{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T19:58:38Z","timestamp":1793735918288,"version":"4.6.1"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007289","name":"Nanjing Medical University","doi-asserted-by":"publisher","award":["NMUB20230039"],"award-info":[{"award-number":["NMUB20230039"]}],"id":[{"id":"10.13039\/501100007289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007289","name":"Nanjing Medical University","doi-asserted-by":"publisher","award":["23YJRC24"],"award-info":[{"award-number":["23YJRC24"]}],"id":[{"id":"10.13039\/501100007289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thrombosisresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.thromres.2025.109537","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T23:06:01Z","timestamp":1762902361000},"page":"109537","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Superiority of a combined antithrombin and activated protein C model for predicting coagulopathy and mortality in pneumonia-related sepsis: A prospective cohort study"],"prefix":"10.1016","volume":"256","author":[{"given":"Tian","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiqin","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vakkas","family":"Qureshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueping","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiujuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjian","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoman","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runkai","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.thromres.2025.109537_bb0005","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1007\/s00134-024-07369-9","article-title":"European Society of Intensive Care Medicine clinical practice guideline on fluid therapy in adult critically ill patients. Part 1: the choice of resuscitation fluids","volume":"50","author":"Arabi","year":"2024","journal-title":"Intensive Care Med."},{"issue":"1","key":"10.1016\/j.thromres.2025.109537_bb0010","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s13613-024-01269-3","article-title":"Community-acquired Klebsiella pneumoniae pneumonia in ICU: a multicenter retrospective study","volume":"14","author":"Grosjean","year":"2024","journal-title":"Ann. Intensive Care"},{"issue":"1","key":"10.1016\/j.thromres.2025.109537_bb0015","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-49855-y","article-title":"Risk stratification utilizing sequential organ failure assessment (SOFA) score, antithrombin activity, and demographic data in sepsis-associated disseminated intravascular coagulation (DIC)","volume":"13","author":"Iba","year":"2023","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.thromres.2025.109537_bb0020","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s12959-023-00523-1","volume":"21","author":"Mori","year":"2023","journal-title":"Thromb. J."},{"issue":"1","key":"10.1016\/j.thromres.2025.109537_bb0025","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s12959-023-00556-6","article-title":"The antithrombin activity recovery after substitution therapy is associated with improved 28-day mortality in patients with sepsis-associated disseminated intravascular coagulation","volume":"21","author":"Iba","year":"2023","journal-title":"Thromb. J."},{"key":"10.1016\/j.thromres.2025.109537_bb0030","article-title":"Disseminated intravascular coagulation: role of the International Society on Thrombosis and Haemostasis (ISTH) diagnostic scoring system","volume":"36","author":"Bouzidi","year":"2020","journal-title":"Pan Afr. Med. J."},{"issue":"7","key":"10.1016\/j.thromres.2025.109537_bb0035","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1177\/0885066618773679","article-title":"Newly proposed sepsis-induced coagulopathy precedes international society on thrombosis and haemostasis overt-disseminated intravascular coagulation and predicts high mortality","volume":"35","author":"Iba","year":"2020","journal-title":"J. Intensive Care Med."},{"issue":"3","key":"10.1016\/j.thromres.2025.109537_bb0040","doi-asserted-by":"crossref","first-page":"477","DOI":"10.21037\/apm-23-535","article-title":"Clinical outcomes of antithrombin III supplementation in an overt disseminated intravascular coagulation: a longitudinal single-institutional experience and retrospective analysis","volume":"13","author":"Lee","year":"2024","journal-title":"Ann. Palliat. Med."},{"issue":"6","key":"10.1016\/j.thromres.2025.109537_bb0045","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1038\/s41591-024-02911-0","article-title":"Editorial expression of concern: activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage","volume":"30","author":"Cheng","year":"2024","journal-title":"Nat. Med."},{"key":"10.1016\/j.thromres.2025.109537_bb0050","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.866751","article-title":"Thrombosis and inflammation\u2014a dynamic interplay and the role of glycosaminoglycans and activated protein C","volume":"9","author":"Kohli","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.thromres.2025.109537_bb0055","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jcrc.2018.06.003","article-title":"The evolution of activated protein C plasma levels in septic shock and its association with mortality: a prospective observational study","volume":"47","author":"Tobias","year":"2018","journal-title":"J. Crit. Care"},{"issue":"22","key":"10.1016\/j.thromres.2025.109537_bb0060","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232214196","article-title":"3K3A-activated protein C prevents microglia activation, inhibits NLRP3 inflammasome and limits ocular inflammation","volume":"23","author":"Palevski","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.thromres.2025.109537_bb0065","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.thromres.2021.03.017","article-title":"Increased activated protein C to protein C ratio in sepsis and cirrhosis","volume":"202","author":"Petros","year":"2021","journal-title":"Thromb. Res."},{"issue":"11","key":"10.1016\/j.thromres.2025.109537_bb0070","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/S2213-2600(23)00237-0","article-title":"Identifying molecular phenotypes in sepsis: an analysis of two prospective observational cohorts and secondary analysis of two randomised controlled trials","volume":"11","author":"Sinha","year":"2023","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.thromres.2025.109537_bb0075","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2021.562495","article-title":"Protein C pathway in paediatric and neonatal sepsis","volume":"9","author":"Eliwan","year":"2022","journal-title":"Front. Pediatr."},{"issue":"4","key":"10.1016\/j.thromres.2025.109537_bb0080","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1111\/ijlh.14447","article-title":"Activated protein C resistance testing: an update from Australasia\/Asia-Pacific","volume":"47","author":"Favaloro","year":"2025","journal-title":"Int. J. Lab. Hematol."},{"issue":"8","key":"10.1016\/j.thromres.2025.109537_bb0085","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1055\/s-0043-1770773","article-title":"Laboratory diagnosis of activated protein C resistance and factor V Leiden","volume":"50","author":"Bahraini","year":"2024","journal-title":"Semin. Thromb. Hemost."},{"issue":"26","key":"10.1016\/j.thromres.2025.109537_bb0090","doi-asserted-by":"crossref","first-page":"3072","DOI":"10.1182\/blood.2025029477","article-title":"Activated protein C takes a bite out of factor Va","volume":"145","author":"Kumar","year":"2025","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.thromres.2025.109537_bb0095","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jtha.2022.10.012","article-title":"Activated protein C inhibits mesothelial-to-mesenchymal transition in experimental peritoneal fibrosis","volume":"21","author":"Giri","year":"2023","journal-title":"J. Thromb. Haemost."},{"issue":"1","key":"10.1016\/j.thromres.2025.109537_bb0100","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23010516","article-title":"Activated protein C protects against murine contact dermatitis by suppressing protease-activated receptor 2","volume":"23","author":"Xue","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.thromres.2025.109537_bb0105","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.758158","article-title":"Activated protein C ameliorates diabetic cardiomyopathy via modulating OTUB1\/YB-1\/MEF2B axis","volume":"8","author":"Zhong","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"issue":"2","key":"10.1016\/j.thromres.2025.109537_bb0110","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1161\/CIRCRESAHA.121.319044","article-title":"Activated protein C strengthens cardiac tolerance to ischemic insults in aging","volume":"130","author":"Ren","year":"2022","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.thromres.2025.109537_bb0115","article-title":"Correction to: activated protein C strengthens cardiac tolerance to ischemic insults in aging","volume":"131","year":"2022","journal-title":"Circ. Res."},{"key":"10.1016\/j.thromres.2025.109537_bb0120","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2023.1251017","article-title":"Activated protein C in epilepsy pathophysiology","volume":"17","author":"Zoungrana","year":"2023","journal-title":"Front. Neurosci."},{"issue":"1","key":"10.1016\/j.thromres.2025.109537_bb0125","first-page":"86","article-title":"Lactoferrin and activated protein C: potential role in prevention of cancer progression and recurrence","volume":"12","author":"Akhtar","year":"2023","journal-title":"Int. J. Mol. Cell Med."},{"issue":"2025","key":"10.1016\/j.thromres.2025.109537_bb0130","article-title":"Protein C in adult patients with sepsis: from pathophysiology to monitoring and supplementation","volume":"21","author":"Coloretti","year":"2025","journal-title":"J. Anesth. Analg. Crit. Care"}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384825002877?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384825002877?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T15:40:14Z","timestamp":1781019614000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049384825002877"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":26,"alternative-id":["S0049384825002877"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2025.109537","relation":{},"ISSN":["0049-3848"],"issn-type":[{"value":"0049-3848","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Superiority of a combined antithrombin and activated protein C model for predicting coagulopathy and mortality in pneumonia-related sepsis: A prospective cohort study","name":"articletitle","label":"Article Title"},{"value":"Thrombosis Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.thromres.2025.109537","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"109537"}}