{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:15:41Z","timestamp":1792192541637,"version":"4.4.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T00:00:00Z","timestamp":1757203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP23K09713"],"award-info":[{"award-number":["JP23K09713"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thrombosisresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.thromres.2025.109455","type":"journal-article","created":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T14:22:10Z","timestamp":1757254930000},"page":"109455","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Incidence and risk factors for ischemic stroke in patients with cancer: A retrospective observational study"],"prefix":"10.1016","volume":"254","author":[{"given":"Hiroaki","family":"Terada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoto","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasufumi","family":"Gon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Kawano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaya","family":"Kitano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junji","family":"Takasugi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Kanki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayo","family":"Komatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuhisa","family":"Kitamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10203","key":"10.1016\/j.thromres.2025.109455_bb0005","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/S0140-6736(19)31674-5","article-title":"Medium and long-term risks of specific cardiovascular diseases in survivors of 20 adult cancers: a population-based cohort study using multiple linked UK electronic health records databases","volume":"394","author":"Strongman","year":"2019","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.thromres.2025.109455_bb0010","doi-asserted-by":"crossref","first-page":"e513","DOI":"10.1212\/WNL.0000000000011264","article-title":"Risk of stroke in cancer survivors: a meta-analysis of population-based cohort studies","volume":"96","author":"Zhang","year":"2021","journal-title":"Neurology"},{"key":"10.1016\/j.thromres.2025.109455_bb0015","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.thromres.2023.01.002","article-title":"Impact of stroke on survival in patients with cancer","volume":"222","author":"Gon","year":"2023","journal-title":"Thromb. Res."},{"key":"10.1016\/j.thromres.2025.109455_bb0020","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.thromres.2024.03.019","article-title":"Cancer patients and ischemic stroke","volume":"237","author":"Kawano","year":"2024","journal-title":"Thromb. Res."},{"issue":"8","key":"10.1016\/j.thromres.2025.109455_bb0025","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.jacc.2017.06.047","article-title":"Risk of arterial thromboembolism in patients with cancer","volume":"70","author":"Navi","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"issue":"2","key":"10.1016\/j.thromres.2025.109455_bb0030","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jaccao.2021.02.007","article-title":"Arterial thromboembolism in cancer patients: a Danish population-based cohort study","volume":"3","author":"Mulder","year":"2021","journal-title":"JACC CardioOncol."},{"issue":"2","key":"10.1016\/j.thromres.2025.109455_bb0035","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.jaccao.2024.01.006","article-title":"Arterial thromboembolism in Japanese patients with cancer: incidence, predictors, and survival impact","volume":"6","author":"Gon","year":"2024","journal-title":"JACC Cardiooncol."},{"issue":"9","key":"10.1016\/j.thromres.2025.109455_bb0040","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.3324\/haematol.2018.192419","article-title":"Frequency, risk factors, and impact on mortality of arterial thromboembolism in patients with cancer","volume":"103","author":"Grilz","year":"2018","journal-title":"Haematologica"},{"issue":"1","key":"10.1016\/j.thromres.2025.109455_bb0045","doi-asserted-by":"crossref","first-page":"5172","DOI":"10.1038\/s41467-019-13120-6","article-title":"Stroke among cancer patients","volume":"10","author":"Zaorsky","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.thromres.2025.109455_bb0050","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.thromres.2023.01.005","article-title":"Stroke mortality in cancer survivors: a population-based study in Japan","volume":"222","author":"Gon","year":"2023","journal-title":"Thromb. Res."},{"issue":"3","key":"10.1016\/j.thromres.2025.109455_bb0055","doi-asserted-by":"crossref","first-page":"147","DOI":"10.2188\/jea.JE20240230","article-title":"Non-cancer-related deaths in cancer survivors: a nationwide population-based study in Japan","volume":"35","author":"Gon","year":"2025","journal-title":"J. Epidemiol."},{"issue":"10","key":"10.1016\/j.thromres.2025.109455_bb0060","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.124.037965","article-title":"Specific cardiovascular mortality in cancer survivors: a nationwide population-based cohort study in Japan","volume":"14","author":"Gon","year":"2025","journal-title":"J. Am. Heart Assoc."},{"issue":"11","key":"10.1016\/j.thromres.2025.109455_bb0065","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1161\/CIRCULATIONAHA.115.020406","article-title":"Shared risk factors in cardiovascular disease and cancer","volume":"133","author":"Koene","year":"2016","journal-title":"Circulation"},{"issue":"11","key":"10.1016\/j.thromres.2025.109455_bb0070","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1016\/j.mayocp.2022.09.003","article-title":"Ischemic stroke in patients with malignancy","volume":"97","author":"Sener","year":"2022","journal-title":"Mayo Clin. Proc."},{"issue":"1","key":"10.1016\/j.thromres.2025.109455_bb0075","first-page":"1039","article-title":"Stroke and cancer\u2014a complicated relationship","volume":"2","author":"Dearborn","year":"2014","journal-title":"J. Neurol. Transl. Neurosci."},{"key":"10.1016\/j.thromres.2025.109455_bb0080","series-title":"TNM Classification of Malignant Tumours","year":"2017"},{"issue":"1","key":"10.1016\/j.thromres.2025.109455_bb0085","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/s12911-017-0554-x","article-title":"Validation of an algorithm that determines stroke diagnostic code accuracy in a Japanese hospital-based cancer registry using electronic medical records","volume":"17","author":"Gon","year":"2017","journal-title":"BMC Med. Inform. Decis. Mak."},{"key":"10.1016\/j.thromres.2025.109455_bb0090","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1080\/01621459.1999.10474144","article-title":"A proportional hazard model for the subdistribution of a competing risk","volume":"94","author":"Fine","year":"1999","journal-title":"J. Am. Stat. Assoc."},{"issue":"10","key":"10.1016\/j.thromres.2025.109455_bb0095","doi-asserted-by":"crossref","first-page":"4902","DOI":"10.1182\/blood-2007-10-116327","article-title":"Development and validation of a predictive model for chemotherapy-associated thrombosis","volume":"111","author":"Khorana","year":"2008","journal-title":"Blood"},{"issue":"12","key":"10.1016\/j.thromres.2025.109455_bb0100","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1161\/STROKEAHA.123.044910","article-title":"Coagulation factor expression and composition of arterial thrombi in cancer-associated stroke","volume":"54","author":"Yoo","year":"2023","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.thromres.2025.109455_bb0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5853\/jos.2019.02278","article-title":"Cancer-related stroke: an emerging subtype of ischemic stroke with unique pathomechanisms","volume":"22","author":"Bang","year":"2020","journal-title":"J. Stroke"},{"issue":"15","key":"10.1016\/j.thromres.2025.109455_bb0110","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.123.029618","article-title":"Predictors of survival in patients with ischemic stroke and active cancer: a prospective, multicenter, observational study","volume":"12","author":"Gon","year":"2023","journal-title":"J. Am. Heart Assoc."},{"issue":"4","key":"10.1016\/j.thromres.2025.109455_bb0115","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1002\/acn3.291","article-title":"Characteristics of cryptogenic stroke in cancer patients","volume":"3","author":"Gon","year":"2016","journal-title":"Ann. Clin. Transl. Neurol."},{"issue":"6","key":"10.1016\/j.thromres.2025.109455_bb0120","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1182\/blood-2006-10-053736","article-title":"Trousseau\u2019s syndrome: multiple definitions and multiple mechanisms","volume":"110","author":"Varki","year":"2007","journal-title":"Blood"},{"issue":"7203","key":"10.1016\/j.thromres.2025.109455_bb0125","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nature07205","article-title":"Cancer-related inflammation","volume":"454","author":"Mantovani","year":"2008","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.thromres.2025.109455_bb0130","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1055\/s-0040-1708484","article-title":"The effect of chemotherapy on stroke risk in cancer patients","volume":"120","author":"Kitano","year":"2020","journal-title":"Thromb. Haemost."},{"issue":"1","key":"10.1016\/j.thromres.2025.109455_bb0135","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.juro.2015.08.088","article-title":"Risk of vascular toxicity with platinum based chemotherapy in elderly patients with bladder cancer","volume":"195","author":"Gupta","year":"2016","journal-title":"J. Urol."},{"issue":"4","key":"10.1016\/j.thromres.2025.109455_bb0140","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1161\/ATVBAHA.120.314378","article-title":"Cancer therapy-associated thrombosis","volume":"41","author":"Grover","year":"2021","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"1","key":"10.1016\/j.thromres.2025.109455_bb0145","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1097\/01.moh.0000190107.54790.de","article-title":"Leukocyte adhesion and thrombosis","volume":"13","author":"Afshar-Kharghan","year":"2006","journal-title":"Curr. Opin. Hematol."},{"issue":"8","key":"10.1016\/j.thromres.2025.109455_bb0150","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1182\/blood-2008-04-153783","article-title":"Thrombocytosis and leukocytosis interaction in vascular complications of essential thrombocythemia","volume":"112","author":"Carobbio","year":"2008","journal-title":"Blood"},{"issue":"12","key":"10.1016\/j.thromres.2025.109455_bb0155","doi-asserted-by":"crossref","first-page":"2556","DOI":"10.3390\/jcm10122556","article-title":"Anemia is a risk factor for the development of ischemic stroke and post-stroke mortality","volume":"10","author":"Heo","year":"2021","journal-title":"J. Clin. Med."}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384825002051?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384825002051?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T09:38:30Z","timestamp":1762249110000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049384825002051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":31,"alternative-id":["S0049384825002051"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2025.109455","relation":{},"ISSN":["0049-3848"],"issn-type":[{"value":"0049-3848","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Incidence and risk factors for ischemic stroke in patients with cancer: A retrospective observational study","name":"articletitle","label":"Article Title"},{"value":"Thrombosis Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.thromres.2025.109455","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"109455"}}