{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T14:48:47Z","timestamp":1791125327879,"version":"4.1.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thrombosisresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.thromres.2025.109401","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T10:35:16Z","timestamp":1752575716000},"page":"109401","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Joint health in Chilean children with haemophilia on primary prophylaxis"],"prefix":"10.1016","volume":"253","author":[{"given":"Ver\u00f3nica","family":"Soto-Arellano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agustina Mar\u00eda","family":"Petracco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Cruz-Montecinos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.thromres.2025.109401_bb0005","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/201271","article-title":"Prevention of the musculoskeletal complications of hemophilia","volume":"2012","author":"Rodriguez-Merchan","year":"2012","journal-title":"Adv. Prev. Med."},{"key":"10.1016\/j.thromres.2025.109401_bb0010","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1586\/ehm.12.27","article-title":"Management of joint bleeding in hemophilia","volume":"5","author":"Simpson","year":"2012","journal-title":"Expert Rev. Hematol."},{"key":"10.1016\/j.thromres.2025.109401_bb0015","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/hae.12006","article-title":"Orthopaedic co-morbidities in the elderly haemophilia population: a review","volume":"19","author":"Stephensen","year":"2013","journal-title":"Haemophilia"},{"issue":"Suppl. 6","key":"10.1016\/j.thromres.2025.109401_bb0020","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/hae.13449","article-title":"Joint disease in haemophilia: pathophysiology, pain and imaging","volume":"24","author":"van Vulpen","year":"2018","journal-title":"Haemophilia"},{"key":"10.1016\/j.thromres.2025.109401_bb0025","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1111\/j.1538-7836.2010.03962.x","article-title":"Blood-induced joint disease: the pathophysiology of hemophilic arthropathy","volume":"8","author":"Valentino","year":"2010","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2025.109401_bb0030","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1055\/s-0035-1564445","article-title":"Blood-induced arthropathy in hemophilia: mechanisms and heterogeneity","volume":"41","author":"Blobel","year":"2015","journal-title":"Semin. Thromb. Hemost."},{"issue":"Suppl. 6","key":"10.1016\/j.thromres.2025.109401_bb0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/hae.14046","article-title":"WFH guidelines for the management of hemophilia, 3rd edition","volume":"26","author":"Srivastava","year":"2020","journal-title":"Haemophilia"},{"key":"10.1016\/j.thromres.2025.109401_bb0040","doi-asserted-by":"crossref","DOI":"10.3390\/ph17070835","article-title":"Changes in quality of life, adherence, and Kinesiophobia in patients with hemophilia treated with extended half-life treatment: final results of the LongHest project","volume":"17","author":"Ucero-Lozano","year":"2024","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.thromres.2025.109401_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.thromres.2025.109306","article-title":"FVIII half-life products: a real-world experience","volume":"249","author":"Zanon","year":"2025","journal-title":"Thromb. Res."},{"key":"10.1016\/j.thromres.2025.109401_bb0050","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1111\/bjh.16704","article-title":"Guidelines on the use of prophylactic factor replacement for children and adults with haemophilia a and b","volume":"190","author":"Rayment","year":"2020","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.thromres.2025.109401_bb0055","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1002\/rth2.12202","article-title":"Impact of prophylaxis on health-related quality of life of boys with hemophilia: an analysis of pooled data from 9 countries","volume":"3","author":"Usuba","year":"2019","journal-title":"Res Pract Thromb Haemost"},{"key":"10.1016\/j.thromres.2025.109401_bb0060","doi-asserted-by":"crossref","DOI":"10.2147\/PPA.S139851","article-title":"Treatment adherence in hemophilia","volume":"11","author":"Thornburg","year":"2017","journal-title":"Patient Prefer. Adherence"},{"key":"10.1016\/j.thromres.2025.109401_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.blre.2021.100852","article-title":"Optimising prophylaxis in haemophilia a: the ups and downs of treatment","volume":"50","author":"Berntorp","year":"2021","journal-title":"Blood Rev."},{"key":"10.1016\/j.thromres.2025.109401_bb0070","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1046\/j.1365-2516.2003.00702.x","article-title":"Value of magnetic resonance imaging for the diagnosis and follow-up of haemophilic arthropathy","volume":"9","author":"Dob\u00f3n","year":"2003","journal-title":"Haemophilia"},{"key":"10.1016\/j.thromres.2025.109401_bb0075","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1053\/j.sult.2013.05.007","article-title":"Hemophilic arthropathy: a review of imaging and staging","volume":"34","author":"Cross","year":"2013","journal-title":"Semin. Ultrasound CT MR"},{"key":"10.1016\/j.thromres.2025.109401_bb0080","doi-asserted-by":"crossref","first-page":"e51","DOI":"10.1111\/hae.12268","article-title":"Comparison of ultrasound and magnetic resonance imaging for diagnosis and follow-up of joint lesions in patients with haemophilia","volume":"20","author":"Sierra Aisa","year":"2014","journal-title":"Haemophilia"},{"key":"10.1016\/j.thromres.2025.109401_bb0085","doi-asserted-by":"crossref","first-page":"e215","DOI":"10.1111\/j.1365-2516.2011.02680.x","article-title":"The role of ultrasonography in the diagnosis of the musculo-skeletal problems of haemophilia","volume":"18","author":"Querol","year":"2012","journal-title":"Haemophilia"},{"key":"10.1016\/j.thromres.2025.109401_bb0090","first-page":"e167","article-title":"Magnetic resonance imaging and ultrasound evaluation of \u201chealthy\u201d joints in young subjects with severe haemophilia a","volume":"19","author":"Iervolino","year":"2013","journal-title":"Haemophilia"},{"key":"10.1016\/j.thromres.2025.109401_bb0095","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1160\/TH12-11-0874","article-title":"Development and definition of a simplified scanning procedure and scoring method for Haemophilia early arthropathy detection with ultrasound (HEAD-US)","volume":"109","author":"Martinoli","year":"2013","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.thromres.2025.109401_bb0100","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.thromres.2023.04.012","article-title":"The hidden joint in children with haemophilia on prophylaxis","volume":"226","author":"Daffunchio","year":"2023","journal-title":"Thromb. Res."},{"key":"10.1016\/j.thromres.2025.109401_bb0105","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/hae.14243","article-title":"Functional and joint evaluation in a prospective cohort of patients with severe haemophilia","volume":"27","author":"Ribeiro","year":"2021","journal-title":"Haemophilia"},{"key":"10.1016\/j.thromres.2025.109401_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.rpth.2022.100005","article-title":"Long-term impact of primary prophylaxis on joint status in patients with severe hemophilia A","volume":"7","author":"Meij\u00f3n Ortigueira","year":"2023","journal-title":"Res. Pract. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2025.109401_bb0115","doi-asserted-by":"crossref","first-page":"3541","DOI":"10.1182\/blood.V126.23.3541.3541","article-title":"Standardized ultrasonography (HEAD-US) of joints and first correlation with function in Haemophilic Arthropathy: results of a clinical trial and potential importance of joint-ultrasound for an individualized prophylaxis in haemophiliacs","volume":"126","author":"Sigl-Kraetzig","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.thromres.2025.109401_bb0120","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/j.1365-2516.2006.01202.x","article-title":"Current co-ordinated activities of the PEDNET (European paediatric network for haemophilia management)","volume":"12","author":"Donadel-Claeyssens","year":"2006","journal-title":"Haemophilia"},{"key":"10.1016\/j.thromres.2025.109401_bb0125","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1080\/17474086.2018.1435269","article-title":"The value of HEAD-US system in detecting subclinical abnormalities in joints of patients with hemophilia","volume":"11","author":"De la Corte-Rodriguez","year":"2018","journal-title":"Expert Rev. Hematol."},{"key":"10.1016\/j.thromres.2025.109401_bb0130","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1055\/s-0036-1579640","article-title":"Assessment of hemophilic arthropathy by ultrasound: where do we stand?","volume":"42","author":"Di Minno","year":"2016","journal-title":"Semin. Thromb. Hemost."},{"key":"10.1016\/j.thromres.2025.109401_bb0135","doi-asserted-by":"crossref","first-page":"e311","DOI":"10.1111\/hae.12935","article-title":"Defining adherence to prophylaxis in haemophilia","volume":"22","author":"Schrijvers","year":"2016","journal-title":"Haemophilia"},{"key":"10.1016\/j.thromres.2025.109401_bb0140","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1365-2516.2009.02129.x","article-title":"VERITAS-pro: a new measure of adherence to prophylactic regimens in haemophilia","volume":"16","author":"Duncan","year":"2010","journal-title":"Haemophilia"},{"key":"10.1016\/j.thromres.2025.109401_bb0145","doi-asserted-by":"crossref","first-page":"e367","DOI":"10.1111\/hae.13003","article-title":"Adherence to prophylactic treatment in patients with haemophilia in Germany","volume":"22","author":"Miesbach","year":"2016","journal-title":"Haemophilia"},{"key":"10.1016\/j.thromres.2025.109401_bb0150","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1111\/j.1365-2516.2008.01843.x","article-title":"A survey of adherence to haemophilia therapy in six European countries: results and recommendations","volume":"14","author":"De Moerloose","year":"2008","journal-title":"Haemophilia"},{"key":"10.1016\/j.thromres.2025.109401_bb0155","first-page":"647","article-title":"Health care costs and resource use of managing hemophilia a: a targeted literature review","volume":"29","author":"Chen","year":"2023","journal-title":"J. Manag. Care Spec. Pharm."},{"key":"10.1016\/j.thromres.2025.109401_bb0160","doi-asserted-by":"crossref","DOI":"10.1007\/s10237-024-01857-z","article-title":"Incorporating pathological gait into patient-specific finite element models of the haemophilic ankle","author":"Talbott","year":"2024","journal-title":"Biomech. Model. Mechanobiol."},{"key":"10.1016\/j.thromres.2025.109401_bb0165","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1111\/hae.14312","article-title":"Clinical and ultrasound evaluation of patients with haemophilia on prophylaxis","volume":"27","author":"Daffunchio","year":"2021","journal-title":"Haemophilia"},{"key":"10.1016\/j.thromres.2025.109401_bb0170","first-page":"314","article-title":"Achieving and maintaining an optimal trough level for prophylaxis in haemophilia: the past, the present and the future","volume":"12","author":"Jim\u00e9nez-Yuste","year":"2014","journal-title":"Blood Transfus."},{"key":"10.1016\/j.thromres.2025.109401_bb0175","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1111\/bjh.14072","article-title":"Adherence to prophylaxis and bleeding outcome in haemophilia: a multicentre study","volume":"174","author":"Schrijvers","year":"2016","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.thromres.2025.109401_bb0180","doi-asserted-by":"crossref","first-page":"e245","DOI":"10.1111\/hae.12951","article-title":"Predictors of non-adherence to prescribed prophylactic clotting-factor treatment regimens among adolescent and young adults with a bleeding disorder","volume":"22","author":"Witkop","year":"2016","journal-title":"Haemophilia"},{"key":"10.1016\/j.thromres.2025.109401_bb0185","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/hae.12079","article-title":"Barriers and motivators of adherence to prophylactic treatment in haemophilia: a systematic review","volume":"19","author":"Schrijvers","year":"2013","journal-title":"Haemophilia"},{"key":"10.1016\/j.thromres.2025.109401_bb0190","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1016\/j.jtha.2023.01.035","article-title":"Magnetic resonance imaging evidence for subclinical joint bleeding in a Dutch population of people with severe hemophilia on prophylaxis","volume":"21","author":"van Leeuwen","year":"2023","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2025.109401_bb0195","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1080\/17474086.2023.2232547","article-title":"Hemophilic arthropathy: how to diagnose subclinical bleeding early and how to orthopedically treat a damaged joint","volume":"16","author":"Rodriguez-Merchan","year":"2023","journal-title":"Expert Rev. Hematol."},{"key":"10.1016\/j.thromres.2025.109401_bb0200","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0248952","article-title":"Correlation between hemophilia early Arthropathy detection with ultrasound (HEAD-US) score and hemophilia joint health score (HJHS) in patients with hemophilic arthropathy","volume":"16","author":"Prasetyo","year":"2021","journal-title":"PloS One"},{"key":"10.1016\/j.thromres.2025.109401_bb0205","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1111\/hae.14861","article-title":"Subclinical synovial proliferation in patients with severe haemophilia a: the value of ultrasound screening and biochemical markers","volume":"29","author":"van Bergen","year":"2023","journal-title":"Haemophilia"},{"key":"10.1016\/j.thromres.2025.109401_bb0210","doi-asserted-by":"crossref","first-page":"12967","DOI":"10.1038\/s41598-021-92245-5","article-title":"Bleeding outcomes and factor utilization after switching to an extended half-life product for prophylaxis in haemophilia a in Austria","volume":"11","author":"Ay","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.thromres.2025.109401_bb0215","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/hae.14960","volume":"30","author":"Matino","year":"2024","journal-title":"Haemophilia"},{"key":"10.1016\/j.thromres.2025.109401_bb0220","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1007\/s11136-018-1792-9","article-title":"The impact of extended half-life versus conventional factor product on hemophilia caregiver burden","volume":"27","author":"Schwartz","year":"2018","journal-title":"Qual. Life Res."},{"key":"10.1016\/j.thromres.2025.109401_bb0225","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1111\/hae.15030","article-title":"Assessing joint health in haemophilia patients: the combined value of physical examination and ultrasound imaging","volume":"30","author":"Gualtierotti","year":"2024","journal-title":"Haemophilia"}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384825001513?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384825001513?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T15:29:36Z","timestamp":1761406176000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049384825001513"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":45,"alternative-id":["S0049384825001513"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2025.109401","relation":{},"ISSN":["0049-3848"],"issn-type":[{"value":"0049-3848","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Joint health in Chilean children with haemophilia on primary prophylaxis","name":"articletitle","label":"Article Title"},{"value":"Thrombosis Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.thromres.2025.109401","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109401"}}