{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T07:57:15Z","timestamp":1789372635546,"version":"build-2803163510"},"reference-count":59,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","cell.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","bmn.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Biotechnology"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.tibtech.2016.10.001","type":"journal-article","created":{"date-parts":[[2016,10,26]],"date-time":"2016-10-26T13:45:28Z","timestamp":1477489528000},"page":"308-317","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":77,"title":["Electrochemical Biosensors for Early Stage Zika Diagnostics"],"prefix":"10.1016","volume":"35","author":[{"given":"Ajeet","family":"Kaushik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sneham","family":"Tiwari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul D.","family":"Jayant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arti","family":"Vashist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roozbeh","family":"Nikkhah-Moshaie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazira","family":"El-Hage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhavan","family":"Nair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tibtech.2016.10.001_bib0300","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1056\/NEJMra1602113","article-title":"Zika virus","volume":"374","author":"Petersen","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.tibtech.2016.10.001_bib0305","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s13337-016-0307-y","article-title":"Zika virus outbreak: an overview of the experimental therapeutics and treatment","volume":"27","author":"Saxena","year":"2016","journal-title":"Virusdisease"},{"key":"10.1016\/j.tibtech.2016.10.001_bib0310","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1021\/acsinfecdis.6b00030","article-title":"Zika virus: diagnosis, therapeutics, and vaccine","volume":"2","author":"Shan","year":"2016","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.tibtech.2016.10.001_bib0315","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1126\/science.aaf5036","article-title":"Zika virus in the Americas: early epidemiological and genetic findings","volume":"352","author":"Faria","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.tibtech.2016.10.001_bib0320","doi-asserted-by":"crossref","first-page":"3429","DOI":"10.1016\/j.jmb.2016.04.024","article-title":"Dengue virus immunopathogenesis: lessons applicable to the emergence of Zika virus","volume":"428","author":"Olagnier","year":"2016","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.tibtech.2016.10.001_bib0325","doi-asserted-by":"crossref","first-page":"927","DOI":"10.3201\/eid2205.160023","article-title":"Detection of autochthonous Zika virus transmission in Sincelejo","volume":"22","author":"Camacho","year":"2016","journal-title":"Colombia. Emerg. Infect. Dis."},{"key":"10.1016\/j.tibtech.2016.10.001_bib0330","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.micinf.2016.03.009","article-title":"Zika virus: epidemiology, clinical features and host-virus interactions","volume":"18","author":"Hamel","year":"2016","journal-title":"Microbes Infect."},{"key":"10.1016\/j.tibtech.2016.10.001_bib0335","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1056\/NEJMe1601862","article-title":"Zika virus and microcephaly","volume":"374","author":"Rubin","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.tibtech.2016.10.001_bib0340","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/nature18296","article-title":"The Brazilian Zika virus strain causes birth defects in experimental models","volume":"534","author":"Cugola","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.tibtech.2016.10.001_bib0345","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/nrmicro.2016.80","article-title":"Viral pathogenesis: tracing the steps of Zika virus","volume":"14","author":"Hofer","year":"2016","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.tibtech.2016.10.001_bib0350","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3201\/eid2102.141363","article-title":"Potential sexual transmission of Zika virus","volume":"21","author":"Musso","year":"2015","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.tibtech.2016.10.001_bib0355","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0140-6736(16)00080-5","article-title":"Anticipating the international spread of Zika virus from Brazil","volume":"387","author":"Bogoch","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.tibtech.2016.10.001_bib0360","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1056\/NEJMoa1600651","article-title":"Zika virus associated with microcephaly","volume":"374","author":"Mlakar","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.tibtech.2016.10.001_bib0365","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.stem.2016.04.017","article-title":"Zika virus disrupts neural progenitor development and leads to microcephaly in mice","volume":"19","author":"Li","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.tibtech.2016.10.001_bib0370","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.cell.2016.05.008","article-title":"Zika virus infection during pregnancy in mice causes placental damage and fetal demise","volume":"165","author":"Miner","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.tibtech.2016.10.001_bib0375","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1126\/science.aaf6116","article-title":"Zika virus impairs growth in human neurospheres and brain organoids","volume":"352","author":"Garcez","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.tibtech.2016.10.001_bib0380","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMoa1602412","article-title":"Zika virus infection in pregnant women in Rio de Janeiro\u2014preliminary report","author":"Brasil","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.tibtech.2016.10.001_bib0385","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1093\/cid\/ciw324","article-title":"Clinical and imaging findings in an infant with Zika embryopathy","volume":"63","author":"Culjat","year":"2016","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.tibtech.2016.10.001_bib0390","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1126\/science.aaf5316","article-title":"The 3.8\u00c5 resolution cryo-EM structure of Zika virus","volume":"352","author":"Sirohi","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.tibtech.2016.10.001_bib0395","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.4269\/ajtmh.16-0111","article-title":"Characterization of a novel murine model to study Zika virus","volume":"94","author":"Rossi","year":"2016","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.tibtech.2016.10.001_bib0400","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1128\/JCM.00279-16","article-title":"Zika virus: diagnostics for an emerging pandemic threat","volume":"54","author":"Waggoner","year":"2016","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.tibtech.2016.10.001_bib0405","doi-asserted-by":"crossref","first-page":"330ed332","DOI":"10.1126\/scitranslmed.aaf4548","article-title":"Once and future epidemics: Zika virus emerging","volume":"8","author":"Nabel","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.tibtech.2016.10.001_bib0410","doi-asserted-by":"crossref","first-page":"30161","DOI":"10.2807\/1560-7917.ES.2016.21.10.30161","article-title":"Letter to the editor: diagnostic challenges to be considered regarding Zika virus in the context of the presence of the vector Aedes albopictus in Europe","volume":"21","author":"Vorou","year":"2016","journal-title":"Euro. Surveill."},{"key":"10.1016\/j.tibtech.2016.10.001_bib0415","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jcv.2008.05.005","article-title":"One-step RT-PCR for detection of Zika virus","volume":"43","author":"Faye","year":"2008","journal-title":"J. Clin. Virol."},{"key":"10.1016\/j.tibtech.2016.10.001_bib0420","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jcv.2015.04.021","article-title":"Detection of Zika virus in saliva","volume":"68","author":"Musso","year":"2015","journal-title":"J. Clin. Virol."},{"key":"10.1016\/j.tibtech.2016.10.001_bib0425","doi-asserted-by":"crossref","first-page":"e20","DOI":"10.1016\/j.ejim.2016.04.022","article-title":"Zika virus in saliva-new challenges for prevention of human to human transmission","volume":"33","author":"Liuzzi","year":"2016","journal-title":"Eur. J. Intern. Med."},{"key":"10.1016\/j.tibtech.2016.10.001_bib0430","doi-asserted-by":"crossref","first-page":"84","DOI":"10.3201\/eid2101.140894","article-title":"Detection of Zika virus in urine","volume":"21","author":"Gourinat","year":"2015","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.tibtech.2016.10.001_bib0435","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jcv.2016.02.009","article-title":"Prolonged detection of Zika virus RNA in urine samples during the ongoing Zika virus epidemic in Brazil","volume":"77","author":"Campos Rde","year":"2016","journal-title":"J. Clin. Virol."},{"key":"10.1016\/j.tibtech.2016.10.001_bib0440","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.3201\/eid2207.160326","article-title":"Single-reaction multiplex reverse transcription PCR for detection of Zika, chikungunya, and dengue viruses","volume":"22","author":"Waggoner","year":"2016","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.tibtech.2016.10.001_bib0445","first-page":"3025","article-title":"Zika virus detection in cerebrospinal fluid from two patients with encephalopathy, Martinique, February 2016","volume":"21","author":"Roze","year":"2016","journal-title":"Euro. Surveill."},{"key":"10.1016\/j.tibtech.2016.10.001_bib0450","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/j.cell.2016.04.059","article-title":"Rapid, low-cost detection of Zika virus using programmable biomolecular components","volume":"165","author":"Pardee","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.tibtech.2016.10.001_bib0455","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.molmed.2016.05.009","article-title":"Engineering paper-based sensors for Zika virus","volume":"22","author":"Meagher","year":"2016","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.tibtech.2016.10.001_bib0460","doi-asserted-by":"crossref","first-page":"7289","DOI":"10.1021\/acs.analchem.6b01632","article-title":"Instrument-free point-of-care molecular detection of Zika virus","volume":"88","author":"Song","year":"2016","journal-title":"Anal. Chem."},{"key":"10.1016\/j.tibtech.2016.10.001_bib0465","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.addr.2016.02.008","article-title":"Getting into the brain: potential of nanotechnology in the management of NeuroAIDS","volume":"103","author":"Nair","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.tibtech.2016.10.001_bib0470","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1146\/annurev-med-092112-143017","article-title":"Emerging technologies for point-of-care management of HIV infection","volume":"66","author":"Shafiee","year":"2015","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.tibtech.2016.10.001_bib0180","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.bios.2016.06.086","article-title":"Electrochemical monitoring-on-chip (E-MoC) of HIV-infection in presence of cocaine and therapeutics","volume":"86","author":"Kaushik","year":"2016","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.tibtech.2016.10.001_bib0475","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.bios.2013.09.060","article-title":"Recent advances in cortisol sensing technologies for point-of-care application","volume":"53","author":"Kaushik","year":"2014","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.tibtech.2016.10.001_bib0480","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.bios.2016.01.065","article-title":"Nano-biosensors to detect beta-amyloid for Alzheimer's disease management","volume":"80","author":"Kaushik","year":"2016","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.tibtech.2016.10.001_bib0485","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.bios.2015.08.040","article-title":"Towards detection and diagnosis of Ebola virus disease at point-of-care","volume":"75","author":"Kaushik","year":"2016","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.tibtech.2016.10.001_bib0490","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/elan.200403113","article-title":"Carbon-nanotube based electrochemical biosensors: a review","volume":"17","author":"Wang","year":"2006","journal-title":"Electroanalysis"},{"key":"10.1016\/j.tibtech.2016.10.001_bib0495","doi-asserted-by":"crossref","first-page":"9134","DOI":"10.1073\/pnas.1633515100","article-title":"Electrochemical interrogation of conformational changes as a reagentless method for the sequence-specific detection of DNA","volume":"100","author":"Fan","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tibtech.2016.10.001_bib0500","doi-asserted-by":"crossref","first-page":"5456","DOI":"10.1002\/anie.200500989","article-title":"Label-free electronic detection of thrombin in blood serum by using an aptamer-based sensor","volume":"44","author":"Xiao","year":"2005","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.tibtech.2016.10.001_bib0505","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.bios.2008.06.045","article-title":"Towards on-site pathogen detection using antibody-based sensors","volume":"24","author":"Skottrup","year":"2008","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.tibtech.2016.10.001_bib0510","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/asiamat.2010.137","article-title":"Nanostructured metal oxide-based biosensors","volume":"3","author":"Solanki","year":"2011","journal-title":"NPG Asia Mater."},{"key":"10.1016\/j.tibtech.2016.10.001_bib0515","doi-asserted-by":"crossref","first-page":"9001","DOI":"10.1021\/acs.chemrev.6b00220","article-title":"Electrochemical methods for the analysis of clinically relevant biomolecules","volume":"116","author":"Labib","year":"2016","journal-title":"Chem. Rev."},{"key":"10.1016\/j.tibtech.2016.10.001_bib0520","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1103\/RevModPhys.77.977","article-title":"Microfluidics: fluid physics at the nanoliter scale","volume":"77","author":"Squires","year":"2005","journal-title":"Rev. Mod. Phys."},{"key":"10.1016\/j.tibtech.2016.10.001_bib0525","doi-asserted-by":"crossref","first-page":"125504","DOI":"10.1088\/0957-4484\/21\/12\/125504","article-title":"The fabrication of low-impedance nanoporous gold multiple-electrode arrays for neural electrophysiology studies","volume":"21","author":"Seker","year":"2010","journal-title":"Nanotechnology"},{"key":"10.1016\/j.tibtech.2016.10.001_bib0530","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nature07110","article-title":"Medium-scale carbon nanotube thin-film integrated circuits on flexible plastic substrates","volume":"454","author":"Cao","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.tibtech.2016.10.001_bib0535","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.tibtech.2013.09.005","article-title":"Electrochemical real-time nucleic acid amplification: towards point-of-care quantification of pathogens","volume":"31","author":"Patterson","year":"2013","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.tibtech.2016.10.001_bib0540","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1021\/ar500456w","article-title":"Integrated electrochemical microsystems for genetic detection of pathogens at the point of care","volume":"48","author":"Hsieh","year":"2015","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.tibtech.2016.10.001_bib0545","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1021\/ac402898j","article-title":"Biosensors as 21st century technology for detecting genetically modified organisms in food and feed","volume":"86","author":"Arugula","year":"2013","journal-title":"Anal. Chem."},{"key":"10.1016\/j.tibtech.2016.10.001_bib0550","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.bios.2008.06.039","article-title":"Engineering of the membrane of fibroblast cells with virus-specific antibodies: a novel biosensor tool for virus detection","volume":"24","author":"Moschopoulou","year":"2008","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.tibtech.2016.10.001_bib0555","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1039\/b603402k","article-title":"The role of biosensors in the detection of emerging infectious diseases","volume":"131","author":"Pejcic","year":"2006","journal-title":"Analyst"},{"key":"10.1016\/j.tibtech.2016.10.001_bib0560","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.tibtech.2011.01.007","article-title":"Point-of-care nucleic acid testing for infectious diseases","volume":"29","author":"Niemz","year":"2011","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.tibtech.2016.10.001_bib0565","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.snb.2013.02.096","article-title":"An LTCC-based microfluidic system for label-free, electrochemical detection of cortisol","volume":"182","author":"Vasudev","year":"2013","journal-title":"Sens. Actuators B Chem."},{"key":"10.1016\/j.tibtech.2016.10.001_bib0570","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.bios.2013.06.012","article-title":"Mediator and label free estimation of stress biomarker using electrophoretically deposited Ag@AgO\u2013polyaniline hybrid nanocomposite","volume":"50","author":"Kaushik","year":"2013","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.tibtech.2016.10.001_bib0575","first-page":"677","article-title":"Electrochemical sensing method for point-of-care cortisol detection in human immunodeficiency virus-infected patients","volume":"10","author":"Kaushik","year":"2015","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.tibtech.2016.10.001_bib0580","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.bios.2014.06.053","article-title":"A low-cost miniaturized potentiostat for point-of-care diagnosis","volume":"62","author":"Cruz","year":"2014","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.tibtech.2016.10.001_bib0585","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1126\/science.352.6292.1375","article-title":"Experts fear Zika's effects may be even worse than thought","volume":"352","author":"Vogel","year":"2016","journal-title":"Science"}],"container-title":["Trends in Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167779916301639?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167779916301639?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,6,27]],"date-time":"2018-06-27T16:33:48Z","timestamp":1530117228000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167779916301639"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":59,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["S0167779916301639"],"URL":"https:\/\/doi.org\/10.1016\/j.tibtech.2016.10.001","relation":{},"ISSN":["0167-7799"],"issn-type":[{"value":"0167-7799","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Electrochemical Biosensors for Early Stage Zika Diagnostics","name":"articletitle","label":"Article Title"},{"value":"Trends in Biotechnology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tibtech.2016.10.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}