{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T09:00:34Z","timestamp":1781168434007,"version":"3.54.1"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T00:00:00Z","timestamp":1780185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thrombosisresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.thromres.2026.109729","type":"journal-article","created":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T15:25:02Z","timestamp":1780154702000},"page":"109729","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Defining a fibrinogen-to-factor XIII replacement ratio in an in-vitro model of dilutional coagulopathy"],"prefix":"10.1016","volume":"262","author":[{"given":"Cristina","family":"Alomar-Dominguez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie Therese","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietmar","family":"Fries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludwig","family":"Deinhart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Gebetsberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjam","family":"Bachler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"B\u00f6sch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Schobersberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Hermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Irsara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Brunelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Katharina","family":"Tobiasch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.thromres.2026.109729_bb0005","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s13054-019-2347-3","article-title":"The European guideline on management of major bleeding and coagulopathy following trauma: fifth edition","volume":"23","author":"Spahn","year":"2019","journal-title":"Crit. Care"},{"issue":"Suppl. 1","key":"10.1016\/j.thromres.2026.109729_bb0010","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/SHK.0000000000000088","article-title":"An update on the coagulopathy of trauma","volume":"41","author":"Maegele","year":"2014","journal-title":"Shock"},{"issue":"1","key":"10.1016\/j.thromres.2026.109729_bb0015","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1097\/ALN.0000000000001428","article-title":"Activated Protein C Drives the Hyperfibrinolysis of Acute Traumatic Coagulopathy","volume":"126","author":"Davenport","year":"2017","journal-title":"Anesthesiology"},{"issue":"1","key":"10.1016\/j.thromres.2026.109729_bb0020","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/bjh.14804","article-title":"Fibrinogen concentration and use of fibrinogen supplementation with cryoprecipitate in patients with critical bleeding receiving massive transfusion: a bi-national cohort study","volume":"179","author":"McQuilten","year":"2017","journal-title":"Br. J. Haematol."},{"issue":"9","key":"10.1016\/j.thromres.2026.109729_bb0025","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1182\/blood-2014-08-552000","article-title":"How I use fibrinogen replacement therapy in acquired bleeding","volume":"125","author":"Levy","year":"2015","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.thromres.2026.109729_bb0030","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1111\/j.1460-9592.2011.03709.x","article-title":"Perioperative course of FXIII in children undergoing major surgery","volume":"22","author":"Haas","year":"2012","journal-title":"Paediatr. Anaesth."},{"issue":"4","key":"10.1016\/j.thromres.2026.109729_bb0035","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/j.1537-2995.2008.02021.x","article-title":"Comparison of coagulation factor XIII content and concentration in cryoprecipitate and fresh-frozen plasma","volume":"49","author":"Caudill","year":"2009","journal-title":"Transfusion"},{"issue":"3","key":"10.1016\/j.thromres.2026.109729_bb0040","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1097\/MBC.0000000000000029","article-title":"Factor XIII deficiency management: a review of the literature","volume":"25","author":"Odame","year":"2014","journal-title":"Blood Coagul. Fibrinolysis"},{"key":"10.1016\/j.thromres.2026.109729_bb0045","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.thromres.2021.06.020","article-title":"Differences in the biochemical composition of three plasma derived human fibrinogen concentrates","volume":"205","author":"Neisser-Svae","year":"2021","journal-title":"Thromb. Res."},{"issue":"1","key":"10.1016\/j.thromres.2026.109729_bb0050","doi-asserted-by":"crossref","first-page":"e2016037","DOI":"10.4084\/mjhid.2016.037","article-title":"Effects of factor XIII deficiency on thromboelastography. Thromboelastography with calcium and streptokinase addition is more sensitive than solubility tests","volume":"8","author":"Martinuzzo","year":"2016","journal-title":"Mediterr. J. Hematol. Infect. Dis."},{"issue":"1","key":"10.1016\/j.thromres.2026.109729_bb0055","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1182\/bloodadvances.2017011890","article-title":"Factor XIII in plasma, but not in platelets, mediates red blood cell retention in clots and venous thrombus size in mice","volume":"2","author":"Kattula","year":"2018","journal-title":"Blood Adv."},{"issue":"2","key":"10.1016\/j.thromres.2026.109729_bb0060","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/jth.12455","article-title":"The effect of blood coagulation factor XIII on fibrin clot structure and fibrinolysis","volume":"12","author":"Hethershaw","year":"2014","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2026.109729_bb0065","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/1209676","article-title":"Inhibition of fibrinolysis by coagulation factor XIII","volume":"2017","author":"Rijken","year":"2017","journal-title":"Biomed. Res. Int."},{"issue":"1","key":"10.1016\/j.thromres.2026.109729_bb0070","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s13054-022-03940-2","article-title":"The impact of acquired coagulation factor XIII deficiency in traumatic bleeding and wound healing","volume":"26","author":"Kleber","year":"2022","journal-title":"Crit. Care"},{"issue":"2","key":"10.1016\/j.thromres.2026.109729_bb0075","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1213\/01.ane.0000194359.06286.d4","article-title":"The effect of fibrinogen substitution on reversal of dilutional coagulopathy: an in vitro model","volume":"102","author":"Fries","year":"2006","journal-title":"Anesth. Analg."},{"issue":"4","key":"10.1016\/j.thromres.2026.109729_bb0080","first-page":"164","article-title":"Current understanding in diagnosis and management of factor XIII deficiency","volume":"3","author":"Naderi","year":"2013","journal-title":"Iran. J. Ped. Hematol. Oncol."},{"issue":"5","key":"10.1016\/j.thromres.2026.109729_bb0085","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1097\/MOH.0b013e3283497e3e","article-title":"Novel aspects of factor XIII deficiency","volume":"18","author":"Muszbek","year":"2011","journal-title":"Curr. Opin. Hematol."},{"issue":"2","key":"10.1016\/j.thromres.2026.109729_bb0090","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1159\/000468946","article-title":"Factor XIII deficiency and thrombocytopenia are frequent modulators of postoperative clot firmness in a surgical intensive care unit","volume":"44","author":"von Rappard","year":"2017","journal-title":"Transfus. Med. Hemother."},{"issue":"1","key":"10.1016\/j.thromres.2026.109729_bb0095","doi-asserted-by":"crossref","DOI":"10.1186\/s13054-023-04327-7","article-title":"The European guideline on management of major bleeding and coagulopathy following trauma: sixth edition","volume":"27","author":"Rossaint","year":"2023","journal-title":"Crit. Care"},{"issue":"3","key":"10.1016\/j.thromres.2026.109729_bb0100","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S0090-3019(00)00308-6","article-title":"Factor XIII deficiency and postoperative hemorrhage after neurosurgical procedures","volume":"54","author":"Gerlach","year":"2000","journal-title":"Surg. Neurol."},{"issue":"6","key":"10.1016\/j.thromres.2026.109729_bb0105","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1161\/01.STR.0000017219.83330.FF","article-title":"Increased risk for postoperative hemorrhage after intracranial surgery in patients with decreased factor XIII activity: implications of a prospective study","volume":"33","author":"Gerlach","year":"2002","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.thromres.2026.109729_bb0110","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.bpa.2009.09.011","article-title":"XIII in perioperative coagulation management","volume":"24","author":"Korte","year":"2010","journal-title":"Best Pract. Res. Clin. Anaesthesiol."},{"issue":"11","key":"10.1016\/j.thromres.2026.109729_bb0115","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1016\/j.hpb.2017.07.002","article-title":"Clinical influence of preoperative factor XIII activity in patients undergoing pancreatoduodenectomy","volume":"19","author":"Watanabe","year":"2017","journal-title":"HPB (Oxford)"},{"issue":"5","key":"10.1016\/j.thromres.2026.109729_bb0120","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1213\/01.ANE.0000134800.46276.21","article-title":"Decreased factor XIII availability for thrombin and early loss of clot firmness in patients with unexplained intraoperative bleeding","volume":"99","author":"Wettstein","year":"2004","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.thromres.2026.109729_bb0125","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jcrc.2019.11.012","article-title":"Factor XIII activity in patients requiring surgical re-exploration for bleeding after elective cardiac surgery - a prospective case control study","volume":"56","author":"Adam","year":"2020","journal-title":"J. Crit. Care"},{"issue":"1","key":"10.1016\/j.thromres.2026.109729_bb0130","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1007\/s00068-025-02984-7","article-title":"Prehospital coagulation management and fluid replacement therapy in patients with multiple and\/or severe injuries - a systematic review and clinical practice guideline update","volume":"51","author":"Hussmann","year":"2025","journal-title":"Eur. J. Trauma Emerg. Surg."},{"issue":"5","key":"10.1016\/j.thromres.2026.109729_bb0135","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1111\/j.1538-7836.2005.01224.x","article-title":"Safety, pharmacokinetics, and immunogenicity of single-dose rFXIII administration to healthy volunteers","volume":"3","author":"Reynolds","year":"2005","journal-title":"J. Thromb. Haemost."},{"issue":"2","key":"10.1016\/j.thromres.2026.109729_bb0140","doi-asserted-by":"crossref","first-page":"276","DOI":"10.18053\/jctres.03.201702.003","article-title":"FITC-linked Fibrin-Binding Peptide and real-time live confocal microscopy as a novel tool to visualize fibrin(ogen) in coagulation","volume":"3","author":"Weiss","year":"2017","journal-title":"J. Clin. Transl. Res."},{"issue":"11","key":"10.1016\/j.thromres.2026.109729_bb0145","article-title":"Live confocal visualization of FXIII activity","volume":"64","author":"Weber","year":"2018","journal-title":"Clin. Lab."},{"issue":"12","key":"10.1016\/j.thromres.2026.109729_bb0150","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1093\/clinchem\/46.12.1946","article-title":"A modified, optimized kinetic photometric assay for the determination of blood coagulation factor XIII activity in plasma","volume":"46","author":"Karpati","year":"2000","journal-title":"Clin. Chem."},{"issue":"5","key":"10.1016\/j.thromres.2026.109729_bb0155","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.injury.2022.12.021","article-title":"Acquired Factor XIII Deficiency in Patients with Multiple Trauma","volume":"54","author":"Hetz","year":"2023","journal-title":"Injury"},{"issue":"6","key":"10.1016\/j.thromres.2026.109729_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/S2352-3026(17)30077-7","article-title":"Reversal of trauma-induced coagulopathy using first-line coagulation factor concentrates or fresh frozen plasma (RETIC): a single-centre, parallel-group, open-label, randomised trial","volume":"4","author":"Innerhofer","year":"2017","journal-title":"Lancet Haematol."},{"issue":"1","key":"10.1016\/j.thromres.2026.109729_bb0165","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1055\/s-2005-872853","article-title":"Coagulation factor XIII reduces postoperative bleeding after coronary surgery with extracorporeal circulation","volume":"54","author":"G\u00f6dje","year":"2006","journal-title":"Thorac. Cardiovasc. Surg."},{"issue":"4","key":"10.1016\/j.thromres.2026.109729_bb0170","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1097\/EJA.0000000000001803","article-title":"Management of severe peri-operative bleeding: Guidelines from the European Society of Anaesthesiology and Intensive Care: second update 2022","volume":"40","author":"Kietaibl","year":"2023","journal-title":"Eur. J. Anaesthesiol."},{"issue":"5","key":"10.1016\/j.thromres.2026.109729_bb0175","first-page":"1221","article-title":"Protransglutaminase (factor XIII) mediated crosslinking of fibrinogen and fibrin","volume":"86","author":"Siebenlist","year":"2001","journal-title":"Thromb. Haemost."},{"issue":"9_suppl","key":"10.1016\/j.thromres.2026.109729_bb0180","doi-asserted-by":"crossref","DOI":"10.1177\/1076029618797472","article-title":"Rotational thromboelastometry for assessing bleeding complications and factor XIII deficiency in cardiac surgery patients","volume":"24","author":"Rasp\u00e9","year":"2018","journal-title":"Clin. Appl. Thromb. Hemost."},{"issue":"2","key":"10.1016\/j.thromres.2026.109729_bb0185","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.bja.2022.09.022","article-title":"Factor XIII levels, clot strength, and impact of fibrinogen concentrate in infants undergoing cardiopulmonary bypass: a mechanistic sub-study of the FIBCON trial","volume":"130","author":"Siemens","year":"2023","journal-title":"Br. J. Anaesth."},{"issue":"2","key":"10.1016\/j.thromres.2026.109729_bb0190","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.jtha.2025.09.028","article-title":"Hypoalbuminemia increases fibrin clot density and impairs fibrinolysis","volume":"24","author":"Waller","year":"2026","journal-title":"J. Thromb. Haemost."},{"issue":"5","key":"10.1016\/j.thromres.2026.109729_bb0195","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s00101-008-1360-8","article-title":"Thrombelastometric detection of factor XIII deficiency","volume":"57","author":"Weber","year":"2008","journal-title":"Anaesthesist"},{"issue":"4","key":"10.1016\/j.thromres.2026.109729_bb0200","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1055\/a-1181-0327","article-title":"Laboratory assessment of coagulation factor XIII","volume":"40","author":"Schroeder","year":"2020","journal-title":"Hamostaseologie"},{"issue":"2","key":"10.1016\/j.thromres.2026.109729_bb0205","first-page":"111","article-title":"Role of thrombelastometry for the monitoring of factor XIII. A prospective observational study in neurosurgical patients","volume":"31","author":"Weber","year":"2011","journal-title":"Hamostaseologie"},{"issue":"6","key":"10.1016\/j.thromres.2026.109729_bb0210","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/tme.12069","article-title":"Thromboelastometric detection of clotting Factor XIII deficiency in cardiac surgery patients","volume":"23","author":"Grossmann","year":"2013","journal-title":"Transfus. Med."},{"issue":"17","key":"10.1016\/j.thromres.2026.109729_bb0215","doi-asserted-by":"crossref","DOI":"10.3390\/jcm10173930","article-title":"First-line administration of fibrinogen concentrate in the bleeding trauma patient: searching for effective dosages and optimal post-treatment levels limiting massive transfusion-further results of the RETIC study","volume":"10","author":"Innerhofer","year":"2021","journal-title":"J. Clin. Med."},{"issue":"1","key":"10.1016\/j.thromres.2026.109729_bb0220","doi-asserted-by":"crossref","first-page":"10","DOI":"10.46989\/001c.155180","article-title":"Factor XIII deficiency: a review of biology, testing, and treatment","volume":"8","author":"Jacobs","year":"2026","journal-title":"Clin. Hematol. Int."},{"issue":"Suppl. 1","key":"10.1016\/j.thromres.2026.109729_bb0225","doi-asserted-by":"crossref","first-page":"i35","DOI":"10.1093\/bja\/aet380","article-title":"Perioperative factor concentrate therapy","volume":"111","author":"Tanaka","year":"2013","journal-title":"Br. J. Anaesth."},{"issue":"6","key":"10.1016\/j.thromres.2026.109729_bb0230","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23062944","article-title":"The efficacy of fibrinogen concentrates in relation to cryoprecipitate in restoring clot integrity and stability against lysis","volume":"23","author":"Whyte","year":"2022","journal-title":"Int. J. Mol. Sci."}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384826001489?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384826001489?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T08:37:18Z","timestamp":1781167038000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049384826001489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":46,"alternative-id":["S0049384826001489"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2026.109729","relation":{},"ISSN":["0049-3848"],"issn-type":[{"value":"0049-3848","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Defining a fibrinogen-to-factor XIII replacement ratio in an in-vitro model of dilutional coagulopathy","name":"articletitle","label":"Article Title"},{"value":"Thrombosis Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.thromres.2026.109729","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"109729"}}