{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T05:09:18Z","timestamp":1778303358859,"version":"3.51.4"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thrombosisresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.thromres.2026.109677","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T07:43:12Z","timestamp":1775720592000},"page":"109677","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Thrombosis after surgical splenectomy \u2013 why, in whom and can we prevent it?"],"prefix":"10.1016","volume":"261","author":[{"given":"Gerard","family":"Gurumurthy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawn","family":"Swan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lara","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicoletta","family":"Riva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Gatt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jecko","family":"Thachil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.thromres.2026.109677_bb0005","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1148\/radiol.2015150887","article-title":"Spleen size is significantly influenced by body height and sex: establishment of normal values for spleen size at US with a cohort of 1200 healthy individuals","volume":"279","author":"Chow","year":"2016","journal-title":"Radiology"},{"issue":"2","key":"10.1016\/j.thromres.2026.109677_bb0010","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1007\/s003300050145","article-title":"Determination of normal splenic volume on computed tomography in relation to age, gender and body habitus","volume":"7","author":"Prassopoulos","year":"1997","journal-title":"Eur. Radiol."},{"issue":"8","key":"10.1016\/j.thromres.2026.109677_bb0015","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/nri1669","article-title":"Structure and function of the spleen","volume":"5","author":"Mebius","year":"2005","journal-title":"Nat. Rev. Immunol."},{"issue":"8","key":"10.1016\/j.thromres.2026.109677_bb0020","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1308\/rcsann.2018.0139","article-title":"Splenic trauma in the twenty-first century: changing trends in management","volume":"100","author":"Roy","year":"2018","journal-title":"Ann. R. Coll. Surg. Engl."},{"issue":"1","key":"10.1016\/j.thromres.2026.109677_bb0025","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ejim.2009.10.003","article-title":"Mortality risk in splenectomised patients: a Danish population-based cohort study","volume":"21","author":"Yong","year":"2010","journal-title":"Eur. J. Intern. Med."},{"issue":"2","key":"10.1016\/j.thromres.2026.109677_bb0030","doi-asserted-by":"crossref","first-page":"392","DOI":"10.3324\/haematol.2013.092460","article-title":"Long-term risks after splenectomy among 8,149 cancer-free American veterans: a cohort study with up to 27 years follow-up","volume":"99","author":"Kristinsson","year":"2014","journal-title":"Haematologica"},{"issue":"6","key":"10.1016\/j.thromres.2026.109677_bb0035","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1111\/j.1538-7836.2010.03849.x","article-title":"Risk of venous thromboembolism in splenectomized patients compared with the general population and appendectomized patients: a 10-year nationwide cohort study","volume":"8","author":"Thomsen","year":"2010","journal-title":"J. Thromb. Haemost."},{"issue":"1","key":"10.1016\/j.thromres.2026.109677_bb0040","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1308\/rcsann.2016.0325","article-title":"A review of the management of blunt splenic trauma in England and Wales: have regional trauma networks influenced management strategies and outcomes?","volume":"99","author":"Yiannoullou","year":"2017","journal-title":"Ann. R. Coll. Surg. Engl."},{"issue":"1","key":"10.1016\/j.thromres.2026.109677_bb0045","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13049-018-0578-y","article-title":"Hospital level variations in the trends and outcomes of the nonoperative management of splenic injuries \u2013 a nationwide cohort study","volume":"27","author":"Liao","year":"2019","journal-title":"Scand. J. Trauma Resusc. Emerg. Med."},{"issue":"6","key":"10.1016\/j.thromres.2026.109677_bb0050","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1089\/sur.2013.051","article-title":"Overwhelming post-splenectomy infection: narrative review of the literature","volume":"15","author":"Taniguchi","year":"2014","journal-title":"Surg. Infect."},{"issue":"5","key":"10.1016\/j.thromres.2026.109677_bb0055","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/0002-9610(82)90158-1","article-title":"Outcome and sepsis after splenectomy in adults","volume":"143","author":"Standage","year":"1982","journal-title":"Am. J. Surg."},{"issue":"7028","key":"10.1016\/j.thromres.2026.109677_bb0060","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1136\/bmj.312.7028.430","article-title":"Guidelines for the prevention and treatment of infection in patients with an absent or dysfunctional spleen: appendix","volume":"312","year":"1996","journal-title":"BMJ"},{"issue":"1","key":"10.1016\/j.thromres.2026.109677_bb0065","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1080\/08998280.2009.11928458","article-title":"Postsplenectomy reactive thrombocytosis","volume":"22","author":"Khan","year":"2009","journal-title":"Baylor Univ. Med. Cent. Proc."},{"issue":"14","key":"10.1016\/j.thromres.2026.109677_bb0070","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1182\/blood-2009-04-210112","article-title":"Vascular complications after splenectomy for hematologic disorders","volume":"114","author":"Crary","year":"2009","journal-title":"Blood"},{"issue":"12","key":"10.1016\/j.thromres.2026.109677_bb0075","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1136\/thx.2004.038083","article-title":"Splenectomy and chronic thromboembolic pulmonary hypertension","volume":"60","author":"Jais","year":"2005","journal-title":"Thorax"},{"key":"10.1016\/j.thromres.2026.109677_bb0080","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ijsu.2015.10.011","article-title":"Splenectomy is associated with a higher risk for venous thromboembolism: a prospective cohort study","volume":"24","author":"Lee","year":"2015","journal-title":"Int. J. Surg."},{"issue":"5","key":"10.1016\/j.thromres.2026.109677_bb0085","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s00423-006-0075-z","article-title":"Thrombosis of the splenoportal axis after splenectomy","volume":"391","author":"Romano","year":"2006","journal-title":"Langenbeck\u2019s Arch. Surg."},{"issue":"7","key":"10.1016\/j.thromres.2026.109677_bb0090","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1007\/s00464-009-0828-1","article-title":"Recommended timing for surveillance ultrasonography to diagnose portal splenic vein thrombosis after laparoscopic splenectomy","volume":"24","author":"Tran","year":"2010","journal-title":"Surg. Endosc."},{"issue":"2","key":"10.1016\/j.thromres.2026.109677_bb0095","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1007\/s00464-023-10566-0","article-title":"Portal vein velocity predicts portal vein system thrombosis after splenectomy with esophagogastric devascularization","volume":"38","author":"Wang","year":"2024","journal-title":"Surg. Endosc."},{"issue":"14","key":"10.1016\/j.thromres.2026.109677_bb0100","article-title":"Porto-spleno-mesenteric venous thrombosis after elective splenectomy: a retrospective cohort study","author":"Baldari","year":"2023","journal-title":"Front. Immunol."},{"issue":"10","key":"10.1016\/j.thromres.2026.109677_bb0105","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1007\/s002689900521","article-title":"Portal vein thrombosis following splenectomy for hematologic disease: prospective study with Doppler color flow imaging","volume":"22","author":"Chaffanjon","year":"1998","journal-title":"World J. Surg."},{"issue":"2","key":"10.1016\/j.thromres.2026.109677_bb0110","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1097\/01.sla.0000151794.28392.a6","article-title":"High incidence of thrombosis of the portal venous system after laparoscopic splenectomy: a prospective study with contrast-enhanced CT scan","volume":"241","author":"Ikeda","year":"2005","journal-title":"Ann. Surg."},{"issue":"8","key":"10.1016\/j.thromres.2026.109677_bb0115","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1002\/ajh.27714","article-title":"Thromboembolic events are increased after splenectomy in postmenopausal women","volume":"100","author":"Feng","year":"2025","journal-title":"Am. J. Hematol."},{"issue":"01","key":"10.1016\/j.thromres.2026.109677_bb0120","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1160\/TH15-05-0381","article-title":"Risk of venous thromboembolism in patients with splenic injury and splenectomy: a nationwide cohort study","volume":"115","author":"Lin","year":"2016","journal-title":"Thromb. Haemost."},{"issue":"5","key":"10.1016\/j.thromres.2026.109677_bb0125","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.surg.2008.06.030","article-title":"Diameter of splenic vein is a risk factor for portal or splenic vein thrombosis after laparoscopic splenectomy","volume":"145","author":"Danno","year":"2009","journal-title":"Surgery"},{"issue":"12","key":"10.1016\/j.thromres.2026.109677_bb0130","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1002\/bjs.9622","article-title":"Effect of laparoscopic splenectomy on portal haemodynamics in patients with liver cirrhosis and portal hypertension","volume":"101","author":"Kawanaka","year":"2014","journal-title":"Br. J. Surg."},{"issue":"11","key":"10.1016\/j.thromres.2026.109677_bb0135","article-title":"A computational model-based study on the feasibility of predicting post-splenectomy thrombosis using hemodynamic metrics","author":"Wang","year":"2024","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"24","key":"10.1016\/j.thromres.2026.109677_bb0140","doi-asserted-by":"crossref","first-page":"4355","DOI":"10.12659\/MSM.909403","article-title":"Association between changes in splanchnic hemodynamics and risk factors of portal venous system thrombosis after splenectomy with periesophagogastric devascularization","author":"Huang","year":"2018","journal-title":"Med. Sci. Monit."},{"issue":"12","key":"10.1016\/j.thromres.2026.109677_bb0145","article-title":"Influences of anatomorphological features of the portal venous system on postsplenectomy hemodynamic characteristics in patients with portal hypertension: a computational model-based study","author":"Wang","year":"2021","journal-title":"Front. Physiol."},{"issue":"5","key":"10.1016\/j.thromres.2026.109677_bb0150","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/ajh.20566","article-title":"Arteriosclerotic events are less frequent in persons with chronic anemia: evidence from families with hereditary spherocytosis","volume":"81","author":"Schilling","year":"2006","journal-title":"Am. J. Hematol."},{"issue":"2","key":"10.1016\/j.thromres.2026.109677_bb0155","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1046\/j.1365-2141.1996.4881033.x","article-title":"Thrombo-embolic disease after splenectomy for hereditary stomatocytosis","volume":"93","author":"Stewart","year":"1996","journal-title":"Br. J. Haematol."},{"issue":"9","key":"10.1016\/j.thromres.2026.109677_bb0160","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1046\/j.1365-2168.2000.01514.x","article-title":"Diagnosis and treatment of portal vein thrombosis following splenectomy","volume":"87","author":"Van \u2019T Riet","year":"2000","journal-title":"J. Br. Surg."},{"issue":"1","key":"10.1016\/j.thromres.2026.109677_bb0165","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.113.000772","article-title":"Splenectomy is modifying the vascular remodeling of thrombosis","volume":"3","author":"Frey","year":"2014","journal-title":"J. Am. Heart Assoc."},{"issue":"6291","key":"10.1016\/j.thromres.2026.109677_bb0170","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1136\/bmj.283.6291.573","article-title":"Blood viscosity after splenectomy","volume":"283","author":"Robertson","year":"1981","journal-title":"BMJ"},{"issue":"6","key":"10.1016\/j.thromres.2026.109677_bb0175","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1002\/pbc.21319","article-title":"Laboratory markers of thrombosis risk in children with hereditary spherocytosis","volume":"49","author":"Troendle","year":"2007","journal-title":"Pediatr. Blood Cancer"},{"issue":"5","key":"10.1016\/j.thromres.2026.109677_bb0180","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.thromres.2007.12.022","article-title":"Increased procoagulant cell-derived microparticles (C-MP) in splenectomized patients with ITP","volume":"122","author":"Fontana","year":"2008","journal-title":"Thromb. Res."},{"issue":"1","key":"10.1016\/j.thromres.2026.109677_bb0185","doi-asserted-by":"crossref","first-page":"13033","DOI":"10.1038\/s41598-018-31386-6","article-title":"Microparticles from \u03b2-thalassaemia\/HbE patients induce endothelial cell dysfunction","volume":"8","author":"Kheansaard","year":"2018","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.thromres.2026.109677_bb0190","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s00277-016-2885-6","article-title":"Microparticles from splenectomized \u03b2-thalassemia\/HbE patients play roles on procoagulant activities with thrombotic potential","volume":"96","author":"Klaihmon","year":"2017","journal-title":"Ann. Hematol."},{"issue":"1","key":"10.1016\/j.thromres.2026.109677_bb0195","doi-asserted-by":"crossref","first-page":"6059","DOI":"10.1038\/s41598-019-42432-2","article-title":"Platelet proteome reveals specific proteins associated with platelet activation and the hypercoagulable state in \u03b2-thalassmia\/HbE patients","volume":"9","author":"Chanpeng","year":"2019","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.thromres.2026.109677_bb0200","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0237016","article-title":"Clinical course and short-term outcome of postsplenectomy reactive thrombocytosis in children without myeloproliferative disorders: a single institutional experience from a developing country. Yeh CC, editor","volume":"15","author":"Zvizdic","year":"2020","journal-title":"PLoS ONE"},{"issue":"7","key":"10.1016\/j.thromres.2026.109677_bb0205","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1001\/archsurg.1978.01370190030004","article-title":"Thromboembolic risk of postsplenectomy thrombocytosis","volume":"113","author":"Boxer","year":"1978","journal-title":"Arch. Surg."},{"issue":"7","key":"10.1016\/j.thromres.2026.109677_bb0210","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1001\/archsurg.141.7.663","article-title":"Prospective study of the incidence and risk factors of postsplenectomy thrombosis of the portal, mesenteric, and splenic veins","volume":"141","author":"Stamou","year":"2006","journal-title":"Arch. Surg."},{"issue":"17","key":"10.1016\/j.thromres.2026.109677_bb0215","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1007\/BF01662780","article-title":"Influence of splenectomy on platelet morphometry and function","volume":"68","author":"Wehmeier","year":"1990","journal-title":"Klin. Wochenschr."},{"issue":"2","key":"10.1016\/j.thromres.2026.109677_bb0220","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/0002-9610(78)90242-8","article-title":"Platelet aggregability after splenectomy in patients with normosplenism and hypersplenism","volume":"136","author":"Nagasue","year":"1978","journal-title":"Am. J. Surg."},{"issue":"4","key":"10.1016\/j.thromres.2026.109677_bb0225","first-page":"284","article-title":"Effect of splenectomy on coagulation and platelet function in adult liver transplant recipients assessed with rotational thromboelastometry and standard coagulation tests","volume":"22","author":"Hegazy","year":"2024","journal-title":"Exp. Clin. Transplant."},{"issue":"5","key":"10.1016\/j.thromres.2026.109677_bb0230","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.amjsurg.2010.01.015","article-title":"Splenectomy leads to a persistent hypercoagulable state after trauma","volume":"199","author":"Watters","year":"2010","journal-title":"Am. J. Surg."},{"issue":"1","key":"10.1016\/j.thromres.2026.109677_bb0235","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1007\/s00383-025-06171-y","article-title":"Splenic vein diameter\/portal vein diameter ratio as a predictor of portal vein thrombosis after laparoscopic splenectomy in children","volume":"41","author":"Fukuta","year":"2025","journal-title":"Pediatr. Surg. Int."},{"key":"10.1016\/j.thromres.2026.109677_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.amsu.2021.102381","article-title":"Evaluation of the risk factors for venous thromboembolism post splenectomy \u2013 a ten year retrospective cohort study in St James\u2019s hospital","volume":"66","author":"Abduljalil","year":"2021","journal-title":"Ann. Med. Surg."},{"issue":"1","key":"10.1016\/j.thromres.2026.109677_bb0245","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1089\/lap.2010.0325","article-title":"Portal vein thrombosis after laparoscopic and open splenectomy","volume":"21","author":"Vecchio","year":"2011","journal-title":"J. Laparoendosc. Adv. Surg. Tech."},{"issue":"8","key":"10.1016\/j.thromres.2026.109677_bb0250","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.3324\/haematol.12682","article-title":"The postoperative splenic\/portal vein thrombosis after splenectomy and its prevention - an unresolved issue","volume":"93","author":"Krauth","year":"2008","journal-title":"Haematologica"},{"issue":"1","key":"10.1016\/j.thromres.2026.109677_bb0255","doi-asserted-by":"crossref","DOI":"10.1136\/bmjhci-2024-101319","article-title":"Development of an explainable prediction model for portal vein system thrombosis post-splenectomy in patients with cirrhosis","volume":"32","author":"Qu","year":"2025","journal-title":"BMJ Health Care Inform."},{"issue":"12","key":"10.1016\/j.thromres.2026.109677_bb0260","doi-asserted-by":"crossref","first-page":"3626","DOI":"10.21037\/apm-22-826","article-title":"Nomogram for prediction of portal vein system thrombosis after splenectomy for hypersplenism in patients with Wilson disease","volume":"11","author":"Yao","year":"2022","journal-title":"Ann. Palliat. Med."},{"key":"10.1016\/j.thromres.2026.109677_bb0265","first-page":"27","article-title":"Nomogram model for prediction of portal vein thrombosis in patients with liver cirrhosis after splenectomy: a retrospective analysis of 2 independent cohorts","author":"Yuan","year":"2021","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.thromres.2026.109677_bb0270","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2023.1103223","article-title":"Nomogram-based prediction of portal vein system thrombosis formation after splenectomy in patients with hepatolenticular degeneration","volume":"10","author":"Zheng","year":"2023","journal-title":"Front. Med."},{"issue":"10","key":"10.1016\/j.thromres.2026.109677_bb0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejso.2025.110300","article-title":"Risk prediction models for portal vein thrombosis (PVT) in patients after splenectomy: a systematic review and meta-analysis","volume":"51","author":"Huang","year":"2025","journal-title":"Eur. J. Surg. Oncol."},{"issue":"23","key":"10.1016\/j.thromres.2026.109677_bb0280","doi-asserted-by":"crossref","first-page":"4782","DOI":"10.1182\/blood-2012-12-467068","article-title":"Splenectomy and the incidence of venous thromboembolism and sepsis in patients with immune thrombocytopenia","volume":"121","author":"Boyle","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.thromres.2026.109677_bb0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcmd.2019.102388","article-title":"Splenectomy and the incidence of venous thromboembolism and sepsis in patients with autoimmune hemolytic anemia","volume":"81","author":"Ho","year":"2020","journal-title":"Blood Cells Mol. Dis."},{"issue":"8","key":"10.1016\/j.thromres.2026.109677_bb0290","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1111\/j.1538-7836.2008.03024.x","article-title":"Delayed adverse vascular events after splenectomy in hereditary spherocytosis","volume":"6","author":"Schilling","year":"2008","journal-title":"J. Thromb. Haemost."},{"issue":"10","key":"10.1016\/j.thromres.2026.109677_bb0295","article-title":"Splenectomy is significantly associated with thrombosis but not with pulmonary hypertension in patients with transfusion-dependent thalassemia: a meta-analysis of observational studies","author":"Kalamara","year":"2023","journal-title":"Front. Med."},{"issue":"3","key":"10.1016\/j.thromres.2026.109677_bb0300","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1007\/s00268-017-4185-2","article-title":"Thromboembolic events following splenectomy: risk factors, prevention, management and outcomes","volume":"42","author":"Rottenstreich","year":"2018","journal-title":"World J. Surg."},{"issue":"4","key":"10.1016\/j.thromres.2026.109677_bb0305","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1007\/s00464-007-9735-5","article-title":"Laparoscopic splenectomy: the clinical practice guidelines of the European Association for Endoscopic Surgery (EAES)","volume":"22","author":"Habermalz","year":"2008","journal-title":"Surg. Endosc."},{"issue":"8","key":"10.1016\/j.thromres.2026.109677_bb0310","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0290164","article-title":"Long term prophylactic anticoagulation for portal vein thrombosis after splenectomy: a systematic review and meta-analysis. Ranjan R, editor","volume":"18","author":"Liao","year":"2023","journal-title":"PLoS ONE"},{"issue":"12","key":"10.1016\/j.thromres.2026.109677_bb0315","doi-asserted-by":"crossref","first-page":"9706","DOI":"10.1097\/JS9.0000000000003220","volume":"111","author":"Cao","year":"2025","journal-title":"Int. J. Surg."},{"issue":"09","key":"10.1016\/j.thromres.2026.109677_bb0320","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1055\/a-2484-0747","article-title":"Comparison of apixaban and aspirin in preventing portal vein thrombosis after laparoscopic splenectomy for cirrhotic hypersplenism","volume":"125","author":"Shi","year":"2025","journal-title":"Thromb. Haemost."},{"issue":"5","key":"10.1016\/j.thromres.2026.109677_bb0325","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1001\/archsurg.1993.01420170101015","article-title":"Portal vein thrombosis after elective splenectomy: an underappreciated, potentially lethal syndrome","volume":"128","author":"Rattner","year":"1993","journal-title":"Arch. Surg."},{"key":"10.1016\/j.thromres.2026.109677_bb0330","article-title":"Management of splanchnic venous thrombosis after splenectomy in hematologic diseases. Systematic review, meta-analysis and consensus guidelines","author":"Llu\u00eds","year":"2025","journal-title":"Int. J. Surg."},{"key":"10.1016\/j.thromres.2026.109677_bb0335","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.jss.2022.06.026","article-title":"Aspirin administration mitigates platelet hyperaggregability after splenectomy in a murine model","volume":"279","author":"Wallen","year":"2022","journal-title":"J. Surg. Res."},{"issue":"10","key":"10.1016\/j.thromres.2026.109677_bb0340","doi-asserted-by":"crossref","DOI":"10.1111\/ans.14395","article-title":"Effects of early antiplatelet therapy after splenectomy with gastro-oesophageal devascularization","volume":"88","author":"Zhou","year":"2018","journal-title":"ANZ J. Surg."},{"issue":"2","key":"10.1016\/j.thromres.2026.109677_bb0345","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1053\/j.gastro.2017.04.042","article-title":"Effects of anticoagulants in patients with cirrhosis and portal vein thrombosis: a systematic review and meta-analysis","volume":"153","author":"Loffredo","year":"2017","journal-title":"Gastroenterology"},{"issue":"143","key":"10.1016\/j.thromres.2026.109677_bb0350","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0112-2016","article-title":"The pathophysiology of chronic thromboembolic pulmonary hypertension","volume":"26","author":"Simonneau","year":"2017","journal-title":"Eur. Respir. Rev."},{"issue":"18","key":"10.1016\/j.thromres.2026.109677_bb0355","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1161\/CIRCULATIONAHA.110.015008","article-title":"Chronic thromboembolic pulmonary hypertension (CTEPH): results from an international prospective registry","volume":"124","author":"Pepke-Zaba","year":"2011","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.thromres.2026.109677_bb0360","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2020-038385","article-title":"Association between splenectomy and chronic thromboembolic pulmonary hypertension: a systematic review and meta-analysis","volume":"11","author":"Zhang","year":"2021","journal-title":"BMJ Open"},{"issue":"38","key":"10.1016\/j.thromres.2026.109677_bb0365","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1093\/eurheartj\/ehac237","article-title":"2022 ESC\/ERS guidelines for the diagnosis and treatment of pulmonary hypertension","volume":"43","author":"Humbert","year":"2022","journal-title":"Eur. Heart J."},{"issue":"1","key":"10.1016\/j.thromres.2026.109677_bb0370","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/jth.14649","article-title":"A multicenter study of anticoagulation in operable chronic thromboembolic pulmonary hypertension","volume":"18","author":"Bunclark","year":"2020","journal-title":"J. Thromb. Haemost."},{"issue":"3","key":"10.1016\/j.thromres.2026.109677_bb0375","doi-asserted-by":"crossref","DOI":"10.1002\/pul2.12110","article-title":"Direct oral anticoagulants in patients with chronic thromboembolic pulmonary hypertension and the presence of recent thrombus during pulmonary endarterectomy","volume":"12","author":"Jeong","year":"2022","journal-title":"Pulm. Circ."},{"key":"10.1016\/j.thromres.2026.109677_bb0380","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.thromres.2023.10.003","article-title":"Anticoagulation in chronic thromboembolic pulmonary hypertension: a systematic review and meta-analysis","volume":"231","author":"Ishisaka","year":"2023","journal-title":"Thromb. Res."},{"issue":"4","key":"10.1016\/j.thromres.2026.109677_bb0385","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/20458940211048703","article-title":"Characteristics of chronic thromboembolic pulmonary hypertension in Ireland","volume":"11","author":"Cullivan","year":"2021","journal-title":"Pulm. Circ."},{"key":"10.1016\/j.thromres.2026.109677_bb0390","series-title":"Pulmonary Embolism [Internet]","first-page":"PA1463","article-title":"Efficacy and safety of inferior vena cava filters in patients with surgically treated chronic thromboembolic pulmonary hypertension","author":"Sasaki","year":"2019"},{"key":"10.1016\/j.thromres.2026.109677_bb0395","doi-asserted-by":"crossref","DOI":"10.1016\/j.clinme.2025.100325","article-title":"Is pulmonary embolism a chronic disease?","author":"Gurumurthy","year":"2025","journal-title":"Clin. Med."}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384826000964?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384826000964?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T04:12:35Z","timestamp":1778299955000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049384826000964"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":79,"alternative-id":["S0049384826000964"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2026.109677","relation":{},"ISSN":["0049-3848"],"issn-type":[{"value":"0049-3848","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Thrombosis after surgical splenectomy \u2013 why, in whom and can we prevent it?","name":"articletitle","label":"Article Title"},{"value":"Thrombosis Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.thromres.2026.109677","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109677"}}