{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T21:25:25Z","timestamp":1793913925730,"version":"4.8.0"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["17\/22047-0"],"award-info":[{"award-number":["17\/22047-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["23\/10291-4"],"award-info":[{"award-number":["23\/10291-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["23\/18285-3"],"award-info":[{"award-number":["23\/18285-3"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018217","name":"Universidade Federal de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018217","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["Print 88881.311044\/2018-00"],"award-info":[{"award-number":["Print 88881.311044\/2018-00"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thrombosisresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.thromres.2026.109810","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T06:17:11Z","timestamp":1787552231000},"page":"109810","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Plasma kallikrein in breast cancer cells: Interactions with urokinase plasminogen activator system and syndecans"],"prefix":"10.1016","volume":"265","author":[{"given":"Samara M.M.","family":"Shimon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Cec\u00edlia Z.","family":"Meneghetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Bromberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renan P.","family":"Cavalheiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos M.V.","family":"Palomino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel S.M.","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariana C.","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena B.","family":"Nader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Aparecida S.","family":"Pinhal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio D.","family":"Nascimento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guacyara","family":"Motta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.thromres.2026.109810_bb0005","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.breast.2022.04.003","article-title":"Global guidelines for breast cancer screening: a systematic review","volume":"64","author":"Ren","year":"2022","journal-title":"Breast"},{"issue":"10","key":"10.1016\/j.thromres.2026.109810_bb0010","first-page":"2929","article-title":"Breast cancer intrinsic subtype classification, clinical use and future trends","volume":"5","author":"Dai","year":"2015","journal-title":"Am. J. Cancer Res."},{"issue":"1","key":"10.1016\/j.thromres.2026.109810_bb0015","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s13058-017-0855-0","article-title":"Molecular characterization of breast cancer cell lines through multiple omic approaches","volume":"19","author":"Smith","year":"2017","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.thromres.2026.109810_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.steroids.2020.108738","article-title":"Effects of synthetic glucocorticoids on breast cancer progression","volume":"164","author":"Pang","year":"2020","journal-title":"Steroids"},{"issue":"6","key":"10.1016\/j.thromres.2026.109810_bb0025","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.3892\/ijo.2020.5135","article-title":"Triple-negative breast cancer therapy: current and future perspectives","volume":"57","author":"Won","year":"2020","journal-title":"Int. J. Oncol."},{"issue":"3","key":"10.1016\/j.thromres.2026.109810_bb0030","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s11523-021-00796-4","article-title":"An overview of PARP inhibitors for the treatment of breast Cancer","volume":"16","author":"Cortesi","year":"2021","journal-title":"Target. Oncol."},{"key":"10.1016\/j.thromres.2026.109810_bb0035","doi-asserted-by":"crossref","first-page":"7247","DOI":"10.1158\/0008-5472.CAN-08-0784","article-title":"Tube travel: the role of proteases in individual and collective cancer cell invasion","volume":"68","author":"Friedl","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.thromres.2026.109810_bb0040","doi-asserted-by":"crossref","first-page":"105","DOI":"10.4137\/BMI.S33372","article-title":"Plasminogen activator system and breast cancer: potential role in therapy decision making and precision medicine","volume":"11","author":"Gouri","year":"2016","journal-title":"Biomark. Insights"},{"issue":"1","key":"10.1016\/j.thromres.2026.109810_bb0045","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s12967-022-03329-3","article-title":"Urokinase-type plasminogen activator receptor (uPAR) as a therapeutic target in cancer","volume":"20","author":"Zhai","year":"2022","journal-title":"J. Transl. Med."},{"issue":"3\u20134","key":"10.1016\/j.thromres.2026.109810_bb0050","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1155\/2009\/504294","article-title":"suPAR: the molecular crystal ball","volume":"27","author":"Thuno","year":"2009","journal-title":"Dis. Markers"},{"key":"10.1016\/j.thromres.2026.109810_bb0055","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1007\/978-3-030-34521-1_36","article-title":"The good and bad sides of heparanase-1 and heparanase-2","volume":"1221","author":"Pinhal","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"issue":"18","key":"10.1016\/j.thromres.2026.109810_bb0060","doi-asserted-by":"crossref","first-page":"9152","DOI":"10.1021\/acs.chemrev.8b00354","article-title":"Proteoglycan chemical diversity drives multifunctional cell regulation and therapeutics","volume":"118","author":"Karamanos","year":"2018","journal-title":"Chem. Rev."},{"issue":"3","key":"10.1016\/j.thromres.2026.109810_bb0065","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1160\/TH12-11-0840","article-title":"Structure of plasma and tissue kallikreins","volume":"110","author":"Pathak","year":"2013","journal-title":"Thromb. Haemost."},{"issue":"1","key":"10.1016\/j.thromres.2026.109810_bb0070","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.canlet.2013.12.009","article-title":"The role of kinin receptors in cancer and therapeutic opportunities","volume":"345","author":"da Costa","year":"2014","journal-title":"Cancer Lett."},{"issue":"6","key":"10.1016\/j.thromres.2026.109810_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2022.188807","article-title":"An overview of kinin mediated events in cancer progression and therapeutic applications","volume":"1877","author":"Deepak","year":"2022","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"issue":"4","key":"10.1016\/j.thromres.2026.109810_bb0080","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.ygeno.2018.03.022","article-title":"Discovery of novel transcripts of the human tissue kallikrein (KLK1) and kallikrein-related peptidase 2 (KLK2) in human cancer cells, exploiting next-generation sequencing technology","volume":"111","author":"Adamopoulos","year":"2019","journal-title":"Genomics"},{"key":"10.1016\/j.thromres.2026.109810_bb0085","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.biochi.2015.09.002","article-title":"The kallikrein-related peptidase family: dysregulation and functions during cancer progression","volume":"122","author":"Kryza","year":"2016","journal-title":"Biochimie"},{"issue":"2","key":"10.1016\/j.thromres.2026.109810_bb0090","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1182\/blood.V91.2.516","article-title":"High molecular weight kininogen regulates prekallikrein assembly and activation on endothelial cells: a novel mechanism for contact activation","volume":"91","author":"Motta","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.thromres.2026.109810_bb0095","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2017.00481","article-title":"Modulation of the plasma kallikrein-kinin system proteins performed by heparan sulfate proteoglycans","volume":"8","author":"Motta","year":"2017","journal-title":"Front. Physiol."},{"key":"10.1016\/j.thromres.2026.109810_bb0100","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2023.1188816","article-title":"Human plasma kallikrein: roles in coagulation, fibrinolysis, inflammation pathways, and beyond","volume":"14","author":"Motta","year":"2023","journal-title":"Front. Physiol."},{"issue":"23","key":"10.1016\/j.thromres.2026.109810_bb0105","doi-asserted-by":"crossref","first-page":"4292","DOI":"10.1002\/pmic.200700433","article-title":"Identification of putative serum glycoprotein biomarkers for human lung adenocarcinoma by multilectin affinity chromatography and LC-MS\/MS","volume":"7","author":"Heo","year":"2007","journal-title":"Proteomics"},{"issue":"9","key":"10.1016\/j.thromres.2026.109810_bb0110","doi-asserted-by":"crossref","first-page":"615","DOI":"10.5483\/BMBRep.2008.41.9.615","article-title":"Biomarkers for the lung cancer diagnosis and their advances in proteomics","volume":"41","author":"Sung","year":"2008","journal-title":"BMB Rep."},{"key":"10.1016\/j.thromres.2026.109810_bb0115","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.687229","article-title":"Molecular characterization of advanced colorectal cancer using serum proteomics and metabolomics","volume":"8","author":"Rao","year":"2021","journal-title":"Front. Mol. Biosci."},{"issue":"2","key":"10.1016\/j.thromres.2026.109810_bb0120","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1096\/fj.13-240879","article-title":"Genome-wide protein QTL mapping identifies human plasma kallikrein as a post-translational regulator of serum uPAR levels","volume":"28","author":"Portelli","year":"2014","journal-title":"FASEB J."},{"key":"10.1016\/j.thromres.2026.109810_bb0125","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1515\/BC.2007.104","article-title":"Cellular expression of plasma prekallikrein in human tissues","volume":"388","author":"Fink","year":"2007","journal-title":"Biol. Chem."},{"issue":"11","key":"10.1016\/j.thromres.2026.109810_bb0130","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1515\/BC.2007.139","article-title":"Novel expression of kallikreins, kallikrein-related peptidases and kinin receptors in human pleural mesothelioma","volume":"388","author":"Chee","year":"2007","journal-title":"Biol. Chem."},{"issue":"9","key":"10.1016\/j.thromres.2026.109810_bb0135","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1515\/BC.2008.139","article-title":"Expression of tissue and plasma kallikreins and kinin B1 and B2 receptors in lung cancer","volume":"389","author":"Chee","year":"2008","journal-title":"Biol. Chem."},{"issue":"13\u201314","key":"10.1016\/j.thromres.2026.109810_bb0140","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.clinbiochem.2015.04.007","article-title":"KLKB1 mRNA overexpression: a novel molecular biomarker for the diagnosis of chronic lymphocytic leukemia","volume":"48","author":"Adamopoulos","year":"2015","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.thromres.2026.109810_bb0145","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1093\/jnci\/51.5.1409","article-title":"A human cell line from a pleural effusion derived from a breast carcinoma","volume":"51","author":"Soule","year":"1973","journal-title":"J. Natl. Cancer Inst."},{"issue":"6","key":"10.1016\/j.thromres.2026.109810_bb0150","first-page":"3147","article-title":"The story of MCF-7 breast cancer cell line: 40 years of experience in research","volume":"35","author":"Com\u015fa","year":"2015","journal-title":"Anticancer Res."},{"issue":"3","key":"10.1016\/j.thromres.2026.109810_bb0155","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1093\/jnci\/53.3.661","article-title":"Breast tumor cell lines from pleural effusions","volume":"53","author":"Cailleau","year":"1974","journal-title":"J. Natl. Cancer Inst."},{"issue":"11","key":"10.1016\/j.thromres.2026.109810_bb0160","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1007\/BF02616120","article-title":"Long-term human breast carcinoma cell lines of metastatic origin: preliminary characterization","volume":"14","author":"Cailleau","year":"1978","journal-title":"In Vitro"},{"issue":"8","key":"10.1016\/j.thromres.2026.109810_bb0165","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1359\/jbmr.2001.16.8.1486","article-title":"A bone-seeking clone exhibits different biological properties from the MDA-MB-231 parental human breast cancer cells and a brain-seeking clone in vivo and in vitro","volume":"16","author":"Yoneda","year":"2001","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.thromres.2026.109810_bb0170","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1515\/BC.2004.141","article-title":"Plasma prekallikrein\/kallikrein processing by lysosomal cysteine proteases","volume":"385","author":"Barros","year":"2004","journal-title":"Biol. Chem."},{"issue":"4","key":"10.1016\/j.thromres.2026.109810_bb0175","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s13402-016-0282-8","article-title":"High glucose and insulin enhance uPA expression, ROS formation and invasiveness in breast cancer-derived cells","volume":"39","author":"Flores-L\u00f3pez","year":"2016","journal-title":"Cell. Oncol."},{"issue":"1","key":"10.1016\/j.thromres.2026.109810_bb0180","doi-asserted-by":"crossref","DOI":"10.1186\/s12967-019-1853-z","article-title":"Crosstalk between tumor cells and lymphocytes modulates heparanase expression","volume":"17","author":"Theodoro","year":"2019","journal-title":"J. Transl. Med."},{"issue":"1","key":"10.1016\/j.thromres.2026.109810_bb0185","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/(SICI)1097-0282(1999)51:1<41::AID-BIP5>3.0.CO;2-Y","article-title":"Development of plasma kallikrein selective inhibitors","volume":"51","author":"Okada","year":"1999","journal-title":"Pept. Sci."},{"issue":"11","key":"10.1016\/j.thromres.2026.109810_bb0190","doi-asserted-by":"crossref","first-page":"2956","DOI":"10.1021\/jm00173a008","article-title":"Selective inhibition of urokinase by substituted phenylguanidines: quantitative structure-activity relationship analyses","volume":"33","author":"Yang","year":"1990","journal-title":"J. Med. Chem."},{"issue":"5","key":"10.1016\/j.thromres.2026.109810_bb0195","doi-asserted-by":"crossref","first-page":"440","DOI":"10.4161\/cam.36224","article-title":"An introduction to the wound healing assay using live-cell microscopy","volume":"8","author":"Jonkman","year":"2014","journal-title":"Cell Adhes. Migr."},{"issue":"9","key":"10.1016\/j.thromres.2026.109810_bb0200","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/1074-5521(95)90120-5","article-title":"Mitomycin C: small, fast and deadly (but very selective)","volume":"2","author":"Tomasz","year":"1995","journal-title":"Chem. Biol."},{"issue":"10","key":"10.1016\/j.thromres.2026.109810_bb0205","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1038\/bjc.1998.261","article-title":"Increased plasminogen binding is associated with metastatic breast cancer cells: differential expression of plasminogen binding proteins","volume":"77","author":"Ranson","year":"1998","journal-title":"Br. J. Cancer"},{"issue":"10","key":"10.1016\/j.thromres.2026.109810_bb0210","first-page":"936","article-title":"Urokinase type plasminogen activator and the molecular mechanisms of its regulation in cancer","volume":"24","author":"Santibanez","year":"2017","journal-title":"Protein Pept. Lett."},{"issue":"10","key":"10.1016\/j.thromres.2026.109810_bb0215","doi-asserted-by":"crossref","first-page":"3819","DOI":"10.1182\/blood.V90.10.3819","article-title":"Contact system: a vascular biology modulator with anticoagulant, profibrinolytic, antiadhesive, and proinflammatory attributes","volume":"90","author":"Colman","year":"1997","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.thromres.2026.109810_bb0220","doi-asserted-by":"crossref","first-page":"R14","DOI":"10.1186\/bcr1647","article-title":"Plasminogen binding and activation at the breast cancer cell surface: the integral role of urokinase activity","volume":"9","author":"Stillfried","year":"2007","journal-title":"Breast Cancer Res."},{"issue":"2","key":"10.1016\/j.thromres.2026.109810_bb0225","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1160\/TH17-08-0596","article-title":"Contact system activation and cancer: new insights in the pathophysiology of cancer-associated thrombosis","volume":"118","author":"Campello","year":"2018","journal-title":"Thromb. Haemost."},{"issue":"4","key":"10.1016\/j.thromres.2026.109810_bb0230","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1055\/s-0039-1688495","article-title":"Fibrin and fibrinolysis in cancer","volume":"45","author":"Kwaan","year":"2019","journal-title":"Semin. Thromb. Hemost."},{"key":"10.1016\/j.thromres.2026.109810_bb0235","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/jth.13194","article-title":"The contact activation and kallikrein\/kinin systems: pathophysiologic and physiologic activities","volume":"14","author":"Schmaier","year":"2016","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.thromres.2026.109810_bb0240","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/946572","article-title":"Involvement of kallikrein-related peptidases in normal and pathologic processes","volume":"2015","author":"Stefanini","year":"2015","journal-title":"Dis. Markers"},{"issue":"4","key":"10.1016\/j.thromres.2026.109810_bb0245","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3109\/10408363.2016.1154643","article-title":"Kallikrein-related peptidases (KLKs) and the hallmarks of cancer","volume":"53","author":"Filippou","year":"2016","journal-title":"Crit. Rev. Clin. Lab. Sci."},{"key":"10.1016\/j.thromres.2026.109810_bb0250","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2018.00024","article-title":"Multifaceted role of the urokinase-type plasminogen activator (uPA) and its receptor (uPAR): diagnostic, prognostic, and therapeutic applications","volume":"8","author":"Mahmood","year":"2018","journal-title":"Front. Oncol."},{"key":"10.1016\/j.thromres.2026.109810_bb0255","doi-asserted-by":"crossref","first-page":"5441","DOI":"10.2741\/3092","article-title":"Structure and ligand interactions of the urokinase receptor (uPAR)","volume":"13","author":"Kjaergaard","year":"2008","journal-title":"Front. Biosci."},{"issue":"19","key":"10.1016\/j.thromres.2026.109810_bb0260","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.2174\/138161211796718215","article-title":"The urokinase receptor interactome","volume":"17","author":"Eden","year":"2011","journal-title":"Curr. Pharm. Des."},{"issue":"3","key":"10.1016\/j.thromres.2026.109810_bb0265","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/j.1365-2141.2005.05444.x","article-title":"Molecular mechanisms of fibrinolysis","volume":"129","author":"Cesarman-Maus","year":"2005","journal-title":"Br. J. Haematol."},{"issue":"19","key":"10.1016\/j.thromres.2026.109810_bb0270","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.2174\/138161211796718152","article-title":"Development of novel therapeutics targeting the urokinase plasminogen activator receptor (uPAR) and their translation toward the clinic","volume":"17","author":"Mazar","year":"2011","journal-title":"Curr. Pharm. Des."},{"issue":"2","key":"10.1016\/j.thromres.2026.109810_bb0275","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1002\/j.1460-2075.1990.tb08132.x","article-title":"Cloning and expression of the receptor for human urokinase plasminogen activator, a central molecule in cell surface, plasmin dependent proteolysis","volume":"9","author":"Roldan","year":"1990","journal-title":"EMBO J."},{"issue":"1","key":"10.1016\/j.thromres.2026.109810_bb0280","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/febs.13940","article-title":"Syndecans - key regulators of cell signaling and biological functions","volume":"284","author":"Afratis","year":"2017","journal-title":"FEBS J."},{"issue":"25","key":"10.1016\/j.thromres.2026.109810_bb0285","doi-asserted-by":"crossref","first-page":"5066","DOI":"10.2174\/0929867328666210629122238","article-title":"Syndecan-1 (CD138) as a pathogenesis factor and therapeutic target in breast cancer","volume":"28","author":"Sheta","year":"2021","journal-title":"Curr. Med. Chem."},{"issue":"5","key":"10.1016\/j.thromres.2026.109810_bb0290","doi-asserted-by":"crossref","first-page":"C1345","DOI":"10.1152\/ajpcell.00152.2022","article-title":"Role of syndecan-4 in breast cancer pathophysiology","volume":"323","author":"Onyeisi","year":"2022","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"3","key":"10.1016\/j.thromres.2026.109810_bb0295","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s00441-016-2452-4","article-title":"Shed proteoglycans in tumor stroma","volume":"365","author":"Piperigkou","year":"2016","journal-title":"Cell Tissue Res."},{"issue":"15","key":"10.1016\/j.thromres.2026.109810_bb0300","doi-asserted-by":"crossref","first-page":"2994","DOI":"10.1111\/febs.14828","article-title":"Structures and interactions of syndecans","volume":"286","author":"Gondelaud","year":"2019","journal-title":"FEBS J."},{"issue":"23","key":"10.1016\/j.thromres.2026.109810_bb0310","doi-asserted-by":"crossref","first-page":"14713","DOI":"10.1074\/jbc.272.23.14713","article-title":"Regulated shedding of syndecan-1 and -4 ectodomains by thrombin and growth factor receptor activation","volume":"272","author":"Subramanian","year":"1997","journal-title":"J. Biol. Chem."}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004938482600229X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004938482600229X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T20:43:18Z","timestamp":1793911398000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004938482600229X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":61,"alternative-id":["S004938482600229X"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2026.109810","relation":{},"ISSN":["0049-3848"],"issn-type":[{"value":"0049-3848","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Plasma kallikrein in breast cancer cells: Interactions with urokinase plasminogen activator system and syndecans","name":"articletitle","label":"Article Title"},{"value":"Thrombosis Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.thromres.2026.109810","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"109810"}}