{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:03:30Z","timestamp":1761059010870},"reference-count":91,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trends in Biotechnology"],"published-print":{"date-parts":[[2010,2]]},"DOI":"10.1016\/j.tibtech.2009.11.004","type":"journal-article","created":{"date-parts":[[2010,1,5]],"date-time":"2010-01-05T09:08:54Z","timestamp":1262682534000},"page":"93-101","source":"Crossref","is-referenced-by-count":14,"title":["Musculoskeletal molecular imaging: a comprehensive overview"],"prefix":"10.1016","volume":"28","author":[{"given":"Marie K.","family":"Reumann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitchell C.","family":"Weiser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Mayer-Kuckuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tibtech.2009.11.004_bib1","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1172\/JCI18855","article-title":"Molecular-genetic imaging: current and future perspectives","volume":"111","author":"Blasberg","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tibtech.2009.11.004_bib2","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S1535-6108(04)00373-3","article-title":"Spying on cancer: molecular imaging in vivo with genetically encoded reporters","volume":"7","author":"Gross","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1016\/j.tibtech.2009.11.004_bib3","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1101\/gad.1047403","article-title":"Molecular imaging in living subjects: seeing fundamental biological processes in a new light","volume":"17","author":"Massoud","year":"2003","journal-title":"Genes Dev."},{"key":"10.1016\/j.tibtech.2009.11.004_bib4","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1148\/radiology.219.2.r01ma19316","article-title":"Molecular imaging","volume":"219","author":"Weissleder","year":"2001","journal-title":"Radiology"},{"key":"10.1016\/j.tibtech.2009.11.004_bib5","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1006\/mthe.2001.0437","article-title":"Imaging transgene expression in live animals","volume":"4","author":"Honigman","year":"2001","journal-title":"Mol. Ther."},{"key":"10.1016\/j.tibtech.2009.11.004_bib6","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1359\/jbmr.2003.18.3.570","article-title":"Molecular imaging of the skeleton: quantitative real-time bioluminescence monitoring gene expression in bone repair and development","volume":"18","author":"Iris","year":"2003","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.tibtech.2009.11.004_bib7","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.bone.2006.01.149","article-title":"In vivo skeletal imaging of 18F-fluoride with positron emission tomography reveals damage- and time-dependent responses to fatigue loading in the rat ulna","volume":"39","author":"Silva","year":"2006","journal-title":"Bone"},{"key":"10.1016\/j.tibtech.2009.11.004_bib8","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1038\/nbt1201-1148","article-title":"In vivo near-infrared fluorescence imaging of osteoblastic activity","volume":"19","author":"Zaheer","year":"2001","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.tibtech.2009.11.004_bib9","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1359\/jbmr.070504","article-title":"Noninvasive optical detection of bone mineral","volume":"22","author":"Kozloff","year":"2007","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.tibtech.2009.11.004_bib10","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.bone.2008.10.036","article-title":"Non-invasive optical detection of cathepsin K-mediated fluorescence reveals osteoclast activity in vitro and in vivo","volume":"44","author":"Kozloff","year":"2009","journal-title":"Bone"},{"key":"10.1016\/j.tibtech.2009.11.004_bib11","first-page":"311","article-title":"Noninvasive imaging of osteoclasts in parathyroid hormone-induced osteolysis using a 64Cu-labeled RGD peptide","volume":"48","author":"Sprague","year":"2007","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.tibtech.2009.11.004_bib12","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1210\/me.15.7.1104","article-title":"Engineering of a mouse for the in vivo profiling of estrogen receptor activity","volume":"15","author":"Ciana","year":"2001","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.tibtech.2009.11.004_bib13","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/nm809","article-title":"In vivo imaging of transcriptionally active estrogen receptors","volume":"9","author":"Ciana","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.tibtech.2009.11.004_bib14","doi-asserted-by":"crossref","first-page":"6307","DOI":"10.4049\/jimmunol.170.12.6307","article-title":"An inducible nitric oxide synthase-luciferase reporter system for in vivo testing of anti-inflammatory compounds in transgenic mice","volume":"170","author":"Zhang","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.tibtech.2009.11.004_bib15","doi-asserted-by":"crossref","first-page":"8125","DOI":"10.4049\/jimmunol.174.12.8125","article-title":"Serum amyloid A-luciferase transgenic mice: response to sepsis, acute arthritis, and contact hypersensitivity and the effects of proteasome inhibition","volume":"174","author":"Zhang","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.tibtech.2009.11.004_bib16","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.4049\/jimmunol.168.3.1441","article-title":"In vivo imaging of NF-kappa B activity","volume":"168","author":"Carlsen","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.tibtech.2009.11.004_bib17","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.2967\/jnumed.108.051755","article-title":"Biodistribution and radiation dosimetry of 99mTc-HMPAO-labeled monocytes in patients with rheumatoid arthritis","volume":"49","author":"Bennink","year":"2008","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.tibtech.2009.11.004_bib18","doi-asserted-by":"crossref","first-page":"R310","DOI":"10.1186\/ar1483","article-title":"Arthritis imaging using a near-infrared fluorescence folate-targeted probe","volume":"7","author":"Chen","year":"2005","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.tibtech.2009.11.004_bib19","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1097\/01.rli.0000139008.04288.fd","article-title":"Diagnosis of arthritis using near-infrared fluorochrome Cy5.5","volume":"39","author":"Hansch","year":"2004","journal-title":"Invest. Radiol."},{"key":"10.1016\/j.tibtech.2009.11.004_bib20","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1002\/art.20112","article-title":"In vivo imaging of experimental arthritis with near-infrared fluorescence","volume":"50","author":"Hansch","year":"2004","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.tibtech.2009.11.004_bib21","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1272\/jnms.73.298","article-title":"Visualization of antigen-specific T cell in living arthritic mice","volume":"73","author":"Nakajima","year":"2006","journal-title":"J. Nippon Med. Sch."},{"key":"10.1016\/j.tibtech.2009.11.004_bib22","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1172\/JCI12037","article-title":"Antigen-specific T cell-mediated gene therapy in collagen-induced arthritis","volume":"107","author":"Nakajima","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tibtech.2009.11.004_bib23","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1007\/s00259-006-0081-y","article-title":"Optical imaging of experimental arthritis using allogeneic leukocytes labeled with a near-infrared fluorescent probe","volume":"33","author":"Simon","year":"2006","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"10.1016\/j.tibtech.2009.11.004_bib24","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1006\/clim.2002.5299","article-title":"Retroviral gene therapy of collagen-induced arthritis by local delivery of IL-4","volume":"105","author":"Tarner","year":"2002","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.tibtech.2009.11.004_bib25","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1002\/art.10405","article-title":"Folate-targeted imaging of activated macrophages in rats with adjuvant-induced arthritis","volume":"46","author":"Turk","year":"2002","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.tibtech.2009.11.004_bib26","doi-asserted-by":"crossref","DOI":"10.1117\/1.2821415","article-title":"Multimodality imaging of T-cell hybridoma trafficking in collagen-induced arthritic mice: image-based estimation of the number of cells accumulating in mouse paws","volume":"12","author":"Yaghoubi","year":"2007","journal-title":"J. Biomed. Opt."},{"key":"10.1016\/j.tibtech.2009.11.004_bib27","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1002\/1529-0131(199908)42:8<1609::AID-ANR7>3.0.CO;2-L","article-title":"Selective expression of folate receptor beta and its possible role in methotrexate transport in synovial macrophages from patients with rheumatoid arthritis","volume":"42","author":"Nakashima-Matsushita","year":"1999","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.tibtech.2009.11.004_bib28","doi-asserted-by":"crossref","first-page":"R77","DOI":"10.1186\/ar1944","article-title":"Folate-targeted immunotherapy effectively treats established adjuvant and collagen-induced arthritis","volume":"8","author":"Paulos","year":"2006","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.tibtech.2009.11.004_bib29","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.berh.2007.05.001","article-title":"Established rheumatoid arthritis \u2013 new imaging modalities","volume":"21","author":"McQueen","year":"2007","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"10.1016\/j.tibtech.2009.11.004_bib30","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/ni775","article-title":"Dynamic visualization of a joint-specific autoimmune response through positron emission tomography","volume":"3","author":"Wipke","year":"2002","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.tibtech.2009.11.004_bib31","doi-asserted-by":"crossref","first-page":"7694","DOI":"10.4049\/jimmunol.172.12.7694","article-title":"Staging the initiation of autoantibody-induced arthritis: a critical role for immune complexes","volume":"172","author":"Wipke","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.tibtech.2009.11.004_bib32","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S1074-7613(02)00275-3","article-title":"Arthritis critically dependent on innate immune system players","volume":"16","author":"Ji","year":"2002","journal-title":"Immunity"},{"key":"10.1016\/j.tibtech.2009.11.004_bib33","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.joca.2003.11.005","article-title":"Early diagnosis of osteoarthritis using cathepsin B sensitive near-infrared fluorescent probes","volume":"12","author":"Lai","year":"2004","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.tibtech.2009.11.004_bib34","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1002\/art.20379","article-title":"In vivo imaging of protease activity in arthritis: a novel approach for monitoring treatment response","volume":"50","author":"Wunder","year":"2004","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.tibtech.2009.11.004_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1162\/15353500200504142","article-title":"Methotrexate-induced accumulation of fluorescent annexin V in collagen-induced arthritis","volume":"4","author":"Wunder","year":"2005","journal-title":"Mol. Imaging"},{"key":"10.1016\/j.tibtech.2009.11.004_bib36","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1162\/1535350042380290","article-title":"Imaging reactive oxygen species in arthritis","volume":"3","author":"Chen","year":"2004","journal-title":"Mol. Imaging"},{"key":"10.1016\/j.tibtech.2009.11.004_bib37","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s10585-007-9127-1","article-title":"Inhibition of RANKL blocks skeletal tumor progression and improves survival in a mouse model of breast cancer bone metastasis","volume":"25","author":"Canon","year":"2008","journal-title":"Clin. Exp. Metastasis"},{"key":"10.1016\/j.tibtech.2009.11.004_bib38","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1359\/jbmr.2001.16.11.2027","article-title":"Early detection of bone metastases in a murine model using fluorescent human breast cancer cells: application to the use of the bisphosphonate zoledronic acid in the treatment of osteolytic lesions","volume":"16","author":"Peyruchaud","year":"2001","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.tibtech.2009.11.004_bib39","doi-asserted-by":"crossref","first-page":"7682","DOI":"10.1158\/0008-5472.CAN-04-4188","article-title":"Interference with the microenvironmental support impairs the de novo formation of bone metastases in vivo","volume":"65","author":"van der Pluijm","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.tibtech.2009.11.004_bib40","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1038\/mt.2008.48","article-title":"Systemic osteoprotegerin gene therapy restores tumor-induced bone loss in a therapeutic model of breast cancer bone metastasis","volume":"16","author":"Chanda","year":"2008","journal-title":"Mol. Ther."},{"key":"10.1016\/j.tibtech.2009.11.004_bib41","doi-asserted-by":"crossref","first-page":"6714","DOI":"10.1158\/0008-5472.CAN-05-3565","article-title":"Inhibition of pulmonary and skeletal metastasis by a transforming growth factor-beta type I receptor kinase inhibitor","volume":"66","author":"Bandyopadhyay","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.tibtech.2009.11.004_bib42","doi-asserted-by":"crossref","first-page":"13909","DOI":"10.1073\/pnas.0506517102","article-title":"Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway","volume":"102","author":"Kang","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.tibtech.2009.11.004_bib43","doi-asserted-by":"crossref","first-page":"8742","DOI":"10.1158\/0008-5472.CAN-06-2490","article-title":"Bone morphogenetic protein 7 in the development and treatment of bone metastases from breast cancer","volume":"67","author":"Buijs","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.tibtech.2009.11.004_bib44","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1023\/B:CLIN.0000006873.65590.68","article-title":"SU11248 inhibits tumor growth and CSF-1R-dependent osteolysis in an experimental breast cancer bone metastasis model","volume":"20","author":"Murray","year":"2003","journal-title":"Clin. Exp. Metastasis"},{"key":"10.1016\/j.tibtech.2009.11.004_bib45","doi-asserted-by":"crossref","first-page":"656","DOI":"10.4161\/cbt.2.6.531","article-title":"In vivo visualization of metastatic prostate cancer and quantitation of disease progression in immunocompromised mice","volume":"2","author":"Kalikin","year":"2003","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.tibtech.2009.11.004_bib46","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1002\/pros.20776","article-title":"Zoledronic acid decreased osteolysis but not bone metastasis in a nude mouse model of canine prostate cancer with mixed bone lesions","volume":"68","author":"Thudi","year":"2008","journal-title":"Prostate"},{"key":"10.1016\/j.tibtech.2009.11.004_bib47","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1158\/1078-0432.CCR-05-2050","article-title":"The bisphosphonate olpadronate inhibits skeletal prostate cancer progression in a green fluorescent protein nude mouse model","volume":"12","author":"Yang","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.tibtech.2009.11.004_bib48","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1002\/pros.20146","article-title":"Monitoring of skeletal progression of prostate cancer by GFP imaging, X-ray, and serum OPG and PTHrP","volume":"62","author":"Burton","year":"2005","journal-title":"Prostate"},{"key":"10.1016\/j.tibtech.2009.11.004_bib49","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1210\/en.2004-1211","article-title":"Bone turnover mediates preferential localization of prostate cancer in the skeleton","volume":"146","author":"Schneider","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.tibtech.2009.11.004_bib50","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1158\/1535-7163.MCT-08-0046","article-title":"RANK ligand inhibition plus docetaxel improves survival and reduces tumor burden in a murine model of prostate cancer bone metastasis","volume":"7","author":"Miller","year":"2008","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.tibtech.2009.11.004_bib51","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.2353\/ajpath.2007.070168","article-title":"BMP7, a putative regulator of epithelial homeostasis in the human prostate, is a potent inhibitor of prostate cancer bone metastasis in vivo","volume":"171","author":"Buijs","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.tibtech.2009.11.004_bib52","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1634\/stemcells.2008-0139","article-title":"Antitumoral activity and osteogenic potential of mesenchymal stem cells expressing the urokinase-type plasminogen antagonist amino-terminal fragment in a murine model of osteolytic tumor","volume":"26","author":"Fritz","year":"2008","journal-title":"Stem Cells"},{"key":"10.1016\/j.tibtech.2009.11.004_bib53","doi-asserted-by":"crossref","first-page":"3424","DOI":"10.1182\/blood-2006-09-048686","article-title":"Granulocyte colony-stimulating factor enhances bone tumor growth in mice in an osteoclast-dependent manner","volume":"109","author":"Hirbe","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.tibtech.2009.11.004_bib54","first-page":"210","article-title":"Neural progenitor cell-mediated delivery of osteoprotegerin limits disease progression in a preclinical model of neuroblastoma bone metastasis","author":"Sims","year":"2009","journal-title":"J. Pediatr. Surg. 44, 204-210; discussion"},{"key":"10.1016\/j.tibtech.2009.11.004_bib55","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s10585-006-9008-z","article-title":"The effect of zoledronic acid and osteoprotegerin on growth of human lung cancer in the tibias of nude mice","volume":"23","author":"Tannehill-Gregg","year":"2006","journal-title":"Clin. Exp. Metastasis."},{"key":"10.1016\/j.tibtech.2009.11.004_bib56","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1097\/00004728-200605000-00030","article-title":"Multimodal imaging analysis of tumor progression and bone resorption in a murine cancer model","volume":"30","author":"Mouchess","year":"2006","journal-title":"J. Comput. Assist Tomogr."},{"key":"10.1016\/j.tibtech.2009.11.004_bib57","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/pros.20019","article-title":"In vivo real-time imaging of TGF-beta-induced transcriptional activation of the RANK ligand gene promoter in intraosseous prostate cancer","volume":"59","author":"Zhang","year":"2004","journal-title":"Prostate"},{"key":"10.1016\/j.tibtech.2009.11.004_bib58","doi-asserted-by":"crossref","first-page":"2662","DOI":"10.1096\/fj.08-126920","article-title":"Multimodality imaging of TGF{beta} signaling in breast cancer metastases","volume":"23","author":"Serganova","year":"2009","journal-title":"FASEB J."},{"key":"10.1016\/j.tibtech.2009.11.004_bib59","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/sj.gt.3303070","article-title":"Ultrasound-based nonviral gene delivery induces bone formation in vivo","volume":"15","author":"Sheyn","year":"2008","journal-title":"Gene Ther."},{"key":"10.1016\/j.tibtech.2009.11.004_bib60","doi-asserted-by":"crossref","first-page":"3882","DOI":"10.1016\/j.biomaterials.2008.06.007","article-title":"The effect of surface demineralization of cortical bone allograft on the properties of recombinant adeno-associated virus coatings","volume":"29","author":"Yazici","year":"2008","journal-title":"Biomaterials"},{"key":"10.1016\/j.tibtech.2009.11.004_bib61","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.ymthe.2004.10.005","article-title":"BMP gene delivery for alveolar bone engineering at dental implant defects","volume":"11","author":"Dunn","year":"2005","journal-title":"Mol. Ther."},{"key":"10.1016\/j.tibtech.2009.11.004_bib62","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.ymthe.2003.12.009","article-title":"Gene therapy platform for bone regeneration using an exogenously regulated, AAV-2-based gene expression system","volume":"9","author":"Gafni","year":"2004","journal-title":"Mol. Ther."},{"key":"10.1016\/j.tibtech.2009.11.004_bib63","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1097\/00007632-200404150-00004","article-title":"In vivo bioluminescent imaging of virus-mediated gene transfer and transduced cell transplantation in the intervertebral disc","volume":"29","author":"Leo","year":"2004","journal-title":"Spine"},{"key":"10.1016\/j.tibtech.2009.11.004_bib64","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1002\/jor.20582","article-title":"In vivo bioluminescence imaging study to monitor ectopic bone formation by luciferase gene marked mesenchymal stem cells","volume":"26","author":"Olivo","year":"2008","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.tibtech.2009.11.004_bib65","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.biomaterials.2007.10.006","article-title":"Bioluminescence imaging of calvarial bone repair using bone marrow and adipose tissue-derived mesenchymal stem cells","volume":"29","author":"Degano","year":"2008","journal-title":"Biomaterials"},{"key":"10.1016\/j.tibtech.2009.11.004_bib66","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/jor.20736","article-title":"Stem cell-mediated accelerated bone healing observed with in vivo molecular and small animal imaging technologies in a model of skeletal injury","volume":"27","author":"Lee","year":"2008","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.tibtech.2009.11.004_bib67","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/nm1533","article-title":"Derivation of engraftable skeletal myoblasts from human embryonic stem cells","volume":"13","author":"Barberi","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.tibtech.2009.11.004_bib68","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.jbspin.2007.09.013","article-title":"In vivo MR imaging tracking of magnetic iron oxide nanoparticle labeled, engineered, autologous bone marrow mesenchymal stem cells following intra-articular injection","volume":"75","author":"Jing","year":"2008","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.tibtech.2009.11.004_bib69","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1002\/jor.20229","article-title":"In vivo molecular imaging of adenoviral versus lentiviral gene therapy in two bone formation models","volume":"24","author":"Feeley","year":"2006","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.tibtech.2009.11.004_bib70","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3171\/spi.2005.3.1.0047","article-title":"Murine spinal fusion induced by engineered mesenchymal stem cells that conditionally express bone morphogenetic protein-2","volume":"3","author":"Hasharoni","year":"2005","journal-title":"J. Neurosurg. Spine"},{"key":"10.1016\/j.tibtech.2009.11.004_bib71","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1359\/jbmr.060819","article-title":"Advanced molecular profiling in vivo detects novel function of dickkopf-3 in the regulation of bone formation","volume":"21","author":"Aslan","year":"2006","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.tibtech.2009.11.004_bib72","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1002\/jor.20518","article-title":"Fluorescence molecular tomography enables in vivo visualization and quantification of nonunion fracture repair induced by genetically engineered mesenchymal stem cells","volume":"26","author":"Zilberman","year":"2008","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.tibtech.2009.11.004_bib73","doi-asserted-by":"crossref","first-page":"4760","DOI":"10.1016\/j.biomaterials.2008.09.004","article-title":"Systemic trafficking of macrophages induced by bone cement particles in nude mice","volume":"29","author":"Ren","year":"2008","journal-title":"Biomaterials"},{"key":"10.1016\/j.tibtech.2009.11.004_bib74","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1002\/jor.20452","article-title":"Quantitative mouse model of implant-associated osteomyelitis and the kinetics of microbial growth, osteolysis, and humoral immunity","volume":"26","author":"Li","year":"2008","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.tibtech.2009.11.004_bib75","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/jcp.21200","article-title":"Adult mesenchymal stem cells for tissue engineering versus regenerative medicine","volume":"213","author":"Caplan","year":"2007","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.tibtech.2009.11.004_bib76","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1126\/science.284.5411.143","article-title":"Multilineage potential of adult human mesenchymal stem cells","volume":"284","author":"Pittenger","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.tibtech.2009.11.004_bib77","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1073\/pnas.96.5.2333","article-title":"Imaging adenoviral-directed reporter gene expression in living animals with positron emission tomography","volume":"96","author":"Gambhir","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.tibtech.2009.11.004_bib78","first-page":"4087","article-title":"Noninvasive imaging of herpes virus thymidine kinase gene transfer and expression: a potential method for monitoring clinical gene therapy","volume":"56","author":"Tjuvajev","year":"1996","journal-title":"Cancer Res."},{"key":"10.1016\/j.tibtech.2009.11.004_bib79","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/j.1751-1097.1997.tb03184.x","article-title":"Visualizing gene expression in living mammals using a bioluminescent reporter","volume":"66","author":"Contag","year":"1997","journal-title":"Photochem. Photobiol."},{"issue":"suppl 2","key":"10.1016\/j.tibtech.2009.11.004_bib80","doi-asserted-by":"crossref","first-page":"5S","DOI":"10.2967\/jnumed.108.045880","article-title":"Latest advances in molecular imaging instrumentation","volume":"49","author":"Pichler","year":"2008","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.tibtech.2009.11.004_bib81","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/7933","article-title":"In vivo imaging of tumors with protease-activated near-infrared fluorescent probes","volume":"17","author":"Weissleder","year":"1999","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.tibtech.2009.11.004_bib82","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1126\/science.1125949","article-title":"Molecular imaging in cancer","volume":"312","author":"Weissleder","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.tibtech.2009.11.004_bib83","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1161\/CIRCULATIONAHA.106.647164","article-title":"Molecular imaging of cardiovascular disease","volume":"116","author":"Jaffer","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.tibtech.2009.11.004_bib84","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.clim.2003.12.018","article-title":"Molecular imaging applications for immunology","volume":"111","author":"Hildebrandt","year":"2004","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.tibtech.2009.11.004_bib85","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1111\/j.1462-5822.2007.00995.x","article-title":"Applications of bioluminescence imaging to the study of infectious diseases","volume":"9","author":"Hutchens","year":"2007","journal-title":"Cell Microbiol."},{"key":"10.1016\/j.tibtech.2009.11.004_bib86","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1148\/radiol.2443060295","article-title":"Molecular imaging: integration of molecular imaging into the musculoskeletal imaging practice","volume":"244","author":"Biswal","year":"2007","journal-title":"Radiology"},{"key":"10.1016\/j.tibtech.2009.11.004_bib87","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.bone.2006.05.009","article-title":"Molecular imaging promotes progress in orthopedic research","volume":"39","author":"Mayer-Kuckuk","year":"2006","journal-title":"Bone"},{"key":"10.1016\/j.tibtech.2009.11.004_bib88","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/978-1-59745-104-8_18","article-title":"Bioluminescent imaging in bone","volume":"455","author":"Zilberman","year":"2008","journal-title":"Methods Mol. Biol."},{"issue":"pt 1","key":"10.1016\/j.tibtech.2009.11.004_bib89","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/978-3-540-72718-7_6","article-title":"Multimodal imaging approaches: PET\/CT and PET\/MRI","volume":"185","author":"Pichler","year":"2008","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.tibtech.2009.11.004_bib90","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nbt1074","article-title":"Looking and listening to light: the evolution of whole-body photonic imaging","volume":"23","author":"Ntziachristos","year":"2005","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.tibtech.2009.11.004_bib91","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/nm0103-123","article-title":"Shedding light onto live molecular targets","volume":"9","author":"Weissleder","year":"2003","journal-title":"Nat. Med."}],"container-title":["Trends in Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167779909002170?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167779909002170?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T22:45:13Z","timestamp":1558737913000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167779909002170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2]]},"references-count":91,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["S0167779909002170"],"URL":"https:\/\/doi.org\/10.1016\/j.tibtech.2009.11.004","relation":{},"ISSN":["0167-7799"],"issn-type":[{"type":"print","value":"0167-7799"}],"subject":[],"published":{"date-parts":[[2010,2]]}}}