{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T05:09:15Z","timestamp":1778303355192,"version":"3.51.4"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thrombosisresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.thromres.2026.109667","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T15:47:45Z","timestamp":1775231265000},"page":"109667","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Safety and efficacy of direct oral anticoagulants in children with infection-related cerebral venous thrombosis: a real-life multicenter retrospective study"],"prefix":"10.1016","volume":"261","author":[{"given":"Adele","family":"Fiordelisi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Banov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Del Borrello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margherita","family":"Nosadini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Sartori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Simioni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Trapani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donatella","family":"Lasagni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.thromres.2026.109667_bb0005","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/dmcn.15331","article-title":"Cerebral sinovenous thrombosis associated with head\/neck infection in children: clues for improved management","volume":"65","author":"Narcy","year":"2023","journal-title":"Dev. Med. Child Neurol."},{"key":"10.1016\/j.thromres.2026.109667_bb0010","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3389\/fped.2017.00163","article-title":"Cerebral sinovenous thrombosis","volume":"5","author":"Ichord","year":"2017","journal-title":"Front. Pediatr."},{"key":"10.1016\/j.thromres.2026.109667_bb0015","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1007\/s00431-024-05965-x","article-title":"Clinical characteristics and predictive factors of thrombotic complications in children with acute mastoiditis: a single center retrospective study","volume":"184","author":"Fiordelisi","year":"2025","journal-title":"Eur. J. Pediatr."},{"key":"10.1016\/j.thromres.2026.109667_bb0020","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1136\/archdischild-2014-306382","article-title":"Paediatric cerebral sinovenous thrombosis: findings of the International Paediatric Stroke Study","volume":"100","author":"Ichord","year":"2015","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.thromres.2026.109667_bb0025","doi-asserted-by":"crossref","first-page":"E8","DOI":"10.3171\/2023.7.FOCUS23374","article-title":"Anticoagulation for the treatment of septic cerebral venous sinus thrombosis in the setting of pediatric sinogenic and otogenic intracranial infections","volume":"55","author":"Sutter","year":"2023","journal-title":"Neurosurg. Focus"},{"key":"10.1016\/j.thromres.2026.109667_bb0030","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1182\/bloodadvances.2024015328","article-title":"American Society of Hematology\/International Society on Thrombosis and Haemostasis 2024 updated guidelines for treatment of venous thromboembolism in pediatric patients","volume":"9","author":"Monagle","year":"2025","journal-title":"Blood Adv."},{"key":"10.1016\/j.thromres.2026.109667_bb0035","doi-asserted-by":"crossref","first-page":"e51","DOI":"10.1161\/STR.0000000000000183","article-title":"Management of stroke in neonates and children: a scientific statement from the American Heart Association\/American Stroke Association","volume":"50","author":"Ferriero","year":"2019","journal-title":"Stroke"},{"key":"10.1016\/j.thromres.2026.109667_bb0040","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1161\/STROKEAHA.115.011875","article-title":"Clinical outcome of anticoagulant treatment in head or neck infection-associated cerebral venous thrombosis","volume":"47","author":"Zuurbier","year":"2016","journal-title":"Stroke"},{"key":"10.1016\/j.thromres.2026.109667_bb0045","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.ijporl.2006.10.014","article-title":"A caution regarding the use of low-molecular weight heparin in pediatric otogenic lateral sinus thrombosis","volume":"71","author":"Shah","year":"2007","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"10.1016\/j.thromres.2026.109667_bb0050","doi-asserted-by":"crossref","first-page":"6250","DOI":"10.1182\/bloodadvances.2020003244","article-title":"Safety and efficacy of rivaroxaban in pediatric cerebral venous thrombosis (EINSTEIN-Jr CVT)","volume":"4","author":"Connor","year":"2020","journal-title":"Blood Adv."},{"key":"10.1016\/j.thromres.2026.109667_bb0055","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.pediatrneurol.2021.12.011","article-title":"Anticoagulant treatment for pediatric infection-related cerebral venous thrombosis","volume":"128","author":"S\u00e1nchez van Kammen","year":"2022","journal-title":"Pediatr. Neurol."},{"key":"10.1016\/j.thromres.2026.109667_bb0060","doi-asserted-by":"crossref","first-page":"2852","DOI":"10.1111\/jth.15048","article-title":"Definition of major bleeding: prognostic classification","volume":"18","author":"Franco","year":"2020","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2026.109667_bb0065","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1007\/s10072-023-06656-5","article-title":"Deep cerebral venous system involvement in patients with cerebral sinus thrombosis: a proposal of neuroradiological score systems useful for clinical assessment","volume":"44","author":"Calandrelli","year":"2023","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.thromres.2026.109667_bb0070","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jocn.2022.06.009","article-title":"Effect of intracranial venous collaterals on neurological outcomes in cerebral venous thrombosis","volume":"102","author":"Zhao","year":"2022","journal-title":"J. Clin. Neurosci."},{"key":"10.1016\/j.thromres.2026.109667_bb0075","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.ijporl.2011.12.025","article-title":"Pediatric otogenic lateral sinus thrombosis: role of anticoagulation and surgery","volume":"76","author":"Sitton","year":"2012","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"10.1016\/j.thromres.2026.109667_bb0080","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.ijporl.2014.03.002","article-title":"Otogenic lateral sinus thrombosis: case series and controversies","volume":"78","author":"Funamura","year":"2014","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"10.1016\/j.thromres.2026.109667_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.rpth.2024.102605","article-title":"Clinical characteristics, treatment, and outcomes of provoked acute cerebral sinovenous thrombosis in patients <21 years old: findings from the Kids-DOTT Multinational Trial","volume":"8","author":"Woods","year":"2024","journal-title":"Res. Pract. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2026.109667_bb0090","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3171\/2023.2.PEDS2319","article-title":"Neurosurgical outcomes of pediatric cerebral venous sinus thrombosis following acute mastoiditis: a systematic review and meta-analysis","volume":"32","author":"Lu","year":"2023","journal-title":"J. Neurosurg. Pediatr."},{"key":"10.1016\/j.thromres.2026.109667_bb0095","doi-asserted-by":"crossref","first-page":"e357","DOI":"10.1016\/S2352-3026(25)00067-5","article-title":"Extended-phase anticoagulant treatment of acute venous thromboembolism in children: a cohort study from the EINSTEIN-Jr phase 3 trial","volume":"12","author":"Male","year":"2025","journal-title":"Lancet Haematol."},{"key":"10.1016\/j.thromres.2026.109667_bb0100","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1161\/CIRCULATIONAHA.109.913673","article-title":"Impact of thrombophilia on risk of arterial ischemic stroke or cerebral sinovenous thrombosis in neonates and children: a systematic review and meta-analysis of observational studies","volume":"121","author":"Kenet","year":"2010","journal-title":"Circulation"}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384826000861?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384826000861?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T04:11:53Z","timestamp":1778299913000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049384826000861"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":20,"alternative-id":["S0049384826000861"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2026.109667","relation":{},"ISSN":["0049-3848"],"issn-type":[{"value":"0049-3848","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Safety and efficacy of direct oral anticoagulants in children with infection-related cerebral venous thrombosis: a real-life multicenter retrospective study","name":"articletitle","label":"Article Title"},{"value":"Thrombosis Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.thromres.2026.109667","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"109667"}}