{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:01:55Z","timestamp":1790240515409,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010425","name":"Tri-Service General Hospital","doi-asserted-by":"publisher","award":["TSGH-PH-E-113015"],"award-info":[{"award-number":["TSGH-PH-E-113015"]}],"id":[{"id":"10.13039\/501100010425","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010425","name":"Tri-Service General Hospital","doi-asserted-by":"publisher","award":["TSGH-E-111254"],"award-info":[{"award-number":["TSGH-E-111254"]}],"id":[{"id":"10.13039\/501100010425","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010425","name":"Tri-Service General Hospital","doi-asserted-by":"publisher","award":["TSGH-PH-E-112018"],"award-info":[{"award-number":["TSGH-PH-E-112018"]}],"id":[{"id":"10.13039\/501100010425","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 113-2314-B-016-013-MY3"],"award-info":[{"award-number":["NSTC 113-2314-B-016-013-MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019000","name":"Ministry of National Defense Republic of China Taiwan Medical Affairs Bureau","doi-asserted-by":"publisher","award":["MND-MAB-C15-112061"],"award-info":[{"award-number":["MND-MAB-C15-112061"]}],"id":[{"id":"10.13039\/501100019000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019000","name":"Ministry of National Defense Republic of China Taiwan Medical Affairs Bureau","doi-asserted-by":"publisher","award":["MND-MAB-C15-112062"],"award-info":[{"award-number":["MND-MAB-C15-112062"]}],"id":[{"id":"10.13039\/501100019000","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thrombosisresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.thromres.2026.109831","type":"journal-article","created":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T22:24:28Z","timestamp":1788733468000},"page":"109831","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Dysregulated autophagic flux is associated with intrinsic platelet dysfunction in heatstroke-induced coagulopathy"],"prefix":"10.1016","volume":"265","author":[{"given":"Mei-Fang","family":"Chou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung-Yen","family":"Ke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Yao","family":"Kao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Ming","family":"Tsao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin-Chen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Chin","family":"Shih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"25","key":"10.1016\/j.thromres.2026.109831_bb0005","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1056\/NEJMra1810762","article-title":"Heatstroke","volume":"380","author":"Epstein","year":"2019","journal-title":"N. Engl. J. Med."},{"issue":"10301","key":"10.1016\/j.thromres.2026.109831_bb0010","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/S0140-6736(21)01208-3","article-title":"Hot weather and heat extremes: health risks","volume":"398","author":"Ebi","year":"2021","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.thromres.2026.109831_bb0015","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41572-021-00334-6","article-title":"Classic and exertional heatstroke","volume":"8","author":"Bouchama","year":"2022","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"7","key":"10.1016\/j.thromres.2026.109831_bb0020","doi-asserted-by":"crossref","first-page":"e415","DOI":"10.1016\/S2542-5196(21)00081-4","article-title":"Global, regional, and national burden of mortality associated with non-optimal ambient temperatures from 2000 to 2019: a three-stage modelling study","volume":"5","author":"Zhao","year":"2021","journal-title":"Lancet Planet Health"},{"issue":"2","key":"10.1016\/j.thromres.2026.109831_bb0025","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines13020261","article-title":"Heatstroke-induced inflammatory response and therapeutic biomarkers","volume":"13","author":"Baindara","year":"2025","journal-title":"Biomedicines"},{"issue":"1","key":"10.1016\/j.thromres.2026.109831_bb0030","first-page":"68","article-title":"Lethal heatstroke with disseminated intravascular coagulopathy","volume":"57","author":"Herpertz","year":"2022","journal-title":"Anasthesiol. Intensivmed. Notfallmed. Schmerzther."},{"issue":"1","key":"10.1016\/j.thromres.2026.109831_bb0035","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s00011-025-02145-x","article-title":"Sepsis and heatstroke: overlapping and distinct mechanisms of systemic inflammation","volume":"74","author":"Iba","year":"2025","journal-title":"Inflamm. Res."},{"issue":"19","key":"10.1016\/j.thromres.2026.109831_bb0040","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph191912448","article-title":"A potential driver of disseminated intravascular coagulation in heat stroke mice: neutrophil extracellular traps","volume":"19","author":"Zhang","year":"2022","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.thromres.2026.109831_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2022.101276","article-title":"Heatstroke-induced coagulopathy: biomarkers, mechanistic insights, and patient management","volume":"44","author":"Iba","year":"2022","journal-title":"eClinicalMedicine"},{"key":"10.1016\/j.thromres.2026.109831_bb0050","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.thromres.2022.08.019","article-title":"Autophagy and its consequences for platelet biology","volume":"231","author":"Schwertz","year":"2023","journal-title":"Thromb. Res."},{"key":"10.1016\/j.thromres.2026.109831_bb0055","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/978-1-4939-8873-0_32","article-title":"Autophagy in platelets","volume":"1880","author":"Banerjee","year":"2019","journal-title":"Methods Mol. Biol."},{"issue":"5","key":"10.1016\/j.thromres.2026.109831_bb0060","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.4103\/NRR.NRR-D-23-00794","article-title":"Endoplasmic reticulum stress and autophagy in cerebral ischemia\/reperfusion injury: PERK as a potential target for intervention","volume":"20","author":"Zheng","year":"2025","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.thromres.2026.109831_bb0065","doi-asserted-by":"crossref","DOI":"10.1093\/burnst\/tkac059","article-title":"Autophagy in acute kidney injury and maladaptive kidney repair","volume":"11","author":"Xiang","year":"2023","journal-title":"Burns Trauma"},{"issue":"1","key":"10.1016\/j.thromres.2026.109831_bb0070","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/s41420-023-01387-0","article-title":"Autophagy in hepatic ischemia-reperfusion injury","volume":"9","author":"Mao","year":"2023","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.thromres.2026.109831_bb0075","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2024.1360014","article-title":"Role of autophagy in ischemic stroke: insights from animal models and preliminary evidence in the human disease","volume":"12","author":"Stanzione","year":"2024","journal-title":"Front. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.thromres.2026.109831_bb0080","doi-asserted-by":"crossref","DOI":"10.1186\/s11658-025-00713-x","article-title":"Autophagy: a double-edged sword in ischemia\u2013reperfusion injury","volume":"30","author":"Tang","year":"2025","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.thromres.2026.109831_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2025.109285","article-title":"Activation of autophagy with PF-06409577 alleviates heatstroke-induced organ injury","volume":"196","author":"Zhang","year":"2025","journal-title":"Environ. Int."},{"issue":"10","key":"10.1016\/j.thromres.2026.109831_bb0090","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1182\/blood-2014-09-598722","article-title":"Autophagy is induced upon platelet activation and is essential for hemostasis and thrombosis","volume":"126","author":"Ouseph","year":"2015","journal-title":"Blood"},{"issue":"12","key":"10.1016\/j.thromres.2026.109831_bb0095","doi-asserted-by":"crossref","first-page":"4141","DOI":"10.1080\/15548627.2021.1904495","article-title":"Platelet autophagic machinery involved in thrombosis through a novel linkage of AMPK-MTOR to sphingolipid metabolism","volume":"17","author":"Lee","year":"2021","journal-title":"Autophagy"},{"issue":"4","key":"10.1016\/j.thromres.2026.109831_bb0100","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1007\/s12288-023-01638-1","article-title":"High autophagy patterns in swelling platelets during apheresis platelet storage","volume":"39","author":"Yu","year":"2023","journal-title":"Indian J. Hematol. Blood Transfus."},{"key":"10.1016\/j.thromres.2026.109831_bb0105","article-title":"Autophagy ameliorates reactive oxygen species-induced platelet storage lesions","volume":"2022","author":"Zhao","year":"2022","journal-title":"Oxidative Med. Cell. Longev."},{"issue":"4","key":"10.1016\/j.thromres.2026.109831_bb0110","doi-asserted-by":"crossref","first-page":"642","DOI":"10.4161\/auto.27832","article-title":"Dissection of autophagy in human platelets","volume":"10","author":"Feng","year":"2014","journal-title":"Autophagy"},{"issue":"4","key":"10.1016\/j.thromres.2026.109831_bb0175","doi-asserted-by":"crossref","first-page":"R170","DOI":"10.1016\/j.cub.2018.01.004","article-title":"Mitophagy and quality control mechanisms in mitochondrial maintenance","volume":"28","author":"Pickles","year":"2018","journal-title":"Curr. Biol."},{"issue":"10","key":"10.1016\/j.thromres.2026.109831_bb0180","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.molmed.2022.06.007","article-title":"Mitophagy in cardiovascular diseases: molecular mechanisms, pathogenesis, and treatment","volume":"28","author":"Ajoolabady","year":"2022","journal-title":"Trends Mol. Med."},{"issue":"4","key":"10.1016\/j.thromres.2026.109831_bb0185","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.tem.2023.11.004","article-title":"Mitochondrial quality control pathways sense mitochondrial protein import","volume":"35","author":"Lee-Glover","year":"2024","journal-title":"Trends Endocrinol. Metab."},{"issue":"10","key":"10.1016\/j.thromres.2026.109831_bb0115","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1113\/EP090142","article-title":"Biomarkers of heatstroke-induced organ injury and repair","volume":"107","author":"Schlader","year":"2022","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.thromres.2026.109831_bb0120","doi-asserted-by":"crossref","first-page":"343","DOI":"10.2147\/OAEM.S419028","article-title":"A systematic review on outcomes of patients with heatstroke and heat exhaustion","volume":"15","author":"Adnan Bukhari","year":"2023","journal-title":"Open Access Emerg. Med."},{"issue":"1","key":"10.1016\/j.thromres.2026.109831_bb0125","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/s41420-024-02210-0","article-title":"The mechanisms behind heatstroke-induced intestinal damage","volume":"10","author":"Sun","year":"2024","journal-title":"Cell Death Discov."},{"issue":"7","key":"10.1016\/j.thromres.2026.109831_bb0130","first-page":"871","article-title":"Ruifuping pectin protects against intestinal mucosal injury in the rat exertional heat stroke model","volume":"33","author":"Xue","year":"2021","journal-title":"Zhonghua Wei Zhong Bing Ji Jiu Yi Xue"},{"key":"10.1016\/j.thromres.2026.109831_bb0135","article-title":"The pathogenesis and therapeutic strategies of heat stroke-induced endothelial injury","volume":"13","author":"Wang","year":"2025","journal-title":"Front. Cell Dev. Biol."},{"issue":"S1","key":"10.1016\/j.thromres.2026.109831_bb0140","first-page":"68","article-title":"Disseminated intravascular coagulation caused by exertional heat stroke: a case report and literature review","volume":"45","author":"Zhang","year":"2024","journal-title":"Zhonghua Xue Ye Xue Za Zhi"},{"key":"10.1016\/j.thromres.2026.109831_bb0145","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2024.1437216","article-title":"How can heatstroke damage the brain? A mini review","volume":"18","author":"Yoneda","year":"2024","journal-title":"Front. Neurosci."},{"issue":"5","key":"10.1016\/j.thromres.2026.109831_bb0150","doi-asserted-by":"crossref","first-page":"308","DOI":"10.14789\/ejmj.JMJ25-0023-P","article-title":"Molecular mechanisms of heatstroke: pathophysiology and cell death pathways","volume":"71","author":"Ferrer","year":"2025","journal-title":"Juntendo Med J"},{"issue":"10","key":"10.1016\/j.thromres.2026.109831_bb0155","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1080\/15548627.2025.2493455","article-title":"METTL3-dependent m(6)A modification of SNAP29 induces \"autophagy-mitochondrial crisis\" in the ischemic microenvironment after soft tissue transplantation","volume":"21","author":"Yang","year":"2025","journal-title":"Autophagy"},{"key":"10.1016\/j.thromres.2026.109831_bb0160","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2024.1460616","article-title":"Autophagy and the pancreas: healthy and disease states","volume":"12","author":"Zhou","year":"2024","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.thromres.2026.109831_bb0165","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.917662","article-title":"Mechanoautophagy: synergies between autophagy and cell Mechanotransduction at adhesive complexes","volume":"10","author":"Ravasio","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.thromres.2026.109831_bb0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15548627.2020.1797280","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)(1)","volume":"17","author":"Klionsky","year":"2021","journal-title":"Autophagy"},{"issue":"8","key":"10.1016\/j.thromres.2026.109831_bb0190","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1080\/15548627.2018.1474314","article-title":"Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion","volume":"14","author":"Mauthe","year":"2018","journal-title":"Autophagy"},{"key":"10.1016\/j.thromres.2026.109831_bb0195","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-32716-4","article-title":"Loss of the mitochondrial kinase PINK1 does not alter platelet function","volume":"8","author":"Walsh","year":"2018","journal-title":"Sci. Rep."}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384826002501?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384826002501?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T08:16:56Z","timestamp":1790237816000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049384826002501"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":39,"alternative-id":["S0049384826002501"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2026.109831","relation":{},"ISSN":["0049-3848"],"issn-type":[{"value":"0049-3848","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dysregulated autophagic flux is associated with intrinsic platelet dysfunction in heatstroke-induced coagulopathy","name":"articletitle","label":"Article Title"},{"value":"Thrombosis Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.thromres.2026.109831","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109831"}}