{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T05:47:35Z","timestamp":1793944055263,"version":"4.8.0"},"reference-count":218,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thrombosisresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.thromres.2025.109561","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T17:06:46Z","timestamp":1764781606000},"page":"109561","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["The maternal hemostatic shift: Understanding VTE risk in pregnancy and postpartum"],"prefix":"10.1016","volume":"257","author":[{"given":"Marie","family":"Didembourg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Morimont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"De Gottal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Douxfils","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.thromres.2025.109561_bb0005","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1111\/j.1538-7836.2008.02921.x","article-title":"Pregnancy, the postpartum period and prothrombotic defects: risk of venous thrombosis in the MEGA study","volume":"6","author":"Pomp","year":"2008","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2025.109561_bb0010","first-page":"697","article-title":"Trends in the incidence of venous thromboembolism during pregnancy or postpartum: a 30-year population-based study","volume":"143","author":"Heit","year":"2005","journal-title":"Am. Coll. Physicians"},{"issue":"3","key":"10.1016\/j.thromres.2025.109561_bb0015","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1161\/ATVBAHA.109.184127","article-title":"Venous thromboembolism in pregnancy","volume":"29","author":"James","year":"2009","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"4","key":"10.1016\/j.thromres.2025.109561_bb0020","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1053\/j.semperi.2019.03.004","article-title":"Venous thromboembolism as a cause of severe maternal morbidity and mortality in the United States","volume":"43","author":"Abe","year":"2019","journal-title":"Semin. Perinatol."},{"issue":"8","key":"10.1016\/j.thromres.2025.109561_bb0025","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1016\/j.jtha.2025.03.009","article-title":"Incidence and time trends of pregnancy-related first-time venous thromboembolism: a 33-year Swedish birth registry study","volume":"23","author":"Philipson","year":"2025","journal-title":"J. Thromb. Haemost."},{"issue":"2","key":"10.1016\/j.thromres.2025.109561_bb0030","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1034\/j.1600-0412.1998.770207.x","article-title":"The cumulative incidence of venous thromboembolism during pregnancy and puerperium","volume":"77","author":"Andersen","year":"1998","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"10.1016\/j.thromres.2025.109561_bb0035","first-page":"730","article-title":"Incidence, clinical characteristics, and timing of objectively diagnosed venous thromboembolism during pregnancy","volume":"95","author":"Gherman","year":"1999","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.thromres.2025.109561_bb0040","first-page":"595","article-title":"Thrombotic risk during pregnancy: a population study","volume":"94","author":"Lindqvist","year":"1999","journal-title":"Thromb. Pregnancy"},{"key":"10.1016\/j.thromres.2025.109561_bb0045","first-page":"56","article-title":"Venous thromboembolism in pregnancy and the puerperium: incidence and additional risk factors from a London perinatal database","volume":"108","author":"Simpson","year":"2001","journal-title":"Br. J. Obstet. Gynaecol."},{"key":"10.1016\/j.thromres.2025.109561_bb0050","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1097\/01.AOG.0000172428.78411.b0","article-title":"Incidence and risk factors for stroke in pregnancy and the puerperium","volume":"106","author":"James","year":"2005","journal-title":"Obstet. Gynecol."},{"issue":"2 Suppl","key":"10.1016\/j.thromres.2025.109561_bb0055","doi-asserted-by":"crossref","first-page":"S57","DOI":"10.1097\/CCM.0b013e3181c9e2bb","article-title":"Pregnancy and thrombotic risk","volume":"38","author":"James","year":"2010","journal-title":"Crit. Care Med."},{"issue":"5","key":"10.1016\/j.thromres.2025.109561_bb0060","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.ajog.2005.11.008","article-title":"Venous thromboembolism during pregnancy and the postpartum period: incidence, risk factors, and mortality","volume":"194","author":"James","year":"2006","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"2","key":"10.1016\/j.thromres.2025.109561_bb0065","doi-asserted-by":"crossref","first-page":"233.e1","DOI":"10.1016\/j.ajog.2007.08.041","article-title":"Incidence and risk patterns of venous thromboembolism in pregnancy and puerperium\u2014a register-based case-control study","volume":"198","author":"Jacobsen","year":"2008","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"1","key":"10.1016\/j.thromres.2025.109561_bb0070","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1182\/hematology.2021000291","article-title":"Prevention and management of venous thromboembolism in pregnancy: cutting through the practice variation","volume":"2021","author":"Skeith","year":"2021","journal-title":"Hematology"},{"issue":"22","key":"10.1016\/j.thromres.2025.109561_bb0075","doi-asserted-by":"crossref","first-page":"3317","DOI":"10.1182\/bloodadvances.2018024802","article-title":"American Society of Hematology 2018 guidelines for management of venous thromboembolism: venous thromboembolism in the context of pregnancy","volume":"2","author":"Bates","year":"2018","journal-title":"Blood Adv."},{"issue":"02","key":"10.1016\/j.thromres.2025.109561_bb0080","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1160\/TH06-11-0650","article-title":"Venous thromboembolism during pregnancy or postpartum: findings from the RIETE registry","volume":"97","author":"Blanco-Molina","year":"2007","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.thromres.2025.109561_bb0085","series-title":"Thromboembolism in Pregnancy","author":"James","year":"2011"},{"issue":"3","key":"10.1016\/j.thromres.2025.109561_bb0090","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.jtha.2024.12.014","article-title":"Pregnancy-associated venous thromboembolism: a window into future health","volume":"23","author":"Xu","year":"2025","journal-title":"J. Thromb. Haemost."},{"issue":"19","key":"10.1016\/j.thromres.2025.109561_bb0095","doi-asserted-by":"crossref","first-page":"3953","DOI":"10.1182\/blood-2012-11-469551","article-title":"Risk factors for first venous thromboembolism around pregnancy: a population-based cohort study from the United Kingdom","volume":"121","author":"Sultan","year":"2013","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.thromres.2025.109561_bb0105","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/bdrc.21105","article-title":"Epidemiology of venous thromboembolism (VTE) associated with pregnancy","volume":"105","author":"Parunov","year":"2015","journal-title":"Birth Defects Res. C Embryo Today"},{"issue":"2","key":"10.1016\/j.thromres.2025.109561_bb0110","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1097\/GRF.0b013e3181deb27e","article-title":"Deep vein thrombosis and pulmonary embolism in pregnancy: diagnosis, complications, and management","volume":"53","author":"Brown","year":"2010","journal-title":"Clin. Obstet. Gynecol."},{"issue":"5","key":"10.1016\/j.thromres.2025.109561_bb0115","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/00006254-199904000-00023","article-title":"Deep vein thrombosis during pregnancy and the puerperium: a meta-analyses of the period of risk and the leg of presentatio","volume":"54","author":"Ray","year":"1999","journal-title":"Obstet. Gynecol. Surv."},{"issue":"4","key":"10.1016\/j.thromres.2025.109561_bb0120","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1055\/s-0038-1657712","article-title":"Risk factors for pregnancy associated venous thromboembolism","volume":"78","author":"McColl","year":"1997","journal-title":"Thromb. Haemost."},{"issue":"1","key":"10.1016\/j.thromres.2025.109561_bb0125","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.ijgo.2015.06.054","article-title":"A systematic review and meta-analysis of the epidemiology and burden of venous thromboembolism among pregnant women","volume":"132","author":"Kourlaba","year":"2016","journal-title":"Int. J. Gynecol. Obstet."},{"key":"10.1016\/j.thromres.2025.109561_bb0130","series-title":"Hemostasis and Thrombosis: Methods and Protocols","first-page":"111","article-title":"Laboratory testing of hemostasis in pregnancy: a brief overview","author":"Othman","year":"2023"},{"issue":"1","key":"10.1016\/j.thromres.2025.109561_bb0135","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1097\/AOG.0000000000002706","article-title":"ACOG practice bulletin no. 196: thromboembolism in pregnancy","volume":"132","author":"ACOG","year":"2018","journal-title":"Obstet. Gynecol."},{"issue":"14","key":"10.1016\/j.thromres.2025.109561_bb0140","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1056\/NEJMoa1311485","article-title":"Risk of a thrombotic event after the 6-week postpartum period","volume":"370","author":"Kamel","year":"2014","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.thromres.2025.109561_bb0145","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1055\/s-2003-38897","article-title":"Hemostasis during normal pregnancy and puerperium","volume":"29","author":"Hellgren","year":"2003","journal-title":"Semin. Thromb. Hemost."},{"issue":"12","key":"10.1016\/j.thromres.2025.109561_bb0150","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1111\/j.1471-0528.2009.02295.x","article-title":"Haemostatic changes in the puerperium \u20186 weeks postpartum\u2019 (HIP Study) - implication for maternal thromboembolism","volume":"116","author":"Saha","year":"2009","journal-title":"BJOG"},{"key":"10.1016\/j.thromres.2025.109561_bb0155","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.thromres.2024.01.025","article-title":"VTE risk assessment, prevention and diagnosis in pregnancy","volume":"235","author":"Lutfi","year":"2024","journal-title":"Thromb. Res."},{"issue":"8","key":"10.1016\/j.thromres.2025.109561_bb0160","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1182\/blood-2016-09-728006","article-title":"Risk of venous thromboembolism in pregnant women with essential thrombocythemia: a systematic review and meta-analysis","volume":"129","author":"Skeith","year":"2017","journal-title":"Blood"},{"issue":"12","key":"10.1016\/j.thromres.2025.109561_bb0170","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1253\/circj.CJ-25-0124","article-title":"Clinical characteristics and outcomes of pregnancy-associated venous thromboembolism - report from the Japanese Nationwide Hospital Administrative Database","volume":"89","author":"Baba","year":"2025","journal-title":"Circ. J."},{"issue":"8","key":"10.1016\/j.thromres.2025.109561_bb0175","first-page":"e193","article-title":"Management of inherited bleeding disorders in pregnancy: green-top guideline no. 71 (joint with UKHCDO)","volume":"124","author":"RCOG","year":"2017","journal-title":"BJOG"},{"issue":"23","key":"10.1016\/j.thromres.2025.109561_bb0180","doi-asserted-by":"crossref","first-page":"e884","DOI":"10.1161\/CIR.0000000000000772","article-title":"Cardiovascular considerations in caring for pregnant patients: a scientific statement from the American Heart Association","volume":"141","author":"Mehta","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.thromres.2025.109561_bb0185","series-title":"Green-top Guideline No. 37b: Thromboembolic Disease in Pregnancy and the Puerperium: Acute Management","author":"RCOG","year":"2015"},{"issue":"6 Suppl","key":"10.1016\/j.thromres.2025.109561_bb0190","doi-asserted-by":"crossref","first-page":"844s","DOI":"10.1378\/chest.08-0761","article-title":"Venous thromboembolism, thrombophilia, antithrombotic therapy, and pregnancy: American College of Chest Physicians evidence-based clinical practice guidelines (8th edition)","volume":"133","author":"Bates","year":"2008","journal-title":"Chest"},{"key":"10.1016\/j.thromres.2025.109561_bb0195","series-title":"Position Statement on Pulmonary Embolism in Pregnancy and Postpartum","author":"SOMANZ T","year":"2021"},{"issue":"1","key":"10.1016\/j.thromres.2025.109561_bb0200","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jogc.2021.04.003","article-title":"Guideline no. 417: prevention of venous thromboembolic disease in gynaecological surgery","volume":"44","author":"Tafler","year":"2022","journal-title":"J. Obstet. Gynaecol. Can."},{"issue":"22","key":"10.1016\/j.thromres.2025.109561_bb0205","doi-asserted-by":"crossref","first-page":"7101","DOI":"10.1182\/bloodadvances.2023010177","article-title":"American Society of Hematology 2023 guidelines for management of venous thromboembolism: thrombophilia testing","volume":"7","author":"Middeldorp","year":"2023","journal-title":"Blood Adv."},{"issue":"1","key":"10.1016\/j.thromres.2025.109561_bb0210","doi-asserted-by":"crossref","DOI":"10.1080\/14767058.2024.2448504","article-title":"Trend, clinical characteristics, and pregnancy outcomes of pregnancy associated venous thromboembolism: a retrospective analysis of nearly 10 years","volume":"38","author":"Wang","year":"2025","journal-title":"J. Matern. Fetal Neonatal Med."},{"issue":"3","key":"10.1016\/j.thromres.2025.109561_bb0215","doi-asserted-by":"crossref","first-page":"123","DOI":"10.21089\/njhs.23.0123","article-title":"A review of hemostasis in normal pregnancy and puerperium","volume":"2","author":"Moiz","year":"2017","journal-title":"Nat. J. Health Sci."},{"issue":"3","key":"10.1016\/j.thromres.2025.109561_bb0220","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.chest.2016.05.021","article-title":"Risks of venous thromboembolism after cesarean sections: a meta-analysis","volume":"150","author":"Blondon","year":"2016","journal-title":"Chest"},{"issue":"11","key":"10.1016\/j.thromres.2025.109561_bb0225","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.ogrm.2018.11.002","article-title":"Venous thromboembolism in pregnancy","volume":"28","author":"Unger","year":"2018","journal-title":"Obstet. Gynaecol. Reprod. Med."},{"key":"10.1016\/j.thromres.2025.109561_bb0230","series-title":"Principles and Practice of Maternal Critical Care","first-page":"47","article-title":"Physiology and pathology of coagulation in pregnancy","author":"Patel","year":"2020"},{"issue":"2","key":"10.1016\/j.thromres.2025.109561_bb0235","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/ejh.13250","article-title":"Pregnancy and delivery in women with von Willebrand disease","volume":"103","author":"Castaman","year":"2019","journal-title":"Eur. J. Haematol."},{"issue":"1","key":"10.1016\/j.thromres.2025.109561_bb0240","doi-asserted-by":"crossref","DOI":"10.4084\/mjhid.2013.052","article-title":"Changes of von Willebrand factor during pregnancy in women with and without von Willebrand disease","volume":"5","author":"Castaman","year":"2013","journal-title":"Mediterr. J. Hematol. Infect. Dis."},{"issue":"1","key":"10.1016\/j.thromres.2025.109561_bb0245","doi-asserted-by":"crossref","DOI":"10.1186\/s12959-025-00727-7","article-title":"Von Willebrand disease (VWD) and pregnancy: a comprehensive overview","volume":"23","author":"Soleimani Samarkhazan","year":"2025","journal-title":"Thromb. J."},{"issue":"2","key":"10.1016\/j.thromres.2025.109561_bb0250","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1365-2516.2011.02625.x","article-title":"Changes in the levels of factor VIII and von Willebrand factor in the puerperium","volume":"18","author":"Huq","year":"2012","journal-title":"Haemophilia"},{"issue":"Supplement 1","key":"10.1016\/j.thromres.2025.109561_bb0255","doi-asserted-by":"crossref","first-page":"5499","DOI":"10.1182\/blood-2023-188011","article-title":"Trend in Von Willebrand factor profile in women with Von Willebrand disease during pregnancy and postpartum","volume":"142","author":"Albusoul","year":"2023","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.thromres.2025.109561_bb0260","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.thromres.2014.07.005","article-title":"A longitudinal study of Factor XIII activity, fibrinogen concentration, platelet count and clot strength during normal pregnancy","volume":"134","author":"Karlsson","year":"2014","journal-title":"Thromb. Res."},{"key":"10.1016\/j.thromres.2025.109561_bb0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijoa.2021.103174","article-title":"Factor XIII activity at onset of labour and association with postpartum haemorrhage: an exploratory post-hoc study","volume":"47","author":"Karlsson","year":"2021","journal-title":"Int. J. Obstet. Anesth."},{"key":"10.1016\/j.thromres.2025.109561_bb0270","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1023\/A:1018726930407","article-title":"Decrease in protein C inhibitor activity and acquired APC resistance during Normal pregnancy","volume":"9","author":"He","year":"2000","journal-title":"J. Thromb. Thrombolysis"},{"key":"10.1016\/j.thromres.2025.109561_bb0275","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.thromres.2023.08.012","article-title":"Activated protein C, protein S, and tissue factor pathway inhibitor cooperate to inhibit thrombin activation","volume":"230","author":"Li","year":"2023","journal-title":"Thromb. Res."},{"issue":"1","key":"10.1016\/j.thromres.2025.109561_bb0280","doi-asserted-by":"crossref","first-page":"160","DOI":"10.25122\/jml-2022-0267","article-title":"Investigating protein C and S levels in pregnant women with recurrent early pregnancy loss versus normal pregnancy","volume":"16","author":"Mukhtar","year":"2023","journal-title":"J. Med. Life"},{"key":"10.1016\/j.thromres.2025.109561_bb0285","article-title":"Thrombomodulin levels during normal pregnancy, at delivery and in the postpartum: comparison with tissue-type plasminogen activator and plasminogen activator inhibitor-1","volume":"79","author":"de Moerloose","year":"1998","journal-title":"Thromb. Haemost."},{"issue":"5","key":"10.1016\/j.thromres.2025.109561_bb0290","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/0049-3848(89)90401-5","article-title":"Extrinsic coagulation inhibitor and heparin cofactor II during normal and hypertensive pregnancy","volume":"55","author":"Sandset","year":"1989","journal-title":"Thromb. Res."},{"issue":"6","key":"10.1016\/j.thromres.2025.109561_bb0295","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1080\/00365513.2023.2233903","article-title":"Trimester-specific reference intervals of hemostasis biomarkers for healthy pregnancy","volume":"83","author":"Xiao","year":"2023","journal-title":"Scand. J. Clin. Lab. Invest."},{"issue":"5","key":"10.1016\/j.thromres.2025.109561_bb0300","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1111\/jth.15680","article-title":"Thrombomodulin and pregnancy in the limelight: insights into the therapeutic aspect of thrombomodulin in pregnancy complications","volume":"20","author":"Oda","year":"2022","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2025.109561_bb0305","doi-asserted-by":"crossref","DOI":"10.1016\/j.cca.2025.120323","article-title":"Soluble thrombomodulin in preeclampsia: systematic review and meta-analysis","volume":"574","author":"de Jesus Fernandes Martins Lima","year":"2025","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.thromres.2025.109561_bb0310","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1055\/s-0037-1614421","article-title":"A longitudinal study of the relationships between haemostatic, lipid, and oestradiol changes during normal human pregnancy","volume":"81","author":"Sattar","year":"1999","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.thromres.2025.109561_bb0315","first-page":"132","article-title":"Enhanced thrombin generation and fibrinolytic activity in normal pregnancy and the puerperium","volume":"80","author":"Bremme","year":"1992","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.thromres.2025.109561_bb0320","doi-asserted-by":"crossref","DOI":"10.1007\/BF02592466","article-title":"Hemostatic parameters and platelet activation by flow-cytometry in normal pregnancy: a longitudinal study","volume":"24","author":"Gatti","year":"1994","journal-title":"Int. J. Clin. Lab. Res."},{"issue":"12","key":"10.1016\/j.thromres.2025.109561_bb0325","doi-asserted-by":"crossref","first-page":"2724","DOI":"10.1111\/j.1538-7836.2006.02197.x","article-title":"Pregnancy loss, tissue factor pathway inhibitor deficiency and resistance to activated protein C","volume":"4","author":"Gardiner","year":"2006","journal-title":"J. Thromb. Haemost."},{"issue":"04","key":"10.1016\/j.thromres.2025.109561_bb0330","doi-asserted-by":"crossref","first-page":"575","DOI":"10.4236\/ojog.2024.144051","article-title":"Activated protein C resistance in patients with pre-eclampsia in Lagos, Nigeria","volume":"14","author":"Davies","year":"2024","journal-title":"Open J. Obstetr. Gynecol."},{"issue":"2","key":"10.1016\/j.thromres.2025.109561_bb0335","doi-asserted-by":"crossref","first-page":"82","DOI":"10.47429\/lmo.2024.14.2.82","article-title":"Changes in protein C and protein S activities and the association with adverse pregnancy outcomes in pregnant Korean women","volume":"14","author":"Jung","year":"2024","journal-title":"Lab. Med. Online"},{"issue":"5","key":"10.1016\/j.thromres.2025.109561_bb0340","first-page":"914","article-title":"Role of protein S and tissue factor pathway inhibitor in the development of activated protein C resistance early in pregnancy in women with a history of preeclampsia","volume":"106","author":"Tchaikovski","year":"2011","journal-title":"Thromb. Haemost."},{"issue":"6","key":"10.1016\/j.thromres.2025.109561_bb7000","first-page":"1074","article-title":"Circulating levels of inflammatory cytokines (IL-1 beta and TNF-alpha), resistance to activated protein C, thrombin and fibrin generation in uncomplicated pregnancies","volume":"90","author":"Ku","year":"2003","journal-title":"Thromb. Haemost."},{"issue":"5","key":"10.1016\/j.thromres.2025.109561_bb0350","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.thromres.2004.08.004","article-title":"Haemostatic changes in pregnancy","volume":"114","author":"Brenner","year":"2004","journal-title":"Thromb. Res."},{"key":"10.1016\/j.thromres.2025.109561_bb0355","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1097\/MBC.0b013e3282f09835","article-title":"Haemostatic changes and acquired activated protein C resistance in normal pregnancy","volume":"18","author":"Mahieu","year":"2007","journal-title":"Blood Coagul. Fibrinolysis"},{"issue":"2","key":"10.1016\/j.thromres.2025.109561_bb0360","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1365-2141.2011.08712.x","article-title":"Resistance to activated protein C is a risk factor for pregnancy-related venous thrombosis in the absence of the F5 rs6025 (factor V Leiden) polymorphism","volume":"154","author":"Bergrem","year":"2011","journal-title":"Br. J. Haematol."},{"issue":"5","key":"10.1016\/j.thromres.2025.109561_bb0365","first-page":"251","article-title":"Activated protein C resistance and deep venous thrombosis in pregnancy","volume":"67","author":"Proch\u00e1zka","year":"2002","journal-title":"Ceska Gynekol."},{"key":"10.1016\/j.thromres.2025.109561_bb0370","doi-asserted-by":"crossref","DOI":"10.1111\/j.1365-2141.1995.tb05610.x","article-title":"Development of resistance to activated protein C during pregnancy","volume":"90","author":"Cumming","year":"1995","journal-title":"Br. J. Haematol."},{"issue":"7\u20138","key":"10.1016\/j.thromres.2025.109561_bb6000","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1080\/00365510310002905","article-title":"Changes in the plasma levels of protein C system parameters in pregnancy","volume":"63","author":"Vodnik","year":"2003","journal-title":"Scand. J. Clin. Lab. Invest."},{"key":"10.1016\/j.thromres.2025.109561_bb0380","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1055\/s-0037-1614518","article-title":"APC resistance and other haemostatic variables during pregnancy and puerperium","volume":"81","author":"Kjellberg","year":"1999","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.thromres.2025.109561_bb0385","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1055\/s-0037-1614519","article-title":"Activated protein C resistance (FV:Q506) and pregnancy","volume":"81","author":"Lindqvist","year":"1999","journal-title":"Thromb. Haemost."},{"issue":"1","key":"10.1016\/j.thromres.2025.109561_bb0390","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S0002-9378(97)70456-3","article-title":"Changes in activated protein C resistance during normal pregnancy","volume":"177","author":"Walker","year":"1997","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"3","key":"10.1016\/j.thromres.2025.109561_bb0395","first-page":"107","article-title":"Acquired resistance to activated protein C in pregnancy","volume":"202","author":"Schneider","year":"1998","journal-title":"Z. Geburtshilfe Neonatol."},{"key":"10.1016\/j.thromres.2025.109561_bb0400","doi-asserted-by":"crossref","DOI":"10.1016\/0002-9378(95)90192-2","article-title":"Resistance to activated protein C as a basis for venous thromboembolism associated with pregnancy and oral contraceptives","volume":"173","author":"Hellgren","year":"1995","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"10","key":"10.1016\/j.thromres.2025.109561_bb0405","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1177\/014107688908201008","article-title":"Changes in protein C and free protein S during pregnancy and following hysterectomy","volume":"82","author":"Warwick","year":"1989","journal-title":"J. R. Soc. Med."},{"issue":"2","key":"10.1016\/j.thromres.2025.109561_bb0410","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1515\/cclm-2019-0471","article-title":"Validation and standardization of the ETP-based activated protein C resistance test for the clinical investigation of steroid contraceptives in women: an unmet clinical and regulatory need","volume":"58","author":"Douxfils","year":"2020","journal-title":"Clin. Chem. Lab. Med."},{"issue":"1","key":"10.1016\/j.thromres.2025.109561_bb0415","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1182\/blood.2023021717","article-title":"Longitudinal profile of estrogen-related thrombotic biomarkers after cessation of combined hormonal contraceptives","volume":"143","author":"Hugon-Rodin","year":"2024","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.thromres.2025.109561_bb0420","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.thromres.2012.07.017","article-title":"Evaluation of a standardized protocol for thrombin generation measurement using the calibrated automated thrombogram: an international multicentre study","volume":"130","author":"Dargaud","year":"2012","journal-title":"Thromb. Res."},{"key":"10.1016\/j.thromres.2025.109561_bb0425","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.thromres.2017.06.027","article-title":"Normal pregnancy is associated with an increase in thrombin generation from the very early stages of the first trimester","volume":"157","author":"Bagot","year":"2017","journal-title":"Thromb. Res."},{"issue":"2","key":"10.1016\/j.thromres.2025.109561_bb0430","doi-asserted-by":"crossref","first-page":"135.e1","DOI":"10.1016\/j.ajog.2012.05.027","article-title":"Tissue factor&#x2013;dependent thrombin generation across pregnancy","volume":"207","author":"McLean","year":"2012","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.thromres.2025.109561_bb0435","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1515\/jpme.1997.25.4.368","article-title":"Fibrinolysis changes in normal pregnancy","volume":"25","author":"Bellart","year":"1997","journal-title":"J. Perinat. Med."},{"key":"10.1016\/j.thromres.2025.109561_bb0440","doi-asserted-by":"crossref","DOI":"10.1159\/000291899","article-title":"Fibrinolysis during normal pregnancy and severe preeclampsia relationships between plasma levels of plasminogen activators and inhibitors","volume":"42","author":"Nakashima","year":"1996","journal-title":"Gynecol. Obstet. Investig."},{"issue":"1","key":"10.1016\/j.thromres.2025.109561_bb0445","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s12959-024-00612-9","article-title":"Systematic review and meta-analysis of association between plasminogen activator inhibitor-1 4G\/5G polymorphism and recurrent pregnancy loss: an update","volume":"22","author":"Maghsudlu","year":"2024","journal-title":"Thromb. J."},{"issue":"6","key":"10.1016\/j.thromres.2025.109561_bb0450","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1007\/s00404-023-07121-6","article-title":"Plasminogen activator inhibitor-2 and impaired fibrinolysis in pregnancy and sickle cell anemia","volume":"309","author":"Shome","year":"2024","journal-title":"Arch. Gynecol. Obstet."},{"key":"10.1016\/j.thromres.2025.109561_bb0455","doi-asserted-by":"crossref","DOI":"10.1177\/10760296221126172","article-title":"Fibrinolytic changes in women with preeclampsia","volume":"28","author":"Godtfredsen","year":"2022","journal-title":"Clin. Appl. Thromb. Hemost."},{"issue":"2","key":"10.1016\/j.thromres.2025.109561_bb9000","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.thromres.2011.09.029","article-title":"Risk of early recurrent fetal loss and levels of thrombin-activatable fibrinolysis inhibitor","volume":"130","author":"Legnani","year":"2012","journal-title":"Thromb. Res."},{"issue":"5","key":"10.1016\/j.thromres.2025.109561_bb0465","doi-asserted-by":"crossref","first-page":"417","DOI":"10.3109\/00016348209156583","article-title":"Alpha 2-antiplasmin and alpha 2-macroglobulin--the main inhibitors of fibrinolysis\u2014during the menstrual cycle, pregnancy, delivery, and treatment with oral contraceptives","volume":"61","author":"Wallmo","year":"1982","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"10.1016\/j.thromres.2025.109561_bb0470","first-page":"61","article-title":"Elucidation of fibrinolysis in pregnant women. One size does not fit all \u2013 letter in response to \u201cVariability of fibrinolytic activity in pregnant patients exposed to tissue plasminogen activator: An in vitro study utilizing rotational thromboelastometry\u201d","author":"Okada","year":"2025","journal-title":"Int. J. Obstet. Anesth."},{"key":"10.1016\/j.thromres.2025.109561_bb0475","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijoa.2024.103994","article-title":"Variability of fibrinolytic activity in pregnant patients exposed to tissue plasminogen activator: an in vitro study utilizing rotational thromboelastometry","volume":"59","author":"Tran","year":"2024","journal-title":"Int. J. Obstet. Anesth."},{"issue":"6","key":"10.1016\/j.thromres.2025.109561_bb0480","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1111\/j.1538-7836.2008.02964.x","article-title":"Comparison of the capacities of two prothrombin complex concentrates to restore thrombin generation in plasma from orally anticoagulated patients: an in vitro study","volume":"6","author":"Dargaud","year":"2008","journal-title":"J. Thromb. Haemost."},{"issue":"6","key":"10.1016\/j.thromres.2025.109561_bb0485","doi-asserted-by":"crossref","DOI":"10.31083\/j.ceog.2020.06.5499","article-title":"Coagulation challenges in pregnancy: from thrombophilia involvement and management to the utility of thrombin generation monitoring","volume":"47","author":"Mih\u0103il\u0103","year":"2020","journal-title":"Clin. Exp. Obstet. Gynecol."},{"issue":"3","key":"10.1016\/j.thromres.2025.109561_bb0490","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.thromres.2013.07.022","article-title":"Comparison of markers of coagulation activation and thrombin generation test in uncomplicated pregnancies","volume":"132","author":"Joly","year":"2013","journal-title":"Thromb. Res."},{"key":"10.1016\/j.thromres.2025.109561_bb0495","first-page":"e1","article-title":"Tissue factor-dependent thrombin generation across pregnancy","volume":"207(2):135","author":"McLean","year":"2012","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"3","key":"10.1016\/j.thromres.2025.109561_bb0500","doi-asserted-by":"crossref","first-page":"150","DOI":"10.5045\/br.2021.2021069","article-title":"New cut-off point for D-dimer in the diagnosis of pulmonary embolism during pregnancy","volume":"56","author":"Sadeghi","year":"2021","journal-title":"Blood Res."},{"issue":"12","key":"10.1016\/j.thromres.2025.109561_bb0505","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1056\/NEJMoa1813865","article-title":"Pregnancy-adapted YEARS algorithm for diagnosis of suspected pulmonary embolism","volume":"380","author":"van der Pol","year":"2019","journal-title":"N. Engl. J. Med."},{"issue":"6","key":"10.1016\/j.thromres.2025.109561_bb0510","first-page":"1345","article-title":"Reference intervals for D-dimer and fibrinogen in the Chinese population during the third trimester of pregnancy","volume":"48","author":"Sun","year":"2021","journal-title":"CEOG"},{"issue":"6","key":"10.1016\/j.thromres.2025.109561_bb0515","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1080\/00365513.2018.1488177","article-title":"D-dimer during pregnancy: establishing trimester-specific reference intervals","volume":"78","author":"Guti\u00e9rrez Garc\u00eda","year":"2018","journal-title":"Scand. J. Clin. Lab. Invest."},{"issue":"1","key":"10.1016\/j.thromres.2025.109561_bb0520","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1186\/s12884-023-05571-z","article-title":"Trimester-specific reference intervals and profile of coagulation parameters for Chinese pregnant women with diverse demographics and obstetric history: a cross-sectional study","volume":"23","author":"Dai","year":"2023","journal-title":"BMC Pregnancy Childbirth"},{"key":"10.1016\/j.thromres.2025.109561_bb0525","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/3192350","article-title":"Reference values of D-dimers and fibrinogen in the course of physiological pregnancy: the potential impact of selected risk factors-a pilot study","volume":"2020","author":"Siennicka","year":"2020","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.thromres.2025.109561_bb0530","doi-asserted-by":"crossref","first-page":"469","DOI":"10.2147\/VHRM.S404537","article-title":"Venous thromboembolism in pregnancy: challenges and solutions","volume":"19","author":"Varrias","year":"2023","journal-title":"Vasc. Health Risk Manag."},{"issue":"1","key":"10.1016\/j.thromres.2025.109561_bb0535","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1055\/s-0039-3402807","article-title":"Mode of delivery does not influence postpartum hypercoagulability measured by thrombin generation or thromboelastometry","volume":"4","author":"Guimicheva","year":"2020","journal-title":"TH Open"},{"issue":"5","key":"10.1016\/j.thromres.2025.109561_bb0545","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.thromres.2012.01.008","article-title":"Thrombin generation post elective caesarean section: effect of low molecular weight heparin","volume":"130","author":"Ismail","year":"2012","journal-title":"Thromb. Res."},{"issue":"3","key":"10.1016\/j.thromres.2025.109561_bb0550","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1046\/j.1365-2141.2003.04443.x","article-title":"Activated protein C resistance determined with a thrombin generation-based test predicts for venous thrombosis in men and women","volume":"122","author":"Tans","year":"2003","journal-title":"Br. J. Haematol."},{"issue":"5","key":"10.1016\/j.thromres.2025.109561_bb0555","first-page":"466","article-title":"Preeclampsia and thrombin generation test","volume":"78","author":"Lattov\u00e1","year":"2013","journal-title":"Ceska Gynekol."},{"issue":"4","key":"10.1016\/j.thromres.2025.109561_bb0560","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1111\/bjh.13521","article-title":"Thrombin generation assays for optimizing low molecular weight heparin dosing in pregnant women at risk of thrombosis","volume":"172","author":"Ismail","year":"2016","journal-title":"Br. J. Haematol."},{"issue":"5","key":"10.1016\/j.thromres.2025.109561_bb0565","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1111\/j.1538-7836.2009.03336.x","article-title":"High thrombin-activatable fibrinolysis inhibitor levels may protect against recurrent fetal loss","volume":"7","author":"Knol","year":"2009","journal-title":"J. Thromb. Haemost."},{"issue":"5","key":"10.1016\/j.thromres.2025.109561_bb0570","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1111\/bjh.13193","article-title":"Thrombin generation assay identifies individual variability in responses to low molecular weight heparin in pregnancy: implications for anticoagulant monitoring","volume":"168","author":"Chowdary","year":"2015","journal-title":"Br. J. Haematol."},{"issue":"4","key":"10.1016\/j.thromres.2025.109561_bb0575","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1111\/bjh.13523","article-title":"Thrombin generation assays for optimizing low molecular weight heparin dosing in pregnant women at risk of thrombosis\u2014response to Ismail et al","volume":"172","author":"Chowdary","year":"2016","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.thromres.2025.109561_bb0580","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1177\/003693309604100305","article-title":"Venous thromboembolic disease in obstetric and gynaecology: the Scottish experience","volume":"41","author":"Macklon","year":"1996","journal-title":"Scott. Med. J."},{"issue":"2","key":"10.1016\/j.thromres.2025.109561_bb0585","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/rth2.12290","article-title":"VTE risk assessment in pregnancy","volume":"4","author":"Ewins","year":"2020","journal-title":"Res. Pract. Thromb. Haemost."},{"issue":"6","key":"10.1016\/j.thromres.2025.109561_bb0590","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1111\/j.1538-7836.2008.02961.x","article-title":"Ante- and postnatal risk factors of venous thrombosis: a hospital-based case-control study","volume":"6","author":"Jacobsen","year":"2008","journal-title":"J. Thromb. Haemost."},{"issue":"3","key":"10.1016\/j.thromres.2025.109561_bb0595","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1111\/j.1365-2141.2011.08956.x","article-title":"Risk of first venous thromboembolism in and around pregnancy: a population-based cohort study","volume":"156","author":"Sultan","year":"2012","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.thromres.2025.109561_bb0600","doi-asserted-by":"crossref","first-page":"3804","DOI":"10.1182\/blood-2018-99-113599","article-title":"Risk factors for pregnancy-associated venous thromboembolism: the role of maternal age, obesity, smoking and other modifiable risk factors","volume":"132","author":"Kohli","year":"2018","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.thromres.2025.109561_bb0610","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajogmf.2024.101566","article-title":"Inpatient pharmacological thromboprophylaxis in the antepartum period: an argument for universal thromboprophylaxis","volume":"7","author":"Burd","year":"2025","journal-title":"Am. J. Obstet. Gynecol. MFM"},{"key":"10.1016\/j.thromres.2025.109561_bb0615","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.thromres.2016.06.026","article-title":"Pre-pregnancy BMI, delivery BMI, gestational weight gain and the risk of postpartum venous thrombosis","volume":"145","author":"Blondon","year":"2016","journal-title":"Thromb. Res."},{"key":"10.1016\/j.thromres.2025.109561_bb0620","doi-asserted-by":"crossref","DOI":"10.1016\/j.bpobgyn.2024.102471","article-title":"Venous thromboembolism in pregnant obese individuals","volume":"94","author":"Navti","year":"2024","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"issue":"7","key":"10.1016\/j.thromres.2025.109561_bb0625","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1097\/OGX.0000000000001043","article-title":"Venous thromboembolism during pregnancy and the postpartum period: risk factors, diagnostic testing, and treatment","volume":"77","author":"Maughan","year":"2022","journal-title":"Obstet. Gynecol. Surv."},{"issue":"2","key":"10.1016\/j.thromres.2025.109561_bb0630","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/rth2.12290","article-title":"VTE risk assessment in pregnancy","volume":"4","author":"Ewins","year":"2020","journal-title":"Res. Pract. Thromb. Haemost."},{"issue":"2","key":"10.1016\/j.thromres.2025.109561_bb0635","article-title":"Risk factors, diagnosis and management of venous thromboembolic disease in pregnancy","volume":"18","author":"Edebiri","year":"2022","journal-title":"Breathe (Sheff.)"},{"issue":"1","key":"10.1016\/j.thromres.2025.109561_bb0640","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-41186-2","article-title":"Prepregnancy overweight and obesity and long-term risk of venous thromboembolism in women","volume":"13","author":"Mahmoud","year":"2023","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.thromres.2025.109561_bb0645","doi-asserted-by":"crossref","DOI":"10.1080\/14767058.2025.2551645","article-title":"Risk factors for venous thromboembolism in pregnant women in Japan: a retrospective study","volume":"38","author":"Miyamoto","year":"2025","journal-title":"J. Matern. Fetal Neonatal Med."},{"issue":"3","key":"10.1016\/j.thromres.2025.109561_bb0650","doi-asserted-by":"crossref","first-page":"323","DOI":"10.23736\/S0392-9590.24.05141-1","article-title":"Risk factors related to venous thromboembolism in pregnant women: a meta-analysis","volume":"43","author":"He","year":"2024","journal-title":"Int. Angiol."},{"key":"10.1016\/j.thromres.2025.109561_bb0655","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.thromres.2016.06.001","article-title":"Low-molecular-weight heparin to prevent recurrent venous thromboembolism in pregnancy: rationale and design of the Highlow study, a randomised trial of two doses","volume":"144","author":"Bleker","year":"2016","journal-title":"Thromb. Res."},{"key":"10.1016\/j.thromres.2025.109561_bb0660","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1159\/000073590","article-title":"Thrombosis during pregnancy: risk factors, diagnosis and treatment","volume":"32","author":"Pabinger","year":"2002","journal-title":"Pathophysiol. Haemost. Thromb."},{"key":"10.1016\/j.thromres.2025.109561_bb0665","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1365-2141.2005.05847.x","article-title":"Thrombophilia in pregnancy: a systematic review","volume":"132","author":"Robertson","year":"2006","journal-title":"Br. J. Haematol."},{"issue":"4","key":"10.1016\/j.thromres.2025.109561_bb0670","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1111\/jth.15639","article-title":"Risk factors for recurrence during a pregnancy following a first venous thromboembolism: A French observational study","volume":"20","author":"de Moreuil","year":"2022","journal-title":"J. Thromb. Haemost."},{"issue":"3","key":"10.1016\/j.thromres.2025.109561_bb0675","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/j.1365-2141.2006.06317.x","article-title":"The risk of recurrent venous thromboembolism in pregnancy and puerperium without antithrombotic prophylaxis","volume":"135","author":"De Stefano","year":"2006","journal-title":"Br. J. Haematol."},{"issue":"5","key":"10.1016\/j.thromres.2025.109561_bb0680","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1111\/j.1538-7836.2005.01307.x","article-title":"Risk of pregnancy-associated recurrent venous thromboembolism in women with a history of venous thrombosis","volume":"3","author":"Pabinger","year":"2005","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2025.109561_bb0685","doi-asserted-by":"crossref","DOI":"10.1016\/j.tru.2023.100150","article-title":"Anticoagulant prophylaxis in pregnant women with a history of venous thromboembolism: a systematic review and meta-analysis","volume":"13","author":"Mansory","year":"2023","journal-title":"Thromb. Update"},{"issue":"Supplement 1","key":"10.1016\/j.thromres.2025.109561_bb0690","doi-asserted-by":"crossref","DOI":"10.1182\/blood-2021-149875","article-title":"Recurrent VTE in pregnant woman with previous personal history of VTE: a systematic review and meta-analysis","volume":"138","author":"Mansory","year":"2021","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.thromres.2025.109561_bb0695","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1056\/NEJM200002103420602","article-title":"Prothrombin and Factor V mutations in women woth a history of thrombosis during pregnancy and the puerperium","volume":"342","author":"Gerhardt","year":"2000","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.thromres.2025.109561_bb0700","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1182\/asheducation-2007.1.143","article-title":"Management of pregnant women with thrombophilia or a history of venous thromboembolism","volume":"2007","author":"Bates","year":"2007","journal-title":"Hematology"},{"issue":"19","key":"10.1016\/j.thromres.2025.109561_bb0705","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1182\/blood-2016-03-703728","article-title":"Hereditary risk factors for thrombophilia and probability of venous thromboembolism during pregnancy and the puerperium","volume":"128","author":"Gerhardt","year":"2016","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.thromres.2025.109561_bb0710","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.thromres.2006.12.003","article-title":"Maternal smoking, obesity, and risk of venous thromboembolism during pregnancy and the puerperium: a population-based nested case-control study","volume":"120","author":"Larsen","year":"2007","journal-title":"Thromb. Res."},{"issue":"4","key":"10.1016\/j.thromres.2025.109561_bb0715","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1590\/S0104-42302002000400042","article-title":"Analysis of coagulation parameters in patients undergoing controlled ovarian hyperstimulation for in vitro fertilization","volume":"48","author":"Michelon","year":"2002","journal-title":"Rev. Assoc. Med. Bras."},{"key":"10.1016\/j.thromres.2025.109561_bb0720","first-page":"283","article-title":"Venous thromboembolism associated with assisted reproductive technology: a systematic review and meta-analysis","volume":"123","author":"Goualou","year":"2022","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.thromres.2025.109561_bb0725","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.e8632","article-title":"Incidence of pulmonary and venous thromboembolism in pregnancies after in vitro fertilisation: cross sectional study","volume":"346","author":"Henriksson","year":"2013","journal-title":"BMJ"},{"issue":"1","key":"10.1016\/j.thromres.2025.109561_bb0730","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.fertnstert.2011.10.038","article-title":"Venous thromboembolism in relation to in vitro fertilization: an approach to determining the incidence and increase in risk in successful cycles","volume":"97","author":"Rova","year":"2012","journal-title":"Fertil. Steril."},{"issue":"2","key":"10.1016\/j.thromres.2025.109561_bb0735","doi-asserted-by":"crossref","first-page":"110","DOI":"10.20953\/1726-1678-2025-2-110-119","article-title":"Effects of multiple pregnancy following IVF on the functional state of the hemostatic system: new views and hypotheses","volume":"24","author":"Yagubova","year":"2025","journal-title":"Vopr. Ginekol. Akush. Perinatol."},{"issue":"3","key":"10.1016\/j.thromres.2025.109561_bb0740","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1093\/humrep\/det458","article-title":"Increased venous thrombosis incidence in pregnancies after in vitro fertilization","volume":"29","author":"Hansen","year":"2014","journal-title":"Hum. Reprod."},{"issue":"3","key":"10.1016\/j.thromres.2025.109561_bb0745","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1093\/humupd\/dmae002","article-title":"Maternal and perinatal outcomes in twin pregnancies following assisted reproduction: a systematic review and meta-analysis involving 802 462 pregnancies","volume":"30","author":"Marleen","year":"2024","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.thromres.2025.109561_bb0750","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1055\/a-1162-3905","article-title":"Pathophysiology of the venous thromboembolism risk in preeclampsia","volume":"40","author":"Kelliher","year":"2020","journal-title":"H\u00e4mostaseologie"},{"issue":"4","key":"10.1016\/j.thromres.2025.109561_bb0755","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1042\/BST20140310","article-title":"Elevated venous thromboembolism risk in preeclampsia: molecular mechanisms and clinical impact","volume":"43","author":"Egan","year":"2015","journal-title":"Biochem. Soc. Trans."},{"issue":"3","key":"10.1016\/j.thromres.2025.109561_bb0760","doi-asserted-by":"crossref","first-page":"306","DOI":"10.17749\/2313-7347\/ob.gyn.rep.2022.315","article-title":"Preeclampsia and venous thromboembolism","volume":"16","author":"Grigoreva","year":"2022","journal-title":"Obstet. Gynecol. Reprod."},{"issue":"1","key":"10.1016\/j.thromres.2025.109561_bb0765","doi-asserted-by":"crossref","first-page":"S460","DOI":"10.1016\/j.ajog.2021.11.763","article-title":"Risk factors for obstetric venous thromboembolism stratified by mode of delivery","volume":"226","author":"Oberlin","year":"2022","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.thromres.2025.109561_bb0770","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1097\/AOG.0000000000000230","article-title":"Postpartum venous thromboembolism: incidence and risk factors","volume":"123","author":"Tepper","year":"2014","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.thromres.2025.109561_bb0780","article-title":"Development and validation of risk prediction model for venous thromboembolism in postpartum women: multinational cohort study","volume":"355","author":"Sultan","year":"2016","journal-title":"BMJ"},{"issue":"5","key":"10.1016\/j.thromres.2025.109561_bb0785","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/S0002-9378(98)70155-3","article-title":"Genetic susceptibility to pregnancy-related venous thromboembolism: roles of factor V Leiden, prothrombin G20210A, and methylenetetrahydrofolate reductase C677T mutations","volume":"179","author":"Grandone","year":"1998","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"5","key":"10.1016\/j.thromres.2025.109561_bb0790","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1067\/mob.2000.106820","article-title":"Genetic factors associated with thrombosis in pregnancy in a United States population","volume":"183","author":"Dilley","year":"2000","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"7607","key":"10.1016\/j.thromres.2025.109561_bb0795","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1136\/bmj.39205.484572.55","article-title":"Inherited thrombophilia and pregnancy associated venous thromboembolism","volume":"334","author":"Lim","year":"2007","journal-title":"BMJ"},{"key":"10.1016\/j.thromres.2025.109561_bb0800","article-title":"Pregnancy, thrombophilia, and the risk of a first venous thrombosis: systematic review and bayesian meta-analysis","volume":"359","author":"Croles","year":"2017","journal-title":"BMJ"},{"issue":"2","key":"10.1016\/j.thromres.2025.109561_bb0805","article-title":"Pregnancy, thrombophilia, and the risk of a first venous thrombosis: systematic review and bayesian meta-analysis","volume":"6","author":"Croles","year":"2018","journal-title":"J. Vasc. Surg. Venous Lymphat. Disord."},{"key":"10.1016\/j.thromres.2025.109561_bb0810","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1097\/MBC.0000000000000348","article-title":"Management and outcome of pregnancies in women with antithrombin deficiency: a single-center experience and review of literature","volume":"26","author":"Ilonczai","year":"2015","journal-title":"Blood Coagul. Fibrinolysis"},{"issue":"1","key":"10.1016\/j.thromres.2025.109561_bb0815","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ejogrb.2009.12.004","article-title":"Inherited antithrombin deficiency and pregnancy: maternal and fetal outcomes","volume":"149","author":"Sabadell","year":"2010","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"issue":"4","key":"10.1016\/j.thromres.2025.109561_bb0820","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/S2352-3026(20)30007-7","article-title":"Risk of pregnancy-related venous thromboembolism and obstetrical complications in women with inherited type I antithrombin deficiency: a retrospective, single-centre, cohort study","volume":"7","author":"Abbattista","year":"2020","journal-title":"Lancet Haematol."},{"key":"10.1016\/j.thromres.2025.109561_bb0825","first-page":"2650","article-title":"How to manage venous thromboembolism risk during pregnancy in patients with inherited antithrombin deficiency?","author":"Mauge","year":"2025","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.thromres.2025.109561_bb0830","doi-asserted-by":"crossref","first-page":"233","DOI":"10.2147\/IJWH.S43190","article-title":"Prevention and treatment of venous thromboembolism in pregnancy in patients with hereditary antithrombin deficiency","volume":"5","author":"James","year":"2013","journal-title":"Int. J. Women\u2019s Health"},{"key":"10.1016\/j.thromres.2025.109561_bb0835","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1055\/s-0037-1616134","article-title":"Risk of pregnancy-related venous thrombosis in carriers of severe inherited thrombophilia","volume":"86","author":"Martinelli","year":"2001","journal-title":"Thromb. Haemost."},{"issue":"12","key":"10.1016\/j.thromres.2025.109561_bb0840","first-page":"1305","article-title":"Factor V Leiden mutation and the risk of venous thromboembolism in pregnant women","volume":"86","author":"Tormene","year":"2001","journal-title":"Haematologica"},{"key":"10.1016\/j.thromres.2025.109561_bb0845","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.ejogrb.2015.06.005","article-title":"Thrombophilia and venous thromboembolism in pregnancy: a meta-analysis of genetic risk","volume":"191","author":"Ziakas","year":"2015","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"issue":"9321","key":"10.1016\/j.thromres.2025.109561_bb0850","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1016\/S0140-6736(02)08740-8","article-title":"Cost-effectiveness of screening for the factor V Leiden mutation in pregnant women","volume":"359","author":"Clark","year":"2002","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.thromres.2025.109561_bb0855","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/S0029-7844(97)00430-4","article-title":"Antenatal screening for factor V Leiden mutation: a critical appraisal","volume":"90","author":"Rouse","year":"1997","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.thromres.2025.109561_bb0860","first-page":"050","article-title":"Inherited thrombophilia and pregnancy complications: should we test?","volume":"45","author":"Arachchillage","year":"2018","journal-title":"Semin. Thromb. Hemost."},{"issue":"11","key":"10.1016\/j.thromres.2025.109561_bb0865","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta10110","article-title":"Screening for thrombophilia in high-risk situations: systematic review and cost-effectiveness analysis. The Thrombosis: Risk and Economic Assessment of Thrombophilia Screening (TREATS) study","volume":"10","author":"Wu","year":"2006","journal-title":"Health Technol. Assess."},{"issue":"1","key":"10.1016\/j.thromres.2025.109561_bb0870","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1024\/0301-1526.37.1.19","article-title":"Evidence-based indications for thrombophilia screening","volume":"37","author":"Lindhoff-Last","year":"2008","journal-title":"VASA Z. Gefasskrankheiten."},{"issue":"2","key":"10.1016\/j.thromres.2025.109561_bb0875","doi-asserted-by":"crossref","first-page":"162","DOI":"10.15386\/mpr-1372","article-title":"Association between obesity and venous thromboembolism","volume":"93","author":"Hotoleanu","year":"2020","journal-title":"Med. Pharm. Rep."},{"key":"10.1016\/j.thromres.2025.109561_bb0880","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1515\/jpm-2013-0207","article-title":"Risk factors for pregnancy-associated venous thromboembolism: a review","volume":"42","author":"Kevane","year":"2014","journal-title":"J. Perinat. Med."},{"key":"10.1016\/j.thromres.2025.109561_bb0885","article-title":"Joint effect of multiple prothrombotic genotypes and obesity on the risk of incident venous thromboembolism","volume":"122","author":"Frischmuth","year":"2022","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.thromres.2025.109561_bb0890","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1186\/s12884-014-0384-0","article-title":"Changes in thrombin generation and D-dimer concentrations in women injecting enoxaparin during pregnancy and the puerperium","volume":"14","author":"Patel","year":"2014","journal-title":"BMC Pregnancy Childbirth"},{"key":"10.1016\/j.thromres.2025.109561_bb0895","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S1521-6926(03)00021-5","article-title":"Haemostatic changes in pregnancy","volume":"16","author":"Bremme","year":"2003","journal-title":"Best Pract. Res. Clin. Haematol."},{"key":"10.1016\/j.thromres.2025.109561_bb0900","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1055\/s-0037-1615035","article-title":"Activated protein C sensitivity, protein C, protein S and coagulation in normal pregnancy","volume":"79","author":"Clark","year":"1998","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.thromres.2025.109561_bb0905","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1111\/j.1471-0528.1993.tb15264.x","article-title":"Evaluation of six markers of haemostatic system in normal pregnancy and pregnancy complicated by hypertension or pre-eclampsia","volume":"100","author":"Cadroy","year":"1993","journal-title":"BJOG"},{"issue":"4","key":"10.1016\/j.thromres.2025.109561_bb8000","first-page":"1232","article-title":"Prospective evaluation of hemostatic system activation and thrombin potential in healthy pregnant women with and without factor V Leiden","volume":"82","author":"Eichinger","year":"1999","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.thromres.2025.109561_bb0915","doi-asserted-by":"crossref","first-page":"983","DOI":"10.3109\/14767058.2014.940891","article-title":"Establishing reference intervals for D-dimer to trimesters","volume":"28","author":"Ercan","year":"2015","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"10.1016\/j.thromres.2025.109561_bb0920","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000015903","article-title":"Variations of plasma D-dimer level at various points of normal pregnancy and its trends in complicated pregnancies","volume":"98","author":"Baboolall","year":"2019","journal-title":"Medicine"},{"issue":"4","key":"10.1016\/j.thromres.2025.109561_bb0925","doi-asserted-by":"crossref","DOI":"10.1002\/rth2.12730","article-title":"D-dimer testing in clinical practice in the era of COVID-19","volume":"6","author":"Auditeau","year":"2022","journal-title":"Res. Pract. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2025.109561_bb0930","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.thromres.2019.04.033","article-title":"A review of global coagulation assays - is there a role in thrombosis risk prediction?","volume":"179","author":"Lim","year":"2019","journal-title":"Thromb. Res."},{"key":"10.1016\/j.thromres.2025.109561_bb0935","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2024.1343060","article-title":"Pregnancy as a susceptible state for thrombotic microangiopathies","volume":"11","author":"Frimat","year":"2024","journal-title":"Front. Med."},{"issue":"4","key":"10.1016\/j.thromres.2025.109561_bb0940","article-title":"HELLP syndrome and differential diagnosis with other thrombotic microangiopathies in pregnancy","volume":"14","author":"Giannubilo","year":"2024","journal-title":"Diagnostics (Basel)."},{"key":"10.1016\/j.thromres.2025.109561_bb0945","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1177\/1753495X211025397","article-title":"Risk stratification for pregnancy-associated venous thromboembolism: potential role for global coagulation assays","volume":"15","author":"O\u2019Keefe","year":"2021","journal-title":"Obstet. Med."},{"key":"10.1016\/j.thromres.2025.109561_bb0950","series-title":"Mise au Point en Anesth\u00e9sie et R\u00e9animation","article-title":"Coagulation chez la femme enceinte","author":"Ducloy-Bouthors","year":"2018"},{"key":"10.1016\/j.thromres.2025.109561_bb0955","first-page":"38","article-title":"Antenatal Venous Thromboembolism and the performance of risk assessment tools","volume":"118","author":"Milne","year":"2025","journal-title":"Irish Med. Org."},{"issue":"1","key":"10.1016\/j.thromres.2025.109561_bb0960","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1186\/s12884-025-07246-3","article-title":"A comparison of international clinical practice guidelines for postpartum venous thromboembolism prophylaxis","volume":"25","author":"Ephraums","year":"2025","journal-title":"BMC Pregnancy Childbirth"},{"issue":"9","key":"10.1016\/j.thromres.2025.109561_bb0965","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1097\/OGX.0000000000001428","article-title":"Prevention of venous thromboembolism in pregnancy and the puerperium: a comparative review of guidelines","volume":"80","author":"Boureka","year":"2025","journal-title":"Obstet. Gynecol. Surv."},{"key":"10.1016\/j.thromres.2025.109561_bb0970","doi-asserted-by":"crossref","DOI":"10.1186\/s12872-019-1183-3","article-title":"Critical appraisal of international guidelines for the prevention and treatment of pregnancy-associated venous thromboembolism: a systematic review","volume":"19","author":"Zheng","year":"2019","journal-title":"BMC Cardiovasc. Disord."},{"key":"10.1016\/j.thromres.2025.109561_bb0975","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.ejogrb.2024.06.027","article-title":"Guideline-based venous thromboprophylaxis in postpartum women: an in-depth evaluation of ACOG and RCOG recommendations and real-life implementation","volume":"299","author":"Kay\u0131k\u00e7\u0131","year":"2024","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.thromres.2025.109561_bb0980","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1097\/AOG.0000000000004521","article-title":"Evaluation of a risk-stratified, heparin-based, obstetric thromboprophylaxis protocol","volume":"138","author":"Lu","year":"2021","journal-title":"Obstet. Gynecol."},{"issue":"7","key":"10.1016\/j.thromres.2025.109561_bb0985","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.jogc.2017.10.010","article-title":"The approach to peripartum management of anticoagulation: a multidisciplinary survey","volume":"40","author":"Rohailla","year":"2018","journal-title":"J. Obstet. Gynaecol. Can."},{"key":"10.1016\/j.thromres.2025.109561_bb0990","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.thromres.2015.12.015","article-title":"Women\u2019s values and preferences and health state valuations for thromboprophylaxis during pregnancy: a cross-sectional interview study","volume":"140","author":"Bates","year":"2016","journal-title":"Thromb. Res."},{"key":"10.1016\/j.thromres.2025.109561_bb0995","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1515\/jpm-2022-0008","article-title":"Venous thrombosis risk factors in pregnant women","volume":"50","author":"Bitsadze","year":"2022","journal-title":"J. Perinat. Med."},{"issue":"10","key":"10.1016\/j.thromres.2025.109561_bb1000","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2022-065892","article-title":"Risk assessment models for venous thromboembolism in pregnancy and in the puerperium: a systematic review","volume":"12","author":"Pandor","year":"2022","journal-title":"BMJ Open"},{"issue":"8","key":"10.1016\/j.thromres.2025.109561_bb1005","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1016\/j.jtha.2025.05.027","article-title":"Venous thromboembolism in pregnancy: more prevention is needed","volume":"23","author":"S\u00f8rensen","year":"2025","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2025.109561_bb1010","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/978-1-0716-3175-1_12","article-title":"Evaluation of activated protein C resistance using thrombin generation test","volume":"2663","author":"Douxfils","year":"2023","journal-title":"Methods Mol. Biol."},{"issue":"3","key":"10.1016\/j.thromres.2025.109561_bb1015","doi-asserted-by":"crossref","DOI":"10.1002\/rth2.12684","article-title":"Analytical performance of the endogenous thrombin potential-based activated protein C resistance assay on the automated ST Genesia system","volume":"6","author":"Morimont","year":"2022","journal-title":"Res. Pract. Thromb. Haemost."},{"issue":"6","key":"10.1016\/j.thromres.2025.109561_bb1020","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1055\/s-0042-1753511","article-title":"Laboratory testing for the evaluation of phenotypic activated protein C resistance","volume":"48","author":"Morimont","year":"2022","journal-title":"Semin. Thromb."},{"issue":"4","key":"10.1016\/j.thromres.2025.109561_bb1025","doi-asserted-by":"crossref","DOI":"10.1016\/j.rpth.2023.100155","article-title":"Hormonal therapies and venous thrombosis: considerations for prevention and management-a reappraisal","volume":"7","author":"Douxfils","year":"2023","journal-title":"Res. Pract. Thromb. Haemost."},{"issue":"4","key":"10.1016\/j.thromres.2025.109561_bb1030","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1111\/jth.14745","article-title":"Proof of concept of a new scale for the harmonization and the standardization of the ETP-based APC resistance","volume":"18","author":"Morimont","year":"2020","journal-title":"J. Thromb. Haemost."},{"issue":"1","key":"10.1016\/j.thromres.2025.109561_bb1035","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1210\/clinem\/dgac511","article-title":"Low thrombin generation in users of a contraceptive containing estetrol and drospirenone","volume":"108","author":"Morimont","year":"2022","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.thromres.2025.109561_bb1040","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2025.1611404","article-title":"Commentary: the ETP-based APC resistance assay remains the gold standard for evaluating the APC resistance phenotype in users of combined oral contraceptives","volume":"12","author":"Morimont","year":"2025","journal-title":"Front. Cardiovasc. Med."},{"issue":"6","key":"10.1016\/j.thromres.2025.109561_bb1045","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.contraception.2020.08.015","article-title":"Evaluation of the effect of a new oral contraceptive containing estetrol and drospirenone on hemostasis parameters","volume":"102","author":"Douxfils","year":"2020","journal-title":"Contraception"},{"issue":"3","key":"10.1016\/j.thromres.2025.109561_bb1050","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1111\/ijlh.14242","article-title":"Hemostatic imbalance induced by tamoxifen in estrogen receptor-positive breast cancer patients: an observational study","volume":"46","author":"Didembourg","year":"2024","journal-title":"Int. J. Lab. Hematol."},{"issue":"1","key":"10.1016\/j.thromres.2025.109561_bb1055","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1080\/13697137.2022.2139599","article-title":"Impact of estetrol (E4) on hemostasis, metabolism and bone turnover in postmenopausal women","volume":"26","author":"Douxfils","year":"2023","journal-title":"Climacteric"},{"key":"10.1016\/j.thromres.2025.109561_bb1060","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.thromres.2019.03.015","article-title":"Changes in laboratory markers of thrombotic risk early in the first trimester of pregnancy may be linked to an increase in estradiol and progesterone","volume":"178","author":"Bagot","year":"2019","journal-title":"Thromb. Res."},{"key":"10.1016\/j.thromres.2025.109561_bb1065","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1161\/ATVBAHA.123.320331","article-title":"Prediction of venous thromboembolism in diverse populations using machine learning and structured electronic health records","volume":"44","author":"Chen","year":"2023","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.thromres.2025.109561_bb1070","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.863612","article-title":"Venous thromboembolism risk score and pregnancy","volume":"9","author":"Raia-Barjat","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"issue":"12","key":"10.1016\/j.thromres.2025.109561_bb1075","doi-asserted-by":"crossref","first-page":"7707","DOI":"10.3934\/mbe.2024339","article-title":"Integrating biomarkers for hemostatic disorders into computational models of blood clot formation: a systematic review","volume":"21","author":"Bannoud","year":"2024","journal-title":"Math. Biosci. Eng."},{"issue":"1","key":"10.1016\/j.thromres.2025.109561_bb1080","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/clinchem\/hvaa298","article-title":"Biomarkers for risk assessment in atrial fibrillation","volume":"67","author":"Berg","year":"2021","journal-title":"Clin. Chem."},{"issue":"4","key":"10.1016\/j.thromres.2025.109561_bb1085","doi-asserted-by":"crossref","first-page":"313","DOI":"10.4103\/joah.joah_106_24","article-title":"Enhancing venous thromboembolism risk prediction through novel biomarkers and inflammatory indicators","volume":"15","author":"Al-Maaroof","year":"2024","journal-title":"J. Appl. Hematol."},{"key":"10.1016\/j.thromres.2025.109561_bb1090","doi-asserted-by":"crossref","DOI":"10.1161\/circ.132.suppl_3.15903","article-title":"Abstract 15903: an improvement of score models in the prediction of deep vein thrombosis of upper and lower limbs in hospitalized patients","volume":"132","author":"Cardella","year":"2015","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.thromres.2025.109561_bb1095","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1111\/ejh.14110","article-title":"Artificial intelligence in the prediction of venous thromboembolism: a systematic review and pooled analysis","volume":"111","author":"Chiasakul","year":"2023","journal-title":"Eur. J. Haematol."},{"issue":"3","key":"10.1016\/j.thromres.2025.109561_bb1100","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1479-828X.2007.00720.x","article-title":"Reduction in protein S activity during normal pregnancy","volume":"47","author":"Kurasawa","year":"2008","journal-title":"Aust. N. Z. J. Obstet. Gynaecol."},{"issue":"4","key":"10.1016\/j.thromres.2025.109561_bb1105","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1160\/TH09-10-0704","article-title":"Haemostatic reference intervals in pregnancy","volume":"103","author":"Szecsi","year":"2010","journal-title":"Thromb. Haemost."},{"issue":"5","key":"10.1016\/j.thromres.2025.109561_bb1110","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1160\/TH09-07-0476","article-title":"Altered reference ranges for protein C and protein S during early pregnancy: implications for the diagnosis of protein C and protein S deficiency during pregnancy","volume":"103","author":"Said","year":"2010","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.thromres.2025.109561_bb1115","first-page":"633","article-title":"Free protein S (PS) in normal pregnancy: a comparison between two analytical methods","volume":"133","author":"PatriciaFardella","year":"2005","journal-title":"Rev. Med. Chile"}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384825003111?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384825003111?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T02:28:41Z","timestamp":1768012121000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049384825003111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":218,"alternative-id":["S0049384825003111"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2025.109561","relation":{},"ISSN":["0049-3848"],"issn-type":[{"value":"0049-3848","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The maternal hemostatic shift: Understanding VTE risk in pregnancy and postpartum","name":"articletitle","label":"Article Title"},{"value":"Thrombosis Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.thromres.2025.109561","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"109561"}}