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Neurosurg."},{"key":"10.1016\/j.tibtech.2026.09.014_bb0395","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s11910-015-0545-1","article-title":"Glutamate and GABA imbalance following traumatic brain injury","volume":"15","author":"Guerriero","year":"2015","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"10.1016\/j.tibtech.2026.09.014_bb0400","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/sj.jcbfm.9600073","article-title":"Metabolic crisis without brain ischemia is common after traumatic brain injury: a combined microdialysis and positron emission tomography study","volume":"25","author":"Vespa","year":"2005","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.tibtech.2026.09.014_bb0405","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1093\/brain\/aws322","article-title":"Inflammation and white matter degeneration persist for years after a single traumatic brain injury","volume":"136","author":"Johnson","year":"2013","journal-title":"Brain"},{"key":"10.1016\/j.tibtech.2026.09.014_bb0410","doi-asserted-by":"crossref","DOI":"10.1126\/science.aal3222","article-title":"An environment-dependent transcriptional network specifies human microglia identity","volume":"356","author":"Gosselin","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.tibtech.2026.09.014_bb0415","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.neuron.2019.06.002","article-title":"Cerebral microvascular injury: a potentially treatable endophenotype of traumatic brain injury-induced neurodegeneration","volume":"103","author":"Sandsmark","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.tibtech.2026.09.014_bb0420","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/s40478-022-01413-9","article-title":"Neuropathology in chronic traumatic encephalopathy: a systematic review of comparative post-mortem histology literature","volume":"10","author":"Murray","year":"2022","journal-title":"Acta Neuropathol. 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