{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:02:30Z","timestamp":1790240550406,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFC0862902"],"award-info":[{"award-number":["2020YFC0862902"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFC0862904"],"award-info":[{"award-number":["2020YFC0862904"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["12372300"],"award-info":[{"award-number":["12372300"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thrombosisresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.thromres.2026.109821","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T16:03:49Z","timestamp":1787587429000},"page":"109821","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Study of centrifugal blood pump non-physiological shear stress induced platelet hemostatic dysfunction"],"prefix":"10.1016","volume":"265","author":[{"given":"Yuan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoning","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifeng","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengsheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.thromres.2026.109821_bb0005","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jchf.2023.06.017","article-title":"Cardiopulmonary performance among heart failure patients before and after left ventricular assist device implantation","volume":"12","author":"Buchanan","year":"2024","journal-title":"JACC Heart Fail."},{"issue":"3","key":"10.1016\/j.thromres.2026.109821_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchf.2025.102769","article-title":"Hemocompatibility outcomes with pharmacological therapy following LVAD implantation: insights from the ARIES-HM3 trial","volume":"14","author":"Katz","year":"2026","journal-title":"JACC Heart Fail."},{"issue":"11","key":"10.1016\/j.thromres.2026.109821_bb0015","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1111\/aor.13751","article-title":"Risk of pump thrombosis and stroke in patients with continuous-flow left ventricular assist devices and gastrointestinal bleeding","volume":"44","author":"Szymanski","year":"2020","journal-title":"Artif. Organs"},{"issue":"19","key":"10.1016\/j.thromres.2026.109821_bb0020","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1016\/j.jacc.2022.02.052","article-title":"Anticoagulation for percutaneous ventricular assist device-supported cardiogenic shock: JACC review topic of the week","volume":"79","author":"Vandenbriele","year":"2022","journal-title":"J. Am. Coll. Cardiol."},{"issue":"17","key":"10.1016\/j.thromres.2026.109821_bb0025","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1056\/NEJMoa1900486","article-title":"A fully magnetically levitated left ventricular assist device - final report","volume":"380","author":"Mehra","year":"2019","journal-title":"N. Engl. J. Med."},{"issue":"12","key":"10.1016\/j.thromres.2026.109821_bb0030","article-title":"Thrombotic and hemorrhagic complications following left ventricular assist device placement: an emphasis on gastrointestinal bleeding, stroke, and pump thrombosis","volume":"15","author":"Phan","year":"2023","journal-title":"Cureus"},{"key":"10.1016\/j.thromres.2026.109821_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmpb.2023.107390","article-title":"A mathematical model for assessing shear induced bleeding risk","volume":"231","author":"Li","year":"2023","journal-title":"Comput. Methods Prog. Biomed."},{"issue":"1","key":"10.1016\/j.thromres.2026.109821_bb0040","article-title":"Comprehensive study on simulation, performance evaluation and optimization strategies for blood pumps","volume":"18","author":"Li","year":"2024","journal-title":"Eng. Appl. Comput. Fluid Mech."},{"key":"10.1016\/j.thromres.2026.109821_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.memsci.2025.124492","article-title":"Construction of bionic enzyme gas channels on the surface of PMP hollow fiber membrane for rapid CO2 removal in ECCO2R system","volume":"734","author":"Wang","year":"2025","journal-title":"J. Membr. Sci."},{"issue":"10","key":"10.1016\/j.thromres.2026.109821_bb0050","doi-asserted-by":"crossref","first-page":"3209","DOI":"10.1007\/s11517-024-03121-z","article-title":"Analysis of non-physiological shear stress-induced red blood cell trauma across different clinical support conditions of the blood pump","volume":"62","author":"Liu","year":"2024","journal-title":"Med. Biol. Eng. Comput."},{"issue":"1","key":"10.1016\/j.thromres.2026.109821_bb0055","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12967-020-02599-z","article-title":"Hemolysis at low blood flow rates: in-vitro and in-silico evaluation of a centrifugal blood pump","volume":"19","author":"Sch\u00f6ps","year":"2021","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.thromres.2026.109821_bb0060","article-title":"Shear-induced acquired von Willebrand syndrome: an accomplice of bleeding events in adults on extracorporeal membrane oxygenation support","volume":"10","author":"Wang","year":"2023","journal-title":"Front. Cardiovasc. Med."},{"issue":"9","key":"10.1016\/j.thromres.2026.109821_bb0065","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1111\/aor.14766","article-title":"In vitro study on device-induced damage to blood cellular components and degradation of von Willebrand factor in a CentriMag pump-assisted circulation","volume":"48","author":"Wang","year":"2024","journal-title":"Artif. Organs"},{"issue":"10","key":"10.1016\/j.thromres.2026.109821_bb0070","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1111\/jocs.13794","article-title":"Changes in Von Willebrand factor profile predicts clinical outcomes in patients on mechanical circulatory support","volume":"33","author":"Oezpeker","year":"2018","journal-title":"J. Card. Surg."},{"issue":"5","key":"10.1016\/j.thromres.2026.109821_bb0075","doi-asserted-by":"crossref","first-page":"E201","DOI":"10.1111\/aor.13609","article-title":"The impact of shear stress on device-induced platelet hemostatic dysfunction relevant to thrombosis and bleeding in mechanically assisted circulation","volume":"44","author":"Chen","year":"2020","journal-title":"Artif. Organs"},{"issue":"4","key":"10.1016\/j.thromres.2026.109821_bb0080","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1161\/ATVBAHA.120.315583","article-title":"Platelet dysfunction during mechanical circulatory support: elevated shear stress promotes downregulation of \u03b1(IIb)\u03b2(3) and GPIb via microparticle shedding decreasing platelet aggregability","volume":"41","author":"Roka-Moiia","year":"2021","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"8","key":"10.1016\/j.thromres.2026.109821_bb0085","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1111\/aor.13445","article-title":"Device-induced platelet dysfunction in mechanically assisted circulation increases the risks of thrombosis and bleeding","volume":"43","author":"Chen","year":"2019","journal-title":"Artif. Organs"},{"issue":"30","key":"10.1016\/j.thromres.2026.109821_bb0090","article-title":"Platelet adhesion and activation in an ECMO thrombosis-on-a-chip model","volume":"11","author":"Goh","year":"2024","journal-title":"Adv. Sci. (Weinheim, Baden-Wurttemberg, Germany)"},{"issue":"3","key":"10.1016\/j.thromres.2026.109821_bb0095","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1161\/ATVBAHA.107.150474","article-title":"Cell adhesion mechanisms in platelets","volume":"28","author":"Varga-Szabo","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"6","key":"10.1016\/j.thromres.2026.109821_bb0100","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1097\/MAT.0000000000000722","article-title":"Quantitative characterization of shear-induced platelet receptor shedding: glycoprotein Ib\u03b1, glycoprotein VI, and glycoprotein IIb\/IIIa","volume":"64","author":"Chen","year":"2018","journal-title":"ASAIO J. (Am. Soc. Artif. Internal Organs: 1992)"},{"issue":"4","key":"10.1016\/j.thromres.2026.109821_bb0105","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1097\/MAT.0000000000002116","article-title":"Multi-method investigation of blood damage induced by blood pumps in different clinical support modes","volume":"70","author":"Li","year":"2024","journal-title":"ASAIO J."},{"issue":"8","key":"10.1016\/j.thromres.2026.109821_bb0110","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1039\/b918719g","article-title":"Platelet retraction force measurements using flexible post force sensors","volume":"10","author":"Liang","year":"2010","journal-title":"Lab Chip"},{"issue":"11","key":"10.1016\/j.thromres.2026.109821_bb0115","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/j.healun.2017.05.008","article-title":"Bleeding and thrombosis associated with ventricular assist device therapy","volume":"36","author":"Shah","year":"2017","journal-title":"J. Heart Lung Transplant."},{"issue":"3","key":"10.1016\/j.thromres.2026.109821_bb0120","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1097\/HCO.0000000000000284","article-title":"Bleeding and thrombosis in chronic ventricular assist device therapy: focus on platelets","volume":"31","author":"Koliopoulou","year":"2016","journal-title":"Curr. Opin. Cardiol."},{"issue":"1","key":"10.1016\/j.thromres.2026.109821_bb0125","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/MAT.0000000000001493","article-title":"Blood pumps for extracorporeal membrane oxygenation: platelet activation during different operating conditions","volume":"68","author":"Fiusco","year":"2022","journal-title":"ASAIO J. (Am. Soc. Artif. Internal Organs: 1992)"},{"issue":"7","key":"10.1016\/j.thromres.2026.109821_bb0130","doi-asserted-by":"crossref","DOI":"10.1007\/s10409-024-24616-x","article-title":"Mathematical model for qualitative assessment of blood pump-induced thrombosis and stroke risk","volume":"42","author":"Li","year":"2025","journal-title":"Acta Mech. Sinica"},{"issue":"13","key":"10.1016\/j.thromres.2026.109821_bb0135","doi-asserted-by":"crossref","first-page":"3796","DOI":"10.1111\/bph.70433","article-title":"Study on the mechanism of the combined effects of high shear stress and antiplatelet drug on platelet haemostatic function","volume":"183","author":"Wang","year":"2026","journal-title":"Br. J. Pharmacol."},{"issue":"10","key":"10.1016\/j.thromres.2026.109821_bb0140","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1111\/aor.12932","article-title":"Shear stress-induced total blood trauma in multiple species","volume":"41","author":"Chan","year":"2017","journal-title":"Artif. Organs"}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384826002409?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384826002409?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T08:17:50Z","timestamp":1790237870000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049384826002409"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":28,"alternative-id":["S0049384826002409"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2026.109821","relation":{},"ISSN":["0049-3848"],"issn-type":[{"value":"0049-3848","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Study of centrifugal blood pump non-physiological shear stress induced platelet hemostatic dysfunction","name":"articletitle","label":"Article Title"},{"value":"Thrombosis Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.thromres.2026.109821","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109821"}}