{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T04:03:20Z","timestamp":1762229000888,"version":"build-2065373602"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100018576","name":"Ten Thousand Talent Plans for Young Top-notch Talents of Yunnan Province","doi-asserted-by":"publisher","award":["425Z2P12D"],"award-info":[{"award-number":["425Z2P12D"]}],"id":[{"id":"10.13039\/501100018576","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017501","name":"Science Health Joint Medical Scientific Research Project of Chongqing","doi-asserted-by":"publisher","award":["2024MSXM177"],"award-info":[{"award-number":["2024MSXM177"]}],"id":[{"id":"10.13039\/100017501","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thrombosisresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.thromres.2025.109498","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T20:08:09Z","timestamp":1758571689000},"page":"109498","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Linezolid impair proplatelet formation by reducing mitochondrial energy metabolism in MEG-01 cells"],"prefix":"10.1016","volume":"255","author":[{"given":"Ya","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lirong","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peishu","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanping","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shenglin","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengjun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peiyuan","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"Suppl. 4","key":"10.1016\/j.thromres.2025.109498_bb0005","first-page":"iv7","article-title":"Linezolid pharmacokinetics and pharmacodynamics in clinical treatment","volume":"66","author":"Dryden","year":"2011","journal-title":"J. Antimicrob. Chemother."},{"issue":"2","key":"10.1016\/j.thromres.2025.109498_bb0010","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1086\/345744","article-title":"Linezolid for the treatment of multidrug-resistant, Gram-positive infections: experience from a compassionate-use program","volume":"36","author":"Birmingham","year":"2003","journal-title":"Clin. Infect. Dis."},{"issue":"21","key":"10.1016\/j.thromres.2025.109498_bb0015","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1056\/NEJM200511243532123","article-title":"Mitochondrial toxicity associated with linezolid","volume":"353","author":"Soriano","year":"2005","journal-title":"N. Engl. J. Med."},{"issue":"7","key":"10.1016\/j.thromres.2025.109498_bb0020","doi-asserted-by":"crossref","first-page":"553","DOI":"10.2174\/1389200216666151001121004","article-title":"Linezolid induced adverse drug reactions \u2014 an update","volume":"16","author":"Kishor","year":"2015","journal-title":"Curr. Drug Metab."},{"issue":"4","key":"10.1016\/j.thromres.2025.109498_bb0025","first-page":"1649","article-title":"Linezolid vs vancomycin in induced thrombocytopenia","volume":"11","author":"Al-Harbi","year":"2022","journal-title":"Infect. Dis. Ther."},{"issue":"4","key":"10.1016\/j.thromres.2025.109498_bb0030","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1007\/s15010-024-02269-y","article-title":"Use of oxazolidinones (linezolid or tedizolid) for the treatment of breast infections. A case series from a tertiary referral hospital","volume":"52","author":"Kirkegaard","year":"2024","journal-title":"Infection"},{"issue":"10","key":"10.1016\/j.thromres.2025.109498_bb0035","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1007\/s00228-023-03542-z","article-title":"Risk factors for thrombocytopenia in patients receiving linezolid therapy: a systematic review and meta-analysis","volume":"79","author":"Zhang","year":"2023","journal-title":"Eur. J. Clin. Pharmacol."},{"issue":"1","key":"10.1016\/j.thromres.2025.109498_bb0040","doi-asserted-by":"crossref","DOI":"10.1186\/s40360-025-00874-7","article-title":"Development and validation of a nomogram to predict linezolid-induced thrombocytopenia in hospitalized adults","volume":"26","author":"Yang","year":"2025","journal-title":"BMC Pharmacol. Toxicol."},{"issue":"8","key":"10.1016\/j.thromres.2025.109498_bb0045","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1111\/j.1538-7836.2005.01426.x","article-title":"Mechanisms of thrombopoiesis","volume":"3","author":"Schulze","year":"2005","journal-title":"J. Thromb. Haemost."},{"issue":"10","key":"10.1016\/j.thromres.2025.109498_bb0050","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1182\/blood-2015-07-607903","article-title":"Linkage between the mechanisms of thrombocytopenia and thrombopoiesis","volume":"127","author":"Eto","year":"2016","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.thromres.2025.109498_bb0055","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1128\/AAC.46.8.2723-2726.2002","article-title":"Hematologic effects of linezolid: summary of clinical experience","volume":"46","author":"Gerson","year":"2002","journal-title":"Antimicrob. Agents Chemother."},{"issue":"11","key":"10.1016\/j.thromres.2025.109498_bb0060","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1248\/bpb.b16-00427","article-title":"Linezolid-induced thrombocytopenia is caused by suppression of platelet production via phosphorylation of myosin light chain 2","volume":"39","author":"Tajima","year":"2016","journal-title":"Biol. Pharm. Bull."},{"issue":"8","key":"10.1016\/j.thromres.2025.109498_bb0065","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1111\/bcp.13262","article-title":"Population pharmacokinetics and pharmacodynamics of linezolid-induced thrombocytopenia in hospitalized patients","volume":"83","author":"Tsuji","year":"2017","journal-title":"Br. J. Clin. Pharmacol."},{"issue":"1","key":"10.1016\/j.thromres.2025.109498_bb0070","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s40261-015-0352-0","article-title":"Thrombocytopenia in patients receiving prolonged linezolid may be caused by oxidative stress","volume":"36","author":"Wang","year":"2016","journal-title":"Clin. Drug Investig."},{"issue":"12","key":"10.1016\/j.thromres.2025.109498_bb0075","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1128\/AAC.42.12.3251","article-title":"The oxazolidinone linezolid inhibits initiation of protein synthesis in bacteria","volume":"42","author":"Swaney","year":"1998","journal-title":"Antimicrob. Agents Chemother."},{"issue":"8","key":"10.1016\/j.thromres.2025.109498_bb0080","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1086\/501356","article-title":"Linezolid-induced inhibition of mitochondrial protein synthesis","volume":"42","author":"De Vriese","year":"2006","journal-title":"Clin. Infect. Dis."},{"issue":"9","key":"10.1016\/j.thromres.2025.109498_bb0085","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.00542-17","article-title":"Influence of mitochondrial genetics on the mitochondrial toxicity of linezolid in blood cells and skin nerve fibers","volume":"61","author":"Garrabou","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"issue":"7","key":"10.1016\/j.thromres.2025.109498_bb0090","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.devcel.2021.02.009","article-title":"Quality control of the mitochondrion","volume":"56","author":"Ng","year":"2021","journal-title":"Dev. Cell"},{"issue":"1","key":"10.1016\/j.thromres.2025.109498_bb0095","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.immuni.2020.11.001","article-title":"Ribosome-targeting antibiotics impair T cell effector function and ameliorate autoimmunity by blocking mitochondrial protein synthesis","volume":"54","author":"Almeida","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.thromres.2025.109498_bb0100","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.biocel.2014.02.015","article-title":"Mitochondria: biological roles in platelet physiology and pathology","volume":"50","author":"Garcia-Souza","year":"2014","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"12","key":"10.1016\/j.thromres.2025.109498_bb0105","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1182\/blood.2020007140","article-title":"The metabolic enzyme pyruvate kinase M2 regulates platelet function and arterial thrombosis","volume":"137","author":"Nayak","year":"2021","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.thromres.2025.109498_bb0110","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.jtha.2022.11.018","article-title":"Akt-mediated mitochondrial metabolism regulates proplatelet formation and platelet shedding post vasopressin exposure","volume":"21","author":"Chen","year":"2023","journal-title":"J. Thromb. Haemost."},{"issue":"6","key":"10.1016\/j.thromres.2025.109498_bb0115","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1083\/jcb.147.6.1299","article-title":"Blood platelets are assembled principally at the ends of proplatelet processes produced by differentiated megakaryocytes","volume":"147","author":"Italiano","year":"1999","journal-title":"J. Cell Biol."},{"issue":"10","key":"10.1016\/j.thromres.2025.109498_bb0120","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.3324\/haematol.2018.204685","article-title":"Anti-apoptotic BCL2L2 increases megakaryocyte proplatelet formation in cultures of human cord blood","volume":"104","author":"Bhatlekar","year":"2019","journal-title":"Haematologica"},{"issue":"8","key":"10.1016\/j.thromres.2025.109498_bb0125","doi-asserted-by":"crossref","first-page":"19096","DOI":"10.3390\/ijms160819096","article-title":"Lead poisoning disturbs oligodendrocytes differentiation involved in decreased expression of NCX3 inducing intracellular calcium overload","volume":"16","author":"Ma","year":"2015","journal-title":"Int. J. Mol. Sci."},{"issue":"11","key":"10.1016\/j.thromres.2025.109498_bb0130","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1016\/j.cmet.2023.09.009","article-title":"High dietary fructose promotes hepatocellular carcinoma progression by enhancing O-GlcNAcylation via microbiota-derived acetate","volume":"35","author":"Zhou","year":"2023","journal-title":"Cell Metab."},{"issue":"5\u20136","key":"10.1016\/j.thromres.2025.109498_bb0135","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1089\/scd.2021.0309","article-title":"Genome-wide CRISPR screen identifies Puf60 as a novel stemness gene of mouse embryonic stem cells","volume":"31","author":"Zhang","year":"2022","journal-title":"Stem Cells Dev."},{"issue":"3","key":"10.1016\/j.thromres.2025.109498_bb0140","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1055\/s-0039-1697930","article-title":"Drug-induced thrombocytopenia: mechanisms and laboratory diagnostics","volume":"46","author":"Danese","year":"2020","journal-title":"Semin. Thromb. Hemost."},{"issue":"5","key":"10.1016\/j.thromres.2025.109498_bb0145","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.ijantimicag.2019.07.021","article-title":"Prolonged inhibition and incomplete recovery of mitochondrial function in oxazolidinone-treated megakaryoblastic cell lines","volume":"54","author":"Milosevic","year":"2019","journal-title":"Int. J. Antimicrob. Agents"},{"issue":"9","key":"10.1016\/j.thromres.2025.109498_bb0150","doi-asserted-by":"crossref","first-page":"3896","DOI":"10.1128\/AAC.49.9.3896-3902.2005","article-title":"Oxazolidinones inhibit cellular proliferation via inhibition of mitochondrial protein synthesis","volume":"49","author":"Nagiec","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.thromres.2025.109498_bb0155","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.ejmech.2014.04.062","article-title":"Oxazolidinone derivatives: cytoxazone-linezolid hybrids induces apoptosis and senescence in DU145 prostate cancer cells","volume":"80","author":"Naresh","year":"2014","journal-title":"Eur. J. Med. Chem."},{"issue":"5","key":"10.1016\/j.thromres.2025.109498_bb0160","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1248\/bpb.b22-00674","article-title":"Effects of antibacterial agents on cancerous cell proliferation","volume":"46","author":"Imai","year":"2023","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.thromres.2025.109498_bb0165","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1146\/annurev-cellbio-092910-154010","article-title":"Driving the cell cycle through metabolism","volume":"28","author":"Cai","year":"2012","journal-title":"Annu. Rev. Cell Dev. Biol."},{"issue":"7","key":"10.1016\/j.thromres.2025.109498_bb0170","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1161\/ATVBAHA.119.312129","article-title":"New insights into the differentiation of megakaryocytes from hematopoietic progenitors","volume":"39","author":"Noetzli","year":"2019","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"3","key":"10.1016\/j.thromres.2025.109498_bb0175","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/s41569-018-0110-0","article-title":"Platelet biology and functions: new concepts and clinical perspectives","volume":"16","author":"van der Meijden","year":"2019","journal-title":"Nat. Rev. Cardiol."},{"issue":"13","key":"10.1016\/j.thromres.2025.109498_bb0180","doi-asserted-by":"crossref","first-page":"4169","DOI":"10.1182\/blood.V96.13.4169","article-title":"The alpha(IIb)beta(3) integrin and GPIb-V-IX complex identify distinct stages in the maturation of CD34+ cord blood cells to megakaryocytes","volume":"96","author":"Lepage","year":"2000","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.thromres.2025.109498_bb0185","doi-asserted-by":"crossref","DOI":"10.1128\/aac.00533-24","article-title":"Oxazolidinone antibiotics impair ex vivo megakaryocyte differentiation from hematopoietic progenitor cells and their maturation into platelets","volume":"68","author":"Milosevic","year":"2024","journal-title":"Antimicrob. Agents Chemother."},{"issue":"5","key":"10.1016\/j.thromres.2025.109498_bb0190","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1055\/s-0041-1731717","article-title":"Megakaryocyte cytoskeletal proteins in platelet biogenesis and diseases","volume":"122","author":"Mbiandjeu","year":"2022","journal-title":"Thromb. Haemost."},{"issue":"8","key":"10.1016\/j.thromres.2025.109498_bb0195","article-title":"Positive relationship of platelet volume indices with HbA1c in unselected type-2 diabetes mellitus patients","volume":"65","author":"Wu","year":"2019","journal-title":"Clin. Lab."},{"key":"10.1016\/j.thromres.2025.109498_bb0200","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12240","article-title":"Glycolytic regulation of cell rearrangement in angiogenesis","volume":"7","author":"Cruys","year":"2016","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.thromres.2025.109498_bb0205","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.funbio.2019.10.005","article-title":"In Saccharomyces cerevisiae, withdrawal of the carbon source results in detachment of glycolytic enzymes from the cytoskeleton and in actin reorganization","volume":"124","author":"Espinoza-Simon","year":"2020","journal-title":"Fungal Biol."},{"issue":"9","key":"10.1016\/j.thromres.2025.109498_bb0210","doi-asserted-by":"crossref","DOI":"10.1007\/s12032-022-01712-0","article-title":"Cytoskeleton disruption by the metabolic inhibitor 3-bromopyruvate: implications in cancer therapy","volume":"39","author":"Azevedo-Silva","year":"2022","journal-title":"Med. Oncol."},{"issue":"3","key":"10.1016\/j.thromres.2025.109498_bb0215","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01599-17","article-title":"Mitochondrial alterations (inhibition of mitochondrial protein expression, oxidative metabolism, and ultrastructure) induced by linezolid and tedizolid at clinically relevant concentrations in cultured human HL-60 promyelocytes and THP-1 monocytes","volume":"62","author":"Milosevic","year":"2018","journal-title":"Antimicrob. Agents Chemother."},{"issue":"4","key":"10.1016\/j.thromres.2025.109498_bb0220","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1002\/ajh.23647","article-title":"Novel type of red blood cell pyruvate kinase hyperactivity predicts a remote regulatory locus involved in PKLR gene expression","volume":"89","author":"van Oirschot","year":"2014","journal-title":"Am. J. Hematol."},{"issue":"1","key":"10.1016\/j.thromres.2025.109498_bb0225","doi-asserted-by":"crossref","first-page":"E33","DOI":"10.1152\/ajpendo.00074.2022","article-title":"The mitochondrial pyruvate carrier at the crossroads of intermediary metabolism","volume":"323","author":"Yiew","year":"2022","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.thromres.2025.109498_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110082","article-title":"Exogenous pyruvate facilitates ultraviolet B-induced DNA damage repair by promoting H3K9 acetylation in keratinocytes and melanocytes","volume":"126","author":"Han","year":"2020","journal-title":"Biomed. Pharmacother."},{"issue":"11","key":"10.1016\/j.thromres.2025.109498_bb0235","doi-asserted-by":"crossref","first-page":"6956","DOI":"10.1007\/s12035-022-03017-9","article-title":"Pyruvate prevents dopaminergic neurodegeneration and motor deficits in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson\u2019s disease","volume":"59","author":"Kim","year":"2022","journal-title":"Mol. Neurobiol."}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384825002488?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384825002488?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T03:59:38Z","timestamp":1762228778000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049384825002488"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":47,"alternative-id":["S0049384825002488"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2025.109498","relation":{},"ISSN":["0049-3848"],"issn-type":[{"type":"print","value":"0049-3848"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Linezolid impair proplatelet formation by reducing mitochondrial energy metabolism in MEG-01 cells","name":"articletitle","label":"Article Title"},{"value":"Thrombosis Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.thromres.2025.109498","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109498"}}