{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T12:24:38Z","timestamp":1793363078507,"version":"4.5.0"},"reference-count":91,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trends in Biochemical Sciences"],"published-print":{"date-parts":[[2006,2]]},"DOI":"10.1016\/j.tibs.2005.12.008","type":"journal-article","created":{"date-parts":[[2006,1,6]],"date-time":"2006-01-06T12:11:08Z","timestamp":1136549468000},"page":"89-97","source":"Crossref","is-referenced-by-count":2111,"title":["Genomic DNA methylation: the mark and its mediators"],"prefix":"10.1016","volume":"31","author":[{"given":"Robert J.","family":"Klose","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian P.","family":"Bird","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tibs.2005.12.008_bib1","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1146\/annurev.ge.25.120191.003101","article-title":"Restriction and modification systems","volume":"25","author":"Wilson","year":"1991","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.tibs.2005.12.008_bib2","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0092-8674(00)81532-9","article-title":"Methylation-induced repression \u2013 belts, braces, and chromatin","volume":"99","author":"Bird","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.tibs.2005.12.008_bib3","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/0092-8674(92)90611-F","article-title":"Targeted mutation of the DNA methyltransferase gene results in embryonic lethality","volume":"69","author":"Li","year":"1992","journal-title":"Cell"},{"key":"10.1016\/j.tibs.2005.12.008_bib4","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0092-8674(00)81656-6","article-title":"DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development","volume":"99","author":"Okano","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.tibs.2005.12.008_bib5","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1101\/gad.2.9.1136","article-title":"Cytosine methylation prevents binding to DNA of a HeLa cell transcription factor required for optimal expression of the adenovirus major late promoter","volume":"2","author":"Watt","year":"1988","journal-title":"Genes Dev."},{"key":"10.1016\/j.tibs.2005.12.008_bib6","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/0092-8674(91)90267-3","article-title":"DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein","volume":"64","author":"Boyes","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.tibs.2005.12.008_bib7","doi-asserted-by":"crossref","first-page":"6538","DOI":"10.1128\/MCB.18.11.6538","article-title":"Identification and characterization of a family of mammalian methyl-CpG binding proteins","volume":"18","author":"Hendrich","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.tibs.2005.12.008_bib8","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/561","article-title":"Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription","volume":"19","author":"Jones","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tibs.2005.12.008_bib9","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/30764","article-title":"Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex","volume":"393","author":"Nan","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.tibs.2005.12.008_bib10","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/12659","article-title":"MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex","volume":"23","author":"Ng","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tibs.2005.12.008_bib11","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.molcel.2004.06.043","article-title":"Methyl-CpG binding protein MBD1 couples histone H3 methylation at lysine 9 by SETDB1 to DNA replication and chromatin assembly","volume":"15","author":"Sarraf","year":"2004","journal-title":"Mol. Cell"},{"key":"10.1016\/j.tibs.2005.12.008_bib12","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/12664","article-title":"Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation","volume":"23","author":"Wade","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tibs.2005.12.008_bib13","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1101\/gad.13.15.1924","article-title":"Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation","volume":"13","author":"Zhang","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/j.tibs.2005.12.008_bib14","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1146\/annurev.arplant.55.031903.141641","article-title":"DNA methylation and epigenetics","volume":"55","author":"Bender","year":"2004","journal-title":"Annu. Rev. Plant Biol."},{"key":"10.1016\/j.tibs.2005.12.008_bib15","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/nrg1601","article-title":"Gardening the genome: DNA methylation in Arabidopsis thaliana","volume":"6","author":"Chan","year":"2005","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.tibs.2005.12.008_bib16","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.gde.2005.02.003","article-title":"Controlling DNA methylation: many roads to one modification","volume":"15","author":"Freitag","year":"2005","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.tibs.2005.12.008_bib17","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1146\/annurev.biochem.74.010904.153721","article-title":"Eukaryotic cytosine methyltransferases","volume":"74","author":"Grace Goll","year":"2005","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.tibs.2005.12.008_bib18","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0168-9525(03)00080-5","article-title":"The methyl-CpG binding domain and the evolving role of DNA methylation in animals","volume":"19","author":"Hendrich","year":"2003","journal-title":"Trends Genet."},{"key":"10.1016\/j.tibs.2005.12.008_bib19","doi-asserted-by":"crossref","first-page":"31717","DOI":"10.1074\/jbc.M305448200","article-title":"The human Dnmt2 has residual DNA-(cytosine-C5) methyltransferase activity","volume":"278","author":"Hermann","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tibs.2005.12.008_bib20","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1093\/nar\/26.11.2536","article-title":"Dnmt2 is not required for de novo and maintenance methylation of viral DNA in embryonic stem cells","volume":"26","author":"Okano","year":"1998","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tibs.2005.12.008_bib21","doi-asserted-by":"crossref","first-page":"27816","DOI":"10.1074\/jbc.M400181200","article-title":"DNMT3L stimulates the DNA methylation activity of Dnmt3a and Dnmt3b through a direct interaction","volume":"279","author":"Suetake","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tibs.2005.12.008_bib22","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1126\/science.1063443","article-title":"Epigenetic reprogramming in mammalian development","volume":"293","author":"Reik","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.tibs.2005.12.008_bib23","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/ajmg.10658","article-title":"Three novel DNMT3B mutations in Japanese patients with ICF syndrome","volume":"112","author":"Shirohzu","year":"2002","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.tibs.2005.12.008_bib24","doi-asserted-by":"crossref","first-page":"25447","DOI":"10.1074\/jbc.M312296200","article-title":"Chromatin targeting of de novo DNA methyltransferases by the PWWP domain","volume":"279","author":"Ge","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tibs.2005.12.008_bib25","first-page":"217","article-title":"The PWWP domain of mammalian DNA methyltransferase Dnmt3b defines a new family of DNA-binding folds","volume":"9","author":"Qiu","year":"2002","journal-title":"Nat. Struct. Biol."},{"key":"10.1016\/j.tibs.2005.12.008_bib26","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/nature03114","article-title":"Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks","volume":"432","author":"Huyen","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.tibs.2005.12.008_bib27","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0968-0004(03)00004-5","article-title":"The Tudor domain \u2018Royal Family\u2019: Tudor, plant Agenet, Chromo, PWWP and MBT domains","volume":"28","author":"Maurer-Stroh","year":"2003","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.tibs.2005.12.008_bib28","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1126\/science.1065173","article-title":"Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor","volume":"295","author":"Di Croce","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.tibs.2005.12.008_bib29","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/sj.emboj.7600509","article-title":"Myc represses transcription through recruitment of DNA methyltransferase corepressor","volume":"24","author":"Brenner","year":"2005","journal-title":"EMBO J."},{"key":"10.1016\/j.tibs.2005.12.008_bib30","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1128\/MCB.25.7.2539-2546.2005","article-title":"Epigenetic mechanism of rRNA gene silencing: temporal order of NoRC-mediated histone modification, chromatin remodeling, and DNA methylation","volume":"25","author":"Santoro","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.tibs.2005.12.008_bib31","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/ng1010","article-title":"The nucleolar remodeling complex NoRC mediates heterochromatin formation and silencing of ribosomal gene transcription","volume":"32","author":"Santoro","year":"2002","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tibs.2005.12.008_bib32","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/nrg1500","article-title":"RNAi-mediated pathways in the nucleus","volume":"6","author":"Matzke","year":"2005","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.tibs.2005.12.008_bib33","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/nature02889","article-title":"Induction of DNA methylation and gene silencing by short interfering RNAs in human cells","volume":"431","author":"Kawasaki","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.tibs.2005.12.008_bib34","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1126\/science.1101372","article-title":"Small interfering RNA-induced transcriptional gene silencing in human cells","volume":"305","author":"Morris","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.tibs.2005.12.008_bib35","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.bbrc.2004.08.096","article-title":"Double-stranded siRNA targeted to the huntingtin gene does not induce DNA methylation","volume":"323","author":"Park","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tibs.2005.12.008_bib36","doi-asserted-by":"crossref","first-page":"3601","DOI":"10.1093\/nar\/gkh697","article-title":"Lack of homologous sequence-specific DNA methylation in response to stable dsRNA expression in mouse oocytes","volume":"32","author":"Svoboda","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tibs.2005.12.008_bib37","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1038\/ng1611","article-title":"Short double-stranded RNA induces transcriptional gene silencing in human cancer cells in the absence of DNA methylation","volume":"37","author":"Ting","year":"2005","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tibs.2005.12.008_bib38","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1101\/gad.1248505","article-title":"Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing","volume":"19","author":"Kanellopoulou","year":"2005","journal-title":"Genes Dev."},{"key":"10.1016\/j.tibs.2005.12.008_bib39","doi-asserted-by":"crossref","first-page":"12135","DOI":"10.1073\/pnas.0505479102","article-title":"Characterization of Dicer-deficient murine embryonic stem cells","volume":"102","author":"Murchison","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tibs.2005.12.008_bib40","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0092-8674(81)90248-8","article-title":"DNA methylation controls the inducibility of the mouse metallothionein-I gene lymphoid cells","volume":"25","author":"Compere","year":"1981","journal-title":"Cell"},{"key":"10.1016\/j.tibs.2005.12.008_bib41","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0960-9822(97)70086-1","article-title":"DNA methylation directs a time-dependent repression of transcription initiation","volume":"7","author":"Kass","year":"1997","journal-title":"Curr. Biol."},{"key":"10.1016\/j.tibs.2005.12.008_bib42","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/9727","article-title":"DNA methylation represses transcription in vivo","volume":"22","author":"Siegfried","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tibs.2005.12.008_bib43","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0092-8674(00)81887-5","article-title":"MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin","volume":"88","author":"Nan","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.tibs.2005.12.008_bib44","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1073\/pnas.84.5.1177","article-title":"Chromatin structure is required to block transcription of the methylated herpes simplex virus thymidine kinase gene","volume":"84","author":"Buschhausen","year":"1987","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tibs.2005.12.008_bib45","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.molcel.2003.08.008","article-title":"N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso","volume":"12","author":"Yoon","year":"2003","journal-title":"Mol. Cell"},{"key":"10.1016\/j.tibs.2005.12.008_bib46","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1002\/bies.10008","article-title":"Methyl CpG-binding proteins and transcriptional repression","volume":"23","author":"Wade","year":"2001","journal-title":"BioEssays"},{"key":"10.1016\/j.tibs.2005.12.008_bib47","doi-asserted-by":"crossref","first-page":"32282","DOI":"10.1074\/jbc.M104661200","article-title":"Dnmt3a and Dnmt3b are transcriptional repressors that exhibit unique localization properties to heterochromatin","volume":"276","author":"Bachman","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tibs.2005.12.008_bib48","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/71750","article-title":"DNA methyltransferase Dnmt1 associates with histone deacetylase activity","volume":"24","author":"Fuks","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tibs.2005.12.008_bib49","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1093\/emboj\/20.10.2536","article-title":"Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription","volume":"20","author":"Fuks","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.tibs.2005.12.008_bib50","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.bbrc.2004.04.058","article-title":"DNMT3B interacts with hSNF2H chromatin remodeling enzyme, HDACs 1 and 2, and components of the histone methylation system","volume":"318","author":"Geiman","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tibs.2005.12.008_bib51","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/S0960-9822(03)00432-9","article-title":"Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin","volume":"13","author":"Lehnertz","year":"2003","journal-title":"Curr. Biol."},{"key":"10.1016\/j.tibs.2005.12.008_bib52","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1093\/nar\/gkg332","article-title":"The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase","volume":"31","author":"Fuks","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tibs.2005.12.008_bib53","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1128\/MCB.25.2.751-766.2005","article-title":"DNA methyltransferase 3b regulates nerve growth factor-induced differentiation of PC12 cells by recruiting histone deacetylase 2","volume":"25","author":"Bai","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.tibs.2005.12.008_bib54","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/77124","article-title":"DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters","volume":"25","author":"Robertson","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tibs.2005.12.008_bib55","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/77023","article-title":"DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci","volume":"25","author":"Rountree","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tibs.2005.12.008_bib56","doi-asserted-by":"crossref","first-page":"5897","DOI":"10.1128\/MCB.17.10.5897","article-title":"Stability of patch methylation and its impact in regions of transcriptional initiation and elongation","volume":"17","author":"Hsieh","year":"1997","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.tibs.2005.12.008_bib57","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1038\/nsmb840","article-title":"Intragenic DNA methylation alters chromatin structure and elongation efficiency in mammalian cells","volume":"11","author":"Lorincz","year":"2004","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.tibs.2005.12.008_bib58","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/0092-8674(92)90610-O","article-title":"Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA","volume":"69","author":"Lewis","year":"1992","journal-title":"Cell"},{"key":"10.1016\/j.tibs.2005.12.008_bib59","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/0092-8674(89)90430-3","article-title":"Identification of a mammalian protein that binds specifically to DNA containing methylated CpGs","volume":"58","author":"Meehan","year":"1989","journal-title":"Cell"},{"key":"10.1016\/j.tibs.2005.12.008_bib60","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1101\/gad.198501","article-title":"The p120 catenin partner Kaiso is a DNA methylation-dependent transcriptional repressor","volume":"15","author":"Prokhortchouk","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/j.tibs.2005.12.008_bib61","first-page":"827","article-title":"The MeCP1 complex represses transcription through preferential binding, remodeling, and deacetylating methylated nucleosomes","volume":"15","author":"Feng","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/j.tibs.2005.12.008_bib62","doi-asserted-by":"crossref","first-page":"46490","DOI":"10.1074\/jbc.M408284200","article-title":"MeCP2 behaves as an elongated monomer that does not stably associate with the Sin3a chromatin remodeling complex","volume":"279","author":"Klose","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tibs.2005.12.008_bib63","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/45843","article-title":"The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites","volume":"401","author":"Hendrich","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.tibs.2005.12.008_bib64","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1126\/science.1073354","article-title":"Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice","volume":"297","author":"Millar","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.tibs.2005.12.008_bib65","doi-asserted-by":"crossref","first-page":"14937","DOI":"10.1073\/pnas.232579299","article-title":"Mbd4 inactivation increases C\u2192T transition mutations and promotes gastrointestinal tumor formation","volume":"99","author":"Wong","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tibs.2005.12.008_bib66","doi-asserted-by":"crossref","first-page":"4388","DOI":"10.1128\/MCB.25.11.4388-4396.2005","article-title":"The thymine DNA glycosylase MBD4 represses transcription and is associated with methylated p16INK4a and hMLH1 genes","volume":"25","author":"Kondo","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.tibs.2005.12.008_bib67","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1093\/nar\/gkf398","article-title":"The p120ctn-binding partner Kaiso is a bi-modal DNA-binding protein that recognizes both a sequence-specific consensus and methylated CpG dinucleotides","volume":"30","author":"Daniel","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tibs.2005.12.008_bib68","doi-asserted-by":"crossref","first-page":"6185","DOI":"10.1242\/dev.01549","article-title":"Kaiso is a genome-wide repressor of transcription that is essential for amphibian development","volume":"131","author":"Ruzov","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.tibs.2005.12.008_bib69","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1038\/ncb1191","article-title":"Non-canonical Wnt signals are modulated by the Kaiso transcriptional repressor and p120-catenin","volume":"6","author":"Kim","year":"2004","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.tibs.2005.12.008_bib70","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1128\/MCB.26.1.199-208.2006","article-title":"Kaiso-deficient mice show resistance to intestinal cancer","volume":"26","author":"Prokhortchouk","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.tibs.2005.12.008_bib71","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.molcel.2003.08.007","article-title":"mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression","volume":"12","author":"Wang","year":"2003","journal-title":"Mol. Cell"},{"key":"10.1016\/j.tibs.2005.12.008_bib72","doi-asserted-by":"crossref","first-page":"6777","DOI":"10.1073\/pnas.1131928100","article-title":"Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function","volume":"100","author":"Zhao","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tibs.2005.12.008_bib73","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1101\/gad.194101","article-title":"Closely related proteins MBD2 and MBD3 play distinctive but interacting roles in mouse development","volume":"15","author":"Hendrich","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/j.tibs.2005.12.008_bib74","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/ng1155","article-title":"Deficiency of Mbd2 suppresses intestinal tumorigenesis","volume":"34","author":"Sansom","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tibs.2005.12.008_bib75","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S1097-2765(02)00564-6","article-title":"Gene silencing quantitatively controls the function of a developmental trans-activator","volume":"10","author":"Hutchins","year":"2002","journal-title":"Mol. Cell"},{"key":"10.1016\/j.tibs.2005.12.008_bib76","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S1074-7613(01)00227-8","article-title":"A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival","volume":"15","author":"Lee","year":"2001","journal-title":"Immunity"},{"issue":"Review Issue 2","key":"10.1016\/j.tibs.2005.12.008_bib77","doi-asserted-by":"crossref","first-page":"R221","DOI":"10.1093\/hmg\/ddg286","article-title":"DNA methylation and Rett syndrome","volume":"12","author":"Kriaucionis","year":"2003","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.tibs.2005.12.008_bib78","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/85906","article-title":"Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice","volume":"27","author":"Chen","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tibs.2005.12.008_bib79","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/85899","article-title":"A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome","volume":"27","author":"Guy","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tibs.2005.12.008_bib80","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1093\/hmg\/ddi229","article-title":"Up-regulation of glucocorticoid-regulated genes in a mouse model of Rett syndrome","volume":"14","author":"Nuber","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.tibs.2005.12.008_bib81","doi-asserted-by":"crossref","first-page":"15536","DOI":"10.1073\/pnas.242566899","article-title":"Transcriptional profiling of a mouse model for Rett syndrome reveals subtle transcriptional changes in the brain","volume":"99","author":"Tudor","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tibs.2005.12.008_bib82","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/ng1491","article-title":"Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome","volume":"37","author":"Horike","year":"2005","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tibs.2005.12.008_bib83","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1093\/hmg\/ddi097","article-title":"MeCP2 deficiency in Rett syndrome causes epigenetic aberrations at the PWS\/AS imprinting center that affects UBE3A expression","volume":"14","author":"Makedonski","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.tibs.2005.12.008_bib84","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1093\/hmg\/ddi045","article-title":"Epigenetic overlap in autism-spectrum neurodevelopmental disorders: MECP2 deficiency causes reduced expression of UBE3A and GABRB3","volume":"14","author":"Samaco","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.tibs.2005.12.008_bib85","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1126\/science.1086446","article-title":"Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2","volume":"302","author":"Chen","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.tibs.2005.12.008_bib86","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1126\/science.1090842","article-title":"DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation","volume":"302","author":"Martinowich","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.tibs.2005.12.008_bib87","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.cell.2005.03.013","article-title":"REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis","volume":"121","author":"Ballas","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.tibs.2005.12.008_bib88","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.molcel.2005.07.021","article-title":"DNA binding selectivity of MeCP2 due to a requirement for A\/T sequences adjacent to methyl-CpG","volume":"19","author":"Klose","year":"2005","journal-title":"Mol. Cell"},{"key":"10.1016\/j.tibs.2005.12.008_bib89","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.1128\/MCB.24.8.3387-3395.2004","article-title":"Mbd1 is recruited to both methylated and nonmethylated CpGs via distinct DNA binding domains","volume":"24","author":"Jorgensen","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.tibs.2005.12.008_bib90","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S1097-2765(03)00276-4","article-title":"A mutant form of MeCP2 protein associated with human Rett syndrome cannot be displaced from methylated DNA by notch in Xenopus embryos","volume":"12","author":"Stancheva","year":"2003","journal-title":"Mol. Cell"},{"key":"10.1016\/j.tibs.2005.12.008_bib91","doi-asserted-by":"crossref","first-page":"17551","DOI":"10.1073\/pnas.0507856102","article-title":"Regulation of RNA splicing by the methylation-dependent transcriptional repressor methyl-CpG binding protein 2","volume":"102","author":"Young","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Trends in Biochemical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096800040500352X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096800040500352X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,13]],"date-time":"2019-04-13T19:03:28Z","timestamp":1555182208000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S096800040500352X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2]]},"references-count":91,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["S096800040500352X"],"URL":"https:\/\/doi.org\/10.1016\/j.tibs.2005.12.008","relation":{},"ISSN":["0968-0004"],"issn-type":[{"value":"0968-0004","type":"print"}],"subject":[],"published":{"date-parts":[[2006,2]]}}}