{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:11:02Z","timestamp":1786997462845,"version":"build-2736575974"},"reference-count":36,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Faculty of Medicine, Cairo University"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.tice.2016.09.006","type":"journal-article","created":{"date-parts":[[2016,9,30]],"date-time":"2016-09-30T09:58:48Z","timestamp":1475229528000},"page":"644-652","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Combined effect of bone marrow derived mesenchymal stem cells and nitric oxide inducer on injured gastric mucosa in a rat model"],"prefix":"10.1016","volume":"48","author":[{"given":"Laila","family":"Rashed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doaa Mostafa","family":"Gharib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rania Elsayed","family":"Hussein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ola","family":"Tork","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azza","family":"Abusree","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tice.2016.09.006_bib0005","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1089\/scd.2004.13.436","article-title":"Mesenchymal stem cells, isolation and therapeutics","volume":"13","author":"Alhadlaq","year":"2004","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.tice.2016.09.006_bib0010","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/1479-5876-10-75","article-title":"Khan SN.Nitric oxide augments mesenchymal stem cell ability to repair liver fibrosis","volume":"10","author":"Ali","year":"2012","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.tice.2016.09.006_bib0015","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s10517-009-0360-2","article-title":"Effects of autologous bone marrow cells on apoptosis and regeneration of non-healing autoimmune gastric ulcers","volume":"146","author":"Askarov","year":"2008","journal-title":"Bull. Exp. Biol. Med."},{"key":"10.1016\/j.tice.2016.09.006_bib0020","series-title":"Theory and Practice of Histological Techniques","author":"Banchroft","year":"1996"},{"key":"10.1016\/j.tice.2016.09.006_bib0025","first-page":"1169","article-title":"In vivo transplantation of bone marrow mesenchymal stem cells accelerates repair of injured gastric mucosa in rats","volume":"125","author":"Chang","year":"2012","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.tice.2016.09.006_bib0030","first-page":"316","article-title":"Cytoprotective effect of American ginseng in a rat ethanol gastric ulcer model","volume":"19","author":"Chi-Chang","year":"2014","journal-title":"Molecules"},{"key":"10.1016\/j.tice.2016.09.006_bib0035","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1084\/jem.185.4.601","article-title":"Suppression of apoptosis by nitric oxide via inhibition of interleukin-1beta-converting enzyme (ICE)-like and cysteine protease protein (CPP)-32-like proteases","volume":"185","author":"Dimmeler","year":"1997","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.tice.2016.09.006_bib0040","first-page":"276","article-title":"Gad MZ.The potential therapeutic effect of nitric oxide modulators in experimentally-induced gastric ulcers","volume":"4","author":"El-Demerdash","year":"2010","journal-title":"Drug Discov Ther."},{"issue":"3","key":"10.1016\/j.tice.2016.09.006_bib0045","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s10238-013-0248-3","article-title":"Mesenchymal stromal cells versus betamethasone can dampen disease activity in the collagen arthritis mouse model","volume":"14","author":"El-Denshary","year":"2014","journal-title":"Clin. Exp. Med."},{"key":"10.1016\/j.tice.2016.09.006_bib0050","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1172\/JCI117869","article-title":"Splenic B lymphocyte programmed cell death is prevented by nitric oxide release through mechanisms involving sustained Bcl-2 levels","volume":"95","author":"Genaro","year":"1995","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.tice.2016.09.006_bib0055","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/scrt2","article-title":"Immunosuppression by mesenchymal stem cells: mechanisms and clinical applications","volume":"1","author":"Ghannam","year":"2010","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.tice.2016.09.006_bib0060","doi-asserted-by":"crossref","first-page":"8733","DOI":"10.1038\/srep08733","article-title":"Mesenchymal stem cells alleviate airway inflammation and emphysema in COPD through down-regulation of cyclooxygenase-2 via p38 and ERK MAPK pathways","volume":"5","author":"Gu","year":"2015","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.tice.2016.09.006_bib0065","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.3892\/ijmm.2013.1340","article-title":"Allogeneic bone marrow-derived mesenchymal stem cells attenuate hepatic ischemia-reperfusion injury by suppressing oxidative stress and inhibiting apoptosis in rats","volume":"31","author":"Guangxin","year":"2013","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.tice.2016.09.006_bib0070","doi-asserted-by":"crossref","first-page":"203","DOI":"10.2174\/0929867053363478","article-title":"Gastric mucosal protection: from prostaglandins to gene-therapy","volume":"12","author":"Gyires","year":"2005","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.tice.2016.09.006_bib0075","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.tox.2004.06.059","article-title":"Involvement of nitric oxide in gastric protection of epinephrine in endotoxin intoxication in rats","volume":"204","author":"Hsu","year":"2004","journal-title":"Toxicology"},{"key":"10.1016\/j.tice.2016.09.006_bib0080","first-page":"433","article-title":"Gastroprotective effect of Cordia myxa L. fruit extract against indomethacin-induced gastric ulceration in rats","volume":"8","author":"Inas","year":"2011","journal-title":"Life Sci. J."},{"key":"10.1016\/j.tice.2016.09.006_bib0085","first-page":"5","article-title":"Regenerative medicine and cell therapy","volume":"24","author":"Jacobo","year":"2013","journal-title":"Stem Cell Biol. Regener. Med."},{"key":"10.1016\/j.tice.2016.09.006_bib0090","doi-asserted-by":"crossref","first-page":"4925","DOI":"10.1158\/1078-0432.CCR-08-3076","article-title":"Targeting rat brainstem glioma using human neural stem cells and human mesenchymal stem cells","volume":"15","author":"Lee","year":"2009","journal-title":"Clin. Cancer Res."},{"issue":"2","key":"10.1016\/j.tice.2016.09.006_bib0095","doi-asserted-by":"crossref","first-page":"e158","DOI":"10.1002\/bjs.9724","article-title":"Effect of local injection of mesenchymal stem cells on healing of sutured gastric perforation in an experimental model","volume":"102","author":"Liu","year":"2015","journal-title":"Br. J. Surg"},{"key":"10.1016\/j.tice.2016.09.006_bib0100","doi-asserted-by":"crossref","first-page":"G341","DOI":"10.1152\/ajpgi.2000.279.2.G341","article-title":"Endothelial nitric oxide synthase modulates gastric ulcer healing in rats","volume":"279","author":"Ma","year":"2000","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.tice.2016.09.006_bib0105","first-page":"5","article-title":"Protective role of Nitric Oxide in Indomethacin induced gastric ulceration by a mechanism independent of gastric acid secretion","volume":"43","author":"Mahmoud","year":"2001","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.tice.2016.09.006_bib0110","doi-asserted-by":"crossref","first-page":"24125","DOI":"10.1074\/jbc.272.39.24125","article-title":"Nitric oxide inhibits Fas-induced apoptosis","volume":"272","author":"Mannick","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tice.2016.09.006_bib0115","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1006\/bbrc.1997.7304","article-title":"Inhibition of caspase-3 by S-nitrosation and oxidation caused by nitric oxide","volume":"238","author":"Mohr","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tice.2016.09.006_bib0120","doi-asserted-by":"crossref","first-page":"G718","DOI":"10.1152\/ajpgi.00435.2006","article-title":"Dietary nitrate increases gastric mucosal blood flow and mucosal defense","volume":"292","author":"Petersson","year":"2007","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.tice.2016.09.006_bib0125","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/mt.2011.211","article-title":"Mesenchymal stem\/stromal cells (MSCs): role as guardians of inflammation","volume":"20","author":"Prockop","year":"2012","journal-title":"Mol. Ther."},{"key":"10.1016\/j.tice.2016.09.006_bib0130","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/sj.bjp.0706361","article-title":"Sildenafil prevents indomethacin-induced gastropathy in rats: role of leukocyte adherence and gastric blood flow","volume":"146","author":"Santos","year":"2005","journal-title":"Br. J. Pharmacol."},{"issue":"8","key":"10.1016\/j.tice.2016.09.006_bib0135","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1007\/s11626-011-9424-5","article-title":"PKH26 as a fluorescent label for live human umbilical mesenchymal stem cells","volume":"47","author":"Shao-Fang","year":"2011","journal-title":"In Vitro Cell. Dev. Biol. Anim."},{"key":"10.1016\/j.tice.2016.09.006_bib0140","first-page":"229","article-title":"Effect of melatonin and beta-carotene on indomethacin induced gastric mucosal injury","volume":"46","author":"Singh","year":"2002","journal-title":"Indian J. Physiol Pharmacol."},{"key":"10.1016\/j.tice.2016.09.006_bib0145","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1472-8206.2004.00203.x","article-title":"Trends in peptic ulcer pharmacotherapy","volume":"18","author":"Sivri","year":"2004","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.tice.2016.09.006_bib0150","series-title":"Gastrointestinal and Liver Disease Pathophysiology\/Diagnosis\/Management","first-page":"747","article-title":"Peptic ulcer disease and its complications","author":"Spechler","year":"2002"},{"issue":"1","key":"10.1016\/j.tice.2016.09.006_bib0155","first-page":"90","article-title":"The impact of asymmetric dimethylarginine (ADAMA), the endogenous nitric oxide (NO) synthase inhibitor, to the pathogenesis of gastric mucosal damage","volume":"19","author":"Szlachcic","year":"2013","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.tice.2016.09.006_bib0160","doi-asserted-by":"crossref","first-page":"5026","DOI":"10.1074\/jbc.M109.032672","article-title":"Growth factor regulation of prostaglandin-endoperoxide synthase 2 (Ptgs2) expression in colonic mesenchymal stem cells","volume":"285","author":"Walker","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tice.2016.09.006_bib0165","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1096\/fasebj.10.7.8635690","article-title":"The cellular and molecular basis of gastric mucosal defense","volume":"10","author":"Wallace","year":"1996","journal-title":"FASEB J."},{"key":"10.1016\/j.tice.2016.09.006_bib0170","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1053\/gast.2000.9304","article-title":"Nitric oxide in mucosal defense: a little goes a long way","volume":"119","author":"Wallace","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1016\/j.tice.2016.09.006_bib0175","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1152\/ajpgi.00468.2007","article-title":"Sunao Kawano Topical transplantation of mesenchymal stem cells accelerates gastric ulcer healing in rats","volume":"294","author":"Yujiro","year":"2008","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.tice.2016.09.006_bib0180","doi-asserted-by":"crossref","first-page":"e30684","DOI":"10.1371\/journal.pone.0030684","article-title":"Suppression of p75 neurotrophin receptor surface expression with intrabodies influences Bcl-xL mRNA expression and neurite outgrowth in PC12Cells","volume":"7","author":"Zhang","year":"2012","journal-title":"PLoS One"}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816616301276?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816616301276?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T20:14:34Z","timestamp":1758572074000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816616301276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S0040816616301276"],"URL":"https:\/\/doi.org\/10.1016\/j.tice.2016.09.006","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Combined effect of bone marrow derived mesenchymal stem cells and nitric oxide inducer on injured gastric mucosa in a rat model","name":"articletitle","label":"Article Title"},{"value":"Tissue and Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tice.2016.09.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}