{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T16:20:05Z","timestamp":1792858805801,"version":"4.5.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004271","name":"Sapienza University of Rome","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004271","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thrombosisresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.thromres.2026.109718","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T23:22:11Z","timestamp":1779319331000},"page":"109718","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Matrix metalloproteinase 2 (MMP-2) and cardiovascular events in atrial fibrillation patients: A nested case control study from the ATHERO-AF cohort"],"prefix":"10.1016","volume":"262","author":[{"given":"Danilo","family":"Menichelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Falcinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Pignatelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Carnevale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"D'Amico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Violi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Gresele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Pastori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Paciullo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.thromres.2026.109718_bb0005","article-title":"Atrial fibrillation: epidemiology, screening and digital health","volume":"37","author":"Linz","year":"2024","journal-title":"Lancet Reg. Health Eur."},{"issue":"3","key":"10.1016\/j.thromres.2026.109718_bb0010","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.mayocp.2020.06.057","article-title":"Long-term risk of major adverse cardiac events in atrial fibrillation patients on direct oral anticoagulants","volume":"96","author":"Pastori","year":"2021","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.thromres.2026.109718_bb0015","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ijcard.2017.12.076","article-title":"Relationship of peripheral and coronary artery disease to cardiovascular events in patients with atrial fibrillation","volume":"255","author":"Pastori","year":"2018","journal-title":"Int. J. Cardiol."},{"issue":"7","key":"10.1016\/j.thromres.2026.109718_bb0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/cvr\/cvab147","article-title":"Optimizing indices of atrial fibrillation susceptibility and burden to evaluate atrial fibrillation severity, risk and outcomes","volume":"117","author":"Boriani","year":"2021","journal-title":"Cardiovasc. Res."},{"issue":"1","key":"10.1016\/j.thromres.2026.109718_bb0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ccep.2020.10.010","article-title":"Epidemiology of atrial fibrillation: geographic\/ecological risk factors, age, sex, genetics","volume":"13","author":"Zhang","year":"2021","journal-title":"Card. Electrophysiol. Clin."},{"issue":"7","key":"10.1016\/j.thromres.2026.109718_bb0030","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.124.037727","article-title":"Polygenic risk and cardiovascular event risk in patients with atrial fibrillation with low to intermediate stroke risk","volume":"14","author":"Kim","year":"2025","journal-title":"J. Am. Heart Assoc."},{"issue":"3","key":"10.1016\/j.thromres.2026.109718_bb0035","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1124\/pharmrev.121.000349","article-title":"Matrix metalloproteinases: from molecular mechanisms to physiology, pathophysiology, and pharmacology","volume":"74","author":"de Almeida","year":"2022","journal-title":"Pharmacol. Rev."},{"issue":"18","key":"10.1016\/j.thromres.2026.109718_bb0040","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.2174\/0929867329666220823112731","article-title":"Physiological properties, functions, and trends in the matrix metalloproteinase inhibitors in inflammation-mediated human diseases","volume":"30","author":"Kim","year":"2023","journal-title":"Curr. Med. Chem."},{"issue":"2","key":"10.1016\/j.thromres.2026.109718_bb0045","doi-asserted-by":"crossref","first-page":"72","DOI":"10.31083\/j.rcm2502072","article-title":"Molecular mechanisms underlying vascular remodeling in hypertension","volume":"25","author":"Zeng","year":"2024","journal-title":"Rev. Cardiovasc. Med."},{"key":"10.1016\/j.thromres.2026.109718_bb0050","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/bs.pmbts.2017.01.002","article-title":"Matrix metalloproteinases and platelet function","volume":"147","author":"Gresele","year":"2017","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"issue":"2","key":"10.1016\/j.thromres.2026.109718_bb0055","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1055\/a-1393-8339","article-title":"Platelets and matrix metalloproteinases: a bidirectional interaction with multiple pathophysiologic implications","volume":"41","author":"Gresele","year":"2021","journal-title":"Hamostaseologie"},{"issue":"6","key":"10.1016\/j.thromres.2026.109718_bb0060","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1093\/eurheartj\/ehab631","article-title":"Matrix metalloproteinase-2 on activated platelets triggers endothelial PAR-1 initiating atherosclerosis","volume":"43","author":"Momi","year":"2022","journal-title":"Eur. Heart J."},{"issue":"7","key":"10.1016\/j.thromres.2026.109718_bb0065","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.tips.2008.05.002","article-title":"Potentiation and priming of platelet activation: a potential target for antiplatelet therapy","volume":"29","author":"Gresele","year":"2008","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.thromres.2026.109718_bb0070","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/bs.apha.2017.08.002","article-title":"Matrix metalloproteinases, vascular remodeling, and vascular disease","volume":"81","author":"Wang","year":"2018","journal-title":"Adv. Pharmacol."},{"issue":"1","key":"10.1016\/j.thromres.2026.109718_bb0075","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s11739-009-0283-y","article-title":"Matrix metalloproteinases and peripheral arterial disease","volume":"5","author":"Busti","year":"2010","journal-title":"Intern. Emerg. Med."},{"issue":"6","key":"10.1016\/j.thromres.2026.109718_bb0080","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1160\/TH13-07-0588","article-title":"Matrix metalloproteinase-2 of human carotid atherosclerotic plaques promotes platelet activation. Correlation with ischaemic events","volume":"111","author":"Lenti","year":"2014","journal-title":"Thromb. Haemost."},{"issue":"3","key":"10.1016\/j.thromres.2026.109718_bb0085","first-page":"385","article-title":"Association of MMP-2 variant with atrial fibrillation in elderly patients: a comparative analysis involving GJA1 and IL-6R variants","volume":"55","author":"Tuncal","year":"2025","journal-title":"Ann. Clin. Lab. Sci."},{"issue":"3","key":"10.1016\/j.thromres.2026.109718_bb0090","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1161\/01.CIR.0000109495.02213.52","article-title":"Atrial extracellular matrix remodeling and the maintenance of atrial fibrillation","volume":"109","author":"Xu","year":"2004","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.thromres.2026.109718_bb0095","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.amjcard.2005.08.073","article-title":"Selective induction of matrix metalloproteinases and tissue inhibitor of metalloproteinases in atrial and ventricular myocardium in patients with atrial fibrillation","volume":"97","author":"Mukherjee","year":"2006","journal-title":"Am. J. Cardiol."},{"issue":"10","key":"10.1016\/j.thromres.2026.109718_bb0100","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1111\/j.1540-8167.2007.00918.x","article-title":"Extracellular matrix remodeling as a cause of persistent atrial fibrillation: another therapeutic target","volume":"18","author":"Okumura","year":"2007","journal-title":"J. Cardiovasc. Electrophysiol."},{"issue":"12","key":"10.1016\/j.thromres.2026.109718_bb0105","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1016\/j.jacc.2017.07.743","article-title":"Relationship of PCSK9 and urinary thromboxane excretion to cardiovascular events in patients with atrial fibrillation","volume":"70","author":"Pastori","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.thromres.2026.109718_bb0110","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.freeradbiomed.2020.03.033","article-title":"A novel role of MMP2 in regulating platelet NOX2 activation","volume":"152","author":"Nocella","year":"2020","journal-title":"Free Radic. Biol. Med."},{"issue":"3","key":"10.1016\/j.thromres.2026.109718_bb0115","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1093\/eurheartj\/ehq390","article-title":"Platelets release matrix metalloproteinase-2 in the coronary circulation of patients with acute coronary syndromes: possible role in sustained platelet activation","volume":"32","author":"Gresele","year":"2011","journal-title":"Eur. Heart J."},{"issue":"7","key":"10.1016\/j.thromres.2026.109718_bb0120","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1097\/MCA.0000000000001414","article-title":"High - but not standard-dose atorvastatin prevents the increase of plasma matrix metalloproteinase-2 triggered by acute coronary syndromes","volume":"35","author":"Paciullo","year":"2024","journal-title":"Coron. Artery Dis."},{"issue":"8","key":"10.1016\/j.thromres.2026.109718_bb0125","first-page":"1281","article-title":"Substrate-zymography: a still worthwhile method for gelatinases analysis in biological samples","volume":"54","author":"Ricci","year":"2016","journal-title":"Clin. Chem. Lab. Med."},{"issue":"5","key":"10.1016\/j.thromres.2026.109718_bb0130","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/jcla.21696","article-title":"Reappraisal of quantitative gel zymography for matrix metalloproteinases","volume":"28","author":"Prescimone","year":"2014","journal-title":"J. Clin. Lab. Anal."},{"key":"10.1016\/j.thromres.2026.109718_bb0135","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/978-1-0716-4478-2_4","article-title":"Detection of gelatinases by substrate zymography","volume":"2917","author":"Falcinelli","year":"2025","journal-title":"Methods Mol. Biol."},{"issue":"7","key":"10.1016\/j.thromres.2026.109718_bb0140","doi-asserted-by":"crossref","first-page":"e316","DOI":"10.1161\/STROKEAHA.120.033041","article-title":"Causal effect of MMP-1 (Matrix Metalloproteinase-1), MMP-8, and MMP-12 levels on ischemic stroke: a Mendelian randomization study","volume":"52","author":"Carcel-Marquez","year":"2021","journal-title":"Stroke"},{"issue":"5\u20136","key":"10.1016\/j.thromres.2026.109718_bb0145","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1159\/000446405","article-title":"True effects or Bias? MMP-2 and MMP-9 serum concentrations after acute stroke","volume":"42","author":"Kreisel","year":"2016","journal-title":"Cerebrovasc. Dis."},{"issue":"11","key":"10.1016\/j.thromres.2026.109718_bb0150","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1007\/s00392-011-0337-9","article-title":"Biomarkers of structural remodelling and endothelial dysfunction for prediction of cardiovascular events or death in patients with atrial fibrillation","volume":"100","author":"Ehrlich","year":"2011","journal-title":"Clin. Res. Cardiol."},{"issue":"4","key":"10.1016\/j.thromres.2026.109718_bb0155","doi-asserted-by":"crossref","first-page":"225","DOI":"10.15420\/aer.2021.51","article-title":"Atrial fibrosis, ischaemic stroke and atrial fibrillation","volume":"10","author":"Mahnkopf","year":"2021","journal-title":"Arrhythmia Electrophysiol. Rev."},{"issue":"2","key":"10.1016\/j.thromres.2026.109718_bb0160","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1242\/dmm.012062","article-title":"Diverse functions of matrix metalloproteinases during fibrosis","volume":"7","author":"Giannandrea","year":"2014","journal-title":"Dis. Model. Mech."},{"issue":"5","key":"10.1016\/j.thromres.2026.109718_bb0165","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/ejhg.2008.204","article-title":"A novel matrix metalloproteinase 2 (MMP2) terminal hemopexin domain mutation in a family with multicentric osteolysis with nodulosis and arthritis with cardiac defects","volume":"17","author":"Tuysuz","year":"2009","journal-title":"Eur. J. Hum. Genet."},{"issue":"4","key":"10.1016\/j.thromres.2026.109718_bb0170","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s00395-008-0715-2","article-title":"Reduced MMP-2 activity contributes to cardiac fibrosis in experimental diabetic cardiomyopathy","volume":"103","author":"Van Linthout","year":"2008","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.thromres.2026.109718_bb0175","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/bs.pmbts.2017.02.001","article-title":"Matrix metalloproteinases in myocardial infarction and heart failure","volume":"147","author":"DeLeon-Pennell","year":"2017","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"issue":"4","key":"10.1016\/j.thromres.2026.109718_bb0180","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24043628","article-title":"Matrix metalloproteinases in cardioembolic stroke: from background to complications","volume":"24","author":"Wysocka","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.thromres.2026.109718_bb0185","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1186\/s12931-022-02105-7","article-title":"Role of matrix metalloprotease-2 and MMP-9 in experimental lung fibrosis in mice","volume":"23","author":"Bormann","year":"2022","journal-title":"Respir. Res."},{"issue":"21","key":"10.1016\/j.thromres.2026.109718_bb0190","doi-asserted-by":"crossref","DOI":"10.3390\/jcm12216866","article-title":"The role of extracellular matrix and inflammation in the stratification of bleeding and thrombotic risk of atrial fibrillation on oral anticoagulant therapy: insights from Strat-Af study","volume":"12","author":"Alfano","year":"2023","journal-title":"J. Clin. Med."},{"issue":"6","key":"10.1016\/j.thromres.2026.109718_bb0195","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1093\/eurheartj\/ehab665","article-title":"Platelet-derived MMP-2 in the prevention of plaque formation: how many strokes is par?","volume":"43","author":"Cosemans","year":"2022","journal-title":"Eur. Heart J."},{"issue":"4","key":"10.1016\/j.thromres.2026.109718_bb0200","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/dmcn.16464","article-title":"Prospective 5-year natural history study of infantile PLA2G6-associated neurodegeneration","volume":"68","author":"Gregory","year":"2025","journal-title":"Dev. Med. Child Neurol."},{"issue":"1","key":"10.1016\/j.thromres.2026.109718_bb0205","doi-asserted-by":"crossref","first-page":"3752","DOI":"10.1038\/s41467-025-59062-0","article-title":"Apolipoprotein-A1 transports and regulates MMP2 in the blood","volume":"16","author":"Sarker","year":"2025","journal-title":"Nat. Commun."},{"issue":"9","key":"10.1016\/j.thromres.2026.109718_bb0210","doi-asserted-by":"crossref","first-page":"598","DOI":"10.14740\/jocmr4284","article-title":"Association between serum Apolipoprotein A1 levels, ischemic stroke subtypes and plaque properties of the carotid artery","volume":"12","author":"Ohtani","year":"2020","journal-title":"J. Clin. Med. Res."}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384826001374?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384826001374?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T08:36:40Z","timestamp":1781167000000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049384826001374"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":42,"alternative-id":["S0049384826001374"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2026.109718","relation":{},"ISSN":["0049-3848"],"issn-type":[{"value":"0049-3848","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Matrix metalloproteinase 2 (MMP-2) and cardiovascular events in atrial fibrillation patients: A nested case control study from the ATHERO-AF cohort","name":"articletitle","label":"Article Title"},{"value":"Thrombosis Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.thromres.2026.109718","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"109718"}}