{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T06:47:30Z","timestamp":1792392450944,"version":"4.4.0"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100011733","name":"Portuguese League Against Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011733","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010434","name":"Caixabank SA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010434","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Foundation for Science and Technology","doi-asserted-by":"publisher","award":["2022.05237.PTDC"],"award-info":[{"award-number":["2022.05237.PTDC"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Biotechnology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.tibtech.2026.09.023","type":"journal-article","created":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T12:21:12Z","timestamp":1792239672000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Microbes as a programmable toolbox for cancer diagnosis, monitoring, and theranostics"],"prefix":"10.1016","author":[{"given":"Isabel","family":"Calejo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael F.","family":"Canadas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tibtech.2026.09.023_bb0005","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/nature06917","article-title":"Imaging in the era of molecular oncology","volume":"452","author":"Weissleder","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.tibtech.2026.09.023_bb0010","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/nature12626","article-title":"Influence of tumour micro-environment heterogeneity on therapeutic response","volume":"501","author":"Junttila","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.tibtech.2026.09.023_bb0015","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/nrmicro.2017.172","article-title":"Engineering bacteria for diagnostic and therapeutic applications","volume":"16","author":"Riglar","year":"2018","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.tibtech.2026.09.023_bb0020","doi-asserted-by":"crossref","first-page":"14429","DOI":"10.1073\/pnas.1508521112","article-title":"Synthetic biology devices for in vitro and in vivo diagnostics","volume":"112","author":"Slomovic","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tibtech.2026.09.023_bb0025","doi-asserted-by":"crossref","first-page":"714","DOI":"10.3390\/biom10050714","article-title":"Phage display selection, identification, and characterization of novel pancreatic cancer targeting peptides","volume":"10","author":"Asar","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.tibtech.2026.09.023_bb0030","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-16066-1","article-title":"Yeast display biopanning identifies human antibodies targeting glioblastoma stem-like cells","volume":"7","author":"Zorniak","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tibtech.2026.09.023_bb0035","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaa3519","article-title":"Programmable probiotics for detection of cancer in urine","volume":"7","author":"Danino","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.tibtech.2026.09.023_bb0040","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1126\/science.adf3974","article-title":"Engineered bacteria detect tumor DNA","volume":"381","author":"Cooper","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.tibtech.2026.09.023_bb0045","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1038\/mt.2008.172","article-title":"Phase I study of noninvasive imaging of adenovirus-mediated gene expression in the human prostate","volume":"16","author":"Barton","year":"2008","journal-title":"Mol. Ther."},{"key":"10.1016\/j.tibtech.2026.09.023_bb0050","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2025.1565244","article-title":"hNIS-based imaging to monitor treatment with the novel oncolytic virus CF33-hNIS-antiPDL1 in humans with advanced triple negative breast cancer","volume":"15","author":"Rand","year":"2025","journal-title":"Front. Oncol."},{"key":"10.1016\/j.tibtech.2026.09.023_bb0055","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02248-18","article-title":"Diagnostic potential and interactive dynamics of the colorectal cancer virome","volume":"9","author":"Hannigan","year":"2018","journal-title":"mBio"},{"key":"10.1016\/j.tibtech.2026.09.023_bb0060","article-title":"Circulating microbiome DNA as biomarkers for early diagnosis and recurrence of lung cancer","volume":"5","author":"Chen","year":"2024","journal-title":"Cell. Rep. Med."},{"key":"10.1016\/j.tibtech.2026.09.023_bb0065","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1126\/science.4001944","article-title":"Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface","volume":"228","author":"Smith","year":"1985","journal-title":"Science"},{"key":"10.1016\/j.tibtech.2026.09.023_bb0070","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1126\/science.1696028","article-title":"Searching for peptide ligands with an epitope library","volume":"249","author":"Scott","year":"1990","journal-title":"Science"},{"key":"10.1016\/j.tibtech.2026.09.023_bb0075","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nbt0697-553","article-title":"Yeast surface display for screening combinatorial polypeptide libraries","volume":"15","author":"Boder","year":"1997","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.tibtech.2026.09.023_bb0080","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/nprot.2006.94","article-title":"Isolating and engineering human antibodies using yeast surface display","volume":"1","author":"Chao","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.tibtech.2026.09.023_bb0085","doi-asserted-by":"crossref","first-page":"7473","DOI":"10.1038\/s41467-023-43038-z","article-title":"Simultaneous selection of nanobodies for accessible epitopes on immune cells in the tumor microenvironment","volume":"14","author":"Sekar","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tibtech.2026.09.023_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2023.109721","article-title":"Differential pulse voltammetric immunosensor for direct and label-free detection of VEGF using variable domain of heavy-chain antibody displaying phage","volume":"197","author":"Rezaei","year":"2024","journal-title":"Microchem. J."},{"key":"10.1016\/j.tibtech.2026.09.023_bb0095","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1158\/0008-5472.CAN-08-2495","article-title":"Engineered knottin peptides: a new class of agents for imaging integrin expression in living subjects","volume":"69","author":"Kimura","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.tibtech.2026.09.023_bb0100","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1074\/mcp.M600246-MCP200","article-title":"Identification of clinically significant tumor antigens by selecting phage antibody library on tumor cells in situ using laser capture microdissection","volume":"5","author":"Ruan","year":"2006","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.tibtech.2026.09.023_bb0105","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/s41587-022-01567-w","article-title":"Facile repurposing of peptide\u2013MHC-restricted antibodies for cancer immunotherapy","volume":"41","author":"Yang","year":"2023","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.tibtech.2026.09.023_bb0110","article-title":"Protocol for design, construction, and selection of genome phage (gPhage) display libraries","volume":"2","author":"Carnero","year":"2021","journal-title":"STAR Protoc."},{"key":"10.1016\/j.tibtech.2026.09.023_bb0115","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1016\/j.chembiol.2024.09.010","article-title":"The liquid lectin array detects compositional glycocalyx differences using multivalent DNA-encoded lectins on phage","volume":"31","author":"Lima","year":"2024","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.tibtech.2026.09.023_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2024.111661","article-title":"Phage display\u2013based acoustic biosensor for early cancer diagnosis","volume":"207","author":"Guliy","year":"2024","journal-title":"Microchem. J."},{"key":"10.1016\/j.tibtech.2026.09.023_bb0125","doi-asserted-by":"crossref","first-page":"4733","DOI":"10.1038\/s41467-026-71174-9","article-title":"Whole-proteome phage immunoprecipitation sequencing reveals germ cell tumor\u2013specific immunosignature","volume":"17","author":"Hammami","year":"2026","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tibtech.2026.09.023_bb0130","doi-asserted-by":"crossref","first-page":"E7","DOI":"10.1371\/journal.pbio.0020007","article-title":"Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds","volume":"2","author":"Chang","year":"2004","journal-title":"PLoS Biol."},{"key":"10.1016\/j.tibtech.2026.09.023_bb0135","doi-asserted-by":"crossref","first-page":"e308","DOI":"10.1038\/emm.2017.22","article-title":"Next-generation sequencing enables the discovery of more diverse positive clones from a phage-displayed antibody library","volume":"49","author":"Yang","year":"2017","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.tibtech.2026.09.023_bb0140","doi-asserted-by":"crossref","first-page":"2780","DOI":"10.1200\/JCO.2014.58.3377","article-title":"Talimogene laherparepvec improves durable response rate in patients with advanced melanoma","volume":"33","author":"Andtbacka","year":"2015","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.tibtech.2026.09.023_bb0145","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.mayocp.2014.04.003","article-title":"Remission of disseminated cancer after systemic oncolytic virotherapy","volume":"89","author":"Russell","year":"2014","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.tibtech.2026.09.023_bb0150","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1158\/0008-5472.CAN-14-2533","article-title":"Oncolytic measles virus expressing the sodium iodide symporter to treat drug-resistant ovarian cancer","volume":"75","author":"Galanis","year":"2015","journal-title":"Cancer Res."},{"key":"10.1016\/j.tibtech.2026.09.023_bb0155","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1038\/leu.2017.120","article-title":"Phase I trial of systemic administration of Edmonston strain of measles virus genetically engineered to express the sodium iodide symporter in patients with recurrent or refractory multiple myeloma","volume":"31","author":"Dispenzieri","year":"2017","journal-title":"Leukemia"},{"key":"10.1016\/j.tibtech.2026.09.023_bb0160","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.surg.2014.09.008","article-title":"Gene therapy using therapeutic and diagnostic recombinant oncolytic vaccinia virus GLV-1h153 for management of colorectal peritoneal carcinomatosis","volume":"157","author":"Eveno","year":"2015","journal-title":"Surgery"},{"key":"10.1016\/j.tibtech.2026.09.023_bb0165","doi-asserted-by":"crossref","first-page":"3316","DOI":"10.1073\/pnas.1216916110","article-title":"Vaccinia virus-mediated melanin production allows MR and optoacoustic deep tissue imaging and laser-induced thermotherapy of cancer","volume":"110","author":"Stritzker","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tibtech.2026.09.023_bb0170","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.7150\/thno.12533","article-title":"Doxycycline inducible melanogenic vaccinia virus as theranostic anti-cancer agent","volume":"5","author":"Kirscher","year":"2015","journal-title":"Theranostics"},{"key":"10.1016\/j.tibtech.2026.09.023_bb0175","doi-asserted-by":"crossref","first-page":"828","DOI":"10.3390\/v15040828","article-title":"Oncolytic efficacy of a recombinant vaccinia virus strain expressing bacterial flagellin in solid tumor models","volume":"15","author":"Shakiba","year":"2023","journal-title":"Viruses"},{"key":"10.1016\/j.tibtech.2026.09.023_bb0180","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202304136","article-title":"Engineered luminescent oncolytic vaccinia virus activation of photodynamic-immune combination therapy for colorectal cancer","volume":"13","author":"Ye","year":"2024","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.tibtech.2026.09.023_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.jviromet.2022.114574","article-title":"Development of an oncolytic mammalian orthoreovirus expressing the near-infrared fluorescent protein iRFP720","volume":"308","author":"Ogawa","year":"2022","journal-title":"J. Virol. Methods"},{"key":"10.1016\/j.tibtech.2026.09.023_bb0190","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.jcis.2024.05.175","article-title":"Platelet membrane-coated oncolytic vaccinia virus with indocyanine green for the second near-infrared imaging guided multi-modal therapy of colorectal cancer","volume":"671","author":"Huang","year":"2024","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.tibtech.2026.09.023_bb0195","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.omto.2021.12.022","article-title":"PET imaging and treatment of pancreatic cancer peritoneal carcinomatosis after subcutaneous intratumoral administration of a novel oncolytic virus, CF33-hNIS-antiPDL1","volume":"24","author":"Zhang","year":"2022","journal-title":"Mol. Ther. Oncolytics"},{"key":"10.1016\/j.tibtech.2026.09.023_bb0200","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/s41467-024-44776-4","article-title":"Engineering tumor-colonizing E. coli Nissle 1917 for detection and treatment of colorectal neoplasia","volume":"15","author":"Gurbatri","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tibtech.2026.09.023_bb0205","doi-asserted-by":"crossref","first-page":"5216","DOI":"10.1038\/s41467-021-25538-y","article-title":"Programmable receptors enable bacterial biosensors to detect pathological biomarkers in clinical samples","volume":"12","author":"Chang","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tibtech.2026.09.023_bb0210","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41522-024-00479-8","article-title":"Enhancing tumor-specific recognition of programmable synthetic bacterial consortium for precision therapy of colorectal cancer","volume":"10","author":"Zhou","year":"2024","journal-title":"NPJ Biofilms Microbiomes"},{"key":"10.1016\/j.tibtech.2026.09.023_bb0215","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2024.1437301","article-title":"Engineering bacterial theranostics: from logic gates to in vivo applications","volume":"12","author":"Armstrong","year":"2024","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.tibtech.2026.09.023_bb0220","doi-asserted-by":"crossref","DOI":"10.1128\/aem.02363-23","article-title":"Long-duration environmental biosensing by recording analyte detection in DNA using recombinase memory","volume":"90","author":"Kalvapalle","year":"2024","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.tibtech.2026.09.023_bb0225","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1038\/s41467-024-46755-1","article-title":"Engineering intelligent chassis cells via recombinase-based MEMORY circuits","volume":"15","author":"Huang","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tibtech.2026.09.023_bb0230","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nature18930","article-title":"Synchronized cycles of bacterial lysis for in vivo delivery","volume":"536","author":"Din","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.tibtech.2026.09.023_bb0235","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aax0876","article-title":"Engineered probiotics for local tumor delivery of checkpoint blockade nanobodies","volume":"12","author":"Gurbatri","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.tibtech.2026.09.023_bb0240","doi-asserted-by":"crossref","first-page":"15687","DOI":"10.1021\/acs.analchem.1c03568","article-title":"Bacteria-based live vehicle for in vivo bioluminescence imaging","volume":"93","author":"Jiang","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.tibtech.2026.09.023_bb0245","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-04047-4","article-title":"Reporter gene-based optoacoustic imaging of E. coli targeted colon cancer in vivo","volume":"11","author":"Yun","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tibtech.2026.09.023_bb0250","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/nature25021","article-title":"Acoustic reporter genes for noninvasive imaging of microorganisms in mammalian hosts","volume":"553","author":"Bourdeau","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.tibtech.2026.09.023_bb0255","article-title":"Ultrasound-visible engineered bacteria for tumor chemo-immunotherapy","volume":"5","author":"Yang","year":"2024","journal-title":"Cell. Rep. Med."},{"key":"10.1016\/j.tibtech.2026.09.023_bb0260","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202305764","article-title":"Image-guided photothermal and immune therapy of tumors via melanin-producing genetically engineered bacteria","volume":"20","author":"Song","year":"2024","journal-title":"Small"},{"key":"10.1016\/j.tibtech.2026.09.023_bb0265","doi-asserted-by":"crossref","first-page":"5945","DOI":"10.7150\/thno.98257","article-title":"Enhancing photothermal therapy of tumors with image-guided thermal control of gene-expressing bacteria","volume":"14","author":"Zeng","year":"2024","journal-title":"Theranostics"},{"key":"10.1016\/j.tibtech.2026.09.023_bb0270","doi-asserted-by":"crossref","first-page":"46351","DOI":"10.1021\/acsami.2c14633","article-title":"Upconversion optogenetic engineered bacteria system for time-resolved imaging diagnosis and light-controlled cancer therapy","volume":"14","author":"Zhang","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.tibtech.2026.09.023_bb0275","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s13036-023-00379-z","article-title":"Engineered live bacteria as disease detection and diagnosis tools","volume":"17","author":"Tanniche","year":"2023","journal-title":"J. Biol. Eng."},{"key":"10.1016\/j.tibtech.2026.09.023_bb0280","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/s41586-024-07656-x","article-title":"Retraction note: microbiome analyses of blood and tissues suggest cancer diagnostic approach","volume":"631","author":"Poore","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.tibtech.2026.09.023_bb0285","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.01607-23","article-title":"Major data analysis errors invalidate cancer microbiome findings","volume":"14","author":"Gihawi","year":"2023","journal-title":"mBio"},{"key":"10.1016\/j.tibtech.2026.09.023_bb0290","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1136\/gutjnl-2021-324755","article-title":"A faecal microbiota signature with high specificity for pancreatic cancer","volume":"71","author":"Kartal","year":"2022","journal-title":"Gut"},{"key":"10.1016\/j.tibtech.2026.09.023_bb0295","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1038\/s41591-025-03693-9","article-title":"Pooled analysis of 3,741 stool metagenomes from 18 cohorts for cross-stage and strain-level reproducible microbial biomarkers of colorectal cancer","volume":"31","author":"Piccinno","year":"2025","journal-title":"Nat. Med."},{"key":"10.1016\/j.tibtech.2026.09.023_bb0300","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1038\/s41591-024-02963-2","article-title":"Microbiome confounders and quantitative profiling challenge predicted microbial targets in colorectal cancer development","volume":"30","author":"Tito","year":"2024","journal-title":"Nat. Med."},{"key":"10.1016\/j.tibtech.2026.09.023_bb0305","doi-asserted-by":"crossref","first-page":"8943","DOI":"10.1073\/pnas.1014501108","article-title":"Deep-tissue anatomical imaging of mice using carbon nanotube fluorophores in the second near-infrared window","volume":"108","author":"Welsher","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tibtech.2026.09.023_bb0310","doi-asserted-by":"crossref","DOI":"10.1111\/1751-7915.14474","article-title":"Bacterial imaging in tumour diagnosis","volume":"17","author":"Chu","year":"2024","journal-title":"Microb. Biotechnol."},{"key":"10.1016\/j.tibtech.2026.09.023_bb0315","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1038\/s41467-020-15508-1","article-title":"Developing a new class of engineered live bacterial therapeutics to treat human diseases","volume":"11","author":"Charbonneau","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tibtech.2026.09.023_bb0320","series-title":"Early Clinical Trials with Live Biotherapeutic Products: Chemistry, Manufacturing, and Control Information. Guidance for Industry","author":"U.S. Food and Drug Administration (FDA)","year":"2016"},{"key":"10.1016\/j.tibtech.2026.09.023_bb0325","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/s43018-026-01121-6","article-title":"Setting higher standards for reports of microbial species in human cancers","volume":"7","author":"Salzberg","year":"2026","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.tibtech.2026.09.023_bb0330","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.tibtech.2018.09.005","article-title":"Engineering microbial living therapeutics: the synthetic biology toolbox","volume":"37","author":"Pedrolli","year":"2019","journal-title":"Trends Biotechnol."}],"container-title":["Trends in Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167779926004178?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167779926004178?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T06:33:34Z","timestamp":1792391614000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167779926004178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":66,"alternative-id":["S0167779926004178"],"URL":"https:\/\/doi.org\/10.1016\/j.tibtech.2026.09.023","relation":{},"ISSN":["0167-7799"],"issn-type":[{"value":"0167-7799","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microbes as a programmable toolbox for cancer diagnosis, monitoring, and theranostics","name":"articletitle","label":"Article Title"},{"value":"Trends in Biotechnology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tibtech.2026.09.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}