{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T15:07:17Z","timestamp":1788793637232,"version":"build-2803163510"},"reference-count":133,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100027426","name":"Schmidt Futures","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100027426","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006754","name":"US Army DEVCOM Army Research Laboratory","doi-asserted-by":"publisher","award":["W911NF-22-2-0210"],"award-info":[{"award-number":["W911NF-22-2-0210"]}],"id":[{"id":"10.13039\/100006754","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000051","name":"National Human Genome Research Institute","doi-asserted-by":"publisher","award":["1K99HG014240"],"award-info":[{"award-number":["1K99HG014240"]}],"id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000183","name":"Army Research Office","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000183","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Biotechnology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.tibtech.2026.07.001","type":"journal-article","created":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T04:17:00Z","timestamp":1785557820000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Responsible biotechnology: an analysis of the Asilomar 2025 entreaties"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0465-9393","authenticated-orcid":false,"given":"Yonatan","family":"Chemla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0844-4776","authenticated-orcid":false,"given":"Christopher A.","family":"Voigt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tibtech.2026.07.001_bb0005","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1073\/pnas.72.6.1981","article-title":"Summary statement of the Asilomar conference on recombinant DNA molecules","volume":"72","author":"Berg","year":"1975","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0010","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/455290a","article-title":"Asilomar 1975: DNA modification secured","volume":"455","author":"Berg","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0015","series-title":"Community matters: A History of Biological Nitrogen Fixation and Nodulation Research, 1965 to 1995","author":"Simmonds","year":"2007"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0020","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1126\/science.287.5458.1584","article-title":"Asilomar revisited: lessons for today?","volume":"287","author":"Barinaga","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0025","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1126\/science.ads7339","article-title":"A little care before we leap","volume":"385","author":"Campos","year":"2024","journal-title":"Science"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0030","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1126\/science.adv3132","article-title":"Taking responsibility: Asilomar and its legacy","volume":"387","author":"Hurlbut","year":"2025","journal-title":"Science"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0035","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1126\/science.adv7574","article-title":"Invoking Asilomar","volume":"387","author":"Campos","year":"2025","journal-title":"Science"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0040","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1021\/acs.chemrev.4c00687","article-title":"Synthetic biology of plants and microbes for agriculture, environment, and future applications","volume":"126","author":"Clauer","year":"2026","journal-title":"Chem. Rev."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0045","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/s41579-023-01007-9","article-title":"Synthetic microbiology in sustainability applications","volume":"22","author":"Jones","year":"2024","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.copbio.2024.103172","article-title":"Roots of synthetic ecology: microbes that foster plant resilience in the changing climate","volume":"88","author":"Kozaeva","year":"2024","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0055","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1051\/ebr:2007031","article-title":"Release and persistence of extracellular DNA in the environment","volume":"6","author":"Nielsen","year":"2007","journal-title":"Environ. Biosaf. Res."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0060","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/S0923-2508(01)01266-9","article-title":"Using inactivated microbial biomass as fertilizer: the fate of antibiotic resistance genes in the environment","volume":"152","author":"Andersen","year":"2001","journal-title":"Res. Microbiol."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0065","doi-asserted-by":"crossref","first-page":"9637","DOI":"10.1038\/s41467-024-53680-w","article-title":"Microbial solutions must be deployed against climate catastrophe","volume":"15","author":"Peixoto","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0070","article-title":"Environmental Galenics: large-scale fortification of extant microbiomes with engineered bioremediation agents","volume":"377","author":"de Lorenzo","year":"2022","journal-title":"Philos. Trans. R. Soc. Lond. Ser. B Biol. Sci."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0075","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1021\/acssynbio.3c00238","article-title":"Synthetic biology\u2014high time to deliver?","volume":"12","author":"Hanson","year":"2023","journal-title":"ACS Synth. Biol."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0080","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/s41564-024-01918-0","article-title":"Design and regulation of engineered bacteria for environmental release","volume":"10","author":"Chemla","year":"2025","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0085","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/s41586-025-09272-9","article-title":"Whole-genome sequencing of 490,640 UK Biobank participants","volume":"645","author":"Carss","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0090","article-title":"How many human genomes have been sequenced?","author":"Benson-Tilsen","year":"2026","journal-title":"Figshare"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0095","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1080\/23808993.2019.1599685","article-title":"Privacy and ethical challenges in next-generation sequencing","volume":"4","author":"Martinez-Martin","year":"2019","journal-title":"Expert Rev. Precis. Med. Drug Dev."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0100","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13002-025-00808-x","article-title":"From forgotten to frontier: vindicating Latin America\u2019s indigenous biotechnology","volume":"21","author":"Villanueva-Flores","year":"2025","journal-title":"J. Ethnobiol. Ethnomed."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0105","doi-asserted-by":"crossref","DOI":"10.1126\/science.ado3979","article-title":"Randomizing the human genome by engineering recombination between repeat elements","volume":"387","author":"Koeppel","year":"2025","journal-title":"Science"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0110","doi-asserted-by":"crossref","first-page":"7278","DOI":"10.1038\/s41467-025-62356-y","article-title":"Iterative SCRaMbLE for engineering synthetic genome modules and chromosomes","volume":"16","author":"Lu","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0115","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/s41573-019-0012-9","article-title":"Adeno-associated virus vector as a platform for gene therapy delivery","volume":"18","author":"Wang","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0120","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/s41586-020-1978-5","article-title":"The promise and challenge of therapeutic genome editing","volume":"578","author":"Doudna","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0125","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1038\/s41587-020-0561-9","article-title":"Genome editing with CRISPR\u2013Cas nucleases, base editors, transposases and prime editors","volume":"38","author":"Anzalone","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0130","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41576-021-00386-0","article-title":"Gene drives gaining speed","volume":"23","author":"Bier","year":"2022","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0135","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3003148","article-title":"Applications and status of gene drive in plants","volume":"23","author":"Hay","year":"2025","journal-title":"PLoS Biol."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0140","article-title":"Between hype and hope: de-extinction is a tool, not a panacea for the biodiversity crisis","volume":"309","author":"B\u00e9llo Carvalho","year":"2025","journal-title":"Biol. Conserv."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0145","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/s41564-021-01014-7","article-title":"Species- and site-specific genome editing in complex bacterial communities","volume":"7","author":"Rubin","year":"2021","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0150","article-title":"Generative design of novel bacteriophages with genome language models","author":"King","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0155","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s44385-025-00021-1","article-title":"The convergence of AI and synthetic biology: the looming deluge","volume":"2","author":"Groff-Vindman","year":"2025","journal-title":"NPJ Biomed. Innov."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0160","doi-asserted-by":"crossref","DOI":"10.1126\/science.ado9336","article-title":"Sequence modeling and design from molecular to genome scale with Evo","volume":"386","author":"Nguyen","year":"2024","journal-title":"Science"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0165","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/s44319-025-00681-5","article-title":"From domination to partnership","volume":"27","author":"de Lorenzo","year":"2026","journal-title":"EMBO Rep."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0170","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2025.1702481","article-title":"A call for congressional action: revisiting the U.S. Coordinated Framework for the regulation of biotechnology","volume":"13","author":"Buchman","year":"2025","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0175","series-title":"The Spirit of Asilomar and the Future of Biotechnology","article-title":"1.1 Towards frameworks for evaluation and governance of Biotechnologies Beyond Conventional Containment","author":"Marken","year":"2025"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0180","series-title":"The Spirit of Asilomar and the Future of Biotechnology","article-title":"1.2 Risk-benefit analysis worksheet for biotechnology beyond conventional containment","author":"Abbott","year":"2025"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0185","series-title":"The Spirit of Asilomar and the Future of Biotechnology","article-title":"1.3 Public infrastructure for analyzing and assessing beyond biocontainment biotechnologies","author":"Hodgson","year":"2025"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0190","series-title":"The Spirit of Asilomar and the Future of Biotechnology","article-title":"1.4 Nature conservation in the age of bioengineering","author":"Moronta-Barrios","year":"2025"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0195","series-title":"The Spirit of Asilomar and the Future of Biotechnology","article-title":"1.5 Identifying and addressing the risk of the environmental release of organisms\u2014engineered or natural","author":"Chemla","year":"2025"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0200","series-title":"The Spirit of Asilomar and the Future of Biotechnology","article-title":"1.6 Identifying intersections between BBCC and ecology and conservation","author":"Kiattisewee","year":"2025"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0205","series-title":"The Spirit of Asilomar and the Future of Biotechnology","article-title":"2.1 Condemning & making obsolete biological weapons","author":"Weber","year":"2025"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0210","series-title":"The Spirit of Asilomar and the Future of Biotechnology","article-title":"2.2 The importance of redlines in the life sciences","author":"Relman","year":"2025"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0215","series-title":"The Spirit of Asilomar and the Future of Biotechnology","article-title":"3.1 Artificial intelligence and the future of biotechnology","author":"Bromberg","year":"2025"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0220","series-title":"The Spirit of Asilomar and the Future of Biotechnology","article-title":"4.1 Safeguarding the benefits of synthetic cell engineering","author":"Smith","year":"2025"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0225","series-title":"The Spirit of Asilomar and the Future of Biotechnology","article-title":"4.2 Synthetic human chromosomes \u2013 a call for global discussion","author":"Tan","year":"2025"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0230","series-title":"The Spirit of Asilomar and the Future of Biotechnology","article-title":"4.3 Synthetic cells for environmental release","author":"Abbott","year":"2025"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0235","series-title":"The Spirit of Asilomar and the Future of Biotechnology","article-title":"4.4 Risks from mirror life","author":"Abbott","year":"2025"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0240","series-title":"The Spirit of Asilomar and the Future of Biotechnology","article-title":"5.1 Biotechnology for a Sustainable & Equitable Global Bioeconomy","author":"Chang","year":"2025"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0245","series-title":"The Spirit of Asilomar and the Future of Biotechnology","article-title":"5.2 Solidarity Bioeconomy","author":"Elcock","year":"2025"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0250","series-title":"The Spirit of Asilomar and the Future of Biotechnology","article-title":"5.3 Broadening Science Education within Existing Structures","author":"Zimmerman","year":"2025"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0255","series-title":"The Spirit of Asilomar and the Future of Biotechnology","article-title":"5.4 Letter to our relatives, ancestors, and future generations: a call to establish Indigenous Biotechnology","author":"Flores","year":"2025"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0260","series-title":"The Spirit of Asilomar and the Future of Biotechnology","article-title":"5.5 The future of biotechnology: a show of good faith","author":"Camenares","year":"2025"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0265","series-title":"The Spirit of Asilomar and the Future of Biotechnology","article-title":"6.1 Establishing the Global Network for Organisms and Multi-disciplinary Exchange (GNOME)","author":"Seah","year":"2025"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0270","series-title":"The Spirit of Asilomar and the Future of Biotechnology","article-title":"6.2 Accessible Biotech Education","author":"Kiattisewee","year":"2025"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0275","series-title":"The Spirit of Asilomar and the Future of Biotechnology","article-title":"6.3 Community biology: advancing responsible biotech innovation","author":"Jannah","year":"2025"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0280","series-title":"The Spirit of Asilomar and the Future of Biotechnology","article-title":"6.4 A statement of shared stewardship (video)","author":"Lee","year":"2025"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0285","series-title":"The Spirit of Asilomar and the Future of Biotechnology","article-title":"6.5 Public engagement","author":"Lovell-Badge","year":"2025"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0290","series-title":"The Spirit of Asilomar and the Future of Biotechnology","article-title":"6.6 On Trust","author":"Kong","year":"2025"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0295","series-title":"The Spirit of Asilomar and the Future of Biotechnology","article-title":"6.7 NGL entreaty on access and equity","author":"Do Nascimento","year":"2025"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0300","series-title":"The Spirit of Asilomar and the Future of Biotechnology","article-title":"6.8 NGL reflection anthology","author":"Johnson","year":"2025"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0305","series-title":"The Spirit of Asilomar and the Future of Biotechnology","article-title":"6.9 NGL proposal for spirit of Asilomar fund","author":"Perez","year":"2025"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0310","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1146\/annurev-biochem-013118-110704","article-title":"Synthetic Genomes","volume":"89","author":"Zhang","year":"2020","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0315","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.cell.2025.12.034","article-title":"Mammalian genome writing: unlocking new length scales for genome engineering","volume":"189","author":"Pinglay","year":"2026","journal-title":"Cell"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0320","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1126\/science.aaf6850","article-title":"The Genome Project-Write","volume":"353","author":"Boeke","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0325","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1126\/science.adv9797","article-title":"High-fidelity human chromosome transfer and elimination","volume":"390","author":"Petris","year":"2025","journal-title":"Science"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0330","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/s41586-023-06957-x","article-title":"Genomic data in the All of Us Research Program","volume":"627","author":"Bick","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0335","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1021\/acs.estlett.0c00713","article-title":"Population-wide exposure to per- and polyfluoroalkyl substances from drinking water in the United States","volume":"7","author":"Andrews","year":"2020","journal-title":"Environ. Sci. Technol. Lett."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0340","doi-asserted-by":"crossref","first-page":"18795","DOI":"10.1021\/acs.est.4c14474","article-title":"The landscape of PFAS contamination in the United States: sources and spatial patterns","volume":"59","author":"Garrett","year":"2025","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0345","doi-asserted-by":"crossref","DOI":"10.1016\/j.copbio.2024.103170","article-title":"Bacterial degradation of perfluoroalkyl acids","volume":"88","author":"Smorada","year":"2024","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0350","first-page":"1","article-title":"Directive 2014\/52\/EU of the European Parliament and of the Council of 16 April 2014 amending Directive 2011\/92\/EU on the assessment of the effects of certain public and private projects on the environment (Text with EEA relevance)","volume":"124","author":"European Parliament and Council of the European Union","year":"2014","journal-title":"Off. J. Eur. Union"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0355","series-title":"Impact Assessment Act, S.C. 2019, c. 28, s. 1","author":"Consolidated federal laws of Canada","year":"2019"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0360","series-title":"Resource Management Act 1991 No 69 (as at 20 October 2025), Public Act Contents","author":"New Zealand Legislation","year":"1991"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0365","series-title":"Environment Protection and Biodiversity Conservation Act 1999 (EPBC Act) \u2013 DCCEEW","author":"Australian Government","year":"1999"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0370","unstructured":"Empresa de Pesquisa Energ\u00e9tica (EPE) Relat\u00f3rio de Impacto Ambiental (RIMA). Minist\u00e9rio de Minas e Energia, Brazil. https:\/\/www.epe.gov.br\/pt\/publicacoes-dados-abertos\/publicacoes\/relatorio-de-impacto-ambiental-rima"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0375","series-title":"Environmental Management and Co-ordination Act CAP 387","author":"Republic of Kenya","year":"2022"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0380","series-title":"The Coordinated Framework for the Regulation of Biotechnology","author":"Office of Science and Technology Policy","year":"1986"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0385","doi-asserted-by":"crossref","first-page":"249","DOI":"10.3391\/mbi.2013.4.3.07","article-title":"Unearthing the habitat of a hyperaccumulator: case study of the invasive plant yellowtuft (Alyssum; Brassicaceae) in Southwest Oregon, USA","volume":"4","author":"Strawn","year":"2013","journal-title":"Manag. Biol. Invasions"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0390","series-title":"Nickel in Soils and Plants","first-page":"341","article-title":"Phytoextraction and phytomining of soil nickel","author":"Chaney","year":"2018"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0395","series-title":"Nickel in Soils and Plants","author":"Tsadilas","year":"2018"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0400","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/s41589-018-0056-x","article-title":"Next-generation biocontainment systems for engineered organisms","volume":"14","author":"Lee","year":"2018","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0405","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0929-1393(98)00129-2","article-title":"Effects of Klebsiella planticola SDF20 on soil biota and wheat growth in sandy soil","volume":"11","author":"Holmes","year":"1999","journal-title":"Appl. Soil Ecol."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0410","article-title":"Federal Government and \u201copposition\u201d sign off on uncontrolled genetic experiment \u2013 facing barbarism","author":"Sales","year":"2020","journal-title":"Chain React."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0415","doi-asserted-by":"crossref","DOI":"10.4324\/9781351190237-5","article-title":"On ignorance and apocalypse: a brief introduction to \u2018epistemic accidents\u2019","author":"Downer","year":"2019","journal-title":"Saf. Sci. Res."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0420","first-page":"11","article-title":"Scientists take a close look at ice-minus","volume":"13","author":"Kibby","year":"1987","journal-title":"EPA J."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0425","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1038\/ismej.2015.42","article-title":"Volatile affairs in microbial interactions","volume":"9","author":"Schmidt","year":"2015","journal-title":"ISME J."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0430","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1146\/annurev.arplant.57.032905.105159","article-title":"The role of root exudates in rhizosphere interactions with plants and other organisms","volume":"57","author":"Bais","year":"2006","journal-title":"Annu. Rev. Plant Biol."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0435","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.scitotenv.2015.11.008","article-title":"Glyphosate effects on soil rhizosphere-associated bacterial communities","volume":"543","author":"Newman","year":"2016","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0440","doi-asserted-by":"crossref","first-page":"6379","DOI":"10.1038\/s41467-020-20122-2","article-title":"Synthetic biology 2020\u20132030: six commercially-available products that are changing our world","volume":"11","author":"Voigt","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0445","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.tibtech.2022.12.015","article-title":"Harnessing synthetic biology to enhance ocean health","volume":"41","author":"Nguyen","year":"2023","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0450","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1111\/1365-2435.12705","article-title":"Pathways to de-extinction: how close can we get to resurrection of an extinct species?","volume":"31","author":"Shapiro","year":"2017","journal-title":"Funct. Ecol."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0455","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1089\/hs.2022.0109","article-title":"Beyond biosecurity by taxonomic lists: lessons, challenges, and opportunities","volume":"21","author":"Millett","year":"2023","journal-title":"Health Secur."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0460","series-title":"OECD Harmonisation of Regulatory Oversight in Biotechnology","author":"Organisation for Economic Co-operation and Development","year":"1995"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0465","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/ajg.2013.407","article-title":"How drugs are developed and approved by the FDA: current process and future directions","volume":"109","author":"Ciociola","year":"2014","journal-title":"Off. J. Am. Coll. Gastroenterol. ACG"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0470","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/s41587-025-02650-8","article-title":"A call for built-in biosecurity safeguards for generative AI tools","volume":"43","author":"Wang","year":"2025","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0475","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/s42256-022-00465-9","article-title":"Dual use of artificial-intelligence-powered drug discovery","volume":"4","author":"Urbina","year":"2022","journal-title":"Nat. Mach. Intell."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0480","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0188453","article-title":"Construction of an infectious horsepox virus vaccine from chemically synthesized DNA fragments","volume":"13","author":"Noyce","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0485","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1126\/science.1119392","article-title":"Characterization of the reconstructed 1918 Spanish Influenza Pandemic Virus","volume":"310","author":"Tumpey","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0490","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2025.1537471","article-title":"Responsible AI in biotechnology: balancing discovery, innovation and biosecurity risks","volume":"13","author":"Wheeler","year":"2025","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0495","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1012975","article-title":"Dual-use capabilities of concern of biological AI models","volume":"21","author":"Pannu","year":"2025","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0500","series-title":"Convention on the Prohibition of the Development, Production and Stockpiling of Bacteriological (Biological) and Toxin Weapons and on Their Destruction","author":"United Nations","year":"1972"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0505","unstructured":"Marino, B.D.V. and Odum, H.T. Biosphere 2: Introduction and Research Progress, Elsevier"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0510","series-title":"Entomopathogenic Bacteria: From Laboratory to Field Application","first-page":"441","article-title":"Biotechnological improvement of Bacillus thuringiensis for agricultural control of insect pests: benefits and ecological implications","author":"Sanchis","year":"2000"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0515","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1126\/science.aba5584","article-title":"Barcoded microbial system for high-resolution object provenance","volume":"368","author":"Qian","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0520","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1126\/science.aax9039","article-title":"Engineered symbionts activate honey bee immunity and limit pathogens","volume":"367","author":"Leonard","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0525","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/nrg1870","article-title":"Gene drive systems for insect disease vectors","volume":"7","author":"Sinkins","year":"2006","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0530","series-title":"Opening Up \u201cContainment\u201d: Technological and Social Dimensions of Biocontainment for Genetically Engineered Organisms Designed for Deliberate Release","author":"George","year":"2025"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0535","doi-asserted-by":"crossref","DOI":"10.1016\/j.mib.2025.102685","article-title":"Emerging governance considerations for the deployment of genetically engineered microbes","volume":"89","author":"Brewer","year":"2026","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0540","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1093\/biosci\/biaf133","article-title":"Ten lessons for controlling invasive species: wisdom from the long-standing sea lamprey control program on the Laurentian Great Lakes","volume":"75","author":"Cooke","year":"2025","journal-title":"BioScience"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0545","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1021\/acs.chemrestox.6b00135","article-title":"ToxCast chemical landscape: paving the road to 21st century toxicology","volume":"29","author":"Richard","year":"2016","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0550","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0166-1280(02)00614-0","article-title":"Quantitative structure\u2013activity relationships (QSARs) in toxicology: a historical perspective","volume":"622","author":"Schultz","year":"2003","journal-title":"J. Mol. Struct. THEOCHEM"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0555","doi-asserted-by":"crossref","DOI":"10.1016\/j.buildenv.2025.112748","article-title":"What is a Digital Twin anyway? Deriving the definition for the built environment from over 15,000 scientific publications","volume":"274","author":"Abdelrahman","year":"2025","journal-title":"Build. Environ."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0560","doi-asserted-by":"crossref","DOI":"10.1016\/j.compag.2020.105942","article-title":"Introducing digital twins to agriculture","volume":"184","author":"Pylianidis","year":"2021","journal-title":"Comput. Electron. Agric."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0565","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s10916-020-01623-5","article-title":"On the integration of agents and digital twins in healthcare","volume":"44","author":"Croatti","year":"2020","journal-title":"J. Med. Syst."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0570","doi-asserted-by":"crossref","first-page":"7045","DOI":"10.1016\/j.cell.2024.11.015","article-title":"How to build the virtual cell with artificial intelligence: priorities and opportunities","volume":"187","author":"Bunne","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0575","series-title":"Export Administration Regulations (EAR) 15 CFR Chapter VII Subchapter C","author":"U.S. Department of Commerce, Bureau of Industry and Security","year":"2025"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0580","unstructured":"U.S. Department of State. International Traffic in Arms Regulations (ITAR), 22 C.F.R. Parts 120\u2013130, Office of the Federal Register"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0585","series-title":"The Wassenaar Arrangement on Export Controls for Conventional Arms and Dual-Use Goods and Technologies","author":"The Wassenaar Arrangement","year":"1996"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0590","series-title":"Nagoya Protocol on Access to Genetic Resources and the Fair and Equitable Sharing of Benefits Arising from Their Utilization to the Convention on Biological Diversity","author":"United Nations Treaty Collection","year":"2010"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0595","first-page":"94","article-title":"Clinical genomics, big data, and electronic medical records: reconciling patient rights with research when privacy and science collide","volume":"4","author":"Kulynych","year":"2017","journal-title":"J. Law Biosci."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0600","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1126\/science.aau4832","article-title":"Identity inference of genomic data using long-range familial searches","volume":"362","author":"Erlich","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0605","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0610","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1038\/s41467-018-05378-z","article-title":"Deep learning to predict the lab-of-origin of engineered DNA","volume":"9","author":"Nielsen","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0615","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/s41580-023-00686-9","article-title":"Present and future of synthetic cell development","volume":"25","author":"Adamala","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0620","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1126\/science.ads9158","article-title":"Confronting risks of mirror life","volume":"386","author":"Adamala","year":"2024","journal-title":"Science"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0625","series-title":"Request for Information on Plant Genetic Engineering for Energy Applications","author":"U.S. Department of Energy and Advanced Research Projects Agency-Energy (ARPA-E) DE-FOA-0003470","year":"2024"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0630","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1038\/s41467-019-10079-2","article-title":"Building a global alliance of biofoundries","volume":"10","author":"Hillson","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0635","doi-asserted-by":"crossref","first-page":"4302","DOI":"10.1021\/jacs.7b13292","article-title":"A pressure test to make 10 molecules in 90 days: external evaluation of methods to engineer biology","volume":"140","author":"Casini","year":"2018","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0640","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1754-1611-7-13","article-title":"A survey of enabling technologies in synthetic biology","volume":"7","author":"Kahl","year":"2013","journal-title":"J. Biol. Eng."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0645","series-title":"Innovating Genomics to Serve the Changing Planet: 5-Year Strategic Plan, US Department of Energy Joint Genome Institute","author":"U.S. Department of Energy Joint Genome Institute","year":"2024"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0650","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1080\/09505431.2014.986320","article-title":"The construction of imaginaries of the public as a threat to synthetic biology","volume":"24","author":"Marris","year":"2015","journal-title":"Sci. Cult."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0655","series-title":"The Feeling of Risk","first-page":"285","article-title":"Expert and public perception of risk from biotechnology","author":"Savadori","year":"2010"},{"key":"10.1016\/j.tibtech.2026.07.001_bb0660","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.3389\/fpls.2016.01121","article-title":"Striga biocontrol on a toothpick: a readily deployable and inexpensive method for smallholder farmers","volume":"7","author":"Nzioki","year":"2016","journal-title":"Front. Plant Sci."},{"key":"10.1016\/j.tibtech.2026.07.001_bb0665","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.03401","article-title":"Concerning RNA-guided gene drives for the alteration of wild populations","volume":"3","author":"Esvelt","year":"2014","journal-title":"Elife"}],"container-title":["Trends in Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167779926002805?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167779926002805?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T14:26:55Z","timestamp":1786026415000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167779926002805"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":133,"alternative-id":["S0167779926002805"],"URL":"https:\/\/doi.org\/10.1016\/j.tibtech.2026.07.001","relation":{},"ISSN":["0167-7799"],"issn-type":[{"value":"0167-7799","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Responsible biotechnology: an analysis of the Asilomar 2025 entreaties","name":"articletitle","label":"Article Title"},{"value":"Trends in Biotechnology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tibtech.2026.07.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}