{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T00:10:13Z","timestamp":1760746213880,"version":"build-2065373602"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thrombosisresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.thromres.2025.109484","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T20:08:03Z","timestamp":1758571683000},"page":"109484","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Safety and effectiveness of statins in hospitalized patients with COVID-19: Systematic review and collaborative meta-analysis of randomized controlled trials"],"prefix":"10.1016","volume":"255","author":[{"given":"Luis","family":"Ortega-Paz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azita H.","family":"Talasaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parham","family":"Sadeghipour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sina","family":"Rashedi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean M.","family":"Connors","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominick J.","family":"Angiolillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larisa H.","family":"Cavallari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Jimenez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Bastidas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Lorenzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsay R.","family":"Berry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Hills","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel Francis","family":"McAuley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tayyab","family":"Shah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra J.","family":"Lansky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siddharthan","family":"Deepti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hernando Guillermo","family":"Gait\u00e1n-Duarte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatjana S.","family":"Potpara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mattia","family":"Galli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dave L.","family":"Dixon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory","family":"Piazza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory Y.H.","family":"Lip","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roxana","family":"Mehran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Libby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harlan M.","family":"Krumholz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Behnood","family":"Bikdeli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"23","key":"10.1016\/j.thromres.2025.109484_bb0005","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.1016\/j.jacc.2020.04.031","article-title":"COVID-19 and thrombotic or thromboembolic disease: implications for prevention, antithrombotic therapy, and follow-up: JACC state-of-the-art review","volume":"75","author":"Bikdeli","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"issue":"16","key":"10.1016\/j.thromres.2025.109484_bb0010","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1016\/j.jacc.2021.08.021","article-title":"Investigating lipid-modulating agents for prevention or treatment of COVID-19: JACC state-of-the-art review","volume":"78","author":"Talasaz","year":"2021","journal-title":"J. Am. Coll. Cardiol."},{"issue":"3","key":"10.1016\/j.thromres.2025.109484_bb0015","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.jacc.2022.10.030","article-title":"Pcsk9 inhibition during the inflammatory stage of SARS-CoV-2 infection","volume":"81","author":"Navarese","year":"2023","journal-title":"J. Am. Coll. Cardiol."},{"issue":"1","key":"10.1016\/j.thromres.2025.109484_bb0020","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1161\/CIRCRESAHA.116.308537","article-title":"Pleiotropic effects of statins on the cardiovascular system","volume":"120","author":"Oesterle","year":"2017","journal-title":"Circ. Res."},{"key":"10.1016\/j.thromres.2025.109484_bb0025","article-title":"Effect of lipid-lowering therapy on platelet reactivity in patients treated with and without antiplatelet therapy","author":"Giordano","year":"2023","journal-title":"Minerva Cardiol. Angiol."},{"issue":"3","key":"10.1016\/j.thromres.2025.109484_bb0030","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.019650","article-title":"Coronavirus disease 2019-associated thrombosis and coagulopathy: review of the pathophysiological characteristics and implications for antithrombotic management","volume":"10","author":"Ortega-Paz","year":"2021","journal-title":"J. Am. Heart Assoc."},{"issue":"12","key":"10.1016\/j.thromres.2025.109484_bb0035","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0279333","article-title":"One-year cardiovascular outcomes after coronavirus disease 2019: the cardiovascular COVID-19 registry","volume":"17","author":"Ortega-Paz","year":"2022","journal-title":"PLoS One"},{"issue":"18","key":"10.1016\/j.thromres.2025.109484_bb0040","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1056\/NEJMoa1403285","article-title":"Simvastatin in the acute respiratory distress syndrome","volume":"371","author":"McAuley","year":"2014","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.thromres.2025.109484_bb0045","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.1161\/ATV.0000000000000073","article-title":"Statin safety and associated adverse events: a scientific statement from the American Heart Association","volume":"39","author":"Newman","year":"2019","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.thromres.2025.109484_bb0050","article-title":"Atorvastatin versus placebo in patients with covid-19 in intensive care: randomized controlled trial","volume":"376","author":"Investigators","year":"2022","journal-title":"Bmj"},{"issue":"7","key":"10.1016\/j.thromres.2025.109484_bb0055","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1055\/a-2059-4844","article-title":"Atorvastatin versus placebo in ICU patients with COVID-19: ninety-day results of the INSPIRATION-S trial","volume":"123","author":"Talasaz","year":"2023","journal-title":"Thromb. Haemost."},{"issue":"25","key":"10.1016\/j.thromres.2025.109484_bb0060","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1056\/NEJMoa2309995","article-title":"Simvastatin in critically ill patients with Covid-19","volume":"389","author":"Investigators","year":"2023","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.thromres.2025.109484_bb0065","doi-asserted-by":"crossref","DOI":"10.1186\/2046-4053-4-1","article-title":"Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement","volume":"4","author":"Moher","year":"2015","journal-title":"Syst. Rev."},{"issue":"6982","key":"10.1016\/j.thromres.2025.109484_bb0070","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1136\/bmj.310.6982.751","article-title":"Magnesium in acute myocardial infarction","volume":"310","author":"Yusuf","year":"1995","journal-title":"Bmj"},{"issue":"13","key":"10.1016\/j.thromres.2025.109484_bb0075","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1001\/jama.2020.17023","article-title":"Association between administration of systemic corticosteroids and mortality among critically ill patients with COVID-19: a meta-analysis","volume":"324","author":"Group WHOREAfC-TW","year":"2020","journal-title":"JAMA"},{"issue":"10","key":"10.1016\/j.thromres.2025.109484_bb0080","article-title":"Prophylactic anticoagulants for people hospitalised with COVID-19","volume":"10","author":"Flumignan","year":"2020","journal-title":"Cochrane Database Syst. Rev."},{"issue":"7","key":"10.1016\/j.thromres.2025.109484_bb0085","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1093\/ehjcvp\/pvab070","article-title":"Safety and efficacy of different prophylactic anticoagulation dosing regimens in critically and non-critically ill patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials","volume":"8","author":"Ortega-Paz","year":"2022","journal-title":"Eur. Heart J. Cardiovasc. Pharmacother."},{"issue":"2","key":"10.1016\/j.thromres.2025.109484_bb0090","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/jrsm.12","article-title":"A basic introduction to fixed-effect and random-effects models for meta-analysis","volume":"1","author":"Borenstein","year":"2010","journal-title":"Res. Synth. Methods"},{"issue":"oct18 2","key":"10.1016\/j.thromres.2025.109484_bb0095","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.d5928","article-title":"The Cochrane collaboration\u2019s tool for assessing risk of bias in randomised trials","volume":"343","author":"Higgins","year":"2011","journal-title":"Bmj"},{"issue":"7650","key":"10.1016\/j.thromres.2025.109484_bb0100","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1136\/bmj.39489.470347.AD","article-title":"GRADE: an emerging consensus on rating quality of evidence and strength of recommendations","volume":"336","author":"Guyatt","year":"2008","journal-title":"BMJ"},{"issue":"2","key":"10.1016\/j.thromres.2025.109484_bb0105","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.cegh.2018.05.005","article-title":"Interpretation of subgroup analyses in systematic reviews: a tutorial","volume":"7","author":"Richardson","year":"2019","journal-title":"Clin. Epidemiol. Glob. Health."},{"issue":"1","key":"10.1016\/j.thromres.2025.109484_bb0110","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1186\/s12879-022-07570-5","article-title":"Statin and aspirin as adjuvant therapy in hospitalised patients with SARS-CoV-2 infection: a randomised clinical trial (RESIST trial)","volume":"22","author":"Ghati","year":"2022","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.thromres.2025.109484_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2021.101242","article-title":"Effectiveness of rosuvastatin plus colchicine, emtricitabine\/tenofovir and combinations thereof in hospitalized patients with COVID-19: a pragmatic, open-label randomized trial","volume":"43","author":"Gaitan-Duarte","year":"2022","journal-title":"EClinicalMedicine"},{"issue":"2","key":"10.1016\/j.thromres.2025.109484_bb0120","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2022-067910","article-title":"Colchicine and high-intensity rosuvastatin in the treatment of non-critically ill patients hospitalised with COVID-19: a randomised clinical trial","volume":"13","author":"Shah","year":"2023","journal-title":"BMJ Open"},{"issue":"1","key":"10.1016\/j.thromres.2025.109484_bb0125","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-21553-1","article-title":"Association between antecedent statin use and decreased mortality in hospitalized patients with COVID-19","volume":"12","author":"Gupta","year":"2021","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.thromres.2025.109484_bb0130","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1056\/NEJMoa2021436","article-title":"Dexamethasone in hospitalized patients with Covid-19","volume":"384","author":"Group","year":"2021","journal-title":"N. Engl. J. Med."},{"issue":"6","key":"10.1016\/j.thromres.2025.109484_bb0135","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1001\/jama.2021.11330","article-title":"Association between administration of IL-6 antagonists and mortality among patients hospitalized for COVID-19: a meta-analysis","volume":"326","author":"Group WHOREAfC-TW","year":"2021","journal-title":"Jama"},{"issue":"10349","key":"10.1016\/j.thromres.2025.109484_bb0140","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0140-6736(22)01109-6","article-title":"Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis","volume":"400","author":"Group","year":"2022","journal-title":"Lancet"},{"issue":"8","key":"10.1016\/j.thromres.2025.109484_bb0145","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1055\/s-0042-1757634","article-title":"COVID-19-associated pulmonary embolism: review of the pathophysiology, epidemiology, prevention, diagnosis, and treatment","volume":"49","author":"Ortega-Paz","year":"2023","journal-title":"Semin. Thromb. Hemost."},{"issue":"1","key":"10.1016\/j.thromres.2025.109484_bb0150","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/s13054-023-04387-9","article-title":"Effect of total cholesterol and statin therapy on mortality in ARDS patients: a secondary analysis of the SAILS and HARP-2 trials","volume":"27","author":"Pienkos","year":"2023","journal-title":"Crit. Care"},{"issue":"2","key":"10.1016\/j.thromres.2025.109484_bb0155","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1055\/a-1956-9641","article-title":"Knowledge gaps for prophylactic use of antithrombotic agents in patients with COVID-19: insights into new SARS-CoV-2 variants, vaccination status, and emerging Oral antivirals","volume":"123","author":"Talasaz","year":"2023","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.thromres.2025.109484_bb0160","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.thromres.2023.05.019","article-title":"Major cardiovascular events after COVID-19, event rates post-vaccination, antiviral or anti-inflammatory therapy, and temporal trends: rationale and methodology of the CORONA-VTE-network study","volume":"228","author":"Bikdeli","year":"2023","journal-title":"Thromb. Res."},{"key":"10.1016\/j.thromres.2025.109484_bb0165","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.48175","article-title":"Ten common statistical mistakes to watch out for when writing or reviewing a manuscript","volume":"8","author":"Makin","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.thromres.2025.109484_bb0180","unstructured":"Health NIo. COVID-19 Ttreatment Gguidelines Ppanel: Coronavirus diseases 2019 (COVID-19) treatment guidelines. 2023."},{"issue":"7","key":"10.1016\/j.thromres.2025.109484_bb0185","doi-asserted-by":"crossref","first-page":"e250","DOI":"10.1093\/cid\/ciac724","article-title":"Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients With COVID-19 (September 2022)","volume":"78","author":"Bhimraj","year":"2024","journal-title":"Clin. Infect. Dis."},{"year":"2021","series-title":"Living Guidance for Clinical Management of COVID-19: Living Guidance, 23 November 2021","author":"Organization WH","key":"10.1016\/j.thromres.2025.109484_bb0190"}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384825002348?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384825002348?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T04:48:35Z","timestamp":1760676515000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049384825002348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":36,"alternative-id":["S0049384825002348"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2025.109484","relation":{},"ISSN":["0049-3848"],"issn-type":[{"type":"print","value":"0049-3848"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Safety and effectiveness of statins in hospitalized patients with COVID-19: Systematic review and collaborative meta-analysis of randomized controlled trials","name":"articletitle","label":"Article Title"},{"value":"Thrombosis Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.thromres.2025.109484","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"109484"}}