"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2025.109384","relation":{},"ISSN":["0049-3848"],"issn-type":[{"value":"0049-3848","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Thrombin generation assay in venous thromboembolism: A scoping review","name":"articletitle","label":"Article Title"},{"value":"Thrombosis Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.thromres.2025.109384","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109384"}}