{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T23:49:18Z","timestamp":1776124158677,"version":"3.50.1"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100016819","name":"Octapharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005200","name":"New Jersey Commission on Spinal Cord Research","doi-asserted-by":"publisher","award":["CSCR23IRG005"],"award-info":[{"award-number":["CSCR23IRG005"]}],"id":[{"id":"10.13039\/100005200","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005200","name":"New Jersey Commission on Spinal Cord Research","doi-asserted-by":"publisher","award":["1R35GM155242"],"award-info":[{"award-number":["1R35GM155242"]}],"id":[{"id":"10.13039\/100005200","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014120","name":"Office of the Vice Provost for Research, Boston College","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014120","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011132","name":"Rutgers, The State University of New Jersey","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011132","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 GM135141"],"award-info":[{"award-number":["T32 GM135141"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thrombosisresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.thromres.2026.109666","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T08:05:10Z","timestamp":1774598710000},"page":"109666","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Blood product supplementation modulates clotting kinetics, mechanics, and fibrin architecture in an in vitro model of trauma-induced coagulopathy"],"prefix":"10.1016","volume":"260","author":[{"given":"Andrew R.","family":"Gosselin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sameer","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph S.","family":"Hanna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Goswami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerie","family":"Tutwiler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.thromres.2026.109666_bb0005","series-title":"Global Health Estimates 2016: Deaths by Cause, Age, Sex, by Country and by Region, 2000\u20132016","author":"World Health Organization","year":"2018"},{"key":"10.1016\/j.thromres.2026.109666_bb0010","author":"Centers for Disease Control and Prevention"},{"issue":"6","key":"10.1016\/j.thromres.2026.109666_bb0015","first-page":"1338","article-title":"Demetriades. Preventable or potentially preventable mortality at a mature trauma center","volume":"63","author":"Teixeira","year":"2007","journal-title":"J. Trauma"},{"issue":"2","key":"10.1016\/j.thromres.2026.109666_bb0020","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/TA.0000000000000292","article-title":"An analysis of prehospital deaths: who can we save?","volume":"77","author":"Davis","year":"2014","journal-title":"J. Trauma Acute Care Surg."},{"issue":"4","key":"10.1016\/j.thromres.2026.109666_bb0025","first-page":"16","article-title":"Trauma-induced coagulopathy: overview of an emerging medical problem from pathophysiology to outcomes","volume":"8","author":"Savioli","year":"2021","journal-title":"Medicines (Basel)"},{"issue":"1","key":"10.1016\/j.thromres.2026.109666_bb0030","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41572-021-00264-3","article-title":"Trauma-induced coagulopathy","volume":"7","author":"Moore","year":"2021","journal-title":"Nat Rev Dis Primers."},{"issue":"2","key":"10.1016\/j.thromres.2026.109666_bb0035","first-page":"160","article-title":"Effects of aging and sex on clot formation, structure, and lysis in trauma patients","volume":"241","author":"Piplani","year":"2025","journal-title":"JACS"},{"issue":"99","key":"10.1016\/j.thromres.2026.109666_bb0040","first-page":"S28","article-title":"Sex dimorphisms in coagulation: implications in trauma-induced coagulopathy and trauma resuscitation","volume":"2","author":"Coleman","year":"2024","journal-title":"Am. J. Hematol."},{"issue":"3","key":"10.1016\/j.thromres.2026.109666_bb0045","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1213\/ANE.0000000000004234","article-title":"Fibrinolysis shutdown in trauma: historical review and clinical implications","volume":"129","author":"Moore","year":"2019","journal-title":"Anesth. Analg."},{"issue":"2","key":"10.1016\/j.thromres.2026.109666_bb0050","doi-asserted-by":"crossref","first-page":"120","DOI":"10.4103\/0974-2700.96479","article-title":"Hemostatic resuscitation with plasma and platelets in trauma","volume":"5","author":"Johansson","year":"2012","journal-title":"J. Emerg. Trauma Shock"},{"issue":"2","key":"10.1016\/j.thromres.2026.109666_bb0055","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1001\/2013.jamasurg.387","article-title":"The Prospective, Observational, Multicenter, Major Trauma Transfusion (PROMMTT) study: comparative effectiveness of a time-varying treatment with competing risks","volume":"148","author":"Holcomb","year":"2013","journal-title":"JAMA Surg."},{"issue":"5","key":"10.1016\/j.thromres.2026.109666_bb0060","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1001\/jama.2015.12","article-title":"Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma","volume":"313","author":"Holcomb","year":"2015","journal-title":"JAMA"},{"issue":"6","key":"10.1016\/j.thromres.2026.109666_bb0065","first-page":"591","article-title":"Haemostatic resuscitation in trauma: the next generation","volume":"22","author":"Stensballe","year":"2016","journal-title":"Curr. Opin. Crit. Care"},{"issue":"3","key":"10.1016\/j.thromres.2026.109666_bb0070","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1097\/TA.0000000000004327","article-title":"Whole blood resuscitation for injured patients requiring transfusion: a systematic review, meta-analysis, and practice management guideline from the Eastern Association for the Surgery of Trauma","volume":"97","author":"Meizoso","year":"2024","journal-title":"J. Trauma Acute Care Surg."},{"key":"10.1016\/j.thromres.2026.109666_bb0075","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jss.2023.02.010","article-title":"Outcomes of transfusion with whole blood, component therapy, or both in adult civilian trauma patients: a systematic review and meta-analysis","volume":"287","author":"Ngatuvai","year":"2023","journal-title":"J. Surg. Res."},{"issue":"3","key":"10.1016\/j.thromres.2026.109666_bb0080","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/jth.14378","article-title":"Towards patient-specific management of trauma hemorrhage: the effect of resuscitation therapy on parameters of thromboelastometry","volume":"17","author":"Juffermans","year":"2019","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2026.109666_bb0085","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.thromres.2020.01.001","article-title":"Fibrin clot formation under diverse clotting conditions: comparing turbidimetry and thromboelastography","volume":"187","author":"Zeng","year":"2020","journal-title":"Thromb. Res."},{"key":"10.1016\/j.thromres.2026.109666_bb0090","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.matbio.2016.08.003","article-title":"Fibrin mechanical properties and their structural origins","volume":"60-61","author":"Litvinov","year":"2017","journal-title":"Matrix Biol."},{"issue":"159","key":"10.1016\/j.thromres.2026.109666_bb0095","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.actbio.2022.12.028","article-title":"Fracture toughness of fibrin gels as a function of protein volume fraction: mechanical origins","volume":"15","author":"Garyfallogiannis","year":"2023","journal-title":"Acta Biomater."},{"key":"10.1016\/j.thromres.2026.109666_bb0100","first-page":"35","article-title":"Coagulation complications following trauma","volume":"3","author":"Martini","year":"2016","journal-title":"Mil. Med. Res."},{"issue":"2","key":"10.1016\/j.thromres.2026.109666_bb0105","doi-asserted-by":"crossref","first-page":"R55","DOI":"10.1186\/cc8948","article-title":"Goal-directed coagulation management of major trauma patients using thromboelastometry (ROTEM)-guided administration of fibrinogen concentrate and prothrombin complex concentrate","volume":"14","author":"Schochl","year":"2010","journal-title":"Crit. Care"},{"key":"10.1016\/j.thromres.2026.109666_bb0110","doi-asserted-by":"crossref","first-page":"R17","DOI":"10.1186\/cc5686","article-title":"Management of bleeding following major trauma: a European guideline","volume":"11","author":"Spahn","year":"2007","journal-title":"Crit. Care"},{"issue":"3","key":"10.1016\/j.thromres.2026.109666_bb0115","first-page":"535","article-title":"Thrombelastography is better than PT, aPTT, and activated clotting time in detecting clinically relevant clotting abnormalities after hypothermia, hemorrhagic shock and resuscitation in pigs","volume":"65","author":"Martini","year":"2008","journal-title":"J. Trauma"},{"key":"10.1016\/j.thromres.2026.109666_bb0120","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1757-7241-19-52","article-title":"Reduced clot strength upon admission, evaluated by thrombelastography (TEG), in trauma patients is independently associated with increased 30-day mortality","volume":"19","author":"Nystrup","year":"2011","journal-title":"Scand. J. Trauma Resusc. Emerg. Med."},{"issue":"1","key":"10.1016\/j.thromres.2026.109666_bb0125","article-title":"Thromboelastography and thromboelastometry in assessment of fibrinogen deficiency and prediction for transfusion requirement: a descriptive review","volume":"2018","author":"Peng","year":"2018","journal-title":"Biomed. Res. Int."},{"issue":"1","key":"10.1016\/j.thromres.2026.109666_bb0130","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/1757-7241-17-45","article-title":"Thrombelastography and thromboelastometry in assessing coagulopathy in trauma","volume":"17","author":"Johansson","year":"2009","journal-title":"Scand. J. Trauma Resusc. Emerg. Med. Emerg. Med."},{"key":"10.1016\/j.thromres.2026.109666_bb0135","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/os.12158","article-title":"Thromboelastography predictive of death in trauma patients","volume":"7","author":"Kane","year":"2015","journal-title":"Orthop. Surg."},{"issue":"4","key":"10.1016\/j.thromres.2026.109666_bb0140","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1097\/SHK.0000000000002544","article-title":"Dysregulated clot mechanics and kinetics impacted by injury severity, predict mortality after trauma","volume":"63","author":"Gosselin","year":"2025","journal-title":"Shock"},{"issue":"220","key":"10.1016\/j.thromres.2026.109666_bb0145","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.thromres.2022.10.017","article-title":"Hyperfibrinolysis drives mechanical instabilities in a simulated model of trauma induced coagulopathy","volume":"220","author":"Gosselin","year":"2022","journal-title":"Thromb. Res."},{"issue":"5","key":"10.1016\/j.thromres.2026.109666_bb0150","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1097\/TA.0000000000003723","article-title":"Plasma-based assays distinguish hyperfibrinolysis and shutdown subgroups in trauma-induced coagulopathy","volume":"93","author":"Lawson","year":"2022","journal-title":"J. Trauma Acute Care Surg."},{"issue":"6","key":"10.1016\/j.thromres.2026.109666_bb0155","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1097\/SLA.0000000000001608","article-title":"Goal-directed hemostatic resuscitation of trauma-induced coagulopathy","volume":"263","author":"Gonzalez","year":"2016","journal-title":"Ann. Surg."},{"issue":"1","key":"10.1016\/j.thromres.2026.109666_bb0160","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s00134-020-06266-1","article-title":"Viscoelastic haemostatic assay augmented protocols for major trauma haemorrhage (ITACTIC): a randomized, controlled trial","volume":"47","author":"Baksaas-Aasen","year":"2020","journal-title":"Intensive Care Med."},{"issue":"5","key":"10.1016\/j.thromres.2026.109666_bb0165","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1097\/MBC.0b013e32835e4246","article-title":"Influence of resuscitation fluids, fresh frozen plasma and antifibrinolytics on fibrinolysis in a thrombelastography-based, in-vitro, whole-blood model","volume":"24","author":"Kostousov","year":"2013","journal-title":"Blood Coagul. Fibrinolysis"},{"key":"10.1016\/j.thromres.2026.109666_bb0170","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1186\/s12884-018-2021-9","article-title":"Association between fluid management and dilutional coagulopathy in severe postpartum haemorrhage: a nationwide retrospective cohort study","volume":"18","author":"Gillissen","year":"2018","journal-title":"BMC Pregnancy Childbirth"},{"issue":"1","key":"10.1016\/j.thromres.2026.109666_bb0175","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1097\/SHK.0000000000002039","article-title":"Pre-hospital crystalloid resuscitation: practice variation & associations with clinical outcomes","volume":"59","author":"Weykamp","year":"2022","journal-title":"Shock"},{"issue":"3","key":"10.1016\/j.thromres.2026.109666_bb0180","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.jamcollsurg.2019.11.011","article-title":"Examining the effect of hypertonic saline administered for reduction of intracranial hypertension on coagulation","volume":"230","author":"Coleman","year":"2019","journal-title":"J. Am. Coll. Surg."},{"issue":"2","key":"10.1016\/j.thromres.2026.109666_bb0185","first-page":"1083","article-title":"Hypertonic saline maintains coagulofibrinolytic homeostasis following moderate-to-severe traumatic brain injury by regulating monocyte phenotype via expression of lncRNAs","volume":"19","author":"Yang","year":"2018","journal-title":"Mol. Med. Rep."},{"issue":"1","key":"10.1016\/j.thromres.2026.109666_bb0190","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/ANA.0000000000000255","article-title":"Equiosmolar solutions of hypertonic saline and mannitol do not impair blood coagulation during elective intracranial surgery","volume":"29","author":"Hernandez-Palazon","year":"2017","journal-title":"J. Neurosurg. Anesthesiol."},{"issue":"1 Suppl 1","key":"10.1016\/j.thromres.2026.109666_bb0195","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1097\/TA.0b013e31828fa3b9","article-title":"Resuscitate early with plasma and platelets or balance blood products gradually: findings from the PROMMTT study","volume":"75","author":"Junco","year":"2013","journal-title":"J. Trauma Acute Care Surg."},{"issue":"4","key":"10.1016\/j.thromres.2026.109666_bb0200","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1097\/TA.0000000000002037","article-title":"Citrated kaolin thrombelastography (TEG) thresholds for goal-directed therapy in injured patients receiving massive transfusion","volume":"85","author":"Stettler","year":"2018","journal-title":"J. Trauma Acute Care Surg."},{"issue":"3","key":"10.1016\/j.thromres.2026.109666_bb0205","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.surg.2014.04.017","article-title":"Activated clotting time of thrombelastography (T-ACT) predicts early postinjury blood component transfusion beyond plasma","volume":"156","author":"Moore","year":"2014","journal-title":"Surgery"},{"issue":"5","key":"10.1016\/j.thromres.2026.109666_bb0210","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.jamcollsurg.2015.01.026","article-title":"Plasma is the physiologic buffer of tissue plasminogen activator-mediated fibrinolysis: rationale for plasma-first resuscitation after life-threatening hemorrhage","volume":"220","author":"Moore","year":"2015","journal-title":"J. Am. Coll. Surg."},{"key":"10.1016\/j.thromres.2026.109666_bb0215","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jss.2017.05.030","article-title":"14-Day thawed plasma retains clot enhancing properties and inhibits tPA-induced fibrinolysis","volume":"219","author":"Huebner","year":"2017","journal-title":"J. Surg. Res."},{"issue":"2","key":"10.1016\/j.thromres.2026.109666_bb0220","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/vox.12997","article-title":"28-day thawed plasma maintains \u03b12 -antiplasmin levels and inhibits tPA-induced fibrinolysis","volume":"116","author":"Stettler","year":"2021","journal-title":"Vox Sang."},{"issue":"8","key":"10.1016\/j.thromres.2026.109666_bb0225","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1111\/trf.14149","article-title":"Freeze-dried plasma enhances clot formation and inhibits fibrinolysis in the presence of tissue plasminogen activator similar to pooled liquid plasma","volume":"57","author":"Huebner","year":"2017","journal-title":"Transfusion"},{"key":"10.1016\/j.thromres.2026.109666_bb0230","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s00068-025-02870-2","article-title":"The impact of the patient\u2019s plasma volume on the amount of fresh frozen plasma needed to normalize the thromboelastographic reaction time","volume":"51","author":"Caplan","year":"2025","journal-title":"Eur. J. Trauma Emerg. Surg."},{"issue":"1","key":"10.1016\/j.thromres.2026.109666_bb0235","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1097\/TA.0000000000001270","article-title":"Rapid thrombelastography thresholds for goal-directed resuscitation of patients at risk for massive transfusion","volume":"82","author":"Einersen","year":"2017","journal-title":"J. Trauma Acute Care Surg."},{"issue":"6","key":"10.1016\/j.thromres.2026.109666_bb0240","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.surg.2011.12.022","article-title":"Quantification of hypercoagulable state after blunt trauma: microparticle and thrombin generation are increased relative to injury severity, while standard markers are not","volume":"151","author":"Park","year":"2012","journal-title":"Surgery"},{"issue":"2","key":"10.1016\/j.thromres.2026.109666_bb0245","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1538-7836.2008.02873.x","article-title":"Tissue-specific hemostasis: role of tissue factor","volume":"6","author":"Mackman","year":"2008","journal-title":"J. Thromb. Haem."},{"issue":"6","key":"10.1016\/j.thromres.2026.109666_bb0250","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1097\/TA.0000000000003164","article-title":"Cryoprecipitate attenuates the endotheliopathy of trauma in mice subjected to hemorrhagic shock and trauma","volume":"90","author":"Barry","year":"2021","journal-title":"J. Trauma Acute Care Surg."},{"issue":"19","key":"10.1016\/j.thromres.2026.109666_bb0255","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1001\/jama.2023.21019","article-title":"Early and empirical high-dose cryoprecipitate for hemorrhage after traumatic injury: the CRYOSTAT-2 randomized clinical trial","volume":"330","author":"Davenport","year":"2023","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.thromres.2026.109666_bb0260","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1186\/s13054-022-04167-x","article-title":"Cryoprecipitate transfusion in trauma patients attenuates hyperfibrinolysis and restores normal clot structure and stability: results from a laboratory sub-study of the FEISTY trial","volume":"26","author":"Morrow","year":"2022","journal-title":"Crit. Care"},{"issue":"6","key":"10.1016\/j.thromres.2026.109666_bb0265","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.3390\/ijms23062944","article-title":"The efficacy of fibrinogen concentrates in relation to cryoprecipitate in restoring clot integrity and stability against lysis","volume":"23","author":"Whyte","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.thromres.2026.109666_bb0270","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.3390\/ijms22042185","article-title":"Fibrinogen replacement therapy for traumatic coagulopathy: does the fibrinogen source matter?","volume":"22","author":"Morrow","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.thromres.2026.109666_bb0275","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0290571","article-title":"Differences in coagulation-relevant parameters: Comparing cryoprecipitate and a human fibrinogen concentrate","volume":"18","author":"Stanford","year":"2023","journal-title":"PloS One"},{"issue":"4","key":"10.1016\/j.thromres.2026.109666_bb0280","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.3390\/ijms22042185","article-title":"Fibrinogen replacement therapy for traumatic coagulopathy: does the fibrinogen source matter?","volume":"22","author":"Morrow","year":"2021","journal-title":"Int. J. Mol. Sci."}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004938482600085X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004938482600085X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T22:58:26Z","timestamp":1776121106000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004938482600085X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":56,"alternative-id":["S004938482600085X"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2026.109666","relation":{},"ISSN":["0049-3848"],"issn-type":[{"value":"0049-3848","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Blood product supplementation modulates clotting kinetics, mechanics, and fibrin architecture in an in vitro model of trauma-induced coagulopathy","name":"articletitle","label":"Article Title"},{"value":"Thrombosis Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.thromres.2026.109666","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"109666"}}