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Soc."},{"key":"10.1016\/j.tibtech.2026.07.002_bb0625","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202101844","article-title":"Engineering DNA nanostructures to manipulate immune receptor signaling and immune cell fates","volume":"11","author":"Tseng","year":"2022","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.tibtech.2026.07.002_bb0630","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1021\/acscentsci.9b00174","article-title":"Uptake and fate of fluorescently labeled DNA nanostructures in cellular environments: a cautionary tale","volume":"5","author":"Lacroix","year":"2019","journal-title":"ACS Cent. 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